9 research outputs found
Pan-cancer analysis of whole genomes
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- Weinberger
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- Weisenberger
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- wf Amary
- Whalley
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- wi Futreal
- Wigle
- Wilkerson M. D. v
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- Wilson G. W. k
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- Wintersinger
- Wiznerowicz
- Wolf
- Wong
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- Woo
- Wood
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- Wright
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- Wright A. J. k
- ws Ang
- Wu
- Wu
- Wu
- wv abg
- wz Hupp
- x Eils
- x Yung
- X. abp
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- X. cq
- X. ez
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- X. fh
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- X. k Mbabaali
- X. oi
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- xb Danilova
- xb Felau
- xc Lovat
- xh Curley
- xh Fulton
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- Xia
- Xiang
- Xiong
- xo Abeshouse
- xp Benz
- xp Edwards
- xr Ghori
- xs Gundem
- Xue
- xv Luxton
- xw McDermott
- xy Visakorpi
- xz Whitaker
- Y. -E. ot
- Y. -J. k
- Y. -J. xn
- Y. abp
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- Yellapantula
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- z ah
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- Z. ep
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- Z. jq
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- zd Gershenwald
- Zenklusen
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- zf Ghossein
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang H. b
- Zhao
- Zheng
- Zhou
- Zhou
- Zhu
- Zhu
- zi zj
- zm Jayaseelan
- Zou
- Zou
- zt Kim
- zw Lewis
- Ă. A. th
- Ă. sk
- Publication venue
- Publication date
- 11/12/2019
- Field of study
Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe
Left Atrial Tachycardia After Right Atrial Separation for Chronic Atrial Fibrillation with Atrial Septal Defects
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Surgical treatment of congenital heart defects in adults
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Atrial septal defect
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- AM Rudolph
- AS Dajani
- AT Nasrallah
- C Ward
- D Shah
- DE Bedford
- FB Saksena
- GG Rowe
- J Chanda
- JD Hosenpud
- JG Murphy
- JK Perloff
- JL Cox
- JV Conte
- K Amplatz
- K Amplatz
- KM Borow
- KS Dave
- L Pinheiro
- M Campbell
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- MK Pasque
- MS Gotsman
- P Syamasundar
- P Wood
- RJV Batista
- S Konstantinides
- SV Praagh Van
- VV McLaughlin
- WE Hopkins
- WE Hopkins
- William E. Hopkins
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Interventional Versus Surgical Closure of Atrial and Ventricular Septal Defects: Advantages and Limitations of the Catheter-Based Approach
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- Beckman RH
- Belder M
- Bridges ND
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- Sievert H
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- Wilmshurst PT
- Publication venue
- 'Wiley'
- Publication date
- Field of study
The ACCF/AHA scientific statement on syncope: A document in need of thoughtful revision
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- Abe H
- Alboni P
- Andresen D
- Axelrod FB
- Benditt DG
- Bennaroch E
- Bergfeldt L
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- Publication venue
- Publication date
- 01/10/2006
- Field of study
Vorhofseptumdefekt
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- A Kitabatake
- A Schaede
- AE Weyman
- AE Weyman
- AE Weyman
- AG Zaver
- AJ Tajik
- AS Pearlman
- AT Nasrallah
- BM Beller
- C Shub
- D Kneissl
- D Young
- DR Pieroni
- E Esscher
- E Grenadier
- ER Kyger
- F Grosse-Brockhoff
- F Grosse-Brockhoff
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- FA Bierman
- FB Saksena
- FN Nasser
- G Kronik
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- I Thormann
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- JE Dalen
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- JK Walker
- JN Schapira
- JP Owens
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- KL Wanderman
- KS Dave
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- LM Valdez-Cruz
- M Campbell
- M Schartl
- MA Diamond
- MD Freed
- MG Sutton
- NC Nanda
- P Markman
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- PDV Bourdillon
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- RE Kerber
- RJ Craig
- RL Popp
- RO Bonow
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- SE Epstein
- SG Haworth
- SP Sanders
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- T Santoso
- TD Fraker
- TD King
- W Doerr
- W Lieppe
- W Schlick
- WE Radtke
- WJ Rashkind
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1989
- Field of study
Religion and Physical Health in Muslims
- Author
- A Abimiku
- A Adlouni
- A Afrasiabi
- A Barkia
- A Bener
- A Bowirrat
- A Lahdimawan
- A Latifynia
- A Latifynia
- A Malhotra
- A Razzaque
- A Sujoldzic
- A Temizhan
- AE Afgin
- AK Rushid
- AK Saha
- AM Salam
- AO Musaiger
- AS Haroon
- B Gaborit
- BB Yeole
- BB Yeole
- BB Yeole
- BB Yeole
- BK Defo
- BM Khaled
- BO Bernieh
- C Duttagupta
- C Kumar
- CJL Murray
- CS Muir
- D Almond
- D Antai
- D Chadee
- DG Cook
- DJ Jussawalla
- DN Rao
- DN Saksena
- E Dikensoy
- E Roshi
- E Ural
- ED Williams
- ED Williams
- EF Funai
- EL Wynder
- F Tesfaye
- FB Aksungar
- FB Aksungar
- FJ Altaf
- G Akhan
- G Burazeri
- G Perk
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- GK Mini
- GW Jones
- H Chamsi-Pasha
- H Solman
- H Topacoglu
- HC Hendrie
- HG Koenig
- I Salti
- IA Kodzi
- II Meshram
- IV Kohler
- IV Kohler
- J Al Suwaidi
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- J Al Suwaidi
- J Danesh
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- M Lerch
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- MMR Miah
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- O Omu
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- S Bhalotra
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- SA Saleh
- SD Israeli-Korn
- SE Khoo
- SO Gyimah
- SS Anand
- T Vos
- V Papadopoulos
- W Hatahet
- W Maziak
- W Naâamnih
- WC Cockerham
- WY Ling
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- Y Amitai
- Y Bhurgri
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- YK Seedat
- YY Al-Kandari
- YY Al-Kandari
- Z Sooki
- ZV Shariatpanahi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study
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- Aawsaj Y
- Abadia M
- AbadâGurumeta A
- AbadâMotos A
- Abassy J
- Abate E
- Abbasov A
- Abbott D
- Abbott Tom EF
- Abdalla M
- Abdeldayem H
- Abdelkabir M
- Abdelkader Salama I
- Abdelkarim M
- Abdelsamed A
- Abdulfattah F
- Abdulwahed E
- AbdurâRahman LO
- Abel MK
- Abelevich A
- Abiyere H
- Aboelkassem Ibrahim A
- Aboharp Hasan Z
- Abou Chaar MK
- Abreu da Silva A
- Abubakar A
- Abukhalaf SA
- Abukhalaf Sadi
- Acebes GarcĂa F
- Achalandabaso Boira M
- Acher A
- Acosta MĂ©rida MA
- Acrich E
- Adam Essa Adam ME
- Adamina M
- Adamina Michel
- Adamina Michel
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O
- Aderombi A
- Adeyeye A
- Adeyeye A
- Adi H
- Adiamah A
- Adisa Adewale
- Afzal MF
- Agapov M
- Agarwal Arnav
- Aggarwal M
- Aghayeva A
- Agilinko J
- Agnes A
- Agostini C
- Agrawal A
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- Agresta F
- Aguado LĂłpez H
- Aguiar JĂșnior S
- Aguilar Gonzalez M
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- Aimé A
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- Akbas A
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- Akkulak Murat
- Akrivou D
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- Al Habes H
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- AlAamer O
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- Alagoa Joao A
- Alakaloko Felix
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- Alanazi F
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- Alser Osaid
- Alshaar Muhammad
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- Yetkin G
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- Yigitbas H
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- Yildiz A
- Yildiz A
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- Yousof EA
- Youssef M
- Yurttas C
- YĂĄnez C
- YĂŒksel E
- Zafar SN
- Zakaria AD
- Zakaria Z
- Zakharenko A
- Zambon M
- ZamfirâChiruâAnton M
- Zanus G
- Zegarac M
- ZeliÄ M
- Zengin AK
- Zerbib P
- Zervas K
- Zese M
- Zhang H
- Zizzo M
- Zmora O
- Zografos C
- Zonta S
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- Zourntou S
- Zubaidi A
- Ăngelo M
- ĂlgĂ„ A
- Ăelebi F
- Ăolak E
- Ăfner D
- Ăhlberger L
- Ăzant A
- Ăzçay N
- ĂÄĂŒcĂŒ H
- ĂberrĂŒck L
- Äoza I
- Ćawnicka A
- ĆœateckĂœ J
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2022
- Field of study
AimThe SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery.MethodsThis was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4âweeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin.ResultsOverall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4âweeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, PÂ =Â 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, PâConclusionOne in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease