141 research outputs found
SBE16 Brazil & Portugal - Sustainable Urban Communities towards a Nearly Zero Impact Built Environment
Get PDFVol. IThe organizers of SBE 16 Brazil & Portugal were challenged to promote discussions and
the development of solutions for an important and, at the same time, very ambitious topic
? Sustainable Urban Communities towards a Nearly Zero Impact Built Environment. This
is the main focus of the international conference SBE16 Brazil & Portugal; the only event
of the SBE16/17 conference series being held in Latin America, more precisely, in Vitória
(Espírito Santo), Brazil, from the 7th until the 9th of September 2016. The conference
offered a unique opportunity to bring together researchers from all over the world to
share evidence-based knowledge in the field and succeeded to achieve its goals since many
contributions from various parts of the planet were received, addressing a tiny part of the
problem or trying to perform the difficult task of making the sum of the parts a coherent
whole.info:eu-repo/semantics/publishedVersio
Pan-cancer analysis of whole genomes
Get PDFCancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe
The hand of accounting and accountancy firms in deepening income and wealth inequalities and the economic crisis: Some evidence
Get PDFThis paper looks at the economic crisis in the UK. It argues that everyday accounting practices are deeply implicated in the inequitable distribution of income and wealth, a major cause of the economic crisis engulfing the neoliberal economies. Without adequate purchasing power middle and low income households cannot make the purchases necessary for a sustained revival of the economic activity. Accounting calculations and discourses play a major role in the determination of wages and taxes. They prioritise the interests of capital over labour and the state and have systematically eroded labour's share of the gross domestic product. At the same time, despite a massive growth in corporate profitability, the UK state's share of the national wealth in the form of tax revenues has also declined. It is argued that accounting practices which label payment of wages to labour and payment of taxes to the state as ?costs? amplify capitalist concerns about private appropriation of surpluses and have played a major role in assigning such payments to negative spaces. Through the sale of tax avoidance schemes to corporations and wealthy elites, accountancy firms have facilitated a skewed distribution of income of wealth and further constrained the state's capacity to reflate the economy. Consequently, the tax burdens on the less well-off have increased and further eroded their purchasing power and possibilities of building a sustainable economy
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