MyoD1 localization at the nuclear periphery is mediated by association of WFS1 with active enhancers - Image Data Set 2

Please refer to the publication currently under review with the same name as the project title for more details. Summary of the study: Spatial organization of the mammalian genome influences gene expression and cell identity. While association of genes with the nuclear periphery is commonly linked to transcriptional repression, also active, expressed genes can localize at the nuclear periphery. The transcriptionally active MyoD1 gene, a master regulator of myogenesis, exhibits peripheral localization in proliferating myoblasts, yet the underlying mechanisms remain elusive. Using a newly generated reporter cell line, we demonstrate here that peripheral association of the MyoD1 locus is independent of mechanisms involved in heterochromatin anchoring. We identify a set of nuclear envelope transmembrane proteins, particularly WFS1, that actively tether MyoD1 to the nuclear periphery. WFS1 primarily associates with active distal enhancer elements upstream of MyoD1, and with a subset of enhancers enriched in active histone marks genome-wide, which are linked to expressed myogenic genes. Overall, our data identify a novel mechanism involved in tethering active genes to the nuclear periphery. This research was funded in whole or in part by the Austrian Science Fund (FWF) [P29713-B28, P32512-B and P36503-B] to Roland Foisner and a doctorate program funded by the Austrian Science Fund (FWF) [W1261-B28]. Data here contains the high resolution immunofluorescence microscopy images of each figure from the publication

Experimental Study on the Relationship Between Interaction Styles in Virtual Reality Cooking Games and Food Choices

This study investigates how interaction styles in virtual reality (VR) cooking games affect food choices. We will conduct two experiments within the same VR cooking game. The first experiment assesses the impact of preparing healthy versus unhealthy foods on participants' subsequent food choices. The second experiment explores the influence of orderly versus cluttered cooking manners, including tasks like ingredient preparation, cooking, plating, and kitchen clean-up, on food selection. The overall aim is to understand how VR cooking experiences might shape real-life dietary decisions and provide insights for promoting healthier eating behaviors

Color-taste incongruency effect in product search based on active selection

A research on effect of Color-taste incongruency effect via product search metho

The COVID-19 Pandemic, Authoritarianism and Rejection of Sexual Dissenters in Poland

A three-wave longitudinal study examining the development of right-wing authoritarianism, national cohesion, and sexual prejudice throughout the unfolding of the Covid-19 pandemic in March and April 202

Cooperative Evolutionary Pressure and Diminishing Returns Might Explain the Fermi Paradox: On What Super-AIs Are Like

https://doi.org/10.48550/arXiv.2404.03685 With an evolutionary approach, the basis of morality can be explained as adaptations to problems of cooperation. With ‘evolution’ taken in a broad sense, AIs that satisfy the conditions for evolution to apply will be subject to the same cooperative evolutionary pressure as biological entities. Here the adaptiveness of increased cooperation as material safety and wealth increase is discussed — for humans, for other societies, and for AIs. Diminishing beneficial returns from increased access to material resources also suggests the possibility that, on the whole, there will be no incentive to for instance colonize entire galaxies, thus providing a possible explanation of the Fermi paradox, wondering where everybody is. It is further argued that old societies could engender, give way to, super-AIs, since it is likely that super-AIs are feasible, and fitter. Closing is an aside on effective ways for morals and goals to affect life and society, emphasizing environments, cultures, and laws, and exemplified by how to eat. `Diminishing returns’ is defined, as less than roots, the inverse of infeasibility. It is also noted that there can be no exponential colonization or reproduction, for mathematical reasons, as each entity takes up a certain amount of space. Appended are an algorithm for colonizing for example a galaxy quickly, models of the evolution of cooperation and fairness under diminishing returns, and software for simulating signaling development

The Neural Replay Thought Experiment: Exploring the Physical Basis of Phenomenal Consciousness and Intelligence

This paper presents an extension of the "neural replay thought experiment" as a heuristic tool for probing the reader’s implicit assumptions regarding the relationship between physical and mental phenomena. By systematically varying the physical instantiation of a recorded neural activity pattern, we aim to elicit divergent intuitions about the persistence of consciousness and intelligence. The analysis focuses on possible arguments asserting the disappearance or alteration of consciousness and intelligence across these scenarios, alongside corresponding counter-arguments. While not exhaustive, this exploration highlights the challenges in articulating a robust physical basis for mental phenomena and underscores the counterintuitive consequences that often arise from seemingly straightforward assumptions. The discussion briefly considers the broader implications of this analysis for theories of mind and intelligence