Relationship Marketing on the Market of Advertising Agencies

In today´s competitive business environment, to achieve and retain business success, it is essential to devote sufficient attention to building business relationships. Recognition of factors, influencing the success of business relationships, has long been a topic of professionals and those who are interested in this field. When getting in touch with a customer, the company aims to establish a strong relationship with the customer, to win indifferent customers and to create customer loyalty. Based on the factors above, we found it important to determine the perception of the importance of factors which determine contacting customers the most from the customers´ point of view in the market of advertising agencies. Regarding further successful cooperation, it is essential to address customers with a proper campaign. Therefore, this paper aims to identify emerging customer groups when building relationships in the advertising market, thus facilitating the realization of personalized campaigns

Altered irisin/BDNF axis parallels excessive daytime sleepiness in obstructive sleep apnea patients

Study objectives: Obstructive sleep apnea hypopnea syndrome (OSAHS) is a sleep-related breathing disorder, characterized by excessive daytime sleepiness (EDS), paralleled by intermittent collapse of the upper airway. EDS may be the symptom of OSAHS per se but may also be due to the alteration of central circadian regulation. Irisin is a putative myokine and has been shown to induce BDNF expression in several sites of the brain. BDNF is a key factor regulating photic entrainment and consequent circadian alignment and adaptation to the environment. Therefore, we hypothesized that EDS accompanying OSAHS is reflected by alteration of irisin/BDNF axis. Methods: Case history, routine laboratory parameters, serum irisin and BDNF levels, polysomnographic measures and Epworth Sleepiness Scale questionnaire (ESS) were performed in a cohort of OSAHS patients (n=69). Simple and then multiple linear regression was used to evaluate data. Results: We found that EDS reflected by the ESS is associated with higher serum irisin and BDNF levels; β: 1.53; CI: 0.35, 6.15; p=0.012 and β: 0.014; CI: 0.0.005, 0.023; p=0.02, respectively. Furthermore, influence of irisin and BDNF was significant even if the model accounted for their interaction (p=0.006 for the terms serum irisin, serum BDNF and their interaction). Furthermore, a concentration-dependent effect of both serum irisin and BDNF was evidenced with respect to their influence on the ESS. Conclusions: These results suggest that the irisin-BDNF axis influences subjective daytime sleepiness in OSAS patients reflected by the ESS. These results further imply the possible disruption of the circadian regulation in OSAHS. Future interventional studies are needed to confirm this observation