Assessment of mono and multi-objective optimization to design a hydrogen supply chain

This work considers the potential future use of hydrogen in fuel cell electrical vehicles to face problems such as global warming, air pollution, energy security and competitiveness. The lack of current infrastructure has been identified as one of the main barriers to develop the hydrogen economy. This work is focused on the design of a hydrogen supply chain through mixed integer linear programming used to find the best solutions for a multiobjective optimization problem in which three objectives are involved, i.e., cost, global warming potential and safety risk. This problem is solved by implementing an 3-constraint method. The solution consists of a Pareto front, corresponding to different design strategies in the associated variable space. Multiple choice decision making is then recommended to find the best solution through an M-TOPSIS analysis. The model is applied to the Great Britain case study previously treated in the dedicated literature. Mono and multicriteria optimizations exhibit some differences concerning the degree of centralization of the network and the selection of the production technology type

Pan-cancer analysis of whole genomes

Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe

Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

Chromothripsis is a mutational phenomenon characterized by massive, clustered genomic rearrangements that occurs in cancer and other diseases. Recent studies in selected cancer types have suggested that chromothripsis may be more common than initially inferred from low-resolution copy-number data. Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA), we analyze patterns of chromothripsis across 2,658 tumors from 38 cancer types using whole-genome sequencing data. We find that chromothripsis events are pervasive across cancers, with a frequency of more than 50% in several cancer types. Whereas canonical chromothripsis profiles display oscillations between two copy-number states, a considerable fraction of events involve multiple chromosomes and additional structural alterations. In addition to non-homologous end joining, we detect signatures of replication-associated processes and templated insertions. Chromothripsis contributes to oncogene amplification and to inactivation of genes such as mismatch-repair-related genes. These findings show that chromothripsis is a major process that drives genome evolution in human cancer

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts

Diseño de una instalación eólica de 20 MW y estudio económico

[ES] El TFG consistirá en el diseño completo de la instalación de una central eólica de unos 20 MW, en la que se incluirá el estudio del recurso eólico, la selección de los aerogeneradores, el cálculo de las líneas desde aerogeneradores a la subestación. El diseño de la subestación y el cálculo de las tomas de tierra. Se incluirá también el estudio económico a partir de la energía generada.Romero Baez, SV. (2022). Diseño de una instalación eólica de 20 MW y estudio económico. Universitat Politècnica de València. http://hdl.handle.net/10251/188052TFG

Autonomous Observations of Light and Temperature under the Arctic Ice Pack from a Buoy Deployed in March 2015

As part of the Arctic Observing Network, an ice-tethered buoy was deployed in first year sea ice in the spring of 2015. The buoy measured light, temperature, salinity and phytoplankton biomass within and under the ice through the spring. The buoy captured the complex light field that developed during the spring ice melt, as well as increased phytoplankton in the water column that represented the spring bloom. The data from the buoys provides unprecedented observations of the upper water column under current ice pack conditions, increasing in our understanding of the physical, biological and chemical impacts of a thinner and more fractured ice pack

Plan de desarrollo de la cultura organizacional en la alcaldía municipal de Córdoba.

Figuras, Tablas, Graficas, Cuadros, Lista de AnexosLa Administración municipal de Córdoba, es una entidad del sector público, que desarrolla su misión en el campo del servicio a la comunidad en la satisfacción de las necesidades básicas y que propende un mejoramiento de su calidad de vida.No contien