The variability of birth weight

The material for this study was obtained from the maternity records relating to single births occurring in Malta throughout 1965. In this year there were 5,719 total births; of these the sample studied covers 2,517 births (44.11 percent). The records were personally examined by one of the authors (Cremona, 1967) from St. Luke's Hospital Malta, from Maltese private Hospitals, and from the District Nursing Association. In Malta the mean birth weight for male babies is 3446g, and for female babies 3358g. The mean birth weight tends to increase with the mother's parity, and this trend continues even with the higher parities. The association between birth weight and rising maternal age remains uncertain. It is also probable that birth weight has a geographical determinant. Birth weight is a multifactorial product and cannot be very reliable as a clinical parameter. A new terminology is necessary to distinguish between three different groups of babies with low birth weights.peer-reviewe

Guidance on noncorticosteroid systemic immunomodulatory therapy in noninfectious uveitis: fundamentals of care for uveitis (focus) initiative

Topic: An international, expert-led consensus initiative to develop systematic, evidence-based recommendations for the treatment of noninfectious uveitis in the era of biologics. Clinical Relevance: The availability of biologic agents for the treatment of human eye disease has altered practice patterns for the management of noninfectious uveitis. Current guidelines are insufficient to assure optimal use of noncorticosteroid systemic immunomodulatory agents. Methods: An international expert steering committee comprising 9 uveitis specialists (including both ophthalmologists and rheumatologists) identified clinical questions and, together with 6 bibliographic fellows trained in uveitis, conducted a Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol systematic reviewof the literature (English language studies from January 1996 through June 2016; Medline [OVID], the Central Cochrane library, EMBASE,CINAHL,SCOPUS,BIOSIS, andWeb of Science). Publications included randomized controlled trials, prospective and retrospective studies with sufficient follow-up, case series with 15 cases or more, peer-reviewed articles, and hand-searched conference abstracts from key conferences. The proposed statements were circulated among 130 international uveitis experts for review.Atotal of 44 globally representativegroupmembersmet in late 2016 to refine these guidelines using a modified Delphi technique and assigned Oxford levels of evidence. Results: In total, 10 questions were addressed resulting in 21 evidence-based guidance statements covering the following topics: when to start noncorticosteroid immunomodulatory therapy, including both biologic and nonbiologic agents; what data to collect before treatment; when to modify or withdraw treatment; how to select agents based on individual efficacy and safety profiles; and evidence in specific uveitic conditions. Shared decision-making, communication among providers and safety monitoring also were addressed as part of the recommendations. Pharmacoeconomic considerations were not addressed. Conclusions: Consensus guidelines were developed based on published literature, expert opinion, and practical experience to bridge the gap between clinical needs and medical evidence to support the treatment of patients with noninfectious uveitis with noncorticosteroid immunomodulatory agents

The redmapper galaxy cluster catalog from DES Science Verification data

We describe updates to the redMaPPer algorithm, a photometric red-sequence cluster finder specifically designed for large photometric surveys. The updated algorithm is applied to 150 {{deg}}2 of Science Verification (SV) data from the Dark Energy Survey (DES), and to the Sloan Digital Sky Survey (SDSS) DR8 photometric data set. The DES SV catalog is locally volume limited and contains 786 clusters with richness lambda \gt 20 (roughly equivalent to {M}{{500c}}≳ {10}14 {h}70-1 {M}o ) and 0.2\lt z\lt 0.9. The DR8 catalog consists of 26,311 clusters with 0.08\lt z\lt 0.6, with a sharply increasing richness threshold as a function of redshift for z≳ 0.35. The photometric redshift performance of both catalogs is shown to be excellent, with photometric redshift uncertainties controlled at the {sigma }z/(1+z)~ 0.01 level for z≲ 0.7, rising to ~0.02 at z~ 0.9 in DES SV. We make use of Chandra and XMM X-ray and South Pole Telescope Sunyaev--Zeldovich data to show that the centering performance and mass--richness scatter are consistent with expectations based on prior runs of redMaPPer on SDSS data. We also show how the redMaPPer photo-z and richness estimates are relatively insensitive to imperfect star/galaxy separation and small-scale star masks

Pan-cancer analysis of whole genomes

Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe

On the need for innovation in road engineering: A Dutch example

In an ever faster changing world, innovation is a crucial tool to maintain the quality of road networks. In order to safely use innovative materials and techniques, validation procedures are needed. Because of the variable and non-standard nature of innovations, it is hard to standardize this kind of validation. Also, ensuring that innovations address the needs of road authorities can be quite a challenge. The Dutch highway authority, Rijkswaterstaat, currently uses a three tier approach to the validation of innovations. These consists of solicited innovations to address specific agency challenges and two systems to address unsolicited innovations. This paper describes the need for innovations, the most urgent topics that require solutions in the Dutch situation, the current approach towards innovation validation including examples of all three types of validation and the further developments foreseen for that system.Pavement Engineerin

Antenatal manifestation of congenital pancreatoblastoma in a fetus with Beckwith-Wiedemann syndrome.

Antenatal detection of an isolated abdominal cyst was found to be a pancreatoblastoma in a female fetus with Beckwith-Wiedemann syndrome. Prenatal and post-natal features and management of this very rare tumour are discussed. Molecular investigation disclosed a mosaic paternal 11p15 uniparental disomy in the tumoral cells. The prognosis of a congenital pancreatoblastoma is good if complete surgical excision is achieved. However, the association with Beckwith-Wiedemann syndrome requires a prolonged follow-up because of the increased risk of developing malignant tumours

Submerged cultural resources assessment : Golden Gate National Recreation Area, Gulf of the Farallones National Marine Sanctuary, and Point Reyes National Seashore /

"Prepared for the United States Department of Commerce, National Oceanic and Atmospheric Administration, Gulf of the Farallones National Maritime Sanctuary and the United States Department of the Interior, National Park Service, Golden Gate National Recreation Area."Includes bibliographical referencesMode of access: Internet

Design, fabrication and performance of the 10-in TOM HPD

The first sealed TOM Hybrid Photon Detector (HPD) with 10-in. diameter has been fabricated and successfully tested at CERN. This HPD has a spherical entrance window and a bialkali photocathode. The fountain focusing optics produces a demagnified image (D = 4) on the round segmented silicon sensor. The signals of the 2048 cells are read out through analog front-end electronics encapsulated in the vacuum envelope. We report on the design, fabrication technique and the experimental results obtained with laboratory test benches. The large TOM HPD is a prototype tube developed for the CLUE cosmic ray experiment. The final tubes, now under development, will be equipped with a solar-blind Rb//2Te photocathode and self triggering front-end electronics