Distributed video coding in wireless multimedia sensor network for multimedia broadcasting

Recently the development of Distributed Video Coding (DVC) has provided the promising theory support to realize the infrastructure of Wireless Multimedia Sensor Network (WMSN), which composed of autonomous hardware for capturing and transmission of quality audio-visual content. The implementation of DVC in WMSN can better solve the problem of energy constraint of the sensor nodes due to the benefit of lower computational encoder in DVC. In this paper, a practical DVC scheme, pixel-domain Wyner-Ziv(PDWZ) video coding, with slice structure and adaptive rate selection(ARS) is proposed to solve the certain problems when applying DVC into WMSN. Firstly, the proposed slice structure in PDWZ has extended the feasibility of PDWZ to work with any interleaver size used in Slepian-wolf turbo codec for heterogeneous applications. Meanwhile, based on the slice structure, an adaptive code rate selection has been proposed aiming at reduce the system delay occurred in feedback request. The simulation results clearly showed the enhancement in R-D performance and perceptual quality. It also can be observed that system delay caused by frequent feedback is greatly reduced, which gives a promising support for WMSN with low latency and facilitates the QoS management

An efficient error resilience scheme based on wyner-ziv coding for region-of-Interest protection of wavelet based video transmission

In this paper, we propose a bandwidth efficient error resilience scheme for wavelet based video transmission over wireless channel by introducing an additional Wyner-Ziv (WZ) stream to protect region of interest (ROI) in a frame. In the proposed architecture, the main video stream is compressed by a generic wavelet domain coding structure and passed through the error prone channel without any protection. Meanwhile, the predefined ROI area related wavelet coefficients obtained after an integer wavelet transform will be specially protected by WZ codec in an additional channel during transmission. At the decoder side, the error-prone ROI related wavelet coefficients will be used as side information to help decoding the WZ stream. Different size of WZ bit streams can be applied in order to meet different bandwidth condition and different requirement of end users. The simulation results clearly revealed that the proposed scheme has distinct advantages in saving bandwidth comparing with fully applied FEC algorithm to whole video stream and in the meantime offer the robust transmission over error prone channel for certain video applications

Dengue Virus Targets the Adaptor Protein MITA to Subvert Host Innate Immunity

Dengue is one of the most important arboviral diseases caused by infection of four serotypes of dengue virus (DEN). We found that activation of interferon regulatory factor 3 (IRF3) triggered by viral infection and by foreign DNA and RNA stimulation was blocked by DEN-encoded NS2B3 through a protease-dependent mechanism. The key adaptor protein in type I interferon pathway, human mediator of IRF3 activation (MITA) but not the murine homologue MPYS, was cleaved in cells infected with DEN-1 or DEN-2 and with expression of the enzymatically active protease NS2B3. The cleavage site of MITA was mapped to LRR↓96G and the function of MITA was suppressed by dengue protease. DEN replication was reduced with overexpression of MPYS but not with MITA, while DEN replication was enhanced by MPYS knockdown, indicating an antiviral role of MITA/MPYS against DEN infection. The involvement of MITA in DEN-triggered innate immune response was evidenced by reduction of IRF3 activation and IFN induction in cells with MITA knockdown upon DEN-2 infection. NS2B3 physically interacted with MITA, and the interaction and cleavage of MITA could be further enhanced by poly(dA:dT) stimulation. Thus, we identified MITA as a novel host target of DEN protease and provide the molecular mechanism of how DEN subverts the host innate immunity

Pan-cancer analysis of whole genomes

Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe

Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.

Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation. Results: A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14·2 per cent (646 of 4544) and the 30-day mortality rate was 1·8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30-day mortality (unadjusted odds ratio 7·61, 95 per cent c.i. 4·49 to 12·90; P < 0·001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c-statistic 0·65). Discussion: Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability

International Consensus Statement on Rhinology and Allergy: Rhinosinusitis

Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICAR‐RS‐2021 as well as updates to the original 140 topics. This executive summary consolidates the evidence‐based findings of the document. Methods: ICAR‐RS presents over 180 topics in the forms of evidence‐based reviews with recommendations (EBRRs), evidence‐based reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results: ICAR‐RS‐2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidence‐based management algorithm is provided. Conclusion: This ICAR‐RS‐2021 executive summary provides a compilation of the evidence‐based recommendations for medical and surgical treatment of the most common forms of RS

Joint source and channel coding for H.264 compliant stereoscopic video transmission

Stereoscopic video coding research has received considerable interest over the past decade as many 3D displays have been developed. Unfortunately, the vast amount of multimedia content needed to transmit or store a stereo image pair or video sequence has hindered its use in commercial applications. As H.264 offers significantly enhanced compression and a "network-friendly" feature, we have used a H.264 compliant stereoscopic video codec [9] to compress stereo video. The data partitioning (DP) mode in NAL unit of the H.264 codec is exploited for the use of joint source and channel coding (JSCC) taking channel qualities and reliabilities into account. In this paper, we propose a framework of using unequal error protection (UEP) based JSCC scheme on the H.264 compliant stereoscopic video transmission for additive white Gaussian noise (AWGN) channel. Different levels of error protection are assigned to different partitions based on their decoding importance. Performance comparisons are made against equal error protection (EEP) schemes. Results from the simulation show that using UEP schemes, the overall quality of the decoded main and auxiliary video sequence were clearly improved in comparison with the EEP scheme at good SNR but EEP schemes outperformed UEP schemes at low SNR values. © 2005 IEEE