20 research outputs found
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
- Abrunhosa A
- Absar M
- Adam S
- Adams D
- Adams G
- Adamson M
- Adekola O
- Adelaja Y
- Ademola A
- Adenekan A
- Adenike O
- Adeolu AA
- Adetoye A
- Adewale B
- Adigun T
- Adolfsson A
- Aflori L
- Africander C
- Afshari A
- Agarwal V
- Agodirin O
- Aguero Vera M
- Aguzzoli C
- Ahmad A
- Ahmad N
- Ahmad T
- Ahmad T
- Ahmad Y
- Ahmed A
- Ahmed J
- Ai Y
- Aignatoaie M
- Aimoniotou-Georgiou E
- Akanmu O
- Akerman N
- Akinwale M
- Akring I
- Al 'Amri K
- Al Anizi M
- Al hussaini S
- Al-Soudaine Y
- Aladin H
- Alagbe-Briggs O
- Alaman Laguarda G
- Albaj S
- Alcock D
- Alcock L
- Aldecoa C
- Aldecoa C
- Aleixo FB
- Alexander H
- Alexander M
- Alexander-Sefre F
- Alherz F
- Ali H
- Ali M
- Ali S
- Alias A
- Alias AH
- Alias RLR
- Alit MA
- Allen S
- Allen SJ
- Allison J
- Alloj C
- Allorto NL
- Allsop J
- Almeida W
- Alonso E
- Alphonsus C
- Alvares D
- Alves MJ
- Amador JCB
- Ameer Y
- Amendola CP
- Ami N
- Amstrup-Hansen L
- Anagnou A
- Andersen C
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- Anderson C
- Anderson F
- Anderson P
- Andreadaki E
- Andreou A
- Andreou P
- Andrew A
- Andrews E
- Angermair S
- Angus K
- Anillo V
- Antal O
- Antill P
- Antoniadou E
- Antonina W
- Apagaki E
- Apostolou K
- Applewhaite C
- Aquino LPG
- Ar P
- Arawwawala D
- Ardern D
- Argue R
- Arkalaki E
- Armaganidis A
- Armstrong J
- Armstrong R
- Arnaoutoglou C
- Arnaoutoglou E
- Arnold G
- Arrandale L
- Arrich J
- Arrigo M
- Arshad H
- Arshad MA
- Arumugam S
- Arustei M
- Arvaniti K
- Arya A
- Arya S
- Asimakos A
- Asudo F
- Athanasakis E
- Atiku M
- Attrill E
- Attwood C
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- Avidan M
- Avila Sanchez FJ
- Avila EJD
- Avis J
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- Ayyaz H
- Azam UAA
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- Azevedo C
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- Baio TH
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- Chandrasekharan S
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- Chin II
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- Chisbert Cuenca V
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- Christofaki M
- Christoforidis D
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- Chung CKE
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- Ciobotaru OR
- Cirstea E
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- Dumitrascu CO
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- Zingg U
- Zoerner F
- Zonneveldt H
- Zou X
- Zoulamoglou M
- Zsisku L
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
Large expert-curated database for benchmarking document similarity detection in biomedical literature search
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- Publication venue
- OXFORD UNIV PRESS
- Publication date
- 29/10/2019
- Field of study
Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency–Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research
Pan-cancer analysis of whole genomes
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- Xi
- Xia
- Xiang
- Xiong
- xo Abeshouse
- xp Benz
- xp Edwards
- xr Ghori
- xs Gundem
- Xue
- xv Luxton
- xw McDermott
- xy Visakorpi
- xz Whitaker
- Y. -E. ot
- Y. -J. k
- Y. -J. xn
- Y. abp
- Y. ae
- Y. ae
- Y. ae
- Y. ae
- Y. ai
- Y. aj
- Y. al
- Y. bk
- Y. dg
- Y. dy
- Y. ef
- Y. ep
- Y. ez
- Y. ff
- Y. fr
- Y. fv
- Y. fv
- Y. gl
- Y. hl
- Y. hq
- Y. hq
- Y. ia
- Y. kq
- Y. lw
- Y. nh
- Y. nk
- Y. nz
- Y. rg
- Y. rj
- Y. rm
- Y. S. jf
- Y. uz
- Y. vr
- Y. wt
- Y. yc
- ya Al-Ahmadie
- Yachida
- Yamaguchi
- Yamaguchi T. N. k
- Yamamoto
- Yamaue
- Yang
- Yang
- Yang
- Yang
- Yang
- Yao
- Yaspo
- Yates
- Yau
- yb Ally
- yd Cherniack
- yd Lai
- yd Schadendorf
- ye Auman
- ye Umbricht
- Yellapantula
- Yellapantula
- yh Bathe
- yj Baylin
- Yoon
- Yu
- Yu
- Yu
- Yuan
- Yugawa
- z ah
- Z. ej
- Z. ep
- Z. fr
- Z. hv
- Z. hy
- Z. jq
- Z. kt
- Z. oe
- Zaikova
- Zapatka
- zd Gershenwald
- Zenklusen
- Zeps
- zf Ghossein
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang H. b
- Zhao
- Zheng
- Zhou
- Zhou
- Zhu
- Zhu
- zi zj
- zm Jayaseelan
- Zou
- Zou
- zt Kim
- zw Lewis
- Ó. A. th
- Ø. sk
- Publication venue
- Publication date
- 11/12/2019
- Field of study
Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe
Mechanical Properties of AAA Tissue
- Author
- A Long
- A Long
- AP Tierney
- B.T. Baxter
- BJ Doyle
- CM He
- D.A. Vorp
- D.R. Holmes
- DA Vorp
- DA Vorp
- DA Vorp
- DS Sumner
- GA Holzapfel
- GA Holzapfel
- GA Holzapfel
- H Wolinsky
- HS Choi
- JP Geest Vande
- JP Geest Vande
- JP Geest Vande
- JP Geest Vande
- K Wilson
- KP Dingemans
- LW Laake van
- M Drangova
- M.L. Raghavan
- MF Fillinger
- MH Sherebrin
- MJ Thubrikar
- MK Ganten
- ML Raghavan
- ML Raghavan
- MR Roach
- MS Sacks
- N Diehm
- N Diehm
- S. Balocco
- SP Marra
- SR Vallabhaneni
- ST MacSweeney
- T Lanne
- X. Zhao
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Possible Roles of Angiotensin II-Forming Enzymes, Angiotensin Converting Enzyme and Chymase-like Enzyme, in the Human Aneurysmal Aorta.
- Author
- Berk BC Haendeler J, Sottile J
- Bigatel DA Elmore JR, Carey DJ, Cizmeci-Smith G, Franklin DP, Youkey JR
- Brophy CM Reilly JM, Smith GJ, Tilson MD
- Campa JS Greenhalgh RM, Powell JT
- Carmeliet P
- Daugherty A Manning MW, Cassis LA
- Delin A Ohlsen H, Swedenborg J
- FRANK B T
- Freestone T Turner RJ, Coady A, Higman DJ, Greenhalgh RM, Powell JT
- Gandhi RH Irizarry E, Cantor JO, et al
- He CM Roach MR
- Holmes DR Liao S, Parks WC, Thompson RW
- IHARA M
- Koch AE Haines GK, Rizzo RJ, et al
- KOHNO M
- MERCATOR Study Group
- MIYAZAKI M
- MIYAZAKI M
- Moore G Liao S, Curci JA, et al
- Nevitt MP Ballard DJ, Hallett JW Jr
- Nishijo N Sugiyama F, Kimoto K, et al
- Peters S Gotting B, Trummel M, Rus H, Brattstrom A
- Powell JS Clozel JP, Muller RK, et al
- Shah PK
- Takai S Jin D, Sakaguchi M, Miyazaki M
- Thompson RW
- Thompson RW Holmes DR, Mertens RA, et al
- Publication venue
- 'Japanese Society of Hypertension'
- Publication date
- 01/01/2002
- Field of study
Patient-Based Abdominal Aortic Aneurysm Rupture Risk Prediction with Fluid Structure Interaction Modeling
- Author
- A Swillens
- A Valencia
- AB Wilmink
- AK Venkatasubramaniam
- Apostolos Tassiopoulos
- AR Zankl
- BJ Wolters
- C Scotti
- C Yang
- CJ Chuong
- CM He
- CP Cheng
- D Bluestein
- D Bluestein
- DA Vorp
- Danny Bluestein
- DH Wang
- E Di Martino
- EA Finol
- ES Di Martino
- ES Di Martino
- ES Di Martino
- FA Lederle
- G Holzapfel
- GA Holzapfel
- GA Holzapfel
- GA Holzapfel
- GA Holzapfel
- GA Holzapfel
- GA Holzapfel
- GA Holzapfel
- H Bengtsson
- J Hua
- JE Moore Jr
- JF Rodriguez
- JJ Paszkowiak
- JJ Ricotta
- JL Cronenwett
- JM Greve
- John J. Ricotta
- JP Geest Vande
- JP Geest Vande
- JP Geest Vande
- JP Geest Vande
- JT Powell
- KA Vardulaki
- LC Brown
- M Bonert
- M Fillinger
- M Mooney
- M Truijers
- MC Boyce
- MF Fillinger
- MF Fillinger
- Michalis Xenos
- ML Raghavan
- ML Raghavan
- ML Raghavan
- MR Roach
- MS Olufsen
- Nicos Labropoulos
- P Rissland
- R Limet
- RP Vito
- RS Reneman
- RS Rivlin
- S Putter de
- Shmuel Einav
- Suraj H. Rambhia
- T Sussman
- Y Papaharilaou
- Y Vengrenyuk
- Yared Alemu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Local Recurrence and Survival Among Black Women With Early-Stage Breast Cancer Treated With Breast-Conservation Therapy or Mastectomy
- Author
- A Damon
- A Fourquet
- A Recht
- A Recht
- A Stotter
- AB Nattinger
- AP Polednak
- B Chauvet
- B Fisher
- B Fisher
- B Fowble
- B Salvadori
- Barry W. Feig
- BG Haffty
- CB Mueller
- CM Sutherland
- D Ansell
- D Fein
- D Sarrazin
- DC Farrow
- DI Gregorio
- E Montague
- EM Mora
- F Leborgne
- Frederick C. Ames
- G Gray
- G Liljegren
- GM Swanson
- Gurpreet Singh
- HB Muss
- HE Ownby
- Henry M. Kuerer
- HH Dayal
- HP Freeman
- I Gage
- J Kovi
- JJ Dignan
- JL Kelsey
- JL Young Jr
- JM Kurtz
- JM Kurtz
- JP Crowe Jr
- JR Harris
- JW Eley
- Kelly K. Hunt
- L Franzini
- LA Newman
- LC Barr
- LD Curcio
- Lisa A. Newman
- LJ Solin
- LP Pierce
- M Bouvet
- M Chung
- M Roach III
- M Simon
- Merrick I. Ross
- MP Osborne
- MR Basset
- N Krieger
- N Natarajan
- NH Gordon
- NK Mittra
- NM Kuderer
- PT Neff
- R Arriagada
- R Calle
- R Heimann
- RH Coates
- RJ Coates
- RL Prentice
- RM Elledge
- RP Bain
- S. Eva Singletary
- SA Joslyn
- Sarah Taylor
- SS Devesa
- SW Vernon
- U Veronesi
- VW Chen
- WA Satariano
- WP McWhorter
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease
- Author
- A Magdaleno
- AE Carpenter
- AM Smith
- Arnab K. Chatterjee
- B Nyfeler
- BL Trumpower
- C Bern
- Case W. McNamara
- CM Calvet
- D Hoepfner
- D Plouffe
- D Xia
- DL Richie
- Dominic Hoepfner
- EB Gutierrez-Cirlos
- Ede F Peloso
- F Perocchi
- Frantisek Supek
- FS Buckner
- G Andriani
- G Carneiro
- G Giaever
- G Giaever
- GI Lang
- H Ke
- H Thorvaldsdottir
- HJ Painter
- I Hurwitz
- I Molina
- IH Gilbert
- J Clayton
- J Lukes
- J.-P. di Rago
- JA Urbina
- Jaime Ballard
- James H. McKerrow
- JC Engel
- JC Engel
- JE Telford
- JH McKerrow
- JL VandeBerg
- JM Bustamante
- JM HE Cherry
- John R. Walker
- JP di Rago
- JR Stringer
- JT Robinson
- JW Choy
- JY Choi
- L Friggeri
- LA Messenger
- LS Huang
- M Spinazzi
- MA Ghannoum
- Margaret A Phillips
- MG Ding
- Michelle R. Arkin
- MJ Pinazo
- MP Soni
- MR Garcia-Silva
- N Fisher
- N Fisher
- NM El-Sayed
- PS Doyle
- R Diaz-Gonzalez
- R Docampo
- R K Holmes
- R. Jeffrey Neitz
- Rassi Anis Jr
- Richard J. Glynne
- RM Martins
- S. Whitney Barnes
- SC Bourguignon
- Shilpi Khare
- SP Rao
- Steven L. Roach
- T Kleinschroth
- TG Nam
- TM Silva
- Valentina Molteni
- Vince Yeh
- Viotti CV Rodolfo
- Yin Lai
- Yue Fu
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Neurostructural Endophenotypes In Autism Spectrum Disorder
- Author
- A Bailey
- A Chenn
- A Pfefferbaum
- A Pickles
- A Pickles
- A Ronald
- AC Stanfield
- AE Doyle
- AE Doyle
- AM Graybiel
- American Psychiatric Organisation
- AR Aron
- AR Hariri
- AY Hardan
- AY Hardan
- AY Hardan
- AY Hardan
- AY Hardan
- B Brierley
- B Egaas
- B John
- BF Sparks
- BM Nacewicz
- BR Collett
- BS Abrahams
- BW Balleine
- CB Boylan
- CE MacLeod
- CM Schumann
- CN Vidal
- CN Vidal
- CW Nordahl
- D Posthuma
- D Riva
- DC Rojas
- DC Rojas
- DG Amaral
- DH Geschwind
- DH Skuse
- DJ Fidler
- E Armstrong
- E Courchesne
- E Courchesne
- E DiCicco-Bloom
- E Fombonne
- E Geuze
- E Hollander
- E Peterson
- E Redcay
- E Simonoff
- E Viding
- EA Phelps
- EH Aylward
- ER Sowell
- ER Sowell
- ES Roach
- FA Middleton
- FJ O'Callaghan
- FR Volkmar
- G Baird
- G Dawson
- GD Waiter
- GL Wallace
- GM McAlonan
- GR Gaffney
- GT Voelbel
- H Asperger
- H Scherk
- HB Cleavinger
- HC Hazlett
- HE Hulshoff Pol
- HY Tan
- I Boger-Megiddo
- I Bukelis
- I-C Wright
- ID Waldman
- II Gottesman
- J Flint
- J Munson
- J Osterling
- J Piven
- J Sebat
- J Veenstra-VanderWeele
- JD Schmahmann
- JE Desmond
- JE Lainhart
- JE Lainhart
- JE Schmitt
- JE Schmitt
- JG Levitt
- JL Rubenstein
- JL Stone
- JN Constantino
- JN Giedd
- JS Peper
- JT Walters
- K Myers
- KD Mraz
- KM Dalton
- KS Kendler
- L Kanner
- L Pezawas
- L Wing
- L Zwaigenbaum
- LA Muscarella
- LJ Lotspeich
- LK Davis
- LL Sears
- LM Elder
- M Conciatori
- M Elia
- M Ewers
- M Langen
- M Losh
- M Murphy
- M Prince
- M Rutter
- MA Gernsbacher
- MA Howard
- MA Just
- MC Craig
- MH Hall
- MK Belmonte
- MM Haznedar
- MR Herbert
- N Hadjikhani
- P Bolton
- P Rakic
- P Shaw
- P Shaw
- P Shaw
- P Szatmari
- P Szatmari
- PF Bolton
- PM Thompson
- PM Thompson
- PR Huttenlocher
- PY Herve
- R Moessner
- R Sacco
- R Sacco
- RA Carper
- RC Knickmeyer
- RE Stevenson
- RK Lenroot
- RT Schultz
- S Kilian
- SF Witelson
- SJ Palmen
- SJ Palmen
- SJ Webb
- SJMC Palmen
- SJMC Palmen
- SZ Sabol
- T Kato
- TD Gould
- TH Wassink
- WF Baare
- World Health Organisation
- WR Kates
- X Zhao
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2009
- Field of study