Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

The Globalization of Spartanburg: A Story of Local Leaders and State Supporters

This essay explains how the globalisation of Spartanburg, South Carolina was enabled by an entrepreneurial chamber of commerce executive who made connections with state political leaders. Utilising archival research, interviews with some players, and scholarship from several fields, this essay shows how Richard Tukey, Spartanburg chamber executive from 1951-1979, used his political skills and interpersonal relationships to benefit Spartanburg. Although never holdingpublic office, Tukey guided South Carolina\u27s political elite, particularly Governors Robert McNair and John West, in preparing South Carolina fo r the global economy. Tukey\u27s partnership with West extended his influence such that his methods shaped the state\u27s economic development strategies fo r decades, and his role at Spartanburg\u27s chamber ensured that it remains a key agent in globalisation today. This story is one of outsiders becoming members of the local elite and, because of the deference to elites in traditionalist political culture, forging personal relationships that shaped the future

'Voyaging in': colonialism and migration

A major reference chapter on the history of the literature of colonialism and migration 1945-70. The book marks an intervention into conventional histories of British Literature. The chapter illustrates and analyses the influential formation of alternative modernities by migrant writers resident in Britain during this period; it also extends the gaze to the period before 1945 earlier in the twentieth century. Maps new ways of reading literary history; broad and wideranging discussion of migration during this period

Reservoir quality of Cenozoic carbonate buildups and coral reef terraces

Almost half of SE Asia's considerable hydrocarbon reserves are contained in carbonates. The majority of these reservoirs are Miocene buildups up to tens of kilometres across. However, with the exception of a few fields, there is little detailed data on how local depositional and diagenetic conditions influence the considerable heterogeneities in reservoir quality often encountered. This study focuses on factors influencing the facies, diagenetic and reservoir variability of comparable Modern, Quaternary and Neogene reef associated deposits from the Tukang Besi Archipelago, Central Indonesia.The Archipelago includes large atolls, a number of smaller buildups and 4 main islands each with modern rimmed shelves or fringing reefs. On the islands, over ten late Neogene and Quaternary coral reef terraces have been uplifted to maximum heights of ~300 m. Analysis of the modern deposits allows initial reservoir potential to be assessed and related to local environmental conditions. The influence of diagenesis on final reservoir quality is evaluated for the depositional facies exposed in the uplifted terraces. The overall spatial distribution of effective porosity across the area is strongly dependent on local energy conditions, water depth, carbonate producers, size of atolls or islands, climate and local meteoric diagenetic processes. This evaluation of spatial variability in carbonate reservoir characteristics provides much needed analogue data as the hydrocarbon industry focuses on improving recovery from existing fields and exploring for new reserves