18,588,709 research outputs found
Measurement of the Bottom-Strange Meson Mixing Phase in the Full CDF Data Set
We report a measurement of the bottom-strange meson mixing phase \beta_s
using the time evolution of B0_s -> J/\psi (->\mu+\mu-) \phi (-> K+ K-) decays
in which the quark-flavor content of the bottom-strange meson is identified at
production. This measurement uses the full data set of proton-antiproton
collisions at sqrt(s)= 1.96 TeV collected by the Collider Detector experiment
at the Fermilab Tevatron, corresponding to 9.6 fb-1 of integrated luminosity.
We report confidence regions in the two-dimensional space of \beta_s and the
B0_s decay-width difference \Delta\Gamma_s, and measure \beta_s in [-\pi/2,
-1.51] U [-0.06, 0.30] U [1.26, \pi/2] at the 68% confidence level, in
agreement with the standard model expectation. Assuming the standard model
value of \beta_s, we also determine \Delta\Gamma_s = 0.068 +- 0.026 (stat) +-
0.009 (syst) ps-1 and the mean B0_s lifetime, \tau_s = 1.528 +- 0.019 (stat) +-
0.009 (syst) ps, which are consistent and competitive with determinations by
other experiments.Comment: 8 pages, 2 figures, Phys. Rev. Lett 109, 171802 (2012
Study of CP violation in Dalitz-plot analyses of B0 --> K+K-KS, B+ --> K+K-K+, and B+ --> KSKSK+
We perform amplitude analyses of the decays , , and , and measure CP-violating
parameters and partial branching fractions. The results are based on a data
sample of approximately decays, collected with the
BABAR detector at the PEP-II asymmetric-energy factory at the SLAC National
Accelerator Laboratory. For , we find a direct CP asymmetry
in of , which differs
from zero by . For , we measure the
CP-violating phase .
For , we measure an overall direct CP asymmetry of
. We also perform an angular-moment analysis of
the three channels, and determine that the state can be described
well by the sum of the resonances , , and
.Comment: 35 pages, 68 postscript figures. v3 - minor modifications to agree
with published versio
Shrinking a large dataset to identify variables associated with increased risk of Plasmodium falciparum infection in Western Kenya
Large datasets are often not amenable to analysis using traditional single-step approaches. Here, our general objective was to apply imputation techniques, principal component analysis (PCA), elastic net and generalized linear models to a large dataset in a systematic approach to extract the most meaningful predictors for a health outcome. We extracted predictors for Plasmodium falciparum infection, from a large covariate dataset while facing limited numbers of observations, using data from the People, Animals, and their Zoonoses (PAZ) project to demonstrate these techniques: data collected from 415 homesteads in western Kenya, contained over 1500 variables that describe the health, environment, and social factors of the humans, livestock, and the homesteads in which they reside. The wide, sparse dataset was simplified to 42 predictors of P. falciparum malaria infection and wealth rankings were produced for all homesteads. The 42 predictors make biological sense and are supported by previous studies. This systematic data-mining approach we used would make many large datasets more manageable and informative for decision-making processes and health policy prioritization
Proteomic profiling reveals the transglutaminase-2 externalization pathway in kidneys after unilateral ureteric obstruction
Increased export of transglutaminase-2 (TG2) by tubular epithelial cells (TECs) into the surrounding interstitium modifies the extracellular homeostatic balance, leading to fibrotic membrane expansion. Although silencing of extracellular TG2 ameliorates progressive kidney scarring in animal models of CKD, the pathway through which TG2 is secreted from TECs and contributes to disease progression has not been elucidated. In this study, we developed a global proteomic approach to identify binding partners of TG2 responsible for TG2 externalization in kidneys subjected to unilateral ureteric obstruction (UUO) using TG2 knockout kidneys as negative controls. We report a robust and unbiased analysis of the membrane interactome of TG2 in fibrotic kidneys relative to the entire proteome after UUO, detected by SWATH mass spectrometry. The data have been deposited to the ProteomeXchange with identifier PXD008173. Clusters of exosomal proteins in the TG2 interactome supported the hypothesis that TG2 is secreted by extracellular membrane vesicles during fibrosis progression. In established TEC lines, we found TG2 in vesicles of both endosomal (exosomes) and plasma membrane origin (microvesicles/ectosomes), and TGF-β1 stimulated TG2 secretion. Knockout of syndecan-4 (SDC4) greatly impaired TG2 exosomal secretion. TG2 coprecipitated with SDC4 from exosome lysate but not ectosome lysate. Ex vivo, EGFP-tagged TG2 accumulated in globular elements (blebs) protruding/retracting from the plasma membrane of primary cortical TECs, and SDC4 knockout impaired bleb formation, affecting TG2 release. Through this combined in vivo and in vitro approach, we have dissected the pathway through which TG2 is secreted from TECs in CKD
Inclusive search for supersymmetry using razor variables in pp collisions at root s=13 TeV
Peer reviewe
Beyond the disk: EUV coronagraphic observations of the Extreme Ultraviolet Imager on board Solar Orbiter
Most observations of the solar corona beyond 2 Rs consist of broadband
visible light imagery from coronagraphs. The associated diagnostics mainly
consist of kinematics and derivations of the electron number density. While the
measurement of the properties of emission lines can provide crucial additional
diagnostics of the coronal plasma (temperatures, velocities, abundances, etc.),
these observations are comparatively rare. In visible wavelengths, observations
at these heights are limited to total eclipses. In the VUV range, very few
additional observations have been achieved since the pioneering results of
UVCS. One of the objectives of the Full Sun Imager (FSI) channel of the EUI
telescope on board the Solar Orbiter mission has been to provide very wide
field-of-view EUV diagnostics of the morphology and dynamics of the solar
atmosphere in temperature regimes that are typical of the lower transition
region and of the corona. FSI carries out observations in two narrowbands of
the EUV spectrum centered on 17.4 nm and 30.4 nm that are dominated,
respectively, by lines of Fe IX/X (formed in the corona around 1 MK) and by the
resonance line of He II (formed around 80 kK in the lower transition region).
Unlike previous EUV imagers, FSI includes a moveable occulting disk that can be
inserted in the optical path to reduce the amount of instrumental stray light
to a minimum. FSI detects signals at 17.4 nm up to the edge of its FOV (7~Rs),
which is about twice further than was previously possible. Comparisons with
observations by the LASCO and Metis coronagraphs confirm the presence of
morphological similarities and differences between the broadband visible light
and EUV emissions, as documented on the basis of prior eclipse and space-based
observations. The very-wide-field observations of FSI are paving the way for
future dedicated instruments
The cosmic flow in the Local Supercluster: Tracing PSCz tidal influence through optimized Least Action Principle
We assess the extent to which the flux-limited PSCz redshift sample is
capable of accounting for the major share of mass concentrations inducing the
external tidal forces affecting the peculiar velocities within the Local
Supercluster (LS). The investigation is based upon a comparison of the ``true''
velocities in 2 large N-body simulations and their reconstruction from
``observation-mimicking'' mock catalogues. The mildly nonlinear ``mock'' LS and
PSCz velocities are analyzed by means of the Least Action Principle technique
in its highly optimized implementation of Nusser & Branchini's Fast Action
Method (FAM). For both model N-body Universes, we conclude that the dipolar and
quadrupolar force field implied by the PSCz galaxy distribution would indeed be
sufficiently representing the full external tidal force field.Comment: 2 pages, 1 figure, contribution to ``Where's the Matter? Tracing Dark
and Bright Matter with the New Generation of Large Scale Surveys'', June
2001, Treyer & Tresse Eds, Frontier Grou
- …