24 research outputs found

    Using Customer Segmentation to Build a Hybrid Recommendation Model

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    Camacho, P., de Almeida, A., & António, N. (2021). Using Customer Segmentation to Build a Hybrid Recommendation Model. In J. V. de Carvalho, P. Liberato, Á. Rocha, & A. Peña (Eds.), Advances in Tourism, Technology and Systems - Selected Papers from ICOTTS20 (pp. 299-308). (Smart Innovation, Systems and Technologies; Vol. 208). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/978-981-33-4256-9_27The growing trend in leisure tourism has been closely followed by the number of hospitality services. Nowadays, customers are more sophisticated and demand a personalized and simplified experience, which is commonly achieved through the use of technological means for anticipating customer behavior. Thus, the ability to predict a customer’s willingness to buy is also a growing trend in hospitality businesses to reach more customers and consolidate existing ones. The acquisition of a transfer service through website reservation generates data that can be used to perform customer segmentation and enable recommendations for other products or services to a customer, like recreation experiences. This work uses data from a Portuguese private transfer company to understand how its private transfer business customers can be segmented and how to predict their behavior to enhance services cross-selling. Information extracted from the data acquired with the private transfer reservations is used to train a model to predict customer willingness to buy, and based on it, offer leisure services to customers. For that, a hybrid classifier was trained to offer recommendations to a customer when he/she is booking a transfer. The model employs a two-phase process: first, a binary classifier asserts if the customer who’s buying the transfer would eventually buy a service experience. In that case, a multi-class model decides what should be the most likely experience to be recommended.authorsversionpublishe

    Pan-cancer analysis of whole genomes

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    Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe

    Dynamics of anterior–posterior axis formation in the developing mouse embryo

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    The development of an anterior–posterior (AP) polarity is a crucial process that in the mouse has been very difficult to analyse, because it takes place as the embryo implants within the mother. To overcome this obstacle, we have established an in-vitro culture system that allows us to follow the step-wise development of anterior visceral endoderm (AVE), critical for establishing AP polarity. Here we use this system to show that the AVE originates in the implanting blastocyst, but that additional cells subsequently acquire AVE characteristics. These 'older' and 'younger' AVE domains coalesce as the egg cylinder emerges from the blastocyst structure. Importantly, we show that AVE migration is led by cells expressing the highest levels of AVE marker, highlighting that asymmetry within the AVE domain dictates the direction of its migration. Ablation of such leading cells prevents AVE migration, suggesting that these cells are important for correct establishment of the AP axis

    The utility of statoliths and bell size to elucidate age and condition of a scyphomedusa (Cassiopea sp.)

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    Scyphomedusae play important roles in marine ecosystems and are of economic significance. However, no reliable techniques for estimating scyphomedusa age have been documented. This study focused on the utility of Cassiopea sp. (Cnidaria: Scyphozoa) statoliths, statocysts, and body size as proxies for age of medusae. Reared medusae of known age and a manipulative experiment were used to assess the accuracy and reliability of four measures of age: number of statoliths, size (diameter) of statoliths, area of statocyst (housing statoliths), and bell diameter. Bell diameter provided the most accurate measure of age under constant conditions, but was increasingly inaccurate under varying environmental conditions. In contrast, the average number of statoliths per medusa reflected age with relatively low accuracy, but did not vary with changes in food availability and salinity. Only temperature influenced the average number of statoliths. Comparisons of bell diameter to the number of statoliths in medusae under low food availability to those fed well showed that the ratio of medusa size to the number of statoliths can be used to recognise medusae that are relatively poorly conditioned. Statoliths, therefore, provide a tool for studying both population ecology and the influence of environmental variation on medusa growth

    Advances in terahertz communications accelerated by photonics

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    Almost 15 years have passed since the initial demonstrations of terahertz (THz) wireless communications were made using both pulsed and continuous waves. THz technologies are attracting great interest and are expected to meet the ever-increasing demand for high-capacity wireless communications. Here, we review the latest trends in THz communications research, focusing on how photonics technologies have played a key role in the development of first-age THz communication systems. We also provide a comparison with other competitive technologies, such as THz transceivers enabled by electronic devices as well as free-space lightwave communications
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