94 research outputs found
Herbal Medicines for Parkinson's Disease: A Systematic Review of Randomized Controlled Trials
- Author
- A Schrag
- A Vickers
- BV Manyam
- CB Carroll
- CH Cheng
- CH Cheng
- CH Dowding
- CH Wu
- CL Qiu
- CX Yuan
- CY Zheng
- D Wang
- DG Altman
- DH Wu
- E Ernst
- E Ernst
- EL Wang
- GH Zhao
- GK Feng
- GQ Zheng
- H Liu
- H Zhang
- H Zhao
- HC Campos
- HX Wang
- IK Kim
- J Higgins
- J Lokk
- JE Ahlskog
- JF Liang
- JP Yuan
- JP Zhang
- JS Ross
- JZ Chen
- KF Schulz
- Ki-Ho Cho
- KW Ming
- L Cui
- L Ma
- L Zhang
- LH Chen
- LJ Yang
- Lx Ai
- LZ An
- M Egger
- M Serrano-Duenas
- Mark R. Cookson
- MH Yang
- MJ Yang
- Myeong Soo Lee
- N Li
- Q Li
- QM Ma
- RT Cui
- S von Campenhausen
- SR Guo
- SS Rao
- SW Teng
- SY Jiang
- Tae-Hun Kim
- V Chung
- V Chung
- W Muangpaisan
- W Shen
- WD Pan
- Woo-Sang Jung
- WR Gibb
- WT Wang
- XC Jiang
- XD Wang
- XF Lian
- XH Chang
- XH Zhao
- XJ Hu
- XJ Tang
- XX Li
- XY Zhu
- XZ Gu
- Y Lu
- Y Shen
- Y Winter
- Y Zhang
- Y Zhang
- YC Bao
- YF Yang
- YL Wang
- YL Wang
- YP Fan
- YQ Dou
- YQ Dou
- YZ Ma
- YZ Ma
- YZ Sun
- ZM Luo
- ZM Yang
- ZY Wang
- ZY Wang
- Publication venue
- Public Library of Science
- Publication date
- 15/05/2012
- Field of study
OBJECTIVE: We conducted systematic review to evaluate current evidence of herbal medicines (HMs) for Parkinson's disease (PD). METHODS: Along with hand searches, relevant literatures were located from the electronic databases including CENTRAL, MEDLINE, EMBASE, CINAHL, AMED, PsycInfo, CNKI, 7 Korean Medical Databases and J-East until August, 2010 without language and publication status. Randomized controlled trials (RCTs), quasi-randomized controlled trials and randomized crossover trials, which evaluate HMs for idiopathic PD were selected for this review. Two independent authors extracted data from the relevant literatures and any disagreement was solved by discussion. RESULTS: From the 3432 of relevant literatures, 64 were included. We failed to suggest overall estimates of treatment effects on PD because of the wide heterogeneity of used herbal recipes and study designs in the included studies. When compared with placebo, specific effects were not observed in favor of HMs definitely. Direct comparison with conventional drugs suggested that there was no evidence of better effect for HMs. Many studies compared combination therapy with single active drugs and combination therapy showed significant improvement in PD related outcomes and decrease in the dose of anti-Parkinson's drugs with low adverse events rate. CONCLUSION: Currently, there is no conclusive evidence about the effectiveness and efficacy of HMs on PD. For establishing clinical evidence of HMs on PD, rigorous RCTs with sufficient statistical power should be promoted in future
δ-Opioid receptor activation attenuates oxidative injury in the ischemic rat brain
- Author
- C Behn
- C Charron
- C Dezfulian
- CV Borlongan
- CV Borlongan
- CV Borlongan
- D Chao
- D Chao
- D Chao
- DS Su
- EZ Longa
- F Locatelli
- GC Higgins
- Guanghua Luo
- H Zhang
- J Bures
- J Huang
- J Zhang
- JA Potashkin
- JH Sung
- JH Zhang
- JH Zhang
- Lu Li
- LZ Xiong
- M Fujimura
- M Iwata
- M Narita
- MC Ma
- ME Pamenter
- P Zhao
- Qiang Wang
- RM Adibhatla
- S Namura
- SS Hong
- SW Ryter
- T Horiuchi
- V Lievre
- Xiwei Xia
- XS Tian
- XZ Kang
- Yi Zhang
- Yilin Yang
- Ying Xia
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Negatively charged AuNP modified with monoclonal antibody against novel tumor antigen FAT1 for tumor targeting
- Author
- A Chompoosor
- A Kumar
- A Rosler
- AF Hoven van den
- Alberto Grandi
- AM Alkilany
- B Kim
- Boquan Jin
- C Aslanidis
- CA Boswell
- Chaojun Song
- DD Yu
- DF Moyano
- DV Voet
- EC Cho
- Elisa De Camilli
- F Tomao
- Giuseppe Viale
- Guido Grandi
- H Gao
- Hong Wu
- J Dunne
- Li Fan
- LM Liz-Marzan
- LZ Yang XZ
- M Montori-Grau
- M Prete Del
- M Raoof
- Matteo Parri
- MK Yu
- MS Mufamadi
- MS Rajput
- MW Mathias Brust
- NM Schaeublin
- NP Nikunj Trivedi
- Piero Pileri
- R Arvizo
- R Grifantini
- R Sardar
- Renata Grifantini
- S Barua
- Susanna Campagnoli
- VI Elisa Panzarini
- WH Jong De
- Y Cheng
- ZY Chen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Pan-cancer analysis of whole genomes
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- The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium View Correspondence (jump link)
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- zt Kim
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- Ó. A. th
- Ø. sk
- Publication venue
- Publication date
- 11/12/2019
- Field of study
Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe
Modification of χc1(3872) and ψ(2S) production in pPb collisions at √sNN = 8.16 TeV
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- Wyllie K
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- Yang D
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- Yang Z
- Yeroshenko V
- Yeung H
- Yin H
- Yu CY
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- Zaffaroni E
- Zavertyaev M
- Zdybal M
- Zeng M
- Zhang C
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- Zhang Y
- Zhang YZ
- Zhao Y
- Zharkova A
- Zhelezov A
- Zheng XZ
- Zheng Y
- Zhou T
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- Zhou Y
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- Zhu LZ
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- Zhu X
- Zhu Z
- Zhukov V
- Zhuo J
- Zou Q
- Zuliani D
- Zunica G
- Publication venue
- American Physical Society
- Publication date
- 01/01/2024
- Field of study
The LHCb Collaboration measures production of the exotic hadron χc1(3872) in proton-nucleus collisions for the first time. Comparison with the charmonium state ψ(2S) suggests that the exotic χc1(3872) experiences different dynamics in the nuclear medium than conventional hadrons, and comparison with data from proton-proton collisions indicates that the presence of the nucleus may modify χc1(3872) production rates. This is the first measurement of the nuclear modification factor of an exotic hadron
Measurements of the branching fraction ratio B(ϕ → μ+μ−) / B(ϕ → e+e−) with charm meson decays
- Author
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- Prouve C
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- Qian W
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- Qu S
- Quagliani R
- Rabadan Trejo RI
- Rachwal B
- Rademacker JH
- Rama M
- Ramos Pernas M
- Ramírez García M
- Rangel MS
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- Rudolph MS
- Ruf T
- Ruiz Diaz M
- Ruiz Fernandez RA
- Ruiz Vidal J
- Ryzhikov A
- Ryzka J
- Saborido Silva JJ
- Sadek R
- Sagidova N
- Sahoo N
- Saitta B
- Salomoni M
- Sanchez Gras C
- Sanderswood I
- Santacesaria R
- Santamarina Rios C
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- Yeung H
- Yin H
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- Zaffaroni E
- Zavertyaev M
- Zdybal M
- Zeng M
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- Zharkova A
- Zhelezov A
- Zheng XZ
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- Zhu LZ
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- Zhu X
- Zhu Z
- Zhukov V
- Zhuo J
- Zou Q
- Zuliani D
- Zunica G
- Publication venue
- Springer
- Publication date
- 01/05/2024
- Field of study
Measurements of the branching fraction ratio B(ϕ → μ+μ−) / B(ϕ → e+e−) with Ds+→π+ϕ and D+→ π+ϕ decays, denoted Rϕπs and Rϕπd, are presented. The analysis is performed using a dataset corresponding to an integrated luminosity of 5.4 fb−1 of pp collision data collected with the LHCb experiment. The branching fractions are normalised with respect to the B+ → K+J/ψ(→ e+e−) and B+ → K+J/ψ(→ μ+μ−) decay modes. The combination of the results yieldsRϕπ=1.022±0.012stat±0.048syst. The result is compatible with previous measurements of the ϕ → ℓ+ℓ− branching fractions and predictions based on the Standard Model
Amplitude analysis of the B0→K*0μ+μ− decay
- Author
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- Sazak H
- Scantlebury Smead LG
- Scarabotto A
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- Scherl S
- Schertz AM
- Schiller M
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- Schmelling M
- Schmidt B
- Schmitt S
- Schmitz H
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- Schulte S
- Schune MH
- Schwemmer R
- Schwering G
- Sciascia B
- Sciuccati A
- Sellam S
- Semennikov A
- Senghi Soares M
- Sergi A
- Serra N
- Sestini L
- Seuthe A
- Shang Y
- Shangase DM
- Shapkin M
- Shchemerov I
- Shchutska L
- Shears T
- Shekhtman L
- Shen Z
- Sheng S
- Shevchenko V
- Shi B
- Shields EB
- Shimizu Y
- Shmanin E
- Shorkin R
- Shupperd JD
- Silva Coutinho R
- Simi G
- Simone S
- Skidmore N
- Skuza R
- Skwarnicki T
- Slater MW
- Smallwood JC
- Smith E
- Smith K
- Smith M
- Snoch A
- Soares Lavra L
- Sokoloff MD
- Soler FJP
- Solomin A
- Solovev A
- Solovyev I
- Song R
- Song Y
- Song Y
- Song YS
- Souza De Almeida FL
- Souza De Paula B
- Spadaro Norella E
- Spedicato E
- Speer JG
- Spiridenkov E
- Spradlin P
- Sriskaran V
- Stagni F
- Stahl M
- Stahl S
- Stanislaus S
- Stein EN
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- Swystun F
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- Szumlak T
- Szymanski M
- T'Jampens S
- Tan Y
- Taneja S
- Tat MD
- Terentev A
- Terzuoli F
- Teubert F
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- Thompson DJD
- Tilquin H
- Tisserand V
- Tobin M
- Tomassetti L
- Tonani G
- Tong X
- Torres Machado D
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- Tou DY
- Trippl C
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- Uecker LH
- Ukleja A
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- Ursov E
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- Ward JA
- Watson NK
- Websdale D
- Wei Y
- Westhenry BDC
- White DJ
- Whitehead M
- Wiederhold AR
- Wiedner D
- Wilkinson G
- Wilkinson MK
- Williams M
- Williams MRJ
- Williams R
- Wilson FF
- Wislicki W
- Witek M
- Witola L
- Wong CP
- Wormser G
- Wotton SA
- Wu H
- Wu J
- Wu Y
- Wyllie K
- Xian S
- Xiang Z
- Xie Y
- Xu A
- Xu J
- Xu L
- Xu L
- Xu M
- Xu Z
- Xu Z
- Xu Z
- Yang D
- Yang S
- Yang X
- Yang Y
- Yang Z
- Yang Z
- Yeroshenko V
- Yeung H
- Yin H
- Yu CY
- Yu J
- Yuan X
- Zaffaroni E
- Zavertyaev M
- Zdybal M
- Zeng M
- Zhang C
- Zhang D
- Zhang J
- Zhang L
- Zhang S
- Zhang S
- Zhang Y
- Zhang Y
- Zhang YZ
- Zhao Y
- Zharkova A
- Zhelezov A
- Zheng XZ
- Zheng Y
- Zhou T
- Zhou X
- Zhou Y
- Zhovkovska V
- Zhu LZ
- Zhu X
- Zhu X
- Zhu Z
- Zhukov V
- Zhuo J
- Zou Q
- Zuliani D
- Zunica G
- Publication venue
- American Physical Society
- Publication date
- 01/01/2024
- Field of study
An amplitude analysis of the
B
0
→
K
*
0
μ
+
μ
−
decay is presented using a dataset corresponding to an integrated luminosity of
4.7
fb
−
1
of
p
p
collision data collected with the LHCb experiment. For the first time, the coefficients associated to short-distance physics effects, sensitive to processes beyond the standard model, are extracted directly from the data through a
q
2
-unbinned amplitude analysis, where
q
2
is the
μ
+
μ
−
invariant mass squared. Long-distance contributions, which originate from nonfactorizable QCD processes, are systematically investigated, and the most accurate assessment to date of their impact on the physical observables is obtained. The pattern of measured corrections to the short-distance couplings is found to be consistent with previous analyses of
b
- to
s
-quark transitions, with the largest discrepancy from the standard model predictions found to be at the level of 1.8 standard deviations. The global significance of the observed differences in the decay is 1.4 standard deviations
Enhanced production of Λb0 baryons in high-multiplicity pp collisions at √s = 13 TeV
- Author
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- Stanislaus S
- Stein EN
- Steinkamp O
- Stenyakin O
- Stevens H
- Strekalina D
- Su Y
- Suljik F
- Sun J
- Sun L
- Sun Y
- Swallow PN
- Swientek K
- Swystun F
- Szabelski A
- Szumlak T
- Szymanski M
- T'Jampens S
- Tan Y
- Taneja S
- Tat MD
- Terentev A
- Terzuoli F
- Teubert F
- Thomas E
- Thompson DJD
- Tilquin H
- Tisserand V
- Tobin M
- Tomassetti L
- Tonani G
- Tong X
- Torres Machado D
- Toscano L
- Tou DY
- Trippl C
- Tuci G
- Tuning N
- Uecker LH
- Ukleja A
- Unverzagt DJ
- Ursov E
- Usachov A
- Ustyuzhanin A
- Uwer U
- Vagnoni V
- Valassi A
- Valenti G
- Valls Canudas N
- Van Hecke H
- van Herwijnen E
- Van Hulse CB
- Van Laak R
- van Veghel M
- Vazquez Gomez R
- Vazquez Regueiro P
- Vecchi S
- Velthuis JJ
- Veltri M
- Venkateswaran A
- Vesterinen M
- Vieira D
- Vieites Diaz M
- Vilasis-Cardona X
- Vilella Figueras E
- Villa A
- Vincent P
- Volle FC
- Vom Bruch D
- Vorobyev V
- Voropaev N
- Vos K
- Vouters G
- Vrahas C
- Vázquez Sierra C
- Walsh J
- Walton EJ
- Wan G
- Wang C
- Wang G
- Wang J
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- Wang M
- Wang NW
- Wang R
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- Wang XW
- Wang Y
- Wang Z
- Wang Z
- Wang Z
- Ward JA
- Watson NK
- Websdale D
- Wei Y
- Westhenry BDC
- White DJ
- Whitehead M
- Wiederhold AR
- Wiedner D
- Wilkinson G
- Wilkinson MK
- Williams M
- Williams MRJ
- Williams R
- Wilson FF
- Wislicki W
- Witek M
- Witola L
- Wong CP
- Wormser G
- Wotton SA
- Wu H
- Wu J
- Wu Y
- Wyllie K
- Xian S
- Xiang Z
- Xie Y
- Xu A
- Xu J
- Xu L
- Xu L
- Xu M
- Xu Z
- Xu Z
- Xu Z
- Yang D
- Yang S
- Yang X
- Yang Y
- Yang Z
- Yang Z
- Yeroshenko V
- Yeung H
- Yin H
- Yu CY
- Yu J
- Yuan X
- Zaffaroni E
- Zavertyaev M
- Zdybal M
- Zeng M
- Zhang C
- Zhang D
- Zhang J
- Zhang L
- Zhang S
- Zhang S
- Zhang Y
- Zhang Y
- Zhang YZ
- Zhao Y
- Zharkova A
- Zhelezov A
- Zheng XZ
- Zheng Y
- Zhou T
- Zhou X
- Zhou Y
- Zhovkovska V
- Zhu LZ
- Zhu X
- Zhu X
- Zhu Z
- Zhukov V
- Zhuo J
- Zou Q
- Zuliani D
- Zunica G
- Publication venue
- American Physical Society
- Publication date
- 01/01/2024
- Field of study
The production rate of
Λ
0
b
baryons relative to
B
0
mesons in
p
p
collisions at a center-of-mass energy
√
s
=
13
TeV
is measured by the LHCb experiment. The ratio of
Λ
0
b
to
B
0
production cross sections shows a significant dependence on both the transverse momentum and the measured charged-particle multiplicity. At low multiplicity, the ratio measured at LHCb is consistent with the value measured in
e
+
e
−
collisions, and increases by a factor of
∼
2
with increasing multiplicity. At relatively low transverse momentum, the ratio of
Λ
0
b
to
B
0
cross sections is higher than what is measured in
e
+
e
−
collisions, but converges with the
e
+
e
−
ratio as the momentum increases. These results imply that the evolution of heavy
b
quarks into final-state hadrons is influenced by the density of the hadronic environment produced in the collision. Comparisons with several models and implications for the mechanisms enforcing quark confinement are discussed
Fraction of χc decays in prompt J/ψ production measured in pPb collisions at √sNN = 8.16 TeV
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- Zhao Y
- Zharkova A
- Zhelezov A
- Zheng XZ
- Zheng Y
- Zhou T
- Zhou X
- Zhou Y
- Zhovkovska V
- Zhu LZ
- Zhu X
- Zhu X
- Zhu Z
- Zhukov V
- Zhuo J
- Zou Q
- Zuliani D
- Zunica G
- Publication venue
- American Physical Society
- Publication date
- 01/01/2024
- Field of study
The fraction of
χ
c
1
and
χ
c
2
decays in the prompt
J
/
ψ
yield,
F
χ
c
→
J
/
ψ
=
σ
χ
c
→
J
/
ψ
/
σ
J
/
ψ
, is measured by the LHCb detector in
p
Pb
collisions at
√
s
NN
=
8.16
TeV
. The study covers the forward (
1.5
<
y
∗
<
4.0
) and backward (
−
5.0
<
y
∗
<
−
2.5
) rapidity regions, where
y
∗
is the
J
/
ψ
rapidity in the nucleon-nucleon center-of-mass system. Forward and backward rapidity samples correspond to integrated luminosities of
13.6
±
0.3
and
20.8
±
0.5
nb
−
1
, respectively. The result is presented as a function of the
J
/
ψ
transverse momentum
p
T
,
J
/
ψ
in the range
1
<
p
T
,
J
/
ψ
<
20
GeV
/
c
. The
F
χ
c
→
J
/
ψ
fraction at forward rapidity is compatible with the LHCb measurement performed in
p
p
collisions at
√
s
=
7
TeV
, whereas the result at backward rapidity is
2.4
σ
larger than in the forward region for
1
<
p
T
,
J
/
ψ
<
3
GeV
/
c
. The increase of
F
χ
c
→
J
/
ψ
at low
p
T
,
J
/
ψ
at backward rapidity is compatible with the suppression of the
ψ
(
2
S
)
contribution to the prompt
J
/
ψ
yield. The lack of in-medium dissociation of
χ
c
states observed in this study sets an upper limit of 180 MeV on the free energy available in these
p
Pb
collisions to dissociate or inhibit charmonium state formation
- …