18 research outputs found
First measurement of the Hubble Constant from a Dark Standard Siren using the Dark Energy Survey Galaxies and the LIGO/Virgo Binary–Black-hole Merger GW170814
- Author
- A
- A
- A
- A
- A
- A J.
- A T.
- Abbott B. P
- Abbott R
- Abbott T. D
- Abbott T. M. C
- Abdalla F. B
- Abhirup and Ghosh
- Abraham S
- Acernese F
- Ackley K
- Adams C
- Adhikari R. X
- Adya V. B
- Affeldt C
- Agathos M
- Agatsuma K
- Aggarwal N
- Aguiar O. D
- Aiello L
- Ain A
- Ajith P
- Allam S
- Allen G
- Allocca A
- Aloy M. A
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- Ananyeva A
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- Angelova
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- Appert S
- Arai K
- Araya M. C
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- Areeda J. S
- Arene M
- Arunava and Mukherjee
- Ascenzi S
- Ashton G
- Aston S. M
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- Aufmuth P
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- Avendano
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- Venkateswara K
- Venugopalan G
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- Westhouse J. W
- Wette K
- Whelan J. T
- Whiting B. F
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- Williams P. K. G
- Williamson A. R
- Willis J. L
- Willke B
- Wimmer M. H
- Winkler W
- Wipf C. C
- Wittel H
- Woan G
- Woehler J
- Wofford J. K
- Worden J
- Wright J. L
- Wysocki D. M
- Xiao L
- Y-M and Kim
- Yamamoto H
- Yancey C. C
- Yang L
- Yap M. J
- Yazback M
- Yeeles D. W
- Yu
- Yvert M
- Z T.
- Zadrozny A. K
- Zelenova T
- Zendri
- Zertuche
- Zevin M
- Zhang J
- Zhang L
- Zhang T
- Zhao C
- Zhou M
- Zhou Z
- Zhu X. J
- Zimmerman A
- Zucker M. E
- Zuntz J
- Zweizig J
- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2019
- Field of study
International audienceWe present a multi-messenger measurement of the Hubble constant H 0 using the binary–black-hole merger GW170814 as a standard siren, combined with a photometric redshift catalog from the Dark Energy Survey (DES). The luminosity distance is obtained from the gravitational wave signal detected by the Laser Interferometer Gravitational-Wave Observatory (LIGO)/Virgo Collaboration (LVC) on 2017 August 14, and the redshift information is provided by the DES Year 3 data. Black hole mergers such as GW170814 are expected to lack bright electromagnetic emission to uniquely identify their host galaxies and build an object-by-object Hubble diagram. However, they are suitable for a statistical measurement, provided that a galaxy catalog of adequate depth and redshift completion is available. Here we present the first Hubble parameter measurement using a black hole merger. Our analysis results in , which is consistent with both SN Ia and cosmic microwave background measurements of the Hubble constant. The quoted 68% credible region comprises 60% of the uniform prior range [20, 140] km s−1 Mpc−1, and it depends on the assumed prior range. If we take a broader prior of [10, 220] km s−1 Mpc−1, we find (57% of the prior range). Although a weak constraint on the Hubble constant from a single event is expected using the dark siren method, a multifold increase in the LVC event rate is anticipated in the coming years and combinations of many sirens will lead to improved constraints on H 0
Multi-messenger observations of a binary neutron star merger
- Author
- Aab A
- Aartsen MG
- Abbott BP
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- Zhao W
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- Zheng SJ
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- Zhu XJ
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- Ziegler A
- Zimmerman AB
- Zimmermann B
- Zimnukhov DS
- Ziolkowski M
- Zoll M
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- Zornoza JD
- Zou CL
- Zuccarello F
- Zucker ME
- Zuniga J
- Zweizig J
- Zywucka N
- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
First Measurement of the Hubble Constant from a Dark Standard Siren using the Dark Energy Survey Galaxies and the LIGO/Virgo Binary-Black-hole Merger GW170814
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- Tuyenbayev D
- Ueno K
- Ugolini D
- Unnikrishnan CS
- Urban AL
- Usman SA
- Vahlbruch H
- Vajente G
- Valdes G
- van Bakel N
- van Beuzekom M
- van den Brand JFJ
- van den Broeck C
- van der Schaaf L
- van Heijningen J
- van Veggel AA
- Vander-Hyde DC
- Vardaro M
- Varma V
- Vass S
- Vasuth M
- Vecchio A
- Vedovato G
- Veitch J
- Veitch PJ
- Venkateswara K
- Venugopalan G
- Verkindt D
- Vetrano F
- Vicere A
- Viets AD
- Vine DJ
- Vinet J-Y
- Vitale S
- Vivanco FH
- Vo T
- Vocca H
- Vorvick C
- Vyatchanin SP
- Wade AR
- Wade LE
- Wade M
- Walet R
- Walker AR
- Walker M
- Wallace L
- Walsh S
- Wang G
- Wang H
- Wang JZ
- Wang WH
- Wang YF
- Ward RL
- Warden ZA
- Warner J
- Was M
- Watchi J
- Weaver B
- Wechsler R
- Wei L-W
- Weinert M
- Weinstein AJ
- Weiss R
- Wellmann F
- Wen L
- Wessel EK
- Wessels P
- Wester W
- Westhouse JW
- Wette K
- Whelan JT
- Whiting BF
- Whittle C
- Wilken DM
- Williams D
- Williams PKG
- Williamson AR
- Willis JL
- Willke B
- Wimmer MH
- Winkler W
- Wipf CC
- Wittel H
- Woan G
- Woehler J
- Wofford JK
- Worden J
- Wright JL
- Wu DS
- Wysocki DM
- Xiao L
- Yamamoto H
- Yancey CC
- Yang L
- Yap MJ
- Yazback M
- Yeeles DW
- Yu H
- Yu H
- Yuen SHR
- Yvert M
- Zadrozny AK
- Zanolin M
- Zelenova T
- Zendri J-P
- Zertuche LM
- Zevin M
- Zhang J
- Zhang L
- Zhang T
- Zhao C
- Zhou M
- Zhou Z
- Zhu XJ
- Zimmerman A
- Zucker ME
- Zuntz J
- Zweizig J
- Publication venue
- IOP PUBLISHING LTD
- Publication date
- 01/05/2019
- Field of study
We present a multi-messenger measurement of the Hubble constant H 0 using the binary–black-hole merger GW170814 as a standard siren, combined with a photometric redshift catalog from the Dark Energy Survey (DES). The luminosity distance is obtained from the gravitational wave signal detected by the Laser Interferometer Gravitational-Wave Observatory (LIGO)/Virgo Collaboration (LVC) on 2017 August 14, and the redshift information is provided by the DES Year 3 data. Black hole mergers such as GW170814 are expected to lack bright electromagnetic emission to uniquely identify their host galaxies and build an object-by-object Hubble diagram. However, they are suitable for a statistical measurement, provided that a galaxy catalog of adequate depth and redshift completion is available. Here we present the first Hubble parameter measurement using a black hole merger. Our analysis results in H0=75−32+40kms−1Mpc−1, which is consistent with both SN Ia and cosmic microwave background measurements of the Hubble constant. The quoted 68% credible region comprises 60% of the uniform prior range [20, 140] km s−1 Mpc−1, and it depends on the assumed prior range. If we take a broader prior of [10, 220] km s−1 Mpc−1, we find {H}_{0 {78}_{-24}^{+96}\,\mathrm{km}\,{{\rm{s}}}^{-1}\,{\mathrm{Mpc}}^{-1} (57% of the prior range). Although a weak constraint on the Hubble constant from a single event is expected using the dark siren method, a multifold increase in the LVC event rate is anticipated in the coming years and combinations of many sirens will lead to improved constraints on H 0
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro Carà Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
- Audry Mathilde
- Austin Karen
- Austin Pauline
- Auvet Adrien
- Avard Bronwyn
- Awan Sidra
- Ayee Robert
- Azaiz Amine
- Azzaui Harun
- Babu Suresh
- Bacon Gina
- Badalamenti Salvatore
- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
- Bailey Lucy
- Baillie Kenneth
- Bain William
- Baker Alice
- Baker Evelyn
- Baker Stuart
- Bakthavatsalam Dhanalakshmi
- Balaie Morteza
- Balls-Burgess Sam
- Bamford Amy
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbash Ian
- Barber Russell
- Barbier François
- Barge Deborah
- Bariola Ryan
- Barker Gareth
- Barker Stephanie
- Barnes Nicky
- Baron Rebecca M.
- Barreau Amelie
- Barreau Amélie
- Bart Robert
- Bartholomew Jazz
- Bartley Shauna
- Barton David
- Barton Frances
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bassford Christopher
- Bastos Joana Margarida Pereira Sousa
- Bates Michelle
- Bates Samantha
- Batista Teresa Margarida Oliveira
- Bauchmuller Kris
- Bayne Madeleine
- Bean Sarah
- Beane Abi
- Beane Abigail
- Beard Gregory
- Beasley Richard
- Beaudoin Rosalie
- Beavis Sarah
- Beddows Seonaid
- Bedford Caroline
- Beer Deborah
- Beer Sally
- Begin Phillipe
- Begum Salma
- Bell Gillian
- Bellemare David
- Belletti Allesandro
- Bendjemar Lynda
- Benettaib Fatna
- Bensen Nicole
- Bentley Andrew
- Benyon Sarah
- Benzekri Dalila
- Beqai Besa
- Berdaguer Fernando
- Beresford Stephanie
- Bergin Colin
- Berry Lindsay R.
- Berry Scott
- Berryman Emily
- Bertel Melanie
- Best-Lane Janis
- Besten Henny
- Bevan Emily
- Bewley Jeremy
- Beyerl Ashley
- Bhagani Sanjay
- Bhandal Khushpreet
- Bharaj Kiranjit
- Bhattarai Bina
- Bhattarai Binita
- Bhonagiri Deepak
- Biddie Simon
- Bigas Judit
- Bihari Shailesh
- Bin Hasan Mohd Shahnaz
- Bindels Manon
- Binnie Alexandra
- Biradar Vishwanath
- Birch Catherine
- Birch Janine
- Birch Sophie
- Birchall Kathrine
- Birkinshaw Isobel
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- Blackledge Bethany
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- Blanck Wendy
- Bland Yvonne
- Blank Elisabeth
- Bleasdale John
- Bloomfield Jack
- Bloos Frank
- Board Jasmin
- Boardman Melanie
- Boari Gianluca
- Bocher Simon
- Bociek Aneta
- Boivin Anne-Helene
- Boivin Anne-Hélène
- Bojunga Jörg
- Bomken Charlotte
- Bonaccorso Allesandra
- Bongaerts Katherine
- Bonner Stephen
- Bonten Marc J. M.
- Borgatta Barbara
- Borislavova Borislava
- Borrill Zoe
- Boschert Catherine
- Bossard Isabelle
- Bothma Pieter
- Boudineau Michel
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- Boumahni Dounia
- Bouman Angela
- Bounab Rania
- Bourgoin Charlotte
- Bourne Michelle
- Bourne Richard
- Boutin Mireille
- Bouvier Elodie
- Bouw-Ruiter Marianne
- Boué Yvonnick
- Bowen James
- Bowler Helen
- Boyd Craig
- Boyles Rebecca
- Bracke Stephanie
- Bradbury Charlotte A.
- Bradley Paul
- Brady Kara
- Brailsford Jane
- Brain Matthew
- Brakké Karen
- Brant Emily
- Brasselet Aurélie
- Breen Patrick
- Bremmer Pamela
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- Brennan Aoife
- Bretagnol Anne
- Brett Stephen
- Brewer Chris
- Brickell Kathy
- Bridges Sarah
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- Brugman Curt
- Brunetta Enrico
- Brunkhorst Frank M.
- Brunskill Nigel
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- Charlton Sam
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- Chartier Delphine
- Chasse Michael
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- Chen Jonathan
- Chen Lixian
- Chen Yan
- Cheng Allen C.
- Cherian Shiney
- Chhablani Manish
- Chin Teri
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- Ciccarelli Michele
- Cirstea Emanuel
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- Constantino-Occhipinti Claudia
- Contou Damien
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- Conway Robert
- Conzelmann Nadine
- Cook Deborah
- Cook Tim
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- Cooper Jamie
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- Corbett Sarah
- Corcoran Ele
- Corcoran Kathleen
- Cornell Sarah
- Cornell Thomas
- Cort Jon
- Costerousse Olivier
- Couillard-Chénard Émilie
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- Dawson Laura Ann
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- Da Rocha Joana
- De Bus Liesbet
- de Courcy-Golder Kim
- de Groot Klaas
- de Jong Menno
- de Jonge Evert
- De Keulenaer Bart
- de la Torre Cisneros Julian
- de Man Angelique
- De Neef Mark
- De Smeytere Anouska
- Deacon Bethan
- Dean Steven
- Dean Tessa
- Dearden Joy
- Dechert William
- Declercq Pierre-Louis
- Degracia Anna
- del Sorbo Lorenzo
- Dela Rosa Arnold
- Delaney Kirsha
- Dell Abbie
- del Prado Michael
- Demetriou Carrie
- Dempster Debra
- Denham Lynn
- Denmade Craig
- Dent Martin
- Depante Maria
- Depuydt Pieter
- Dequin Pierre-François
- Derde Lennie P. G.
- Deshpande Kush
- Detry Michelle A.
- Deye Nicolas
- de la Fuente Carmen
- De Waele Jan
- Dheke Krishan
- Di Lucca Giuseppe
- Dias Priya
- Dice Julie
- Digby Stephen
- Diridis Kristina
- Distler Michael
- Dobell-Brown Kelsey
- Doble Patricia
- Dobson Jade
- Doherty Kaleigh
- Doherty Ronan
- Doi Yohei
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- Duric Natalie
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- Dyas Sarah
- Eapen Beena
- Eastgate Christine
- Ebenezer R
- Edmunds Natasha
- Edwards Alexandra
- Efford Georgia
- Egreteau Pierre
- Ehrmann Stephan
- Eichenauer Dennis
- Eisenbeis Simone
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- Fujitani Shigeki
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- Hernandez Erik
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- Hey Samuel
- Hickey John
- Hierons Sarah
- Higgins Alisa M.
- Hill Claire
- Hill Dianne
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- Hornsby James
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- Horvat Christopher M.
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- Huang David T.
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- Kamra Maneesha
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- Kato Hideaki
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- Wunderley Renee
- Wyatt Rachel
- Wylie Katharine
- Xavier Kugan
- Yamagishi Yoshiaki
- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
Multi-messenger Observations of a Binary Neutron Star Merger
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- Publication venue
- 'American Astronomical Society'
- Publication date
- 28/10/2022
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later
designated GW170817) with merger time 12:41:04 UTC was observed through
gravitational waves by the Advanced LIGO and Advanced Virgo detectors.
The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray
burst (GRB 170817A) with a time delay of ∼ 1.7 {{s}} with respect to
the merger time. From the gravitational-wave signal, the source was
initially localized to a sky region of 31 deg2 at a
luminosity distance of {40}-8+8 Mpc and with
component masses consistent with neutron stars. The component masses
were later measured to be in the range 0.86 to 2.26 {M}ȯ
. An extensive observing campaign was launched across the
electromagnetic spectrum leading to the discovery of a bright optical
transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC
4993 (at ∼ 40 {{Mpc}}) less than 11 hours after the merger by the
One-Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The
optical transient was independently detected by multiple teams within an
hour. Subsequent observations targeted the object and its environment.
Early ultraviolet observations revealed a blue transient that faded
within 48 hours. Optical and infrared observations showed a redward
evolution over ∼10 days. Following early non-detections, X-ray and
radio emission were discovered at the transient’s position ∼ 9
and ∼ 16 days, respectively, after the merger. Both the X-ray and
radio emission likely arise from a physical process that is distinct
from the one that generates the UV/optical/near-infrared emission. No
ultra-high-energy gamma-rays and no neutrino candidates consistent with
the source were found in follow-up searches. These observations support
the hypothesis that GW170817 was produced by the merger of two neutron
stars in NGC 4993 followed by a short gamma-ray burst (GRB 170817A) and
a kilonova/macronova powered by the radioactive decay of r-process
nuclei synthesized in the ejecta.</p
Thigh-length compression stockings and DVT after stroke
- Author
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- Abbasi S
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- Willetts S
- Williams A
- Williams C
- Williams C
- Williams G
- Williams J
- Williams J
- Williams J
- Williams JR
- Williams K
- Williams K Barker
- Williams M
- Williams P
- Williams S
- Williams S
- Williams T
- Williamson C
- Williamson D
- Williamson J
- Willis E
- Willis H
- Willis H
- Willis J
- Willis J
- Wilson A
- Wilson A
- Wilson A
- Wilson D
- Wilson J
- Wilson J
- Wilson K
- Wilson L
- Wilson T
- Win M
- Winder L
- Winder P
- Winn S
- Winstanley M
- Winter H
- Winter J
- Wiselka M
- Wittes J
- Wolodimeroff E
- Wong N
- Wood C
- Wood F
- Wood J
- Wood L
- Wood T
- Woodford J
- Woodhead L
- Woodland P
- Woodward Z
- Wooldridge G
- Woollen L
- Woosey D
- Wootton D
- Worton S
- Wright D
- Wright R
- Wroe C
- Wu P
- Wyness K
- Wynter I
- Xavier B
- Xia Z
- Yan M
- Yanney M
- Yasmin S
- Yates B
- Yates B
- Yates D
- Yates H
- Yein K
- Yelnoorkar F
- Yip K
- Ynter I
- Yorke J
- Youssouf S
- Yousuf A
- Yung B
- Zafar A-M
- Zaher S
- Zalewska K
- Zaman M
- Zaman S
- Zammit L
- Zammit-Mangion M
- Zdanaviciene A
- Zehnde D
- Zhixin J
- Zhu D
- Zia M
- Zin E Thant
- Zinyemba V
- Zipitis C
- Zmierczak A
- Zuhra N
- Zulaikha R
- Zullo C
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/1994
- Field of study
Controversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease
Trends in Belgian premature avoidable deaths over a 20 year period
- Author
- Albert X.
- Boys R.J.
- Charlton JR, Hartley
- Gaizauskiene A.
- Gaizauskiene A.
- Gezondheidsindicatoren
- GI Correa Corrales
- Holland W.W.
- Holland W.W.
- Holland W.W.
- Holland W.W.
- Humblet P.C.
- LA Garcia Rodriguez
- Lagasse R.
- Levi F.
- Levêque A.
- Levêque A.
- Levêque A.
- Mackenbach J.P.
- McDonnel S.
- Ortega A.
- P C Humblet
- Pampalon R.
- Romeder J.-M.
- Rutstein D.
- Westerling R.
- Westerling R.
- Westerling R.
- Westerling R.
- Westerling R.
- Woolhandler S.
- Publication venue
- BMJ Group
- Publication date
- 01/01/2000
- Field of study
STUDY OBJECTIVES—To analyse over a 20 year period the level and trends in the "EC avoidable death indicators".
DESIGN—The Years of Potential Life Lost (YPLL) method applied to curative and preventive avoidable mortality indicators in Belgium for four successive five year periods, countrywide as well as by district, separately for women and men. Ratios of YPLL rates (age standardised) describe changes between 1974-78 and 1990-94.
SETTING—Belgium for the periods 1974-78, 1980-84, 1985-89, 1990-94.
PARTICIPANTS—All avoidable death cases aged 1-64.
MAIN RESULTS—Ratio of YPLL rates indicated a more favourable development between 1974-78 and 1990-94 in the EC avoidable indicators than in all causes premature mortality. The EC avoidable mortality indicators have been assigned to two categories, curative indicators and preventive indicators. The best ratio of YPLL rates was found in curative indicators for men but the largest gains in YPLL rates over the periods come from the "preventive indicators" in men. For women, malignant neoplasm of the breast rose to the first ranked in 1985-1989 and 1990-1994, where it contributed to more years of YPLL loss than motor vehicle accidents, and malignant neoplasm of the trachea, bronchus and lung had risen to the fifth ranked since 1985-89. The order of the top causes for men did not change between 1974 and 1994, except for cirrhosis of liver, which rose from the fifth to the fourth rank. In the particular case of one "preventive indicator", malignant neoplasm of the trachea, bronchus and lung, the regional analysis of time trend between 1974-78 and 1990-94 showed more districts with a favourable development for both men and women in the Flemish region than in Wallonia.
CONCLUSION—The YPLL method combined with the avoidable mortality indicators enabled us to compare the changes of curative and preventive EC avoidable indicators between 1974-78 and 1990-94. In the case of malignant neoplasm of the trachea, bronchus and lung, which is of major concern to the health promotion policies, changes over the periods have widened a "north/south" health contrast.
Keywords: avoidable mortality; YPLL; Belgiu
The impact of rural residence on adult brain cancer survival in the United States
- Author
- AL Miranda Filho
- Arash Delavar
- Arvin R. Wali
- BG Kaufman
- C Lopez Ramos
- CA Bellera
- D Hartley
- DA Leon
- GK Singh
- HH Engelhard
- J Pearl
- J Textor
- JC Spencer
- Jo C. Phelan
- JS Cossman
- K-M Choi
- Kathleen R. Maguire
- LE McCullough
- M Charlton
- Martin H. Pham
- MD Colton
- MS Eberhardt
- N Villapiano
- Omar M. Al Jammal
- P Tehranifar
- QT Ostrom
- Quinn T Ostrom
- Rajesh Dikshit
- RE Nelson
- RL Siegel
- S Deorah
- TE Byers
- W Chen
- WT Curry Jr
- X Li
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The safety and efficacy of inhaled dry powder mannitol as a bronchial provocation test for airway hyperresponsiveness: a phase 3 comparison study with hypertonic (4.5%) saline
- Author
- Anderson SD
- Belessis Y
- Bell N
- Berend N
- Borg B
- Borgas T
- Bovington K
- Boynton A
- Brannan JD
- Briffa P
- Charlton B
- Cossa G
- De Torres C
- Dent A
- Dixon S
- Eckert B
- Ellis M
- Fitzgerald D
- Freed-Martens R
- Furler J
- Gibson P
- Hartley F
- Henry R
- Hukins C
- Hurwitz M
- Jack S
- Keatley L
- Kennedy B
- Khov S
- Kippelen P
- Lassig AR
- Lee S
- Martin B
- Mayrhofer P
- McArthur M
- McElrea M
- McKay K
- McLennan S
- McNamara S
- Middleton P
- Morton J
- Nassar S
- Nogrady S
- Numa A
- O'Donovan B
- Perry CP
- Peters M
- Plowman L
- Roberts M
- Robertson C
- Rodwell L
- Rogers P
- Ruedinger L
- Sarunac J
- Schoeffel R
- Seccombe L
- Serwach N
- Sheridan S
- Simmul R
- Smart J
- Smith J
- Stirling R
- Sunderland J
- Thompson B
- Tourniea W
- Turton J
- Van Asperen P
- Veitch E
- West S
- Wheatley JR
- Young I
- Zimmerman P
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2005
- Field of study
BACKGROUND: Inhaled mannitol is a new bronchial provocation test (BPT) developed to improve portability and standardisation of osmotic challenge testing. Osmotic challenge tests have an advantage over the traditional methods of measuring airway hyperresponsiveness using methacholine as they demonstrate higher specificity to identify asthma and thus the need for treatment with inhaled corticosteroids (ICS). The safety and the efficacy of mannitol (M) as a BPT to measure airway hyperresponsiveness were compared to hypertonic (4.5%) saline (HS) in people both with and without signs and symptoms of asthma. METHODS: A phase III, multi-centre, open label, operator-blinded, crossover design, randomised trial, with follow-up. Asthmatics and non-asthmatics (6-83 yr) were recruited and 592 subjects completed the study. Mannitol was delivered using a low resistance dry powder inhaler and HS was delivered using an ultrasonic nebuliser. The FEV1 was measured 60 seconds after each dose of mannitol (5,10,20,40,80,160,160,160 mg) and after each exposure to HS (0.5,1.0,2.0,4.0,8.0 minutes). A 15% fall in FEV1 defined a positive test. Adverse events were monitored and diaries kept for 7 days following the tests. RESULTS: Mean pre-test FEV1 (mean +/- SD) was 95.5 +/- 14% predicted. 296 were positive to mannitol (M+) and 322 positive to HS (HS+). A post study physician conducted clinical assessment identified 82.3% asthmatic (44% classified mild) and 17.7% non-asthmatic. Of those M+, 70.1% were taking ICS and of those mannitol negative (M-), 81.1 % were taking ICS. The % fall in FEV1 for mannitol in asthmatics was 21.0% +/- 5.7 and for the non-asthmatics, 5.5% +/- 4.8. The median PD15 M was 148 mg and PD15 HS 6.2 ml. The sensitivity of M to identify HS+ was 80.7% and the specificity 86.7%. The sensitivity of M compared with the clinical assessment was 59.8% and specificity 95.2% and increased to 88.7% and 95.0% respectively when the M- subjects taking ICS were excluded. Cough was common during testing. There were no serious adverse events. The diarised events were similar for mannitol and HS, the most common being headache (17.2%M, 19%HS), pharyngolaryngeal pain (5.1%M, 3%HS), nausea (4.3%M, 3%HS), and cough (2.2%M, 2.4%HS). CONCLUSION: The efficacy and safety of mannitol was demonstrated in non-asthmatic and clinically diagnosed asthmatic adults and children
Fatty liver disease in children: eat now pay later
- Author
- A Franzese
- A Fraser
- A Kapoor
- A Watanabe
- A Wieckowska
- A Wieckowska
- AD Baldridge
- AJ Sanyal
- Anil Dhawan
- B Fromenty
- C Taghibiglou
- CL Ogden
- CL Wang
- CP Day
- CT Wai
- D Cai
- D Prati
- DE Kleiner
- DF Chan
- DL Diab
- E Stamatakis
- EA Roberts
- Emer Fitzpatrick
- F Imbert-Bismut
- F Marra
- G Musso
- G Quash
- G Radetti
- HM Patton
- HS Park
- I Ciba
- IN Guha
- IR Willner
- J Guechot
- JB Dixon
- JB Schwimmer
- JB Schwimmer
- JB Schwimmer
- JB Schwimmer
- JB Schwimmer
- JE Lavine
- JJ Reilly
- JL Hartley
- JR Moran
- K Begriche
- K Iizuka
- K Tokushige
- K Tominaga
- KJ Nadeau
- KM Utzschneider
- L Carulli
- L Miele
- L Tock
- LA Adams
- M Charlton
- M Duvnjak
- M Fishbein
- M Fraquelli
- M Manco
- M Manco
- M Rashid
- M Ricchi
- MH Jarrar
- NA Palekar
- ND Manton
- P Angulo
- P Cales
- P Vajro
- P Vajro
- P Vajro
- R Dentin
- R Ludwig
- RE Quiros-Tejeira
- RS Strauss
- Ruth M. L. De Bruyne
- S Romeo
- S Saadeh
- S Tamura
- SA Harrison
- SH Caldwell
- T Reinehr
- TK Lam
- V Nobili
- V Nobili
- V Nobili
- V Nobili
- V Nobili
- X Forns
- X Ouyang
- YH Paik
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2010
- Field of study
With the recent epidemic in childhood obesity, nonalcoholic fatty liver disease (NAFLD) has become an emerging problem and a common cause of chronic liver disease in children.
In this review, the most recent insights on the pathogenesis, diagnosis, natural history, and treatment of NAFLD in children are discussed