A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

Pan-cancer analysis of whole genomes

Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe

Amplitude analysis of the B0→K*0μ+μ− decay

An amplitude analysis of the B 0 → K * 0 μ + μ − decay is presented using a dataset corresponding to an integrated luminosity of 4.7     fb − 1 of p p collision data collected with the LHCb experiment. For the first time, the coefficients associated to short-distance physics effects, sensitive to processes beyond the standard model, are extracted directly from the data through a q 2 -unbinned amplitude analysis, where q 2 is the μ + μ − invariant mass squared. Long-distance contributions, which originate from nonfactorizable QCD processes, are systematically investigated, and the most accurate assessment to date of their impact on the physical observables is obtained. The pattern of measured corrections to the short-distance couplings is found to be consistent with previous analyses of b - to s -quark transitions, with the largest discrepancy from the standard model predictions found to be at the level of 1.8 standard deviations. The global significance of the observed differences in the decay is 1.4 standard deviations

Transverse polarization measurement of Λ hyperons in pNe collisions at sNN \sqrt{{\textrm{s}}_{\textrm{NN}}} = 68.4 GeV with the LHCb detector

Abstract A measurement of the transverse polarization of the Λ and $$\overline{\varLambda}$$ Λ ¯ hyperons in pNe fixed-target collisions at $$\sqrt{{\textrm{s}}_{\textrm{NN}}}$$ s NN = 68.4 GeV is presented using data collected by the LHCb detector. The polarization is studied using the decay Λ → pπ− together with its charge conjugated process, the integrated values measured are$${\displaystyle \begin{array}{c}{P}_{\varLambda }=0.029\pm 0.019\left(\textrm{stat}\right)\pm 0.012\left(\textrm{syst}\right),\\ {}{P}_{\overline{\varLambda}}=0.003\pm 0.023\left(\textrm{stat}\right)\pm 0.014\left(\textrm{syst}\right).\end{array}}$$ P Λ = 0.029 ± 0.019 stat ± 0.012 syst , P Λ ¯ = 0.003 ± 0.023 stat ± 0.014 syst . Furthermore, the results are shown as a function of the Feynman x variable, transverse momentum, pseudorapidity and rapidity of the hyperons, and are compared with previous measurements.</jats:p

Measurement of the branching fraction of B0 → J/ψπ0 decays

Abstract The ratio of branching fractions between B0 → J/ψπ0 and B+ → J/ψK*+ decays is measured with proton-proton collision data collected by the LHCb experiment, corresponding to an integrated luminosity of 9 fb−1. The measured value is$$\frac{{\mathcal{B}}_{B^0\to J/\psi {\pi}^0}}{{\mathcal{B}}_{B^{+}\to J/\psi {K}^{\ast +}}}=\left(1.153\pm 0.053\pm 0.048\right)\times {10}^{-2},$$ B B 0 → J / ψ π 0 B B + → J / ψ K ∗ + = 1.153 ± 0.053 ± 0.048 × 10 − 2 , where the first uncertainty is statistical and the second is systematic. The branching fraction for B0 → J/ψπ0 decays is determined using the branching fraction of the normalisation channel, resulting in$${\mathcal{B}}_{B^0\to J/\psi {\pi}^0}=\left(1.670\pm 0.077\pm 0.069\pm 0.095\right)\times {10}^{-5},$$ B B 0 → J / ψ π 0 = 1.670 ± 0.077 ± 0.069 ± 0.095 × 10 − 5 , where the last uncertainty corresponds to that of the external input. This result is consistent with the current world average value and competitive with the most precise single measurement to date.</jats:p