The evolution of the galaxy luminosity function in the rest frame blue band up to z=3.5

We present an estimate of the cosmological evolution of the field galaxy luminosity function (LF) in the rest frame 4400 Angstrom B -band up to redshift z=3.5. To this purpose, we use a composite sample of 1541 I--selected galaxies selected down to I_(AB)=27.2 and 138 galaxies selected down to K_(AB)=25 from ground-based and HST multicolor surveys, most notably the new deep JHK images in the Hubble Deep Field South (HDF-S) taken with the ISAAC instrument at the ESO-VLT telescope. About 21% of the sample has spectroscopic redshifts, and the remaining fraction well calibrated photometric redshifts. The resulting blue LF shows little density evolution at the faint end with respect to the local values, while at the bright end (M_B(AB)<-20) a brightening increasing with redshift is apparent with respect to the local LF. Hierarchical CDM models overpredict the number of faint galaxies by about a factor 3 at z=1. At the bright end the predicted LFs are in reasonable agreement only at low and intermediate redshifts (z=1), but fail to reproduce the pronounced brightening observed in the high redshift (z=2-3) LF. This brightening could mark the epoch where a major star formation activity is present in the galaxy evolution.Comment: 14 pages, 2 figures, Astrophysical Journal Letters, in pres

Measurement of the Bottom-Strange Meson Mixing Phase in the Full CDF Data Set

We report a measurement of the bottom-strange meson mixing phase \beta_s using the time evolution of B0_s -> J/\psi (->\mu+\mu-) \phi (-> K+ K-) decays in which the quark-flavor content of the bottom-strange meson is identified at production. This measurement uses the full data set of proton-antiproton collisions at sqrt(s)= 1.96 TeV collected by the Collider Detector experiment at the Fermilab Tevatron, corresponding to 9.6 fb-1 of integrated luminosity. We report confidence regions in the two-dimensional space of \beta_s and the B0_s decay-width difference \Delta\Gamma_s, and measure \beta_s in [-\pi/2, -1.51] U [-0.06, 0.30] U [1.26, \pi/2] at the 68% confidence level, in agreement with the standard model expectation. Assuming the standard model value of \beta_s, we also determine \Delta\Gamma_s = 0.068 +- 0.026 (stat) +- 0.009 (syst) ps-1 and the mean B0_s lifetime, \tau_s = 1.528 +- 0.019 (stat) +- 0.009 (syst) ps, which are consistent and competitive with determinations by other experiments.Comment: 8 pages, 2 figures, Phys. Rev. Lett 109, 171802 (2012

Shrinking a large dataset to identify variables associated with increased risk of Plasmodium falciparum infection in Western Kenya

Large datasets are often not amenable to analysis using traditional single-step approaches. Here, our general objective was to apply imputation techniques, principal component analysis (PCA), elastic net and generalized linear models to a large dataset in a systematic approach to extract the most meaningful predictors for a health outcome. We extracted predictors for Plasmodium falciparum infection, from a large covariate dataset while facing limited numbers of observations, using data from the People, Animals, and their Zoonoses (PAZ) project to demonstrate these techniques: data collected from 415 homesteads in western Kenya, contained over 1500 variables that describe the health, environment, and social factors of the humans, livestock, and the homesteads in which they reside. The wide, sparse dataset was simplified to 42 predictors of P. falciparum malaria infection and wealth rankings were produced for all homesteads. The 42 predictors make biological sense and are supported by previous studies. This systematic data-mining approach we used would make many large datasets more manageable and informative for decision-making processes and health policy prioritization

Clinical use of the co-formulation of insulin degludec and insulin aspart

AimsTo provide a review of the available data and practical use of insulin degludec with insulin aspart (IDegAsp). Premixed insulins provide basal and prandial glucose control; however, they have an intermediate-acting prandial insulin component and do not provide as effective basal coverage as true long-acting insulins, owing to the physicochemical incompatibility of their individual components, coupled with the inflexibility of adjustment. The molecular structure of the co-formulation of IDegAsp, a novel insulin preparation, allows these two molecules to coexist without affecting their individual pharmacodynamic profiles. MethodsClinical evidence in phase 2/3 trials of IDegAsp efficacy and safety in type 1 and type 2 diabetes mellitus (T1DM and T2DM) have been assessed and summarised. ResultsIn people with T2DM, once- and twice-daily dosing provides similar overall glycaemic control (HbA(1c)) to current modern insulins, but with lower risk of nocturnal hypoglycaemia. In prior insulin users, glycaemic control was achieved with lower or equal insulin doses vs. other basal+meal-time or premix insulin regimens. In insulin-naive patients with T2DM, IDegAsp can be started once or twice-daily, based on individual need. People switching from more than once-daily basal or premix insulin therapy can be converted unit-to-unit to once-daily IDegAsp, although this strategy should be assessed by the physician on an individual basis. ConclusionsIDegAsp offers physicians and people with T2DM a simpler insulin regimen than other available basal-bolus or premix-based insulin regimens, with stable daytime basal coverage, a lower rate of hypoglycaemia and some flexibility in injection timing compared with premix insulins.708657667Novo Nordis

Inclusive search for supersymmetry using razor variables in pp collisions at root s=13 TeV

Peer reviewe

The CMS trigger system

Peer reviewe

Jet energy scale and resolution in the CMS experiment in pp collisions at 8 TeV

Peer reviewe

The Darkside-50 Outer Detectors

DarkSide-50 is a dark matter detection experiment searching for Weakly Interacting Massive Particles (WIMPs), in Gran Sasso National Laboratory. For experiments like DarkSide-50, neutrons are one of the primary backgrounds that can mimic WIMP signals. The experiment consists of three nested detectors: a liquid argon time projection chamber surrounded by two outer detectors. The outermost detector is a 10 m by 11 m cylindrical water Cherenkov detector with 80 PMTs, designed to provide shielding and muon vetoing. Inside the water Cherenkov detector is the 4 m diameter spherical boron-loaded liquid scintillator veto, with a cocktail of pseudocumene, trimethyl borate, and PPO wavelength shifter, designed to provide shielding, neutron vetoing, and in situ measurements of the TPC backgrounds. We present design and performance details of the DarkSide-50 outer detectors.71814th International Conference on Topics in Astroparticle and Underground Physics (TAUP)Sep 07-11, 2015Torino, ITAL

A Targeted Search For Point Sources Of Eeev Photons With The Pierre Auger Observatory

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Simultaneous measurements of air showers with the fluorescence and surface detectors of the Pierre Auger Observatory allow a sensitive search for EeV photon point sources. Several Galactic and extragalactic candidate objects are grouped in classes to reduce the statistical penalty of many trials from that of a blind search and are analyzed for a significant excess above the background expectation. The presented search does not find any evidence for photon emission at candidate sources, and combined p-values for every class are reported. Particle and energy flux upper limits are given for selected candidate sources. These limits significantly constrain predictions of EeV proton emission models from non-transient Galactic and nearby extragalactic sources, as illustrated for the particular case of the Galactic center region.8372Argentina-Comision Nacional de Energia AtomicaAgencia Nacional de Promocion Cientifica y Tecnologica (ANPCyT)Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)Gobierno de la Provincia de MendozaMunicipalidad de MalargueNDM Holdings and Valle Las Lenas, in gratitude for their continuing cooperation over land accessAustralia-the Australian Research CouncilBrazilConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)Financiadora de Estudos e Projetos (FINEP)Fundacao de Amparo a Pesquisa do Estado de Rio de Janeiro (FAPERJ)Sao Paulo Research Foundation (FAPESP) [2010/07359-6, 1999/05404-3]Ministerio de Ciencia e Tecnologia (MCT)Czech Republic-Grant [MSMT CR LG15014, LO1305, LM2015038]Czech Science Foundation [14-17501S]FranceCentre de Calcul [IN2P3/CNRS]Centre National de la Recherche Scientifique (CNRS)Conseil Regional Ile-deFranceDepartement Physique Nucleaire et Corpusculaire [PNC-IN2P3/CNRS]Departement Sciences de l'Univers [SDU-INSU/CNRS]Institut Lagrange de Paris (ILP), Investissements d'Avenir Programme Grant [LABEX ANR-10-LABX-63, ANR-11-IDEX-0004-02]Germany-Bundesministerium fur Bildung und Forschung (BMBF)Deutsche Forschungsgemeinschaft (DFG)Finanzministerium Baden-WurttembergHelmholtz Alliance for Astroparticle Physics (HAP)Helmholtz-Gemeinschaft Deutscher Forschungszentren (HGF)Ministerium fur Innovation, Wissenschaft und Forschung des Landes NordrheinWestfalenMinisterium fur Wissenschaft, Forschung und Kunst des Landes Baden-WurttembergItaly-Istituto Nazionale di Fisica Nucleare (INFN)Istituto Nazionale di Astrofisica (INAF)Ministero dell'Istruzione, dell'Universita e della Ricerca (MIUR)CETEMPS Center of ExcellenceMinistero degli Affari Esteri (MAE)Mexico-Consejo Nacional de Ciencia y Tecnologia (CONACYT) [167733]Universidad Nacional Autonoma de Mexico (UNAM)PAPIIT DGAPAUNAMNetherlands-Ministerie van Onderwijs, Cultuur en WetenschapNederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO)Stichting voor Fundamenteel Onderzoek der Materie (FOM)Poland-National Centre for Research and Development [ERA-NETASPERA/01/11, ERA-NET-ASPERA/02/11]National Science Centre [2013/08/M/ST9/00322, 2013/08/M/ST9/00728, HARMONIA 5-2013/10/M/ST9/00062]Portugal-Portuguese national fundsFEDER funds within Programa Operacional Factores de Competitividade through Fundacao para a Ciencia e a Tecnologia (COMPETE)Romania-Romanian Authority for Scientific Research ANCSCNDI-UEFISCDI [20/2012, 194/2012, PN 16 42 01 02]Slovenia-Slovenian Research AgencySpainComunidad de MadridFondo Europeo de Desarrollo Regional (FEDER) fundsMinisterio de Economia y CompetitividadXunta de GaliciaEuropean Community 7th Framework Program [FP7-PEOPLE-2012-IEF-328826]USA Department of Energy [DE-AC02-07CH11359, DE-FR02-04ER41300, DE-FG02-99ER41107, DE-SC0011689]National Science Foundation [0450696]Grainger FoundationMarie Curie-IRSES/EPLANETEuropean Particle Physics Latin American NetworkEuropean Union 7th Framework Program [PIRSES-2009-GA-246806]UNESCOConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP