Impacts of wind forcing on sea level variations in the East China Sea: Local and remote effects

The regional sea level variation in the East China Sea (ECS) was influenced not only by local factors but also by remote wind from adjoining ocean with the oceanic connectivity influenced by upper-ocean circulation. The satellite altimeter observations showed that from 1993 to 2008, the inter-annual sea level variation in the ECS was negatively related to the strength of Kuroshio. To investigate the relative role of local and remote wind, two sensitive experiments were carried out using the POP model. Model experiments revealed that wind-induced redistributions of water played a significant role in the sea level variation of the ECS. The seasonal variations were induced by both local winds and remote Pacific wind stress with approximately equal contribution. However, on the inter-annual sea level variations, the remote wind forcing over the North Pacific could contribute substantially more than that of local wind which modulated sea level immediately. Remote wind influenced the China Sea in forms of changing of wind stress curl and ocean currents, which influenced the intensity of the Kuroshio, especially during El Nino episodes. (C) 2015 Elsevier B.V. All rights reserved

An integrated proteomic and metabolomic study on the gender-specific responses of mussels Mytilus galloprovincialis to tetrabromobisphenol A (TBBPA)

Tetrabromobisphenol A (TBBPA), accounting for the largest production of brominated flame-retardants (BFRs) along the Laizhou Bay in China, is of great concern due to its diverse toxicities. In this study, we focused on the gender-specific responses of TBBPA in mussel Mytilus galloprovincialis using an integrated proteomic and metabolomic approach. After exposure of TBBPA (10 mu g L-1) for one month, a total of 9 metabolites and 67 proteins were altered in mussel gills from exposed group. The significant changes of metabolites in female mussel gills from exposed group exhibited the disturbances in energy metabolism and osmotic regulation, while in male samples only be found the variation of metabolites related to osmotic regulation. iTRAQ-based proteomic analysis showed biological differences between male and female mussel gills from solvent control group. The higher levels of proteins related to primary and energy metabolism and defense mechanisms in male mussel gills meant a greater anti-stress capability of male mussels. Further analysis revealed that TBBPA exposure affected multiple biological processes consisting of production and development, material and energy metabolism, signal transduction, gene expression, defense mechanisms and apoptosis in both male and female mussels with different mechanisms. Specially, the responsive proteins of TBBPA in male mussels signified higher tolerance limits than those in female individuals, which was consistent with the biological differences between male and female mussel gills from solvent control group. This work suggested that the gender differences should be considered in ecotoxicology. (C) 2015 Elsevier Ltd. All rights reserved

c-axis preferential orientation of hydroxyapatite accounts for the high wear resistance of the teeth of black carp (Mylopharyngodon piceus)

Biological armors such as mollusk shells have long been recognized and studied for their values in inspiring novel designs of engineering materials with higher toughness and strength. However, no material is invincible and biological armors also have their rivals. In this paper, our attention is focused on the teeth of black carp (Mylopharyngodon piceus) which is a predator of shelled mollusks like snails and mussels. Nanoscratching test on the enameloid, the outermost layer of the teeth, indicates that the natural occlusal surface (OS) has much higher wear resistance compared to the other sections. Subsequent X-ray diffraction analysis reveals that the hydroxyapatite (HAp) crystallites in the vicinity of OS possess c-axis preferential orientation. The superior wear resistance of black carp teeth is attributed to the c-axis preferential orientation of HAp near the OS since the (001) surface of HAp crystal, which is perpendicular to the c-axis, exhibits much better wear resistance compared to the other surfaces as demonstrated by the molecular dynamics simulation. Our results not only shed light on the origin of the good wear resistance exhibited by the black carp teeth but are of great value to the design of engineering materials with better abrasion resistance

A molecular imprinting-based turn-on Ratiometric fluorescence sensor for highly selective and sensitive detection of 2,4-dichlorophenoxyacetic acid (2,4-D)

A novel molecular imprinting-based turn-on ratiometric fluorescence sensor was constructed via a facile sol-gel polymerization for detection of 2,4-dichlorophenoxyacetic acid (2,4-D) on the basis of photo induced electron transfer (PET) by using nitrobenzoxadiazole (NBD) as detection signal source and quantum dots (QDs) as reference signal source. With the presence and increase of 2,4-D, the amine groups on the surface of QDs@SiO2 could bind with 2,4-D and thereby the NBD fluorescence intensities could be significantly enhanced since the PET process was inhibited, while the QDs maintained constant intensities. Accordingly, the ratio of the dual-emission intensities of green NBD and red QDs could be utilized for turn-on fluorescent detection of 2,4-D, along with continuous color changes from orange-red to green readily observed by the naked eye. The as-prepared fluorescence sensor obtained high sensitivity with a low detection limit of 0.14 mu M within 5 min, and distinguished recognition selectivity for 2,4-D over its analogs. Moreover, the sensor was successfully applied to determine 2,4-D in real water samples, and high recoveries at three spiking levels of 2,4-D ranged from 95.0% to 110.1% with precisions below 4.5%. The simple, rapid and reliable visual sensing strategy would not only provide potential applications for high selective ultratrace analysis of complicated matrices, but also greatly enrich the research connotations of molecularly imprinted sensors. (C) 2016 Elsevier B.V. All rights reserved

Pan-cancer analysis of whole genomes

Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe

Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine

[This corrects the article DOI: 10.1186/s13054-016-1208-6.]

Response of monopiles subjected to combined vertical and lateral loads, lateral cyclic load, and scour erosion in sand

Although wind energy capacity has increased significantly in the last few decades, the installed capacity of offshore wind turbine still lags far behind that of onshore wind turbines due to the installation and foundation cost. The aim of this research project has been to clarify the influence of combined vertical and lateral loads, lateral cyclic load, and scour erosion on monopile foundations, in order to achieve more realistic and cost beneficial solutions for offshore wind turbine foundations and thereby increase its competitiveness when compared with other energy sources. Monopiles are the most popular foundation system today for offshore wind turbines installed in shallow to medium water depths. These relatively light structures (low vertical load), need to resist substantial lateral and moment loads. There have been a dearth of studies conducted to investigate the influence of vertical load on the lateral response of these rigid monopiles and the few available have drawn contradictory conclusions. In addition the lateral and moment loading exerted on monopiles due to wind, wave, and water currents is cyclic in nature. This type of loading can lead to the accumulation of lateral displacement/rotation and possible degradation of soil resistance over time. This evolution of pile head displacement and the change in soil stiffness with increasing cycles of load is poorly understood. Cylindrical structures, like monopiles, founded in offshore regions are commonly subjected to scour erosion caused by flowing water and currents, which induces loss of soil support around the pile, reducing the lateral load capacity and causing increased pile displacement. As a result, the system dynamics of the structure might be adversely affected. The results of numerical models suggest that the shape of the scour hole affects the loss of pile lateral capacity, however, there is a shortage of experimental test data that measure this effect. More than 60 centrifuge tests which are categorized into three groups are presented in this thesis, which consider the interaction of combined vertical and lateral loads, lateral cyclic load and scour erosion on the behaviour of rigid monopiles. The tests have been performed in homogeneous dry Geba sand in order to mimic simplified drained offshore soil conditions.Geo-engineerin

Renovation of Water-related City Border

The Delta Intervention Studio Deals with the practical problem of the water?related architecture design and urban planning. It’s a combination of architecture, civil engineering and management which provide practical reference for the real project in Houston. Due to a changing climate and changing insights concerning sustainable relations between cities and water?landscapes, new interventions will be needed to create a new urban delta?landscape. The task of an architect in this studio is to develop an architectural object in such a waters cape. This Project researched the possibilities in architecture to provide better waterfront public space and flood protection for TMC and the Brays Bayou. Like the subject of the studio, this project is a research of the different aspects of the delta and the possibilities this brings for an architectural design. It focus on the bayou water type in Houston, deals with the sustainable, economic and social topics of Brays Bayou in TMC.Delta InterventionArchitectureArchitecture and The Built Environmen

Grey-Box System Identification of a Quadrotor Unmanned Aerial Vehicle

Control EngineeringDelft Center for Systems and ControlMechanical, Maritime and Materials Engineerin

United Nations Environmental Council

United Nations Environment Council plays an important role as the connection from urban to costline in New York city. ZIGZAG concept solves the 7meter height difference on site with a staircase combining landscape, seatings, tourism functions. It is the collective space inside new UNEC. Vertically the building is divided into three parts, upper part is UNEC private office zone, middle is collective space, bottom is the UNEC council and auditoriums. With ZIGZAG shape, each part can enjoy an unique view either to the city or the ocean. With a strong identical shape, the new UNEC corresponds to the United Nations Headquater designed by Le Corbusier, and will be a new icon for Manhattan costline.SADD Graduation StudioSADDArchitecture and The Built Environmen