The Origin of the Universe as Revealed Through the Polarization of the Cosmic Microwave Background

Modern cosmology has sharpened questions posed for millennia about the origin of our cosmic habitat. The age-old questions have been transformed into two pressing issues primed for attack in the coming decade: How did the Universe begin? and What physical laws govern the Universe at the highest energies? The clearest window onto these questions is the pattern of polarization in the Cosmic Microwave Background (CMB), which is uniquely sensitive to primordial gravity waves. A detection of the special pattern produced by gravity waves would be not only an unprecedented discovery, but also a direct probe of physics at the earliest observable instants of our Universe. Experiments which map CMB polarization over the coming decade will lead us on our first steps towards answering these age-old questions.Comment: Science White Paper submitted to the US Astro2010 Decadal Survey. Full list of 212 author available at http://cmbpol.uchicago.ed

Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine

[This corrects the article DOI: 10.1186/s13054-016-1208-6.]

Pan-cancer analysis of whole genomes

Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe

More than smell - COVID-19 is associated with severe impairment of smell, taste, and chemesthesis

Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments, such as anosmia. However, these reports have downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, and generally lacked quantitative measurements. Here, we report the development, implementation, and initial results of a multilingual, international questionnaire to assess self-reported quantity and quality of perception in 3 distinct chemosensory modalities (smell, taste, and chemesthesis) before and during COVID-19. In the first 11 days after questionnaire launch, 4039 participants (2913 women, 1118 men, and 8 others, aged 19-79) reported a COVID-19 diagnosis either via laboratory tests or clinical assessment. Importantly, smell, taste, and chemesthetic function were each significantly reduced compared to their status before the disease. Difference scores (maximum possible change ±100) revealed a mean reduction of smell (-79.7 ± 28.7, mean ± standard deviation), taste (-69.0 ± 32.6), and chemesthetic (-37.3 ± 36.2) function during COVID-19. Qualitative changes in olfactory ability (parosmia and phantosmia) were relatively rare and correlated with smell loss. Importantly, perceived nasal obstruction did not account for smell loss. Furthermore, chemosensory impairments were similar between participants in the laboratory test and clinical assessment groups. These results show that COVID-19-associated chemosensory impairment is not limited to smell but also affects taste and chemesthesis. The multimodal impact of COVID-19 and the lack of perceived nasal obstruction suggest that severe acute respiratory syndrome coronavirus strain 2 (SARS-CoV-2) infection may disrupt sensory-neural mechanisms. © 2020 The Author(s) 2020. Published by Oxford University Press. All rights reserved

Topological properties of multiterminal superconducting nanostructures: Effect of a continuous spectrum

Recently, it has been shown that multiterminal superconducting nanostructures may possess topological properties that involve Berry curvatures in the parametric space of the superconducting phases of the terminals, and associated Chern numbers that are manifested in quantized transconductances of the nanostructure. In this paper, we investigate how the continuous spectrum that is intrinsically present in superconductors, affects these properties. We model the nanostructure within scattering formalism deriving the action and the response function that permits a redefinition of Berry curvature for continuous spectrum. We have found that the redefined Berry curvature may have a nontopological phase-independent contribution that adds a nonquantized part to the transconductances. This contribution vanishes for a time-reversible scattering matrix. We have found compact expressions for the redefined Berry curvature for the cases of weak energy dependence of the scattering matrix and investigated the vicinity of Weyl singularities in the spectrum.QN/Nazarov Grou

Bond of steel-mortar interface interfered by stray current

The focus of this work is to present test results on the bond of steel-mortar interface undergoing stray current. The bond strength, derived by pull-out tests, is correlated to the electrochemical response of the steel rebar and the properties of the mortar bulk matrix. The effects of curing regimes (in terms of duration of curing) and starting point of stray current are also investigated. It is found that stray current exerts bond degradation of the steel-mortar interface in all investigated cases, irrespective of the presence or absence of a corrodent (Cl−) in the external medium. For the ease of operation in lab tests, the stray current is generally simulated by anodic polarization, although fundamentally, the stray current effect on the steel surface is composed of both anodic and cathodic polarizations. Hence this work also differentiates the effects of stray current on steel-mortar bond, versus the effects of anodic polarization.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Materials and Environmen

Effect of different grade levels of calcined clays on fresh and hardened properties of ternary-blended cementitious materials for 3D printing

This study aims to investigate the influences of different grades of calcined clay on 3D printability, compressive strength (7 days), and hydration of limestone and calcined clay-based cementitious materials. Calcined clays that contained various amounts of metakaolin were achieved by blending low-grade calcined clay (LGCC) and high-grade calcined clay (HGCC) in three different proportions. The results revealed that increasing the HGCC% ranging from 0 wt% to 50 wt% in calcined clay could: (1) increase the flow consistency; (2) impressively improve the buildability, and reduce the printability window of the fresh mixtures; (3) enhance and accelerate the cement hydration. The reduction of mean interparticle distance induced by increasing HGCC% may be the primary reason for the enhancement of buildability and very early-age hydration. However, increasing HGCC% led to an increase of air void content in the interface region of the printed sample, which weakened the compressive strength of the printed sample at 7 days. Besides, it confirmed that the cold-joint/weak interface was easily formed by using the fresh mixture with a high structuration rate.Materials and Environmen

A review of methods on buildability quantification of extrusion-based 3D concrete printing: From analytical modelling to numerical simulation

Herein, different kinds of methods for buildability quantification of 3D concrete printing are reviewed, including experimental approaches, analytical modelling, and numerical simulations. A brief introduction on printing process is first given. This discusses the material properties in different stages. Material printability, which encompasses pumpability, extrudability and buildability, is then discussed. Subsequently, a brief review of the experimental and analytical models for buildability quantification is presented and they're discussed. An overview on the numerical tools for 3DCP is then given. These numerical models can quantify structural buildability and optimize the printing parameters, therefore, providing a more economical solution for buildability quantification. In the end, a summary and discussion on the limitations of numerical tools for buildability quantification are provided, as well as recommendations for their improvement.Materials and Environmen

The Effect Of Viscosity Modifier Agent On The Early Age Strength Of The Limestone And Calcined Clay-Based Sustainable And 3D Printable Cementitious Material

Recently, our group attempted to develop the ternary blended (Portland cement, calcined clay and limestone) cementitious material for 3D concrete printing (3DCP). Due to the elimination of formwork during the layer-by-layer casting process, the printed material should have favorable elastic properties and green strength at the fresh state. A small amount of Hydroxypropyl methylcellulose (HPMC) based viscosity modifier agent (VMA) is used in the printable mixture to enhance the printing shape stability during the printing process. However, adding VMA may delay the hydration of cement-based materials and affect the strength development at an early age. It is necessary to determine how the VMA additions affect the early age strength development of a 3D printable cementitious material. In this paper, three mix designs with different amounts of VMA were selected to perform the uniaxial compression test at different early ages (30 min, 1, 2, 3, 4, 6h). The setting time and compressive strength tests at 1, 7 and 28 days of those mix designs were also measured. Besides, the heat flow of different mix designs was recorded by using the isothermal calorimeter. Finally, it has been found that: (1) adding VMA could contribute to increase the green strength within the first 2h after mixing water and weaken the strength development from 2h to 6h; (2) the VMA additions mainly delayed the initial set and small effects on the final set; (3) about 50% of compressive strength at 1, 7 and 28 days were reduced for the specimens with VMA. (4) the more amounts of VMA was used in the mixture, the more retarding effects on cement hydration.Materials and Environmen