La dynamique spatio-temporelle de l’attention en lecture chez les dyslexiques

La dyslexie est un trouble neurodéveloppemental nuisant au développement normal de la fluidité en lecture. Certains processus de base à la lecture pourraient être atteints chez les dyslexiques et entraîner des répercussions touchant les représentations de haut niveau des mots en découlant : orthographique, phonologique et sémantique. Un de ces processus de base est le déploiement spatio-temporel de l’attention sur des séquences de stimuli multiples alignés à l’horizontale. L’efficacité de ce déploiement pourrait être étroitement liée à l’expertise en lecture chez les normo-lecteurs, et des irrégularités dans celui-ci pourraient être observées chez des dyslexiques. Malheureusement, la caractérisation de ce déploiement en contexte de reconnaissance de mots écrits, son implication dans la vitesse de lecture et (potentiellement) même dans certaines habiletés langagières demeurent largement sous-spécifiées. Le premier article de cette thèse vise à révéler les divergences du déploiement de l’attention dans le temps et dans l’espace pendant la reconnaissance d’un mot familier chez un groupe d’adultes dyslexiques par rapport à un groupe de normo-lecteurs. Les groupes sont appariés en termes d’âge et de fonctionnement intellectuel. Cet objectif est poursuivi avec la technique de sonde attentionnelle. Les résultats révèlent que les dyslexiques dirigent moins de ressources attentionnelles vers la première lettre d’un mot, ce qui est sous-optimal considérant que la première lettre d’un mot est particulièrement informative sur son identité. Le deuxième article de cette thèse vise à déterminer si les habiletés en lecture de texte et de traitement phonologique chez les dyslexiques peuvent bénéficier d’un entraînement attentionnel court. Un protocole utilisant un entraînement visuo-attentionnel (NeuroTracker) et un entraînement placebo chez une vingtaine d’adultes dyslexiques met en évidence des gains systématiques immédiatement après l’entraînement actif. L’ordre des entraînements (actif puis placebo, ou placebo puis actif) était contrebalancé entre deux groupes. Ces gains s’observent en vitesse de lecture, et même au niveau de la conscience phonologique. Le troisième article de cette thèse apporte finalement une contribution additionnelle significative pour l’évaluation de la vitesse de la lecture chez les adultes universitaires franco-québécois. L’utilisation des phrases-tests d’un outil existant (MNRead) a été intégrée à un protocole de présentation visuelle sérielle rapide pour l’évaluation de la vitesse de lecture. En plus de cet ensemble de phrases-test, quatre autres ensembles de phrases-test ont été normés. L’outil développé permet d’obtenir une mesure de la vitesse de lecture fiable chez un même individu à différentes reprises (Exp. 1) et il satisfait différents standards psychométriques (Exps. 1 et 2), en étant notamment sensible à la présence des difficultés en lecture retrouvées chez les dyslexiques (Exp. 2). En somme, il appert que certains processus visuo-attentionnels sous-tendent l’expertise en lecture et que ceux-ci pourraient présenter des irrégularités chez les dyslexiques. La caractérisation d’un déploiement attentionnel sous-optimal en reconnaissance de mots familiers tout comme les bénéfices obtenus en lecture et en traitement phonologique subséquents à un entraînement attentionnels mettent en lumière l’importance de ces processus de base en lecture.Dyslexia is a neurodevelopmental disorder that affects the normal development of reading fluency. Deficits affecting basic reading processes may affect dyslexics and would thus alter high-level word representations: orthographic, phonological, and semantic. One of these basic processes is the attentional mechanism that is involved in the visual processing of horizontal multi-element strings such as words. The effectiveness of this mechanism could be closely related to reading expertise in normal readers and anomalies thereof could be observed in dyslexics. Unfortunately, it remains unclear how attention is deployed during visual word recognition and how it may impact on reading speed and potentially on certain language skills. The first article of this thesis aims to shed light on divergences in the deployment of attention through time and space during the recognition of familiar words in a group of adults with dyslexia in comparison to normal readers. These groups were matched in terms of age and intellectual functioning. This objective is pursued with the attentional probe technique. Results reveal that less attentional resources are directed to the first letter of a word in dyslexics, which is suboptimal considering that the first letter of a word has a higher diagnostic value than any other letter position. The goal of the second article is to determine if reading fluency and phonological awareness in dyslexics may benefit from a short attentional training. The effects of an active training using the NeuroTracker program and a placebo training in adults with dyslexia shows systematic gains immediately after active training. The order of the training (active then placebo, or placebo then active) was counter-balanced across two groups. These gains are observed on reading speed as well as on phonological awareness. The third article of this thesis finally brings a significant additional contribution to the evaluation of reading speed among Quebec university students. The use of test sentences from an existing tool (MNRead) has been incorporated into a rapid visual serial presentation protocol to assess reading speed. In addition to this set of test sentences, four other sets of test sentences have been standardized. The tool is reliable, as reading speed measurements are similar in the same individual at different times (Exp 1). Moreover, it meets different psychometric standards (Exps 1 and 2) while being particularly sensitive to the presence of the reading difficulties found in dyslexics (Exp.2). In sum, it appears that particular visual-attention processes underlie reading expertise and that these show anomalies in dyslexics. The characterization of a suboptimal attention deployment in visual word recognition as well as the benefits obtained in reading and phonological awareness subsequent to an attentional training highlight the importance of these basic processes in reading

Effects of reflux laryngitis on non-nutritive swallowing in newborn lambs

Reflux laryngitis in infants may be involved not only in laryngeal disorders, but also in disorders of cardiorespiratory control through its impact on laryngeal function. Our objective was to study the effect of reflux laryngitis on non-nutritive swallowing (NNS) and NNS-breathing coordination. Two groups of six newborn lambs, randomized into laryngitis and control groups, were surgically instrumented for recording states of alertness, swallowing and cardiorespiratory variables without sedation. A mild to moderate reflux laryngitis was induced in lambs from the experimental group. A significant decrease in the number of NNS bursts and apneas was observed in the laryngitis group in active sleep (p=0.03). In addition, lower heart and respiratory rates, as well as prolonged apnea duration (p<0.0001) were observed. No physiologically significant alterations in NNS-breathing coordination were observed in the laryngitis group. We conclude that a mild to moderate reflux laryngitis alters NNS burst frequency and autonomous control of cardiac activity and respiration in lambs

Links Between Metabolic and Structural Changes in the Brain of Cognitively Normal Older Adults: A 4-Year Longitudinal Follow-Up

We aimed to longitudinally assess the relationship between changing brain energy metabolism (glucose and acetoacetate) and cognition during healthy aging. Participants aged 71 ± 5 year underwent cognitive evaluation and quantitative positron emission tomography (PET) and magnetic resonance imaging (MRI) scans at baseline (N = 25) and two (N = 25) and four (N = 16) years later. During the follow-up, the rate constant for brain extraction of glucose (Kglc) declined by 6%–12% mainly in the temporo-parietal lobes and cingulate gyri (p ≤ 0.05), whereas brain acetoacetate extraction (Kacac) and utilization remained unchanged in all brain regions (p ≥ 0.06). Over the 4 years, cognitive results remained within the normal age range but an age-related decline was observed in processing speed. Kglc in the caudate was directly related to performance on several cognitive tests (r = +0.41 to +0.43, allp ≤ 0.04). Peripheral insulin resistance assessed by the homeostasis model assessment of insulin resistance (HOMA-IR) was significantly inversely related to Kglc in the thalamus (r = −0.44, p = 0.04) and in the caudate (r = −0.43, p = 0.05), and also inversely related to executive function, attention and processing speed (r = −0.45 to −0.53, all p ≤ 0.03). We confirm in a longitudinal setting that the age-related decline in Kglc is directly associated with declining performance on some tests of cognition but does not significantly affect Kacac

Eccentric Exercise Activates Novel Transcriptional Regulation of Hypertrophic Signaling Pathways Not Affected by Hormone Changes

Unaccustomed eccentric exercise damages skeletal muscle tissue, activating mechanisms of recovery and remodeling that may be influenced by the female sex hormone 17β-estradiol (E2). Using high density oligonucleotide based microarrays, we screened for differences in mRNA expression caused by E2 and eccentric exercise. After random assignment to 8 days of either placebo (CON) or E2 (EXP), eighteen men performed 150 single-leg eccentric contractions. Muscle biopsies were collected at baseline (BL), following supplementation (PS), +3 hours (3H) and +48 hours (48H) after exercise. Serum E2 concentrations increased significantly with supplementation (P<0.001) but did not affect microarray results. Exercise led to early transcriptional changes in striated muscle activator of Rho signaling (STARS), Rho family GTPase 3 (RND3), mitogen activated protein kinase (MAPK) regulation and the downstream transcription factor FOS. Targeted RT-PCR analysis identified concurrent induction of negative regulators of calcineurin signaling RCAN (P<0.001) and HMOX1 (P = 0.009). Protein contents were elevated for RND3 at 3H (P = 0.02) and FOS at 48H (P<0.05). These findings indicate that early RhoA and NFAT signaling and regulation are altered following exercise for muscle remodeling and repair, but are not affected by E2

The tree to the left, the forest to the right: Political attitude and perceptual bias

International audienceA prominent model suggests that individuals to the right of the political spectrum are more cognitively rigid and less tolerant of ambiguity than individuals to the left. On the basis of this model, we predicted that a psychological mechanism linked to the resolution of visual ambiguity – perceptual bias – would be linked to political attitude. Perceptual bias causes western individuals to favour a global interpretation when scrutinizing ambiguous hierarchical displays (e.g., alignment of trees) that can be perceived either in terms of their local elements (e.g., several trees) or in terms of their global structure (e.g., a forest). Using three tasks (based on Navon-like hierarchical figures or on the Ebbinghaus illusion), we demonstrate (1) that right-oriented Westerners present a stronger bias towards global perception than left-oriented Westerners and (2) that this stronger bias is linked to higher cognitive rigidity. This study establishes for the first time that political ideology, a high-level construct, is directly reflected in low-level perception. Right- and left-oriented individuals actually see the world differently