MyoD1 localization at the nuclear periphery is mediated by association of WFS1 with active enhancers - Image Data Set 2

Please refer to the publication currently under review with the same name as the project title for more details. Summary of the study: Spatial organization of the mammalian genome influences gene expression and cell identity. While association of genes with the nuclear periphery is commonly linked to transcriptional repression, also active, expressed genes can localize at the nuclear periphery. The transcriptionally active MyoD1 gene, a master regulator of myogenesis, exhibits peripheral localization in proliferating myoblasts, yet the underlying mechanisms remain elusive. Using a newly generated reporter cell line, we demonstrate here that peripheral association of the MyoD1 locus is independent of mechanisms involved in heterochromatin anchoring. We identify a set of nuclear envelope transmembrane proteins, particularly WFS1, that actively tether MyoD1 to the nuclear periphery. WFS1 primarily associates with active distal enhancer elements upstream of MyoD1, and with a subset of enhancers enriched in active histone marks genome-wide, which are linked to expressed myogenic genes. Overall, our data identify a novel mechanism involved in tethering active genes to the nuclear periphery. This research was funded in whole or in part by the Austrian Science Fund (FWF) [P29713-B28, P32512-B and P36503-B] to Roland Foisner and a doctorate program funded by the Austrian Science Fund (FWF) [W1261-B28]. Data here contains the high resolution immunofluorescence microscopy images of each figure from the publication

Experimental Study on the Relationship Between Interaction Styles in Virtual Reality Cooking Games and Food Choices

This study investigates how interaction styles in virtual reality (VR) cooking games affect food choices. We will conduct two experiments within the same VR cooking game. The first experiment assesses the impact of preparing healthy versus unhealthy foods on participants' subsequent food choices. The second experiment explores the influence of orderly versus cluttered cooking manners, including tasks like ingredient preparation, cooking, plating, and kitchen clean-up, on food selection. The overall aim is to understand how VR cooking experiences might shape real-life dietary decisions and provide insights for promoting healthier eating behaviors

Color-taste incongruency effect in product search based on active selection

A research on effect of Color-taste incongruency effect via product search metho

The COVID-19 Pandemic, Authoritarianism and Rejection of Sexual Dissenters in Poland

A three-wave longitudinal study examining the development of right-wing authoritarianism, national cohesion, and sexual prejudice throughout the unfolding of the Covid-19 pandemic in March and April 202

Peer assessment using criteria or comparative judgement? A replication study on the learning effect of two peer assessment methods

This project accompanies the book chapter 'Peer assessment using criteria or comparative judgement? A replication study into the learning effect of two assessment methods' that is part of the book 'The Power of Peer Learning' edited by Omid Noroozi and Bram De Wever (see https://link.springer.com/book/10.1007/978-3-031-29411-2). This project contains all materials used during data collection, the raw and processed data, code, the fitted models, the figures and tables that appear in the book chapter. All code can be found at https://lucid-bardeen-01fda1.netlify.app. The RMarkdown-file used to create this website can be found in the project component 'Code')