Thermoacoustic stirling power generation from LNG cold energy and low-temperature waste heat

Recovering cold energy generated in the regasification process of liquefied natural gas (LNG) can help to improve the energy efficiency of LNG power generation systems, meanwhile, abundant low-grade waste heat can also be exploited from the exhaust gas of gas turbines. This study proposes to apply the thermoacoustic Stirling electric generator to recover LNG cold energy and waste heat simultaneously. A pair of linear alternators is directly coupled with the thermoacoustic loop by replacing the long and bulky resonator completely. Numerical simulation is conducted on the basis of the thermoacoustic theory to characterize and optimize the operations of the system. The effects of the back volumes of linear alternators, feedback tube length and regenerator length on the output performances are investigated. The distributions of key parameters, including pressure, volume flow rate, phase difference, acoustic power and exergy flow, are further studied. One design of the thermoacoustic Stirling electric generator operated with 4 MPa helium gas is capable of generating 2.3 kW electric power with the highest exergy efficiency of 0.253 when the cold and hot ends are maintained at 110 K and 500 K. Performances can be further improved if the conversion efficiency of the linear alternators is further increased

All that glisters is not gold: a comparison of electronic monitoring versus filled prescriptions – an observational study

BACKGROUND: Poor compliance with antihypertensive medication is assumed to be an important reason for unsatisfactory control of blood pressure. Poor compliance is difficult to detect. Each method of measuring compliance has its own strengths and weaknesses. The aim of the present study was to compare patient compliance with antihypertensive drugs as measured by two methods, electronic monitoring versus refill compliance. METHODS: 161 patients with a diagnosis of hypertension for at least a year prior to inclusion, and inadequate blood pressure control (systolic blood pressure ≥ 160 mmHg and/or diastolic blood pressure ≥ 95 mmHg) despite the use of antihypertensive drugs, were included. Patients' pharmacy records from 12 months prior to inclusion were obtained. Refill compliance was calculated as the number of days for which the pills were prescribed divided by the total number of days in this period. After inclusion compliance was measured with an electronic monitor that records time and date of each opening of the pillbox. Agreement between both compliance measures was calculated using Spearman's correlation coefficient and Cohen's kappa coefficient. RESULTS: There was very little agreement between the two measures. Whereas refill compliance showed a large range of values, compliance as measured by electronic monitoring was high in almost all patients with estimates between 90% and 100%. Cohen's kappa coefficient was 0.005. CONCLUSION: While electronic monitoring is often considered to be the gold standard for compliance measurements, our results suggest that a short-term electronic monitoring period with the patient being aware of electronic monitoring is probably insufficient to obtain valid compliance data. We conclude that there is a strong need for more studies that explore the effect of electronic monitoring on patient's compliance

A Therapeutic Chemical Chaperone Inhibits Cholera Intoxication and Unfolding/Translocation of the Cholera Toxin A1 Subunit

Cholera toxin (CT) travels as an intact AB5 protein toxin from the cell surface to the endoplasmic reticulum (ER) of an intoxicated cell. In the ER, the catalytic A1 subunit dissociates from the rest of the toxin. Translocation of CTA1 from the ER to the cytosol is then facilitated by the quality control mechanism of ER-associated degradation (ERAD). Thermal instability in the isolated CTA1 subunit generates an unfolded toxin conformation that acts as the trigger for ERAD-mediated translocation to the cytosol. In this work, we show by circular dichroism and fluorescence spectroscopy that exposure to 4-phenylbutyric acid (PBA) inhibited the thermal unfolding of CTA1. This, in turn, blocked the ER-to-cytosol export of CTA1 and productive intoxication of either cultured cells or rat ileal loops. In cell culture studies PBA did not affect CT trafficking to the ER, CTA1 dissociation from the holotoxin, or functioning of the ERAD system. PBA is currently used as a therapeutic agent to treat urea cycle disorders. Our data suggest PBA could also be used in a new application to prevent or possibly treat cholera

Pan-cancer analysis of whole genomes

Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe

A transient one-dimensional numerical model for kinetic Stirling engine

A third-order numerical model based on one-dimensional computational fluid dynamics is developed for kinetic Stirling engines. Various loss mechanisms in Stirling engines, including gas spring hysteresis loss, shuttle loss, appendix displacer gap loss, gas leakage loss, finite speed loss, piston friction loss, pressure drop loss, heat conduction loss, mechanical loss and imperfect heat transfer, are considered and embedded into the basic control equations. The non-equilibrium thermal model is adopted for the regenerator to capture the oscillating features of the gas and solid temperatures. To improve the numerical stability and accuracy, the implicit second-order time difference scheme and the second-order upwind scheme are adopted for discretizing the time differential terms and convective terms, respectively. Experimental validations are then conducted on a beta-type Stirling engine with the extensive experimental data for diverse working conditions. The results show that the developed model has better accuracies than the previous second-order models. Good agreements are achieved for predicting various critical system parameters, including pressure-volume diagram, indicated power, brake power, indicated efficiency, brake efficiency and mechanical efficiency. In particular, both the experiments and simulations show that the Stirling engine charged with helium tends to have much lower optimal working frequencies and poorer performances compared to the hydrogen system. Based on the analyses of the losses, it reveals that the pressure drop in the flow channels plays a critical role in shaping the different behaviors. The pressure drop in the helium system is much larger and more sensitive to the frequency increase due to the much larger viscosity of gaseous helium. Hydrogen is a superior working gas for a Stirling engine. The transient characteristics of the oscillating flow and the associated thermal interactions between gas and solid in the regenerator are finally analyzed in order to have an insight of the complex thermodynamic process. The study provides a promising numerical approach in simulating Stirling engines for further understandings of their operating characteristics and the underling mechanisms

Modelling of pulse tube refrigerators with inertance tube and mass-spring feedback mechanism

Most of the current Stirling-type pulse tube refrigerators (PTRs) adopt inertance tubes with large reservoirs for phase shifting. Recovering the acoustic power dissipated in the inertance tube provides a great potential for improving the efficiency of a PTR. In this study, an inertance tube PTR is modified by replacing the dissipative inertance tube and reservoir with a mass-spring displacer directly coupled to a compression space. Numerical simulations are conducted on both the PTRs based on a validated one-dimensional computational fluid dynamics model. Optimization of the inertance tube PTR shows that the coefficient of performance (COP) is limited within 0.103 at the cooling temperature of 77 K. The simulation of the PTR with the feedback mechanism indicates that COP can be significantly improved due to the extra power recovered by the mass-spring displacer. The parametric analyses of the moving mass, spring stiffness, mechanical resistance, piston diameter, and working frequency of the mass-spring displacer are finally performed. The phase relations at both ends of the regenerator are significantly influenced by the geometric and operating parameters, which further affect the performance. The designing parameters have been optimized, COP reaches about 0.13–0.14 with the relative Carnot COP of around 0.4. It demonstrates that adopting the mass-spring displacer to feed the expansion power back into the compression space is an effective way of improving the performance of PTRs. This work provides comprehensive understanding of the mechanisms and characteristics of the PTRs with the mass-spring displacer. It would be helpful for future designs of such systems

Stirling cycle engines for recovering low and moderate temperature heat: A review

A review is presented for the research development of Stirling cycle engines for recovering low and moderate temperature heat. The Stirling cycle engines are categorized into four types, including kinetic, thermoacoustic, free-piston, and liquid piston types. The working characteristics, features, technological details, and performances of the related Stirling cycle engines are summarized. Upon comparing the available experimental results and the technology potentials, the research directions and the possible applications of different Stirling cycle engines are further discussed and identified. It is concluded that kinetic Stirling engines and thermoacoustic engines have the greatest application prospect in low and moderate temperature heat recoveries in terms of output power scale, conversion efficiency, and costs. In particular, kinetic Stirling engines should be oriented toward two directions for practical applications, including providing low-cost solutions for low temperatures, and moderate efficient solutions with moderate costs for medium temperatures. Thermoacoustic engines for low temperature applications are especially attractive due to their low costs, high efficiencies, superior reliabilities, and simplicities over the other mechanical Stirling engines. This work indicates that a cost effective Stirling cycle engine is practical for recovering small-scale distributed low-grade thermal energy from various sources