¡Ha desaparecido un ratón! ¿Nos ayudáis a buscar al culpable? : Análisis del impacto didáctico y emocional de un encargo ficticio

Se analiza el impacto didáctico y emocional de la contextualización de los contenidos de un curso de verano de biología molecular. Se propuso a tres grupos de estudiantes de educación secundaria un encargo ficticio. Consistía en descubrir al culpable del robo de un ratón de laboratorio a partir del análisis de muestras biológicas encontradas en el lugar de la desaparición. Resolver el caso requería diseñar experimentos, aplicar técnicas básicas de biología molecular, analizar los resultados y preparar una comunicación científica. Se valoró el aprendizaje de 20 conceptos clave de biología molecular al inicio y al final del curso, lo que demostró la efectividad didáctica de este tipo de contextos. Además, se evidenció que el alumnado mejoró su percepción sobre la naturaleza de la ciencia y que se generaron emociones positivas.S'analitza l'impacte didàctic i emocional de la contextualització dels continguts d'un curs d'estiu de biologia molecular. Es va proposar a tres grups d'estudiants d'educació secundària un encàrrec fictici. Consistia a descobrir al culpable del robatori d'un ratolí de laboratori a partir de l'anàlisi de mostres biològiques oposades en el lloc de la desaparició. Resoldre el cas requeria dissenyar experiments, aplicar tècniques bàsiques de biologia molecular, analitzar els resultats i preparar una comunicació científica. Es va valorar l'aprenentatge de 20 conceptes clau de biologia molecular a l'inici i al final del curs, la qual cosa va demostrar l'efectivitat didàctica d'aquest tipus de contextos. A més, es va evidenciar que l'alumnat va millorar la seva percepció sobre la naturalesa de la ciència i que es van generar emocions positives.Educational and emotional impact of contents contextualization of a summer course in molecular biology is analyzed. A simulated mission of discovering the guilty of stealing a laboratory mouse from biological samples was proposed to three groups of high school students. Solving the case required to design experiments, apply basic molecular biology techniques, analyze data and prepare a scientific communication. The level of 20 key concepts of molecular biology learning was assessed at the beginning and at the end of the course, demonstrating the effectiveness of this teaching approach. Moreover, the students' improvement on their vision of the nature of science was evidenced and positive emotions were generated

La xarxa Edumet : meteorologia en directe sense moure's de l'aula

La Xarxa Meteorològica Educativa de Catalunya (Edumet) és un projecte de l'àmbit de les ciències que el Departament d'Educació de la Generalitat de Catalunya va iniciar a principis de 2004. El formen un conjunt d'estacions meteorològiques automàtiques instal·lades en centres educatius de diferents zones climàtiques de Catalunya que subministren dades a Internet, a través del servidor web http://www.xtec.cat/edumet. Aquest recurs TIC permet accedir de forma permanent a dades meteorològiques en temps real, així com a visualitzar l'evolució del temps atmosfèric en diferents períodes de temps, a 57 estacions meteorològiques

Els gèneres de comunicació científica i el laboratori com a espai didàctic per a l'ensenyament de les Ciències basat en Projectes

Els contextos de Creació del Coneixement Científic són espais clau perquè l'alumnat desenvolupi els procediments i visions epistèmiques de la Ciència, a més d'una apropiació profunda dels models científics. En aquest sentit, l'Aprenentatge Basat en Projectes és una oportunitat per desenvolupar activitats en les que els alumnes aprenguin ciències participant en aquests contextos. Es proposen quatre activitats ABP ubicades en diferents contextos de creació de coneixement científic (congressos científics, ciència ciutadana, indagacióal laboratori) i es discuteixen les aportacions que fan aquests diversos gèneres científics a l'ensenyament de les Ciències.Contexts of construction of scientific knowledge are key places to develop procedural and epistemic aspects of scientific competence, together with a deeper understanding of scientific models. Project-Based Learning is an opportunity to develop learning activities wherestudents learn sciences participating in these contexts. We propose four PBL activities situated in different contexts of construction of scientific knowledge (scientific congresses, citizen science, laboratory inquiry) and we discuss the application of these scientific genera toScience Education

Selvitys maaseutumatkailuyritysten neuvontapalvelujen tarpeesta Pohjois-Savossa

Tämän opinnäytetyön tarkoituksena oli selvittää, vastaavatko maa- ja kotitalousnaisten neuvontapalvelut maaseutumatkailuyritysten tarvitsemia palveluja. Liittyykö maaseutumatkailuyrittäjien yritystoimintaan ongelmia ja haasteita, joista syntyy tarve käyttää yritysneuvonnan palveluja? Onko yrittäjillä ongelmia yritystoiminnassa? Voivatko yrittäjät saada apua kyseisiin ongelmiin yritysneuvonnan palveluista? Lisäksi tarkoituksena oli selvittää tulevaisuuden tarpeita neuvontapalveluiden tuotekehitystyölle. Tutkimusmenetelmänä käytettiin laadullista tukimusta. Haastateltaviksi valittiin kahdeksan maaseutumatkailuyrittäjää Pohjois-Savon alueelta. Lisäksi valintakriteereinä oli se, että heillä tuli olla yritystoiminnassaan majoituksen lisäksi ruokapalvelua. Yritysten iän tuli olla vähintään kaksi vuotta ja heidän tuli olla alansa kärkiyrityksiä. Tutkimus toteutettiin puolistrukturoidulla teemahaastattelulla. Matkailu kasvavana, kehittyvänä ja työllistävänä elinkeinona tuo maaseudulle toimeentuloa ja vireyttä. Maaseutumatkailu pitää maaseutualueita elinkelpoisina ja säilyttää alueen palvelurakennetta. Muutokset yhteiskunnassa ja matkailijoiden vaatimustasossa luovat haasteita myös matkailuyrittäjille. Tehtyjen tutkimustulosten perusteella voidaan havaita, että maaseutumatkailuyrittäjien yritystoimintaan liittyy monenlaisia ongelmia ja haasteita. Tulosten perusteella voidaan päätellä, että monet tutkimuksessa esille tulleet yrittäjien ongelmat voidaan sopivilla neuvontapalveluilla ratkaista. Tutkimus osoittaa myös sen, että neuvojan kokemuksella on ratkaiseva merkitys siihen, miten neuvontapalvelut koetaan ja miten ne voidaan hyödyntää parhaalla mahdollisella tavalla yrityksen menestykseksi.The purpose of this thesis was to determine whether the counselling services provided by Rural Women’s Advisory Organization meet the needs of the rural tourism entrepreneurs. Are there specific problems and challenges associated with the business, generating needs for services of the Advisory Organization? Do entrepreneurs get help in their specific problems? In addition, the purpose of this study was to clarify the future needs in order to further develop the counselling services of the Rural Women’s Advisory Organization. This study was carried out by interviewing eight rural tourism family businesses in the area of Northern Savo. The criteria for choosing the businesses was that they had to offer catering services in addition to lodging, with at least two years of running business and they had to be within the top of their field. Tourism as a growing field offers multiple working opportunities and income for the countryside. Tourism and catering services keep the rural area viable and preserve the service structure of the countryside. Changes in the society and the increasing demands of the travellers create new challenges for the tourism entrepreneurs. The results of this study show that there are various specific problems and challenges related to rural tourism. Based on the results, the multiple problems associated with the field can be solved by tailored advisory services. This study also points out that the knowledge of the consultant plays a crucial role in how the advisory services are experienced and how they can be turned into success of the company

Measurement of the Bottom-Strange Meson Mixing Phase in the Full CDF Data Set

We report a measurement of the bottom-strange meson mixing phase \beta_s using the time evolution of B0_s -> J/\psi (->\mu+\mu-) \phi (-> K+ K-) decays in which the quark-flavor content of the bottom-strange meson is identified at production. This measurement uses the full data set of proton-antiproton collisions at sqrt(s)= 1.96 TeV collected by the Collider Detector experiment at the Fermilab Tevatron, corresponding to 9.6 fb-1 of integrated luminosity. We report confidence regions in the two-dimensional space of \beta_s and the B0_s decay-width difference \Delta\Gamma_s, and measure \beta_s in [-\pi/2, -1.51] U [-0.06, 0.30] U [1.26, \pi/2] at the 68% confidence level, in agreement with the standard model expectation. Assuming the standard model value of \beta_s, we also determine \Delta\Gamma_s = 0.068 +- 0.026 (stat) +- 0.009 (syst) ps-1 and the mean B0_s lifetime, \tau_s = 1.528 +- 0.019 (stat) +- 0.009 (syst) ps, which are consistent and competitive with determinations by other experiments.Comment: 8 pages, 2 figures, Phys. Rev. Lett 109, 171802 (2012

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis

The CMS Phase-1 pixel detector upgrade

The CMS detector at the CERN LHC features a silicon pixel detector as its innermost subdetector. The original CMS pixel detector has been replaced with an upgraded pixel system (CMS Phase-1 pixel detector) in the extended year-end technical stop of the LHC in 2016/2017. The upgraded CMS pixel detector is designed to cope with the higher instantaneous luminosities that have been achieved by the LHC after the upgrades to the accelerator during the first long shutdown in 2013–2014. Compared to the original pixel detector, the upgraded detector has a better tracking performance and lower mass with four barrel layers and three endcap disks on each side to provide hit coverage up to an absolute value of pseudorapidity of 2.5. This paper describes the design and construction of the CMS Phase-1 pixel detector as well as its performance from commissioning to early operation in collision data-taking.Peer reviewe

Search for heavy resonances decaying to two Higgs bosons in final states containing four b quarks

A search is presented for narrow heavy resonances X decaying into pairs of Higgs bosons (H) in proton-proton collisions collected by the CMS experiment at the LHC at root s = 8 TeV. The data correspond to an integrated luminosity of 19.7 fb(-1). The search considers HH resonances with masses between 1 and 3 TeV, having final states of two b quark pairs. Each Higgs boson is produced with large momentum, and the hadronization products of the pair of b quarks can usually be reconstructed as single large jets. The background from multijet and t (t) over bar events is significantly reduced by applying requirements related to the flavor of the jet, its mass, and its substructure. The signal would be identified as a peak on top of the dijet invariant mass spectrum of the remaining background events. No evidence is observed for such a signal. Upper limits obtained at 95 confidence level for the product of the production cross section and branching fraction sigma(gg -> X) B(X -> HH -> b (b) over barb (b) over bar) range from 10 to 1.5 fb for the mass of X from 1.15 to 2.0 TeV, significantly extending previous searches. For a warped extra dimension theory with amass scale Lambda(R) = 1 TeV, the data exclude radion scalar masses between 1.15 and 1.55 TeV

Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

Search for supersymmetry in events with one lepton and multiple jets in proton-proton collisions at root s=13 TeV

Peer reviewe