115 research outputs found
Medical student attitudes to patient involvement in healthcare decision-making and research
- Publication venue
- BMJ Publishing Group
- Publication date
- 21/11/2023
- Field of study
Objective: Patient involvement is used to describe the inclusion of patients as active participants in healthcare decision-making and research. This study aimed to investigate incoming year 1 medical (MBChB) students’ attitudes and opinions regarding patient involvement in this context.
Methods: We established a staff–student partnership to formulate the design of an online research survey, which included Likert scale questions and three short vignette scenarios designed to probe student attitudes towards patient involvement linked to existing legal precedent. Incoming year 1 medical students (n=333) were invited to participate in the survey before formal teaching commenced.
Results: Survey data (49 participants) indicate that students were broadly familiar with, and supportive of, patient involvement in medical treatment. There was least support for patient involvement in conducting (23.9%), contributing to (37.0%) or communicating research (32.6%), whereas there was unanimous support for patients choosing treatment from a selection of options (100%).
Conclusion: Incoming members of the medical profession demonstrate awareness of the need to actively involve patients in healthcare decision-making but are unfamiliar with the utility and value of such involvement in research. Further empirical studies are required to examine attitudes to patient involvement in healthcare
CCL18 from ascites promotes ovarian cancer cell migration through proline-rich tyrosine kinase 2 signaling
- Author
- A Ayhan
- A Maccio
- A Mantovani
- AA Ayantunde
- Alain Piché
- Alex Carignan
- B Zhang
- CA Lipinski
- CK Sun
- CK Sun
- CK Sun
- Claude Laplante
- Claudine Rancourt
- CW Lo
- D Bian
- D Lane
- D Lane
- D Lane
- Denis Lane
- DJ Sieg
- E Schutyser
- G Germano
- H Sasaki
- H Zhao
- HY Li
- I Matte
- I Matte
- Isabelle Matte
- J Cao
- J Chen
- J Shen-Gunther
- K Shield
- LM Coussens
- M Okigaki
- M Selitrennik
- M-L Puiffe
- N Goncharenko-Khaider
- N Verma
- NG Yousif
- Paul Bessette
- Perrine Garde-Granger
- Q Wang
- RC Bast
- RF Ozols
- RL Giuntoli
- S Furukama
- S Keleg
- S Lev
- SF Zohny
- ST Lim
- TC Hamilton
- V Kodelja
- X Hou
- Y Matsuo
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Contemporary management of cancer of the oral cavity
- Author
- A Alvi
- A Bilde
- A Bolzoni Villaret
- A Capote
- A Ferlito
- A Ferlito
- A Ferlito
- A Ferlito
- A Ferlito
- A Ferlito
- A Kreeft
- A Leslie
- A Matta
- A Matta
- A Terada
- A Torres-Rendon
- AA Abdel Razek
- AA Molinolo
- AD Rapidis
- AG Sikora
- AK Chaturvedi
- Alessandra Rinaldo
- Alexander D. Rapidis
- Alfio Ferlito
- AM Velly
- AP Lane
- AP Yuen
- AR Shaha
- Ashok R. Shaha
- B Misselwitz
- BF Branstetter 4th
- C Garnis
- C Klug
- C Schrag
- CA Waldron
- Carl E. Silver
- Carlos Suárez
- CL Estilo
- CT Viet
- DG Sessions
- E Di Martino
- EE Cohen
- EJ Nieuwenhuis
- EM Cann Van
- Eric M. Genden
- FJ Civantos
- FJ Civantos
- G Ross
- GL Ross
- GL Ross
- H Fukano
- H Kawaguchi
- H Schöder
- HD Curtin
- HJ Nyst
- IS Haring van der
- J Bernier
- J Brouwer
- J Lea
- JA Svirsky
- JA Woolgar
- JF Bremmer
- JJ Beitler
- JL Roh
- JM Brockenbrough
- JP Rodrigo
- JS Brown
- JS Brown
- JS Cooper
- JS Cooper
- JS Greenberg
- JT Gemert van
- Juan Pablo Rodrigo
- JW Braams
- JW Vegers
- JW Werning
- KO Devaney
- KT Robbins
- L Tschopp
- LW Alkureishi
- M Brandwein-Gensler
- M Hashibe
- M Pandey
- M Sharma
- M Siemionow
- MG Mack
- Missak Haigentz
- MJ Imola
- MM Hanasono
- MN Elsheikh
- MW Brekel van den
- MW Brekel van den
- NJ Fischbein
- NJ Yousif
- P Ambrosch
- P Holmstrup
- P Roepman
- PG Cordeiro
- PT Hennessey
- R Bree de
- R Sigal
- Randall P. Owen
- RJ Baatenburg de Jong
- RJ Shaw
- RJ Wong
- RM Byers
- Robert P. Takes
- RP Takes
- RS Patel
- RS Patel
- S Fleskens
- S Hu
- S Pohar
- Sandro J. Stoeckli
- SH Ng
- SJ Smeets
- SJ Stoeckli
- SJ Stoeckli
- SJ Stoeckli
- SJ Stoeckli
- SJ Stoeckli
- SM Longnecker
- T Asakage
- T Ho
- T Shoaib
- T Stuckensen
- T Upile
- TS Atula
- TT Tsue
- TW Poate
- V Paleri
- V Paleri
- WF McGuirt Jr
- WL Hicks Jr
- Y Anzai
- Y Li
- YC Lim
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2010
- Field of study
Oral cancer represents a common entity comprising a third of all head and neck malignant tumors. The options for curative treatment of oral cavity cancer have not changed significantly in the last three decades; however, the work up, the approach to surveillance, and the options for reconstruction have evolved significantly. Because of the profound functional and cosmetic importance of the oral cavity, management of oral cavity cancers requires a thorough understanding of disease progression, approaches to management and options for reconstruction. The purpose of this review is to discuss the most current management options for oral cavity cancers
Factors associated with spontaneous stone passage in a contemporary cohort of patients presenting with acute ureteric colic. Results from the MIMIC Study (A Multi-centre cohort study evaluating the role of Inflammatory Markers in patients presenting with acute ureteric Colic)
- Author
- Abboudi H
- Abdaal AC
- Abdelmoteleb H
- Abu Yousif M
- Acher P
- Adams R
- Ager M
- Ahmed I
- Ajayi L
- Akintimehin A
- Akman J
- Al Hayek S
- Al-Dhahir W
- Al-Qassim Z
- Al-Shakhshir S
- Alberto M
- Arya M
- Assaf N
- Ayres B
- Badgery H
- Bateman K
- Bdesha A
- Bedi N
- Begum R
- Belal M
- Biyani CS
- Bolton D
- Bultitude M
- Burge F
- Bycroft J
- Cameron F
- Campbell A
- Cannon A
- Carrie A
- Cashman S
- Chappell B
- Chin AOL
- Chow K
- Christidis D
- Clements J
- Coode-Bate J
- Cronbach P
- Cumberbatch M
- Curry D
- Dasgupta R
- Demirel S
- Derbyshire L
- Din W
- Docherty E
- Edison E
- Eldred-Evans D
- Ellis G
- Erotocritou P
- Evans S
- Foley R
- Frymann R
- Gallagher M
- Gao C
- Gowardhan B
- Graham J
- Graham S
- Gray S
- Grice P
- Gupta S
- Hamad S
- Hann GA
- Hussain Z
- Ibrahim H
- Irving S
- Ivin N
- Jaffer A
- Jalil R
- Kashora F
- Kasivisvanathan V
- Kavia R
- Kerr L
- Khadouri S
- Khan A
- Khan M
- Khan S
- Koschel S
- Kozan AA
- Kum F
- Kynaston H
- Laird A
- Lamb B
- Lavan L
- Lawrentschuk N
- Lee JCM
- Lee S
- Liew M
- Mackenzie K
- Malki M
- Manning T
- Manson-Bahr D
- Mason H
- Matanhelia M
- Maw J
- Mbuvi J
- Mc Cauley N
- Mc Kay AC
- McGrath S
- Mcilhenny C
- Miakhil I
- Miller M
- Mirza AB
- Morrison-Jones V
- Morrow J
- Mosey R
- Murtagh K
- Nambiar A
- Natarajan M
- Nehikhare Y
- Ness D
- Ng A
- Ngweso S
- Nkwam N
- Nyandoro M
- Nzenza T
- O'Brien J
- O'Brien J
- O'Rourke J
- Olaniyi P
- Olivier J
- Osman B
- Oyekan A
- Pang K
- Pankhania R
- Parwaiz I
- Parys B
- Patterson J
- Peacock A
- Pearce I
- Peters M
- Phipps S
- Pickard R
- Premakumar Y
- Probert JL
- Quinlan D
- Ratan H
- Reid K
- Rezacova M
- Rezvani S
- Rodger F
- Rogers A
- Ross D
- Rowbotham C
- Rujancich P
- Ruljancich P
- Sadien I
- Sakthivel A
- Saleemi A
- Samsudin A
- Sandhu S
- Seaward L
- Shah TT
- Sharma A
- Sharma S
- Shergill I
- Shetty A
- Shingles C
- Simmons L
- Simpson R
- Simson N
- Singh H
- Smith D
- Smith D
- Sriprasad S
- Stammeijer R
- Steen C
- Stewart H
- Stonier T
- Suraparaj L
- Swallow D
- Symes A
- Symes R
- Tailor K
- Tait C
- Tam JP
- Tay J
- Tay LJ
- Tregunna R
- Tudor E
- Udovicich C
- Umez-Eronini N
- van Rossum PSN
- Van Son MJ
- Wang L
- Ward A
- Weeratunga G
- Withington J
- Wong C
- Wozniak S
- Yassaie O
- Young M
- Publication venue
- 'Wiley'
- Publication date
- 22/08/2019
- Field of study
Objectives
There is conflicting data on the role of white blood cell count (WBC) and other inflammatory markers in spontaneous stone passage in patients with acute ureteric colic. The aim of the study was to assess the relationship of WBC and other routinely collected inflammatory and clinical markers including stone size, stone position and Medically Expulsive Therapy use (MET) with spontaneous stone passage (SSP) in a large contemporary cohort of patients with acute ureteric colic.
Subjects and Methods
Multi‐centre retrospective cohort study coordinated by the British Urology Researchers in Surgical Training (BURST) Research Collaborative at 71 secondary care hospitals across 4 countries (United Kingdom, Republic of Ireland, Australia and New Zealand). 4170 patients presented with acute ureteric colic and a computer tomography confirmed single ureteric stone. Our primary outcome measure was SSP as defined by the absence of need for intervention to assist stone passage. Multivariable mixed effects logistic regression was used to explore the relationship between key patient factors and SSP.
Results
2518 patients were discharged with conservative management and had further follow up with a SSP rate of 74% (n = 1874/2518). Sepsis after discharge with conservative management was reported in 0.6% (n = 16/2518). On multivariable analysis neither WBC, Neutrophils or CRP were seen to predict SSP, with an adjusted OR of 0.97 [95% CI 0.91 to 1.04, p = 0.38], 1.06 [95% CI 0.99 to 1.13, p = 0.1] and 1.00 [95% CI 0.99 to 1.00, p = 0.17], respectively. Medical expulsive therapy (MET) also did not predict SSP [adjusted OR 1.11 [95% CI 0.76 to 1.61]). However, stone size and stone position were significant predictors. SSP for stones 7mm. For stones in the upper ureter the SSP rate was 52% [95% CI 48 to 56], middle ureter was 70% [95% CI 64 to 76], and lower ureter was 83% [95% CI 81 to 85].
Conclusion
In contrast to the previously published literature, we found that in patients with acute ureteric colic who are discharged with initial conservative management, neither WBC, Neutrophil count or CRP help determine the likelihood of spontaneous stone passage. We also found no overall benefit from the use of MET. Stone size and position are important predictors and our findings represent the most comprehensive stone passage rates for each mm increase in stone size from a large contemporary cohort adjusting for key potential confounders. We anticipate that these data will aid clinicians managing patients with acute ureteric colic and help guide management decisions and the need for intervention
Pan-cancer analysis of whole genomes
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- A. Z. at
- aaa Mardis
- aab Marks
- aac Marra
- aag Mose
- aaz Schein
- ab ac
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- abd Sipahimalani
- abk Winterhoff
- abn Wong
- abp Baez-Ortega
- abp Kazanov
- abp Kong
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- abp Nik-Zainal
- abp P’ng
- abp Rabionet
- abp Roberts
- abp Wu
- abpEmail Author
- Aburatani
- ac ek
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- ad Zhang
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- ag Ding
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- bk Madsen
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- The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium View Correspondence (jump link)
- Thiessen
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- Publication venue
- Publication date
- 11/12/2019
- Field of study
Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe
Impact of primary kidney disease on the effects of empagliflozin in patients with chronic kidney disease: secondary analyses of the EMPA-KIDNEY trial
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- Yahaya H.
- Yalamanchili H.
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- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: The EMPA KIDNEY trial showed that empagliflozin reduced the risk of the primary composite outcome of kidney disease progression or cardiovascular death in patients with chronic kidney disease mainly through slowing progression. We aimed to assess how effects of empagliflozin might differ by primary kidney disease across its broad population. Methods: EMPA-KIDNEY, a randomised, controlled, phase 3 trial, was conducted at 241 centres in eight countries (Canada, China, Germany, Italy, Japan, Malaysia, the UK, and the USA). Patients were eligible if their estimated glomerular filtration rate (eGFR) was 20 to less than 45 mL/min per 1·73 m2, or 45 to less than 90 mL/min per 1·73 m2 with a urinary albumin-to-creatinine ratio (uACR) of 200 mg/g or higher at screening. They were randomly assigned (1:1) to 10 mg oral empagliflozin once daily or matching placebo. Effects on kidney disease progression (defined as a sustained ≥40% eGFR decline from randomisation, end-stage kidney disease, a sustained eGFR below 10 mL/min per 1·73 m2, or death from kidney failure) were assessed using prespecified Cox models, and eGFR slope analyses used shared parameter models. Subgroup comparisons were performed by including relevant interaction terms in models. EMPA-KIDNEY is registered with ClinicalTrials.gov, NCT03594110. Findings: Between May 15, 2019, and April 16, 2021, 6609 participants were randomly assigned and followed up for a median of 2·0 years (IQR 1·5–2·4). Prespecified subgroupings by primary kidney disease included 2057 (31·1%) participants with diabetic kidney disease, 1669 (25·3%) with glomerular disease, 1445 (21·9%) with hypertensive or renovascular disease, and 1438 (21·8%) with other or unknown causes. Kidney disease progression occurred in 384 (11·6%) of 3304 patients in the empagliflozin group and 504 (15·2%) of 3305 patients in the placebo group (hazard ratio 0·71 [95% CI 0·62–0·81]), with no evidence that the relative effect size varied significantly by primary kidney disease (pheterogeneity=0·62). The between-group difference in chronic eGFR slopes (ie, from 2 months to final follow-up) was 1·37 mL/min per 1·73 m2 per year (95% CI 1·16–1·59), representing a 50% (42–58) reduction in the rate of chronic eGFR decline. This relative effect of empagliflozin on chronic eGFR slope was similar in analyses by different primary kidney diseases, including in explorations by type of glomerular disease and diabetes (p values for heterogeneity all >0·1). Interpretation: In a broad range of patients with chronic kidney disease at risk of progression, including a wide range of non-diabetic causes of chronic kidney disease, empagliflozin reduced risk of kidney disease progression. Relative effect sizes were broadly similar irrespective of the cause of primary kidney disease, suggesting that SGLT2 inhibitors should be part of a standard of care to minimise risk of kidney failure in chronic kidney disease. Funding: Boehringer Ingelheim, Eli Lilly, and UK Medical Research Council
Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries
- Author
- Aamir Faiqa Binte
- Aamir Syed Roohan
- Ababneh Adnan
- Abbal Muhammad Anas
- Abbas Ahmed M
- Abbas Mostafa
- Abd-Albain Montasir A
- Abdalei Abdulwahab
- Abdalla Ahmed
- Abdalla Ahmed Yassir
- Abdalla Mohamed Galal Ali
- Abdalla Zainab
- Abdallah Mohamed M
- Abdalmahmoud Noon Ezzeldien
- Abdalsadeg Rowa
- Abdelaal Ahmed M
- Abdelbagi Alnazeer Y
- Abdelbaky Mostafa
- Abdelbaset Doaa
- AbdElbaset Esraa
- Abdelbast Menhag
- Abdelfatah Mohammed Abdelnasser
- Abdelgawad Samia
- Abdelhamid Mohamed M
- Abdeljaber Mahmoud
- Abdelkhalig Mubarak
- Abdelmaksoud Mohamed
- Abdelmeguid Rana
- Abdelmelek Dhia Errahmane
- Abdelnaeam Samah
- Abdelnasser Mohammad K
- Abdelrahim Najwa
- Abdelrahman Amira
- Abdelrahman Ayman
- Abdelsalam Hebatalla
- Abdelsamed Enas Abdelbaset
- Abdelwahab Khaled
- Abdoun Meriem
- Abdulali Fatima
- Abdulaziz Mohamed
- Abdulla Dheba Almukhtar
- Abdullah Bahiyah
- Abdullah Bahiyah
- Abdullah Walaa
- Abdullahi Habiba Ibrahim
- Abdulrahman Ahmed
- Abdulrasheed Lubabatu
- Abdulwahed Eman
- Abdulwahed Eman
- Abeysirigunawardana Dewmi
- Abidin Muhammad Fihmi Zainal
- Abiola Olukayode
- Abiyere Henry
- Abodina Ahmed Mohammed
- Aboelela Reham
- AboElfarh Hadeer Elsaeed
- Aboudlal Husein
- AbouHiekal Osama
- Aboulfotouh Ahmed
- Abozid Anwaar
- Abubaker Noora
- Abubaker Noora
- Abufanas Asma
- Abughanima Mahmoud
- Abuhashem Shehab
- Abulafia Daniel
- Abushaala Fatima
- Abushanab Khaled
- AbuShawareb Issa
- Abuuqteish Hamza
- Abuzaho Amany
- Achem Arome
- Adam Eithar
- Adam Mohammed
- Adam Mohammed A
- Addalla Mohamed
- Addley Jordan
- Adeleye Gbadebo
- Adeniyi Adebayo
- Adewole Nathaniel
- Adeyemo Olabisi
- Adeyeye Ademola
- Adeyeye Ademola
- Adly Michael
- Adnan Siti Nasyirah Nisya
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adze Joel Amwe
- Afeikhena Ehis
- Agida Teddy
- Agilla Hamza
- Agnew Emilie
- Agu Joy Onyekachi
- Ahmad Zatul Akmar
- Ahmed Abdalla
- Ahmed Ahmed
- Ahmed Ahmed
- Ahmed Alaaaldeen
- Ahmed Entisar
- Ahmed Habeeba
- Ahmed Hatem
- Ahmed Reem
- Ahmed Rehab
- Ahmed Rihab
- Ahmed Rogia Ahmed Abdalla
- Ahmed Ruaa
- Ahmed Sharwany
- Ahmed Uzair
- Ahmed Wahiba
- Ahmeed Sultan
- Airede Lydia Regina
- Aitchison Lori
- Ajredini Mirac
- Ajulo Adeshina A
- Akaba Godwin
- Akasha Mazin
- Akbar Maha Ghulam
- Akbuz Seyma Orcan
- Akdere Hakan
- Akın Bilge
- Akkaya Ege Nur
- Akpamgbo Chukwunonso Nnamdi
- Akwaisah Ayoub
- Al Hammoud Amr
- Al Rawashdeh Toka
- Al-Baw Mahmoud
- Al-Dahdouh Mosheer
- Al-Haek Safa’
- Al-Hazaimeh Mo'ath
- Al-issawi Dima
- Al-Issawi Subhi
- Al-jammal Maryam
- Al-Juaifari Maytham A
- Al-Mwajeh Tesneem
- Al-Omary Sohaib
- Al-Quossi Mohammed
- Al-Shambaty Yasir Babkir Ali
- Al-Shami Qotadah
- Al-Smirat Heba
- Al-Tahayneh Sief-Addeen
- Al-Touny Aiman
- Al-Touny Shimaa
- Al-zawaydeh Alia
- Alaa Ali
- Alabed Ebtihal
- Alagelli Fatma
- Alagoz Ahmet Can
- Alameen Hind
- Alameen Maram
- Alamlih Laith
- Alaqoubi Retaj
- Alarabi Rehab
- Alariby Fatima
- Alatefi Dawood
- Alathameen Nassar
- Albakosh Bashir Abobaker
- Albanopoulos Konstantinos
- Albarhomy Osama
- Albarki Aisha
- Albashaireh Alaa
- Albatni Safa Sasi
- Albayadi Eslam
- Alboon Mosab
- Alboridy Muneera
- Alboueishi Asraa Ali
- Aldeges Marwan
- Aldreawi Mohammed
- Alflite Asil Omar Saleh
- Alfrijat Tamam
- Alfrjani Tariq
- Algabbasi Salima
- Algatanesh Nassib
- Alhadad Qamrah
- Alhaddad Hoda Salem
- Alhaleem Ayah
- Alhaleeq Saif
- Alharam Abtisam
- Alhashimi Abdulhadi Mohammed Alhadi
- Alhassan Monzer
- Alhudhairy Sara
- Ali Ahmed
- Ali Aml
- Ali Doua
- Ali Eithar M
- Ali Iqra Fatima Munawar
- Ali Maab
- Ali Manal
- Ali Muhammad
- Ali Radwa
- Ali Rawan Alsheikh
- Ali Rzan Ali Hamedelneel
- Ali Shehroz
- Aliosin Oleg
- Aljamal Mohammad
- Aljamal Sarah
- Alkaraja Layth
- Alkaseek Akram
- Alkazali Mustafa
- Alkchr Hayat Ben Hasan Mohamed A A
- Alkhatib Abed Alazeez
- Allam Shereen
- Almahroush Marin
- Almakki Doha Mohammed Ahmed
- Alnajjar Lara
- Alnajjar Majjd
- Alnatsheh Wesam
- Alnour Ammar
- Alomar Rabiaa
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- Alqaarh Aya
- Alragig Zahra
- Alrifae Ghaliya Mohamed H
- Alrosan Risan
- Alsagoff Sharifah Nor Amirah Syed Abdul Latiff
- Alsaid Hamza
- Alsaify Esmat
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- Alshawadfy Abdelrhman
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- Alsoudani Ali
- Altabbaa Hashem
- Altahir Mohamed
- Altair Mawadda
- Altaweel Ahmad
- Altughar Bushra
- Alvarez Matias
- Alvarez-Lozada Luis Adrian
- Alvarez-Lozada Luis Adrian
- Alwahaib Anas
- Alwash Mohammed
- Alzarga Ali
- Alzarouq Ebtisam
- Alzarroug Amal
- Alzghoul Bader
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- Amarasekara Mishka
- Amary Marwa
- Ametov Amet
- Amin Mostafa K
- Aminu Bashiru
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- Hilder Amie
- Hilder Amie
- Hill Terrence
- Ho Annie
- Ho Jess
- Ho Jess
- Hobbs Katie
- Hodgson Russell
- Hogan Lucinda
- Hokelekli Furkan
- Hong Jonathan
- Honore Elodie
- Hoosenally Mariyah
- Hopping Eve
- Horsburgh Eleanor
- Hou Lachlan
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- House Colin
- How Ming Zhou
- Hsieh Justin
- Hu Nelson
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- Huang Sarah
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- Hung Wing
- Husein Abrar
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- Hussein Aisha
- Hussien Ahmed
- Hussien Aya
- Hussien Tarek A
- Ibiyemi Femi
- Ibraheem Gbadebo Hakeem
- Ibrahim Abdullahi
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- Ibtisam Muhammad
- Ifoto Oghenekaro
- Iftikhar Hareem
- Imran Aliza
- Incoll Ian
- Innes Michael
- Ioannidis Orestis
- Ioannidis Orestis
- Ioannidis Orestis
- Isaac Hope
- Isah AliyuYabagi
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- Isahak Mohamed Izzad
- Isais Jorge Arath Rosales
- Ismail Samir
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- Isopi Claudio
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- Iya Abdulkarim
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- Jabur Aiden
- Jabur Aiden
- Jabur Aiden
- Jaffry Kumail
- Jaffry Kumail
- Jakanovski Philip
- Jamal Sami
- Jamali Salma
- Jamieson Jodie
- Jamil Muhammad Badrul Hisyam Mohamad
- Jangam Aishwarya
- Jangra Muskan
- Javed Imran
- Jawa Timothy
- Jayatilleke Shenuka
- Jayyab Mustafa Abu
- Jeffery Fraser
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- Jeyamohan Ragavi
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- Jin Rong
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- Kalogiannidis Ioannis
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- Mohammed Mansour
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- Mohmmed Sara
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- Morsi Ahmed
- Morsi Salma
- Mosaad Abdelrahman
- Mostafa Esraa
- Motajo Oluwatosin Olakunle
- Moustafa Ahmad
- Muchabaiwa Ropafadzo
- Mufarrih Syed Musa
- Mugassabi Hoda El
- Muhammad Ismail
- Muhib Muhammad
- Mukhtar Maha Mukhtar Ahmed
- Mulder Fraizer
- Muller Maddison
- Muneer Urwah
- Muqbel Ro-a
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- Muschitiello Davide
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- Ozkan Esin
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- Palacios Diana Sofia Garces
- Palaniappan Ramanathan Rm
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- Pantoja Maria Alejandra Nanez
- Papanikolaou Evangelos
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- Park Heejun
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- Park Melissa
- Park Melissa
- Patel Diya
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- Pathak Upasana
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- Patil Aditya
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- Paul Rohit
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- Pehlivan Dilan
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- Pockney Peter
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- Prasad Shaamnil
- Prasad Shalvin
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- Proud David
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- Qazi Arisha
- Qian Gemma
- Qian Helena
- Quadros Dwain
- Quek Nicholas
- Quinlan Liam
- Qureshi Faiza
- Radovanovich Jess
- Rae Hamish
- Rafaei Rawan
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- Raja Sajjan
- Rajabi Munia
- Rajesh Krishnankutty
- Raji Hadijat Olaide
- Ramadan Mohamed
- Ramadan Mohamed F
- Ramlee Afiq Aizat
- Ramphal Shanay
- Rashed Osama Fathy Ali Ali
- Rasheed Ayat
- Raslan Bassma
- Rasslan Esraa
- Rathnayake Athulya
- Ratnayake Milidu
- Ratnayake Milidu
- Raubenheimer Kyle
- Raubenheimer Kyle
- Raubenheimer Kyle
- Rauf Abdul
- Ravi Anjana
- Rawal Alisha
- Raza Muhammad
- Razmi Akeedh
- Reed Catherine
- Rehfisch Peter
- Rehman Saif Ur
- Reinke Caroline
- Reis Murat Emre
- Ren Seifei
- Restini Enrico
- Reyes Bernardo Alfonso Fernández
- Rhuma Heba
- Richter Konrad
- Rifaioglu Kerem
- Roata Cristian Ene
- Robinson Samuel
- Romano Angela
- Rosello-Añon Alejandro
- Roshdy Mo'men
- Ross Jessica Stott
- Ross Poppy
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- Roth Charles
- Rottoli Matteo
- Ruiz Enrique
- Rumble William
- Rusli Siti Mayuha
- Russo Iris Shari
- Saad Mahmoud M
- Saada Hind
- Saber Mona
- Sabry Ahmed Abdelfatah
- Sabuncu Kubilay
- Sadauskas Tomas
- Sadek Mirna
- Saeed Abdallah
- Saeed Umar
- Safar Amna
- Saha Sushanth
- Sahin Berfin İlgaz
- Sahin Melek
- Sajo Isa Mienda
- Sakr Ahmed
- Sakthivel Mahesh
- Salah Asmaa
- Salah Doaa
- Salah Mohamed
- Salah Salem
- Salaheldein Mohamed
- Salameh Alaa Eddin
- Salawu Adedayo
- Salawu Hafeez
- Saleh Ahmad
- Saleh Sara Ahmed
- Salem Ebrahim
- Salem Mohammed
- Saliaris Konstantinos
- Salih Alaa A
- Salihu Makama Baje
- Sallam Abdelaziz
- Samalavicius Narimantas
- Sami Wesam
- Sammour Tarik
- Sampatha-Waduge Tharushi
- Sanad Aly
- Sandhu Jaspreet Kaur
- Sanguesa Maria Jose
- Sani Samuel Ali
- Sanli Ahmet Necati
- Sanz-Romera Jorge
- Sara Rachel
- Saraçoğlu Ayten
- Sarafi Aikaterini
- Sarangadasa Pavatharane
- Sarhan Osama
- Sarı Ahmet Can
- Sarih Monira
- Sarwar Albash
- Sathasivam Vinogi
- Sathiyaseelan Avinash
- Sawaftah Khaled
- Sayed Ahmed M
- Sayed Mohamed Al
- Sayed Yasmeen
- Saylar Alparslan
- Saylar Alparslan
- Sánchez Luis Antonio Heredia
- Schizas Dimitrios
- Segaran Sharrada
- Seldon Alexandra
- Selim Kamar
- Selim Osama
- Seneviratne Dharani
- Sengupta Shomik
- Senthilrajan Rahavi
- Seow Warren
- Shaaban Abdelrahman
- Shaban Aya
- Shaban Walid
- Shabaneh Amin
- Shafaat Amna
- Shagroun Esra
- Shah Jainil
- Shah Jainil
- Shahat Mohammed A
- Shaheen Nourhan
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- Shalaby Mostafa
- Shalalfeh Sa'ed
- Shaltout Asmaa S
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- Shanag Hadeel
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- Shehab Ali Fahmy
- Shehahda Sireen
- Shehata Mena
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- Sherif Yara
- Sheriff Arfaan
- Shetwan Sundes
- Shipa Ahmed
- Shiru Mariam Motunrayo
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- Shuaibu Ibrahim Shaphat
- Shui Amanda
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- Sierra Oscar Alonso Verduzco
- Silem Yousra Othman Reham
- Silva Yannick De
- Silverii Julia
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- Singer David
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- Stevens Sean
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- Studd Rod
- Sulaiman Bilal
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- Suliman Merna Ezz
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- Surkitt Amy
- Suttor Sean
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- Swan Daniel
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- Şenödeyici Eylül
- Tabak Elif Zeynep
- Taha Hala Abdelhalim Mohamed
- Taha Ibrahim
- Taha Omima
- Tahir Farah
- Tahir Izza
- Taingson Mathew Chum
- Talaat Omnia
- Talavera Elena
- Taman Mohamed
- Tan Kevin
- Tan Sarah
- Tan Sarah
- Tan Suqi
- Tan Wen Po Jonathan
- Tandogan Yusuf Iskender
- Tang Howard
- Tang Patrick
- Tang-Ieam Pattarapan
- Tao Steve
- Tarek Yousef
- Tariq
- Tarmidi Jazmina
- Tasi Zoya
- Taşcı Muhammed Enes
- Taufiq Maliha
- Tay Kai Yun Jodene
- Taylor Emily
- Taylor Isobel
- Teema Eman
- Telci Hatice
- Temerik Abdallah Rashad
- Teng Cherilyn
- Tepe Mustafa Deniz
- Tepe Mustafa Deniz
- Terrosu Giovanni
- Theophilus Mary
- Thompson Nasya
- Thornton-Hume David
- Tiffany Lea
- Ting Clarissa
- Tiras Hale Nur
- Titan Ashley
- Toft Alexandra
- Traina Francesco
- Tran Anthony
- Tran Quang
- Tran Tam
- Tran Will
- Trotta Georgina
- Tsakiridis Ioannis
- Tsakiridis Nikolaos
- Tsourouflis Gerasimos
- Tsui Sonia Ching Ting
- Tu Hien
- Tun Than
- Tung Melody
- Tuzuner Filiz
- Tynan Dominic
- Ugool Mahmoud
- Uğurlu Mustafa Ümit
- Ukrani Ronika Devi
- Ukwuoma Ohia Ernest
- Ulkucu Attila
- Uludag Server Sezgin
- Ulusahin Mehmet
- umar Abubakar
- Umar Gabi Ibrahim
- Uprak Tevfik Kıvılcım
- Ureña Violeta
- Usman Liman Haruna
- Uyanık Mustafa Safa
- Uzair Ahmad
- Uzel Kadir
- Vadioaloo Dinesh Kumar
- Valaroutsou Olga Maria
- Valverde-Vazquez Rocio
- Vance Lucille
- Vanguardia Kristina
- Vanguardia Maria Kristina
- Vanzuylekom Katie
- Varesano Marco
- Varghese Chris
- Varghese Chris
- Velenciuc Natalia
- Vermeulen Wikus
- Vidanagama Sasini
- Vimalan Vineeth
- Virani Sehar Salim
- Vollenhoven Beverley
- Vong Crystal
- Vrakopoulou Gavriella Zoi
- Vu Jennifer
- Vu Jennifer
- Waaka Nicholas
- Wadhwa Sanya
- Wagaarachchi Prabhath
- Waheed Ayesha Akbar
- Waldin Lucy
- Walsh Eamon
- Walters Chris
- Wang Bill
- Wang Christine
- Wang Erica
- Wang Grace
- Wang Katie
- Wang Nicole Qiwen
- Wang Pengnan
- Wang Qiwen
- Wang Shelley
- Wang Yantong
- Wang Zixuan
- Waqar Usama
- Waraich Abdullah
- Ward Jack
- Wardeh Salah Abu
- Wasim Tayyiba
- Watson David
- Watson David
- Wedatalla Mansour
- Weeda Lewis
- Wells Cameron
- Wells Cameron
- Wells Cameron
- Wells Oliver
- Werenski Hope
- Wijayaratne Rivindu
- Wijetunga Asanka
- Williams Brittany
- Williams Peter
- Wilson Thomas
- Windsor John
- Windsor John
- Winthrop Lily
- Withanage Indrajith
- Wong James
- Wong Jason
- Wong Kenneth
- Wong King Ho
- Wong Patrick
- Wong Samantha
- Woodbridge Christian
- Wright Deborah
- Wright Deborah
- Wright Deborah
- Wu Alan
- Wu Alan
- Wu Chun-Yen
- Wu Hongyi
- Wycliff Daniel
- Xiao Haotian
- Xie Maria
- Xu Cindy
- Xu William
- Xu William
- Xu William
- Yaghmour Jamal
- Yahya Bilal Shuaibu
- Yahya Rawad
- Yang Wah
- Yao Michelle
- Yao Sunny
- Yao Sunny
- Yasar Meltem
- Yasir Ruaa
- Yassin Mohamed
- Yavuz Dogancan
- Yavuz Ikranur
- Yaytokgil Muhammet
- Yazgan Yasemin
- Yee Su-Ann
- Yeung Justin
- Yeung Kar Long
- Yew Anthea
- Yi Kevin
- Yiannakopoulos Christos
- Yildirim Yasemin
- Yildiz Ahmet
- Yıldız Berkay
- Yilmaz Hakan
- Yin Chonghao
- Ying Geoffrey
- Yodkitydomying Chatnapa
- Yong Nathania
- Yoon Si Woo
- You Ha Seong
- Young Simon
- Young Stevie
- Younus Khadijah
- Yousif Fatima Imad
- Yousri Mohamed
- Youssef Ahmed A
- Youssef Arkan
- Yu Hoi Hang
- Yu Victor
- Yuan Grace
- Yue Bosco
- Yue Tiffany
- Yunos Mohamed Haseef Mohamed
- Yusuf Stephen
- Yuzgec Ayse Nilufer
- Zachomitros Fotios
- Zaed Moahmed
- Zafar Fatima
- Zaghloul Ahmed
- Zaheer Adil
- Zaidi Faseeh
- Zain Ahmad
- Zakaria Ahmed
- Zakaria Andee Dzulkarnaen
- Zakaria Mohd Zaim
- Zalloum Jihad
- Zamanbandhon Bushra
- Zambon Mattia
- Zapsalis Konstantinos
- Zargar Kamran
- Zarzour Mohamed A
- Zeng Raymond
- Zeng Raymond
- Zengin Kagan
- Zertuche Juventino Tadeo Guerrero
- Zhang Caitlin
- Zhang Edward
- Zhang Shane
- Zhang Yichi
- Zhao Hailin
- Zheng Helen
- Zhou Karen
- Zhou Yida
- Ziergiebel Felix
- Zou Peishan
- Zuylekom Kate Van
- Zuylekom Katie Van
- Zwain Yasir Adnan
- Zyul'korneeva Sof'ya
- Aladna Abdallah
- Aljoumaa Abdullah
- Nawfal Hamdi
- Niazi Ammar
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 02/03/2020
- Field of study
Chromothripsis is a mutational phenomenon characterized by massive, clustered genomic rearrangements that occurs in cancer and other diseases. Recent studies in selected cancer types have suggested that chromothripsis may be more common than initially inferred from low-resolution copy-number data. Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA), we analyze patterns of chromothripsis across 2,658 tumors from 38 cancer types using whole-genome sequencing data. We find that chromothripsis events are pervasive across cancers, with a frequency of more than 50% in several cancer types. Whereas canonical chromothripsis profiles display oscillations between two copy-number states, a considerable fraction of events involve multiple chromosomes and additional structural alterations. In addition to non-homologous end joining, we detect signatures of replication-associated processes and templated insertions. Chromothripsis contributes to oncogene amplification and to inactivation of genes such as mismatch-repair-related genes. These findings show that chromothripsis is a major process that drives genome evolution in human cancer
Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
- Author
- A Gordon Robertson
- Abdullah Kahraman
- Abel Gonzalez-Perez
- Adam A Margolin
- Adam Abeshouse
- Adam Grundhoff
- Adam J Struck
- Adam J Struck
- Adam J Wright
- Adam Lambert
- Adam P Butler
- Adam P Butler
- Adel El-Naggar
- Adnan M Nagrial
- Adrian Ally
- Adrian Baez-Ortega
- Adrian Thorogood
- Adriana Salcedo
- Adrienne M Flanagan
- Ake Borg
- Akihiro Fujimoto
- Akihiro Suzuki
- Akinyemi I Ojesina
- Alain Viari
- Alan J Robertson
- Alan P Hoyle
- Alan Thompson
- Alasdair Stenhouse
- Alastair M Thompson
- Aldo Scarpa
- Alessandro Pastore
- Alex Buchanan
- Alex Buchanan
- Alexander Claviez
- Alexander J Lazar
- Alexander Martinez-Fundichely
- Alfonso Muñoz
- Alfonso Valencia
- Aliaksei Z Holik
- Alice Meng
- Alicia L Bruzos
- Allison Creason
- Allison P Heath
- Alvin Wei Tian Ng
- Alvis Brazma
- Amaro Taylor-Weiner
- Amber L Johns
- Amie Radenbaugh
- Amit G Deshwar
- Ana Dueso-Barroso
- Ana Mijalkovic Mijalkovic-Lazic
- Ana Milovanovic
- Ana Milovanovic
- Andre Kahles
- Andrea Haake
- Andrea Holbrook
- Andrea L Richardson
- Andrea Mafficini
- Andrea Ruzzenente
- Andreas Behren
- Andreas Rosenwald
- Andreia V Pinho
- Andrew Berchuck
- Andrew D Cherniack
- Andrew J Dunford
- Andrew J Mungall
- Andrew J Spillane
- Andrew Menzies
- Andrew Menzies
- Andrew P Barbour
- Andrew Tutt
- Andrew V Biankin
- Andrey Korshunov
- Andrés Lanzós
- Andy Cafferkey
- Andy G Lynch
- Angela Chou
- Angela N Brooks
- Angela Tam
- Angelica Ochoa
- Angelika N Christ
- Angelo P Dei Tos
- Anieta M Sieuwerts
- Anil K Sood
- Anita Langerød
- Anja Füllgrabe
- Anke K Bergmann
- Ann-Marie Patch
- Anna deFazio
- Anna Ehinger
- Anna Fitzgerald
- Anne Hamilton
- Anne Vincent-Salomon
- Anne Y Warren
- Anne-Lise Børresen-Dale
- Annegien Broeks
- Anthony DiBiase
- Anthony J Gill
- Anthony Ng
- Anthony R Green
- Antonia L Pritchard
- Antonio Pea
- Antonios Koures
- Aparna Prasad
- Apurva M Hegde
- Aquila Fatima
- Arcadi Navarro
- Arie B Brinkman
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- Armando Lopez-Guillermo
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- Austin J Hepperla
- Axel Aretz
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- Tomoko Urushidate
- Torill Sauer
- Toru Nakamura
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- Vasilisa A Rudneva
- Venkata D Yellapantula
- Venkata D Yellapantula
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- Veronica Y Sabelnykova
- Victor Reuter
- Vikram Deshpande
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- Vincent Huang
- Vincent J Gnanapragasam
- Vincent Khoo
- Vincenzo Corbo
- Vishal S Chandan
- Volker Hovestadt
- W Kimryn Rathmell
- W M Linehan
- Walker Hale
- Wan Choi
- Wanding Zhou
- Wang Liang-Bo
- Weerasinghe Amila
- Wei Jiao
- Wendl Michael C
- Wenyi Wang
- Wenyi Wang
- Wenyi Wang
- Wheeler David A
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- William C Faquin
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- William Howat
- William U Meyerson
- Willie Yu
- Winghing Wong
- Wojciech Bazant
- Wolfgang Huber
- Wolfram Klapper
- Xavier Estivill
- Xavier Pivot
- Xiao Xiao
- Xiaobo Li
- Xiaoping Su
- Xiaotong Li
- Xiaotong Yao
- Xing Hua
- Xingmin Liu
- Xinyue Li
- Xiuqing Zhang
- Xiuqing Zheng
- Xose S Puente
- Xuan Le
- Xuanping Zhang
- Xuemei Luo
- Xueqing Zou
- Yan Shi
- Yan Zhang
- Yang Wu
- Yang Yang
- Yann Joly
- Yanxun Xu
- Yao He
- Yasin Senbabaoglu
- Yassen Assenov
- Yasser Riazalhosseini
- Yasuhito Arai
- Yasushi Rino
- Yasushi Totoki
- Yeng Ang
- Yi Huang
- Yi Huang
- Yifei Men
- Yiling Lu
- Yilong Li
- Yingyan Yu
- Yiwen Chen
- Yogesh Kumar
- Yogesh Kumar
- Yoke-Eng Chiew
- Yong Hou
- Yong Zhou
- Yong-Jie Lu
- Yongzhan Nie
- Yosef E Maruvka
- Yosef E Maruvka
- Yoshiiku Kawakami
- Young Seok Ju
- Youngchoon Woo
- Youngil Koh
- Youngwook Kim
- Youyong Lu
- Yu Fan
- Yu Fan
- Yu Fan
- Yu-Jia Shiah
- Yuan Ji
- Yuan Yuan
- Yuichi Shiraishi
- Yulia Newton
- Yulia Rubanova
- Yumeng Wang
- Yupeng Cun
- Yussanne Ma
- Zachary Heins
- Zechen Chong
- Zechen Chong
- Zemin Zhang
- Zhaohong Chen
- Zhenggang Wu
- Zhenggang Wu
- Zhining Wang
- Zhongming Zhao
- Ziao Lin
- Zsofia Kote-Jarai
- Ólafur Andri Stefánsson
- Øystein Garred
- Publication venue
- Nature Communications
- Publication date
- 01/01/2020
- Field of study
Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts
The History of Barbed Suture Suspension: Applications, and Visions for the Future
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2008
- Field of study
- …