Pan-cancer analysis of whole genomes

Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe

Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial-to-mesenchymal transition

In most colorectal cancer (CRC) patients, outcome cannot be predicted because tumors with similar clinicopathological features can have differences in disease progression and treatment response. Therefore, a better understanding of the CRC biology is required to identify those patients who will benefit from chemotherapy and to find a more tailored therapy plan for other patients. Based on unsupervised classification of whole genome data from 188 stages I–IV CRC patients, a molecular classification was developed that consist of at least three major intrinsic subtypes (A-, B- and C-type). The subtypes were validated in 543 stages II and III patients and were associated with prognosis and benefit from chemotherapy. The heterogeneity of the intrinsic subtypes is largely based on three biological hallmarks of the tumor: epithelial-to-mesenchymal transition, deficiency in mismatch repair genes that result in high mutation frequency associated with microsatellite instability and cellular proliferation. A-type tumors, observed in 22% of the patients, have the best prognosis, have frequent BRAF mutations and a deficient DNA mismatch repair system. C-type patients (16%) have the worst outcome, a mesenchymal gene expression phenotype and show no benefit from adjuvant chemotherapy treatment. Both A-type and B-type tumors have a more proliferative and epithelial phenotype and B-types benefit from adjuvant chemotherapy. B-type tumors (62%) show a low overall mutation frequency consistent with the absence of DNA mismatch repair deficiency. Classification based on molecular subtypes made it possible to expand and improve CRC classification beyond standard molecular and immunohistochemical assessment and might help in the future to guide treatment in CRC patients.Intelligent SystemsElectrical Engineering, Mathematics and Computer Scienc

Bishop Fulton J. Sheen: America’s public critic of psychoanalysis, 1947–1957

This paper examines the role of Bishop Fulton Sheen in the popularization of Freudian psychoanalysis in the United States during the 1940s and 50s. Social historians argue that Freudian ideas were pervasive in American culture during this period. While their claim speaks mainly to the impact of psychoanalysis on the cultural elite and college educated, they also suggest that Freudian ideas affected ordinary men and women. In the former case, the group impacted is small and not representative of the population as a whole; in the latter, the evidence is sparse and impressionistic. Neglected in their consideration is the influence of Fulton Sheen whose opinions on Freud reached an audience of 30,000,000 during the height of the popularity of his TV show, Life is Worth Living. Sheen\u27s audience was more inclusive and representative of mainstream America. The negative and highly cautionary view of psychoanalysis he presented to many Americans was contrary to that which was promoted to and embraced by many of the college educated and likely shaped both their views of Freud and psychoanalytic therapy

Search for anomaly-mediated supersymmetry breaking with the ATLAS detector based on a disappearing-track signature in pp collisions at sqrt(s) = 7TeV$

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Bartsch;R. L. Bates;L. Batkova;J. R. Batley;A. Battaglia;M. Battistin;G. Battistoni;F. Bauer;H. S. Bawa;S. Beale;B. Beare;T. Beau;P. H. Beauchemin;R. Beccherle;P. Bechtle;H. P. Beck;S. Becker;M. Beckingham;K. H. Becks;A. J. Beddall;A. Beddall;S. Bedikian;V. A. Bednyakov;C. P. Bee;M. Begel;S. Behar Harpaz;P. K. Behera;M. Beimforde;C. Belanger-Champagne;P. J. Bell;W. H. Bell;G. Bella;L. Bellagamba;F. Bellina;M. Bellomo;A. Belloni;O. Beloborodova;K. Belotskiy;O. Beltramello;S. Ben Ami;O. Benary;D. Benchekroun;C. Benchouk;M. Bendel;N. Benekos;Y. Benhammou;J. A. Benitez Garcia;D. P. Benjamin;M. Benoit;J. R. Bensinger;K. Benslama;S. Bentvelsen;D. Berge;E. Bergeaas Kuutmann;N. Berger;F. Berghaus;E. Berglund;J. Beringer;P. Bernat;R. Bernhard;C. Bernius;T. Berry;C. Bertella;A. Bertin;F. Bertinelli;F. Bertolucci;M. I. Besana;N. Besson;S. Bethke;W. Bhimji;R. M. Bianchi;M. Bianco;O. Biebel;S. P. Bieniek;K. Bierwagen;J. Biesiada;M. Biglietti;H. Bilokon;M. Bindi;S. Binet;A. Bingul;C. Bini;C. 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Brown;P. A. Bruckman de Renstrom;D. Bruncko;R. Bruneliere;S. Brunet;A. Bruni;G. Bruni;M. Bruschi;T. Buanes;Q. Buat;F. Bucci;J. Buchanan;N. J. Buchanan;P. Buchholz;R. M. Buckingham;A. G. Buckley;S. I. Buda;I. A. Budagov;B. Budick;V. Büscher;L. Bugge;D. Buira-Clark;O. Bulekov;M. Bunse;T. Buran;H. Burckhart;S. Burdin;T. Burgess;S. Burke;E. Busato;P. Bussey;C. P. Buszello;F. Butin;B. Butler;J. M. Butler;C. M. Buttar;J. M. Butterworth;W. Buttinger;S. Cabrera Urbán;D. Caforio;O. Cakir;P. Calafiura;G. Calderini;P. Calfayan;R. Calkins;L. P. Caloba;R. Caloi;D. Calvet;S. Calvet;R. Camacho Toro;P. Camarri;M. Cambiaghi;D. Cameron;L. M. Caminada;S. Campana;M. Campanelli;V. Canale;F. Canelli;A. Canepa;J. Cantero;L. Capasso;M. D. M. Capeans Garrido;I. Caprini;M. Caprini;D. Capriotti;M. Capua;R. Caputo;C. Caramarcu;R. Cardarelli;T. Carli;G. Carlino;L. Carminati;B. Caron;S. Caron;G. D. Carrillo Montoya;A. A. Carter;J. R. Carter;J. Carvalho;D. Casadei;M. P. Casado;M. Cascella;C. Caso;A. M. Castaneda Hernandez;E. Castaneda-Miranda;V. Castillo Gimenez;N. F. Castro;G. Cataldi;F. Cataneo;A. Catinaccio;J. R. Catmore;A. Cattai;G. Cattani;S. Caughron;D. Cauz;P. Cavalleri;D. Cavalli;M. Cavalli-Sforza;V. Cavasinni;F. Ceradini;A. S. Cerqueira;A. Cerri;L. Cerrito;F. Cerutti;S. A. Cetin;F. Cevenini;A. Chafaq;D. Chakraborty;K. Chan;B. Chapleau;J. D. Chapman;J. W. Chapman;E. Chareyre;D. G. Charlton;V. Chavda;C. A. Chavez Barajas;S. Cheatham;S. Chekanov;S. V. Chekulaev;G. A. Chelkov;M. A. Chelstowska;C. Chen;H. Chen;S. Chen;T. Chen;X. Chen;S. Cheng;A. Cheplakov;V. F. Chepurnov;R. Cherkaoui El Moursli;V. Chernyatin;E. Cheu;S. L. Cheung;L. Chevalier;G. Chiefari;L. Chikovani;J. T. Childers;A. Chilingarov;G. Chiodini;M. V. Chizhov;G. Choudalakis;S. Chouridou;I. A. Christidi;A. Christov;D. Chromek-Burckhart;M. L. Chu;J. Chudoba;G. Ciapetti;K. Ciba;A. K. Ciftci;R. Ciftci;D. Cinca;V. Cindro;M. D. Ciobotaru;C. Ciocca;A. Ciocio;M. Cirilli;M. Citterio;M. Ciubancan;A. Clark;P. J. Clark;W. Cleland;J. C. Clemens;B. Clement;C. Clement;R. W. Clifft;Y. Coadou;M. Cobal;A. Coccaro;J. Cochran;P. Coe;J. G. Cogan;J. Coggeshall;E. Cogneras;C. D. Cojocaru;J. Colas;A. P. Colijn;N. J. Collins;C. Collins-Tooth;J. Collot;G. Colon;P. Conde Muiño;E. Coniavitis;M. C. Conidi;M. Consonni;V. Consorti;S. Constantinescu;C. Conta;F. Conventi;J. Cook;M. Cooke;B. D. Cooper;A. M. Cooper-Sarkar;K. Copic;T. Cornelissen;M. Corradi;F. Corriveau;A. Cortes-Gonzalez;G. Cortiana;G. Costa;M. J. Costa;D. Costanzo;T. Costin;D. Côté;R. Coura Torres;L. Courneyea;G. Cowan;C. Cowden;B. E. Cox;K. Cranmer;F. Crescioli;M. Cristinziani;G. Crosetti;R. Crupi;S. Crépé-Renaudin;C.-M. Cuciuc;C. Cuenca Almenar;T. Cuhadar Donszelmann;M. Curatolo;C. J. Curtis;C. Cuthbert;P. Cwetanski;H. Czirr;Z. Czyczula;S. D’Auria;M. D’Onofrio;A. D’Orazio;P. V. M. Silva;C. Via;W. Dabrowski;T. Dai;C. Dallapiccola;M. Dam;M. Dameri;D. S. Damiani;H. O. Danielsson;D. Dannheim;V. Dao;G. Darbo;G. L. Darlea;C. Daum;W. Davey;T. Davidek;N. 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Djobava;M. A. B. Vale;A. Valle Wemans;T. K. O. Doan;M. Dobbs;R. Dobinson;D. Dobos;E. Dobson;J. Dodd;C. Doglioni;T. Doherty;Y. Doi;J. Dolejsi;I. Dolenc;Z. Dolezal;B. A. Dolgoshein;T. Dohmae;M. Donadelli;M. Donega;J. Donini;J. Dopke;A. Doria;A. Anjos;M. Dosil;A. Dotti;M. T. Dova;J. D. Dowell;A. D. Doxiadis;A. T. Doyle;Z. Drasal;J. Drees;N. Dressnandt;H. Drevermann;C. Driouichi;M. Dris;J. Dubbert;S. Dube;E. Duchovni;G. Duckeck;A. Dudarev;F. Dudziak;M. Dührssen;I. P. Duerdoth;L. Duflot;M-A. Dufour;M. Dunford;H. Duran Yildiz;R. Duxfield;M. Dwuznik;F. Dydak;M. Düren;W. L. Ebenstein;J. Ebke;S. Eckweiler;K. Edmonds;C. A. Edwards;N. C. Edwards;W. Ehrenfeld;T. Ehrich;T. Eifert;G. Eigen;K. Einsweiler;E. Eisenhandler;T. Ekelof;M. Kacimi;M. Ellert;S. Elles;F. Ellinghaus;K. Ellis;N. Ellis;J. Elmsheuser;M. Elsing;D. Emeliyanov;R. Engelmann;A. Engl;B. Epp;A. Eppig;J. Erdmann;A. Ereditato;D. Eriksson;J. Ernst;M. Ernst;J. Ernwein;D. Errede;S. Errede;E. Ertel;M. Escalier;C. Escobar;X. Espinal Curull;B. Esposito;F. Etienne;A. I. Etienvre;E. Etzion;D. Evangelakou;H. Evans;L. Fabbri;C. Fabre;R. M. Fakhrutdinov;S. Falciano;Y. Fang;M. Fanti;A. Farbin;A. Farilla;J. Farley;T. Farooque;S. M. Farrington;P. Farthouat;P. Fassnacht;D. Fassouliotis;B. Fatholahzadeh;A. Favareto;L. Fayard;S. Fazio;R. Febbraro;P. Federic;O. L. Fedin;W. Fedorko;M. Fehling-Kaschek;L. Feligioni;D. Fellmann;C. Feng;E. J. Feng;A. B. Fenyuk;J. Ferencei;J. Ferland;W. Fernando;S. Ferrag;J. Ferrando;V. Ferrara;A. Ferrari;P. Ferrari;R. Ferrari;A. Ferrer;M. L. Ferrer;D. Ferrere;C. Ferretti;A. Ferretto Parodi;M. Fiascaris;F. Fiedler;A. Filipčič;A. Filippas;F. Filthaut;M. Fincke-Keeler;M. C. N. Fiolhais;L. Fiorini;A. Firan;G. Fischer;P. Fischer;M. J. Fisher;M. Flechl;I. Fleck;J. Fleckner;P. Fleischmann;S. Fleischmann;T. Flick;L. R. Flores Castillo;M. J. Flowerdew;M. Fokitis;T. Fonseca Martin;J. Fopma;D. A. Forbush;A. Formica;A. Forti;D. Fortin;J. M. Foster;D. Fournier;A. Foussat;A. J. Fowler;K. Fowler;H. Fox;P. Francavilla;S. Franchino;D. Francis;T. Frank;M. Franklin;S. Franz;M. Fraternali;S. Fratina;S. T. French;F. Friedrich;R. Froeschl;D. Froidevaux;J. A. Frost;C. Fukunaga;E. Fullana Torregrosa;J. Fuster;C. Gabaldon;O. Gabizon;T. Gadfort;S. Gadomski;G. Gagliardi;P. Gagnon;C. Galea;E. J. Gallas;V. Gallo;B. J. Gallop;P. Gallus;K. K. Gan;Y. S. Gao;V. A. Gapienko;A. Gaponenko;F. Garberson;M. Garcia-Sciveres;C. García;J. E. García Navarro;R. W. Gardner;N. Garelli;H. Garitaonandia;V. Garonne;J. Garvey;C. Gatti;G. Gaudio;O. Gaumer;B. Gaur;L. Gauthier;I. L. Gavrilenko;C. Gay;G. Gaycken;J-C. Gayde;E. N. Gazis;P. Ge;C. N. P. Gee;D. A. A. Geerts;Ch. Geich-Gimbel;K. Gellerstedt;C. Gemme;A. Gemmell;M. H. Genest;S. Gentile;M. George;S. George;P. Gerlach;A. Gershon;C. Geweniger;H. Ghazlane;N. Ghodbane;B. Giacobbe;S. Giagu;V. Giakoumopoulou;V. Giangiobbe;F. Gianotti;B. Gibbard;A. Gibson;S. M. Gibson;L. M. Gilbert;V. Gilewsky;D. Gillberg;A. R. Gillman;D. M. Gingrich;J. Ginzburg;N. Giokaris;M. P. Giordani;R. Giordano;F. M. Giorgi;P. Giovannini;P. F. Giraud;D. Giugni;M. Giunta;P. Giusti;B. K. Gjelsten;L. K. Gladilin;C. Glasman;J. Glatzer;A. Glazov;K. W. Glitza;G. L. Glonti;J. Godfrey;J. Godlewski;M. Goebel;T. Göpfert;C. Goeringer;C. Gössling;T. Göttfert;S. Goldfarb;T. Golling;S. N. Golovnia;A. Gomes;L. S. Gomez Fajardo;R. Gonçalo;J. Goncalves Pinto Firmino Da Costa;L. Gonella;A. Gonidec;S. Gonzalez;S. González de la Hoz;G. Gonzalez Parra;M. L. Gonzalez Silva;S. Gonzalez-Sevilla;J. J. Goodson;L. Goossens;P. A. Gorbounov;H. A. Gordon;I. Gorelov;G. Gorfine;B. Gorini;E. Gorini;A. Gorišek;E. Gornicki;S. A. Gorokhov;V. N. Goryachev;B. Gosdzik;M. Gosselink;M. I. Gostkin;I. Gough Eschrich;M. Gouighri;D. Goujdami;M. P. Goulette;A. G. Goussiou;C. Goy;S. Gozpinar;I. Grabowska-Bold;P. Grafström;K-J. Grahn;F. Grancagnolo;S. Grancagnolo;V. Grassi;V. Gratchev;N. Grau;H. M. Gray;J. A. Gray;E. Graziani;O. G. Grebenyuk;T. Greenshaw;Z. D. Greenwood;K. Gregersen;I. M. Gregor;P. Grenier;J. Griffiths;N. Grigalashvili;A. A. Grillo;S. Grinstein;Y. V. Grishkevich;J.-F. Grivaz;M. Groh;E. Gross;J. Grosse-Knetter;J. Groth-Jensen;K. Grybel;V. J. Guarino;D. Guest;C. Guicheney;A. Guida;S. Guindon;H. Guler;J. Gunther;B. Guo;J. Guo;A. Gupta;Y. Gusakov;V. N. Gushchin;A. Gutierrez;P. Gutierrez;N. Guttman;O. Gutzwiller;C. Guyot;C. Gwenlan;C. B. Gwilliam;A. Haas;S. Haas;C. Haber;H. K. Hadavand;D. R. Hadley;P. Haefner;F. Hahn;S. Haider;Z. Hajduk;H. Hakobyan;D. Hall;J. Haller;K. Hamacher;P. Hamal;M. Hamer;A. Hamilton;S. Hamilton;H. Han;L. Han;K. Hanagaki;K. Hanawa;M. Hance;C. Handel;P. Hanke;J. R. Hansen;J. B. Hansen;J. D. Hansen;P. H. Hansen;P. Hansson;K. Hara;G. A. Hare;T. Harenberg;S. Harkusha;D. Harper;R. D. Harrington;O. M. Harris;K. Harrison;J. Hartert;F. Hartjes;T. Haruyama;A. Harvey;S. Hasegawa;Y. Hasegawa;S. Hassani;M. Hatch;D. Hauff;S. Haug;M. Hauschild;R. Hauser;M. Havranek;B. M. Hawes;C. M. Hawkes;R. J. Hawkings;D. Hawkins;T. Hayakawa;T. Hayashi;D. Hayden;H. S. Hayward;S. J. Haywood;E. Hazen;M. He;S. J. Head;V. Hedberg;L. Heelan;S. Heim;B. Heinemann;S. Heisterkamp;L. Helary;C. Heller;M. Heller;S. Hellman;D. Hellmich;C. Helsens;R. C. W. Henderson;M. Henke;A. Henrichs;A. M. Henriques Correia;S. Henrot-Versille;F. Henry-Couannier;C. Hensel;T. Henß;C. M. Hernandez;Y. Hernández Jiménez;R. Herrberg;A. D. Hershenhorn;G. Herten;R. Hertenberger;L. Hervas;N. P. Hessey;E. Higón-Rodriguez;D. Hill;J. C. Hill;N. Hill;K. H. Hiller;S. Hillert;S. J. Hillier;I. Hinchliffe;E. Hines;M. Hirose;F. Hirsch;D. Hirschbuehl;J. Hobbs;N. Hod;M. C. Hodgkinson;P. Hodgson;A. Hoecker;M. R. Hoeferkamp;J. Hoffman;D. Hoffmann;M. Hohlfeld;M. Holder;S. O. Holmgren;T. Holy;J. L. Holzbauer;Y. Homma;T. M. Hong;L. Hooft van Huysduynen;T. Horazdovsky;C. Horn;S. Horner;J-Y. Hostachy;S. Hou;M. A. Houlden;A. Hoummada;J. Howarth;D. F. Howell;I. Hristova;J. Hrivnac;I. Hruska;T. Hryn’ova;P. J. Hsu;S.-C. Hsu;G. S. Huang;Z. Hubacek;F. Hubaut;F. Huegging;T. B. Huffman;E. W. Hughes;G. Hughes;R. E. Hughes-Jones;M. Huhtinen;P. Hurst;M. 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Jussel;A. Juste Rozas;V. V. Kabachenko;S. Kabana;M. Kaci;A. Kaczmarska;P. Kadlecik;M. Kado;H. Kagan;M. Kagan;S. Kaiser;E. Kajomovitz;S. Kalinin;L. V. Kalinovskaya;S. Kama;N. Kanaya;M. Kaneda;T. Kanno;V. A. Kantserov;J. Kanzaki;B. Kaplan;A. Kapliy;J. Kaplon;D. Kar;M. Karagounis;M. Karagoz;M. Karnevskiy;K. Karr;V. Kartvelishvili;A. N. Karyukhin;L. Kashif;G. Kasieczka;R. D. Kass;A. Kastanas;M. Kataoka;Y. Kataoka;E. Katsoufis;J. Katzy;V. Kaushik;K. Kawagoe;T. Kawamoto;G. Kawamura;M. S. Kayl;V. A. Kazanin;M. Y. Kazarinov;J. R. Keates;R. Keeler;R. Kehoe;M. Keil;G. D. Kekelidze;J. Kennedy;C. J. Kenney;M. Kenyon;O. Kepka;N. Kerschen;B. P. Kerševan;S. Kersten;K. Kessoku;J. Keung;F. Khalil-zada;H. Khandanyan;A. Khanov;D. Kharchenko;A. Khodinov;A. G. Kholodenko;A. Khomich;T. J. Khoo;G. Khoriauli;A. Khoroshilov;N. Khovanskiy;V. Khovanskiy;E. Khramov;J. Khubua;H. Kim;M. S. Kim;P. C. Kim;S. H. Kim;N. Kimura;O. Kind;B. T. King;M. King;R. S. B. King;J. Kirk;L. E. Kirsch;A. E. Kiryunin;T. Kishimoto;D. Kisielewska;T. Kittelmann;A. M. Kiver;E. Kladiva;J. Klaiber-Lodewigs;M. Klein;U. Klein;K. Kleinknecht;M. Klemetti;A. Klier;A. Klimentov;R. Klingenberg;E. B. Klinkby;T. Klioutchnikova;P. F. Klok;S. Klous;E.-E. Kluge;T. Kluge;P. Kluit;S. Kluth;N. S. Knecht;E. Kneringer;J. Knobloch;E. B. F. G. Knoops;A. Knue;B. R. Ko;T. Kobayashi;M. Kobel;M. Kocian;P. Kodys;K. Köneke;A. C. König;S. Koenig;L. Köpke;F. Koetsveld;P. Koevesarki;T. Koffas;E. Koffeman;F. Kohn;Z. Kohout;T. Kohriki;T. Koi;T. Kokott;G. M. Kolachev;H. Kolanoski;V. Kolesnikov;I. Koletsou;J. Koll;D. Kollar;M. Kollefrath;S. D. Kolya;A. A. Komar;Y. Komori;T. Kondo;T. Kono;A. I. Kononov;R. Konoplich;N. Konstantinidis;A. Kootz;S. Koperny;S. V. Kopikov;K. Korcyl;K. Kordas;V. Koreshev;A. Korn;A. Korol;I. Korolkov;E. V. Korolkova;V. A. Korotkov;O. Kortner;S. Kortner;V. V. Kostyukhin;M. J. Kotamäki;S. Kotov;V. M. Kotov;A. Kotwal;C. Kourkoumelis;V. Kouskoura;A. Koutsman;R. Kowalewski;T. Z. Kowalski;W. Kozanecki;A. S. Kozhin;V. Kral;V. A. Kramarenko;G. Kramberger;M. W. Krasny;A. Krasznahorkay;J. Kraus;J. K. Kraus;A. Kreisel;F. Krejci;J. Kretzschmar;N. Krieger;P. Krieger;K. Kroeninger;H. Kroha;J. Kroll;J. Kroseberg;J. Krstic;U. Kruchonak;H. Krüger;T. Kruker;N. Krumnack;Z. V. Krumshteyn;A. Kruth;T. Kubota;S. Kuehn;A. Kugel;T. Kuhl;D. Kuhn;V. Kukhtin;Y. Kulchitsky;S. Kuleshov;C. Kummer;M. Kuna;N. Kundu;J. Kunkle;A. Kupco;H. Kurashige;M. Kurata;Y. A. Kurochkin;V. Kus;M. Kuze;J. Kvita;R. Kwee;A. Rosa;L. Rotonda;L. Labarga;J. Labbe;S. Lablak;C. Lacasta;F. Lacava;H. Lacker;D. Lacour;V. R. Lacuesta;E. Ladygin;R. Lafaye;B. Laforge;T. Lagouri;S. Lai;E. Laisne;M. Lamanna;C. L. Lampen;W. Lampl;E. Lancon;U. Landgraf;M. P. J. Landon;H. Landsman;J. L. Lane;C. Lange;A. J. Lankford;F. Lanni;K. Lantzsch;S. Laplace;C. Lapoire;J. F. Laporte;T. Lari;A. V. Larionov;A. Larner;C. Lasseur;M. Lassnig;P. Laurelli;W. Lavrijsen;P. Laycock;A. B. Lazarev;O. Dortz;E. Guirriec;C. Maner;E. Menedeu;C. Lebel;T. LeCompte;F. Ledroit-Guillon;H. Lee;J. S. H. Lee;S. C. Lee;L. Lee;M. Lefebvre;M. Legendre;A. Leger;B. C. LeGeyt;F. Legger;C. Leggett;M. Lehmacher;G. Lehmann Miotto;X. Lei;M. A. L. Leite;R. Leitner;D. Lellouch;M. Leltchouk;B. Lemmer;V. Lendermann;K. J. C. Leney;T. Lenz;G. Lenzen;B. Lenzi;K. Leonhardt;S. Leontsinis;C. Leroy;J-R. Lessard;J. Lesser;C. G. Lester;A. Leung Fook Cheong;J. Levêque;D. Levin;L. J. Levinson;M. S. Levitski;A. Lewis;G. H. Lewis;A. M. Leyko;M. Leyton;B. Li;H. Li;S. Li;X. Li;Z. Liang;H. Liao;B. Liberti;P. Lichard;M. Lichtnecker;K. Lie;W. Liebig;R. Lifshitz;C. Limbach;A. Limosani;M. Limper;S. C. Lin;F. Linde;J. T. Linnemann;E. Lipeles;L. Lipinsky;A. Lipniacka;T. M. Liss;D. Lissauer;A. Lister;A. M. Litke;C. Liu;D. Liu;H. Liu;J. B. Liu;M. Liu;S. Liu;Y. Liu;M. Livan;S. S. A. Livermore;A. Lleres;J. Llorente Merino;S. L. Lloyd;E. Lobodzinska;P. Loch;W. S. Lockman;T. Loddenkoetter;F. K. Loebinger;A. Loginov;C. W. Loh;T. Lohse;K. Lohwasser;M. Lokajicek;J. Loken;V. P. Lombardo;R. E. Long;L. Lopes;D. Lopez Mateos;J. Lorenz;M. Losada;P. Loscutoff;F. Lo Sterzo;M. J. Losty;X. Lou;A. Lounis;K. F. Loureiro;J. Love;P. A. Love;A. J. Lowe;F. Lu;H. J. Lubatti;C. Luci;A. Lucotte;A. Ludwig;D. Ludwig;I. Ludwig;J. Ludwig;F. Luehring;G. Luijckx;D. Lumb;L. Luminari;E. Lund;B. Lund-Jensen;B. Lundberg;J. Lundberg;J. Lundquist;M. Lungwitz;G. Lutz;D. Lynn;J. Lys;E. Lytken;H. Ma;L. L. Ma;J. A. Macana Goia;G. Maccarrone;A. Macchiolo;B. Maček;J. Machado Miguens;R. Mackeprang;R. J. Madaras;W. F. Mader;R. Maenner;T. Maeno;P. Mättig;S. Mättig;L. Magnoni;E. Magradze;Y. Mahalalel;K. Mahboubi;G. Mahout;C. Maiani;C. Maidantchik;A. Maio;S. Majewski;Y. Makida;N. Makovec;P. Mal;Pa. Malecki;P. Malecki;V. P. Maleev;F. Malek;U. Mallik;D. Malon;C. Malone;S. Maltezos;V. Malyshev;S. Malyukov;R. Mameghani;J. Mamuzic;A. Manabe;L. Mandelli;I. Mandić;R. Mandrysch;J. Maneira;P. S. Mangeard;I. D. Manjavidze;A. Mann;P. M. Manning;A. Manousakis-Katsikakis;B. Mansoulie;A. Manz;A. Mapelli;L. Mapelli;L. March;J. F. Marchand;F. Marchese;G. Marchiori;M. Marcisovsky;A. Marin;C. P. Marino;F. Marroquim;R. Marshall;Z. Marshall;F. K. Martens;S. Marti-Garcia;A. J. Martin;B. Martin;B. Martin;F. F. Martin;J. P. Martin;Ph. Martin;T. A. Martin;V. J. Martin;B. Ma