Paleomagnetic and rock magnetic study in the Saldaña Formation and Overlying Cretaceous Units in the northern Upper Magdalena Valley, Colombia

Rocas pertenecientes a las Formaciones Saldaña (Triásico Superior-Jurásico Inferior), Yaví y Alpujarra (Aptiano) en el sector Norte del Valle Superior del Magdalena en las localidades de Olaya Herrera y Alpujarra, se de smagnetizaron por los métodos térmico y de campo alterno con el fin de aislar componentes de magnetización y establecer su edad relativa a partir de pruebas de campo (horizontalización de capas, prueba de dique y discordancia). Análisis de mineralogía magnética permitieron reconocer qué minerales magnéticos registran dichos componentes. En estas unidades se logró aislar tanto el componente que registra la dirección del dipolo actual, así como componentes estables (característicos y primarios) de magnetización correspondientes a la edad de formación de cada unidad. El componente primario de la Fm. Saldaña se aisló confiablemente en el sector de Olaya Herrera (D=179.9 I=7.1 N=8 k=17.19 a95=13.7), en donde se documentan rotaciones de bloques anti-horario de 43º previo a la acumulación de la Fm. Yaví; se determinó que el mineral que registra este componente es principalmente magnetita. El componente estable de la Fm. Yaví se aisló en lavas y lodolitas del sector de Alpujarra y su dirección (D=5.2 I=6.2 N=7 k=40.15 a95=9.6) sugiere un tiempo de magnetización pre-deformación del Yaví. Hematita y magnetita son los minerales magnéticos que llevan este componente en la Fm. Yaví.Lavas, mudstones and volcaniclastics rocks from the Saldaña (Upper Triassic - Lower Jurassic), Yaví and Alpujarra (Aptian) formations in the northern Upper Magdalena Valley were demagnetized using thermal and alternating field methods in order to isolate magnetic components and to establish a relative age of magnetization using several field tests. Magnetic mineralogy analyses permit the identification of the minerals that record uncovered magnetic components. Isolated components represent different events of magnetization. Directions parallel to the present Earth magnetic field were isolated in all the studied units. Characteristic components isolated from the Yaví Formation in Alpujarra area and from the Saldaña Formation in Olaya Herrera area, may correspond to primary or near-to-deposition events of magnetization. In Olaya Herrera, the characteristic component of the Saldaña Formation (D=179.9 I=7.1 N=8 k=17.19 α95=13.7) is carried by magnetite. Characteristic components uncovered in two different structural domains document 43±29ºcounterclockwise rotations previous to deposition of the Aptian Yaví Formation. Characteristic directions of the Yaví Formation are carried by hematite and magnetite, and the mean-site direction (D=5.2 I=6.2 N=7 k=40.15 α95=9.6) suggests a pre-folding event of magnetization.Fil: Bayona, Germán. Corporación Geológica ARES; ColombiaFil: Silva, Carlos. Corporación Geológica ARES; Colombia. Universidad Nacional de Colombia; ColombiaFil: Rapalini, Augusto Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires; ArgentinaFil: Costanzo-Alvarez, Vincenzo. Universidad Simón Bolívar; VenezuelaFil: Aldana, Milagrosa. Universidad Simón Bolívar; VenezuelaFil: Roncancio, Juan. Corporación Geológica ARES; Colombi

Hydrocarbon-induced magnetic contrasts in some Venezuelan and Colombian oil wells

In this work we present a review of our current research on the subject of near-surface hydrocarbon-induced magnetic contrasts. Samples are drill cuttings from number of Venezuelan and Colombian oil fields, and some soils from an oil prospective area. Results from rock magnetic, electronic paramagnetic resonance (EPR), extractable organic matter (EOM) and scanning electron microscopy (SEM) are discussed in light of new experiments. Two types of magnetic susceptibility (MS) anomalies have been recognized in oil well samples (i.e. A and B-like). A-like anomalies are probably associated to a reducing environment caused by the underlying reservoirs, whereas B-like anomalies might reflect lithological contrasts. Samples from A-like anomalous levels reveal the restrictive presence of authigenic spherical aggregates of submicronic Fe-rich magnetic crystals. Peaks of organic matter free radical concentration (OMFRC) and EOM are also observed at depth levels that lie close to those with A-like anomalies. Hysteresis ratios J rs /J s and H cr /H c could be used as additional criteria to recognize A-like magnetic contrasts. In soil samples, MS and OMFRC anomalies coincide with peaks of ethane concentration and an area underneath where source rock has reached appropriate conditions of pressure and temperature to generate hydrocarbons (Cretaceous kitchen). Different types of crude oils and subsurface structures could have also a direct effect on the observed amplitude of A-like anomalies

Paleomagnetismo y mineralogia magnetica en las unidades del Mesozoico de Bucaramanga y Macizo de Floresta

Análisis de paleomagnetismo y de mineralogía magnética en rocas del Jurásico y Cretácico Inferior del área de Bucaramanga (Fms. Bocas, Jordán, Girón y Los Santos), y del sur del Macizo de Floresta (Fms. Girón y Tibasosa) permitieron determinar componentes característicos y secundarios de magnetización, y establecer el mineral asociado a dicho componente magnético. Componentes secundarios con una dirección paralela a la dirección del campo magnético actual fueron aislados en todas las unidades y en rango de temperaturas bajas a intermedias ( 4 km) entre estas dos áreas soporta la posibilidad de rotación y/o basculamiento de bloques tectónicos previos a los eventos de magnetización de la Fm. Girón. Los componentes magnéticos característicos (primarios) aislados en ambos sectores muestran una clara diferencia entre las paleolatitudes del Jurásico Temprano- Cretácico Temprano con las determinadas para unidades de edad similar en el cratón, sugiriendo así posibles movimientos translacionales de bloques con respecto a la margen occidental del Cratón Suramericano.Paleomagnetic and magnetic mineralogy analyses from Jurassic – Lower Cretaceous rocks (Bocas, Jordán, Girón, Los Santos Fms) in the Bucaramanga area and in the southern segment of the Floresta Massif (Girón and Tibasosa Fms.) allow to determine characteristic (primary) and secondary magnetic components and to identify the carrying minerals. Secondary components have directions parallel to the current magnetic field direction; they were isolated in all the units and in unblocking temperature below 620ºC or by Alternating Field. Characterisitc (primary) components were isolated at unblocking temperatures ranging between 550º and 700ºC, with exception of limestones of the Tibasosa Formation that had unblocking temperatures between 300º and 500ºC. The relative time of magnetization was constrained from fold, conglomerate, unconformity, and baked contact tests. The characteristic component isolated in the Middle(?) Jurassic Jordan Fm. constrains 96±16º counterclockwise rotation of fault-bounded blocks at La Mesa de Los Santos area with respect to the Rionegro area. In addition, abrupt thickness change in the Girón Fm. from 100m to >4 km between those areas support the possibility of rotation and/or tilting of tectonic blocks, previous to the time of magnetization of the Girón Fm. The characteristic (primary) magnetic components isolated in both areas show a noticeable difference among the Early Jurassic-Early Cretaceous paleolatitudes and paleolatitudes calculated by other authors in rocks of the same age in the stable craton, suggesting possible translations of these blocks with respect to the western plate margin of South America.Fil: Ayala Calvo, Rosa Carolina. Corporación Geológica ARES; ColombiaFil: Veloza Fajardo, Gabriel Eduardo. Corporación Geológica ARES; ColombiaFil: Bayona, Germán. Corporación Geológica ARES; ColombiaFil: Gomez Casallas, Mayeli. Ministerio de Minas y Energía. Servicio Geológico Colombiano; ColombiaFil: Rapalini, Augusto Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires; ArgentinaFil: Costanzo-Alvarez, Vincenzo. Universidad Simón Bolivar; VenezuelaFil: Aldana, Milagrosa. Universidad Simón Bolivar; VenezuelaFil: Cortés, Martín. Corporación Geológica ARES; Colombi

Restoration of replication fork stability in BRCA1- and BRCA2-deficient cells by inactivation of SNF2-family fork remodelers

To ensure the completion of DNA replication and maintenance of genome integrity, DNA repair factors protect stalled replication forks upon replication stress. Previous studies have identified a critical role for the tumor suppressors BRCA1 and BRCA2 in preventing the degradation of nascent DNA by the MRE11 nuclease after replication stress. Here we show that depletion of SMARCAL1, a SNF2-family DNA translocase that remodels stalled forks, restores replication fork stability and reduces the formation of replication stress-induced DNA breaks and chromosomal aberrations in BRCA1/2-deficient cells. In addition to SMARCAL1, other SNF2-family fork remodelers, including ZRANB3 and HLTF, cause nascent DNA degradation and genomic instability in BRCA1/2-deficient cells upon replication stress. Our observations indicate that nascent DNA degradation in BRCA1/2-deficient cells occurs as a consequence of MRE11-dependent nucleolytic processing of reversed forks generated by fork remodelers. These studies provide mechanistic insights into the processes that cause genome instability in BRCA1/2- deficient cells

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Muon reconstruction performance of the ATLAS detector in proton–proton collision data at √s = 13 TeV

This article documents the performance of the ATLAS muon identification and reconstruction using the LHC dataset recorded at √s = 13 TeV in 2015. Using a large sample of J/ψ→μμ and Z→μμ decays from 3.2 fb−1 of pp collision data, measurements of the reconstruction efficiency, as well as of the momentum scale and resolution, are presented and compared to Monte Carlo simulations. The reconstruction efficiency is measured to be close to 99% over most of the covered phase space (|η| 2.2, the pT resolution for muons from Z→μμ decays is 2.9 % while the precision of the momentum scale for low-pT muons from J/ψ→μμ decays is about 0.2%

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field

Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities(.)(1,2) This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity(3-6). Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to 2017. We show that, contrary to the dominant paradigm, more than 55% of the global rise in mean BMI from 1985 to 2017-and more than 80% in some low- and middle-income regions-was due to increases in BMI in rural areas. This large contribution stems from the fact that, with the exception of women in sub-Saharan Africa, BMI is increasing at the same rate or faster in rural areas than in cities in low- and middle-income regions. These trends have in turn resulted in a closing-and in some countries reversal-of the gap in BMI between urban and rural areas in low- and middle-income countries, especially for women. In high-income and industrialized countries, we noted a persistently higher rural BMI, especially for women. There is an urgent need for an integrated approach to rural nutrition that enhances financial and physical access to healthy foods, to avoid replacing the rural undernutrition disadvantage in poor countries with a more general malnutrition disadvantage that entails excessive consumption of low-quality calories.Peer reviewe

Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants

Summary Background Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which measures weight gain beyond what is expected from height gain, for school-aged children and adolescents. Methods For this pooled analysis, we used a database of cardiometabolic risk factors collated by the Non-Communicable Disease Risk Factor Collaboration. We applied a Bayesian hierarchical model to estimate trends from 1985 to 2019 in mean height and mean BMI in 1-year age groups for ages 5–19 years. The model allowed for non-linear changes over time in mean height and mean BMI and for non-linear changes with age of children and adolescents, including periods of rapid growth during adolescence. Findings We pooled data from 2181 population-based studies, with measurements of height and weight in 65 million participants in 200 countries and territories. In 2019, we estimated a difference of 20 cm or higher in mean height of 19-year-old adolescents between countries with the tallest populations (the Netherlands, Montenegro, Estonia, and Bosnia and Herzegovina for boys; and the Netherlands, Montenegro, Denmark, and Iceland for girls) and those with the shortest populations (Timor-Leste, Laos, Solomon Islands, and Papua New Guinea for boys; and Guatemala, Bangladesh, Nepal, and Timor-Leste for girls). In the same year, the difference between the highest mean BMI (in Pacific island countries, Kuwait, Bahrain, The Bahamas, Chile, the USA, and New Zealand for both boys and girls and in South Africa for girls) and lowest mean BMI (in India, Bangladesh, Timor-Leste, Ethiopia, and Chad for boys and girls; and in Japan and Romania for girls) was approximately 9–10 kg/m2. In some countries, children aged 5 years started with healthier height or BMI than the global median and, in some cases, as healthy as the best performing countries, but they became progressively less healthy compared with their comparators as they grew older by not growing as tall (eg, boys in Austria and Barbados, and girls in Belgium and Puerto Rico) or gaining too much weight for their height (eg, girls and boys in Kuwait, Bahrain, Fiji, Jamaica, and Mexico; and girls in South Africa and New Zealand). In other countries, growing children overtook the height of their comparators (eg, Latvia, Czech Republic, Morocco, and Iran) or curbed their weight gain (eg, Italy, France, and Croatia) in late childhood and adolescence. When changes in both height and BMI were considered, girls in South Korea, Vietnam, Saudi Arabia, Turkey, and some central Asian countries (eg, Armenia and Azerbaijan), and boys in central and western Europe (eg, Portugal, Denmark, Poland, and Montenegro) had the healthiest changes in anthropometric status over the past 3·5 decades because, compared with children and adolescents in other countries, they had a much larger gain in height than they did in BMI. The unhealthiest changes—gaining too little height, too much weight for their height compared with children in other countries, or both—occurred in many countries in sub-Saharan Africa, New Zealand, and the USA for boys and girls; in Malaysia and some Pacific island nations for boys; and in Mexico for girls. Interpretation The height and BMI trajectories over age and time of school-aged children and adolescents are highly variable across countries, which indicates heterogeneous nutritional quality and lifelong health advantages and risks

Constraints on new phenomena via Higgs boson couplings and invisible decays with the ATLAS detector

Abstract: The ATLAS experiment at the LHC has measured the Higgs boson couplings and mass, and searched for invisible Higgs boson decays, using multiple production and decay channels with up to 4.7 fb−1 of pp collision data at−1at TeV. In the current study, the measured production and decay rates of the observed Higgs boson in the γγ, ZZ, W W , Zγ, bb, τ τ , and μμ decay channels, along with results from the associated production of a Higgs boson with a top-quark pair, are used to probe the scaling of the couplings with mass. Limits are set on parameters in extensions of the Standard Model including a composite Higgs boson, an additional electroweak singlet, and two-Higgs-doublet models. Together with the measured mass of the scalar Higgs boson in the γγ and ZZ decay modes, a lower limit is set on the pseudoscalar Higgs boson mass of mA> 370 GeV in the “hMSSM” simplified Minimal Supersymmetric Standard Model. Results from direct searches for heavy Higgs bosons are also interpreted in the hMSSM. Direct searches for invisible Higgs boson decays in the vector-boson fusion and associated production of a Higgs boson with W/Z (Z → ℓℓ, W/Z → jj) modes are statistically combined to set an upper limit on the Higgs boson invisible branching ratio of 0.25. The use of the measured visible decay rates in a more general coupling fit improves the upper limit to 0.23, constraining a Higgs portal model of dark matter.[Figure not available: see fulltext.