36 research outputs found
Granzyme B-inhibitor serpina3n induces neuroprotection in vitro and in vivo
- Author
- A Compston
- A Linkermann
- AJ Bredemeyer
- AJ Bredemeyer
- B Engelhardt
- B Sobottka
- BD Trapp
- BD Trapp
- BM Keegan
- Bradley Kerr
- C Wuthrich
- CA Benson
- Camille Olechowski
- CG Bien
- CJ Olechowski
- CL Ewen
- D Kaiserman
- E Zastepa
- ER Podack
- F Giuliani
- F Luessi
- F Zipp
- Fabrizio Giuliani
- G Berke
- G Kobelt
- GV Chaitanya
- H Lassmann
- H Neumann
- H Toft-Hansen
- I Hsu
- J Havla
- JH Russell
- JJ Geurts
- JL Zamanian
- JM Frischer
- JQ Lu
- JW Peterson
- K Richter
- Katia Carmine-Simmen
- LP Shriver
- LS Ang
- M Barry
- M Bots
- M Marta
- MD Prakash
- MJ Coronado
- MJ Redmond
- PA Henkart
- R Gold
- R. Chris Bleackley
- RA Diotti
- S Mun-Bryce
- S Sipione
- SJ Pittock
- SL Hauser
- SM Agrawal
- SM Agrawal
- SP Cullen
- T Musgrave
- T Wang
- TW Phares
- U Kniesel
- WA Boivin
- Y Haile
- Yohannes Haile
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
ICAR: endoscopic skull‐base surgery
- Author
- Aaron G
- Aaron GP
- Abergel A
- Abouaf L
- Abrishamkar S
- Acioly MA
- Acioly MA
- Acuna RT
- Adams AS
- Adappa ND
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- Agaimy A
- Agarwal A
- Aggarwal A
- Agrawal D
- Ahmed OH
- Aihara M
- Akagami R
- Alahmadi H
- Albu S
- Albu S
- Albu S
- Alexander A
- Alimohamadi M
- Almefty R
- Almeida JR
- Almeida JR
- Almeida JR
- Almeida JR
- Almeida JR
- Almeida JR
- Almeida JR
- Almond MC
- Alobaid A
- Alobid I
- Alobid I
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- AlQahtani A
- Altay T
- Alvarez FL
- Alves MV
- Al‐Mamgani A
- Al‐Mefty O
- Al‐Sheibani S
- Amano K
- Amdur RJ
- Amelot A
- American Academy of Pediatrics Steering Committee on Quality Improvement and Management
- Amichetti M
- Amin SM
- Amit M
- Amit M
- Amit M
- Ammirati M
- Anari S
- Anderson D
- Anderson RL
- Andrade NA
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- Weiland DA
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- Weiss M
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- Wenig BM
- Wessell A
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- Wilson PJ
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- Wiseman SM
- Witte O
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- Wood JW
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- Wormald PJ
- Wu JS
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- Xie L
- Xie T
- Xie T
- Xiong L
- Xu CC
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- Yang QT
- Yang T
- Yano S
- Yano S
- Yao WC
- Yasargil MG
- Yasargil MG
- Yasargil MG
- Ye L
- Yildirim AE
- Yilmazlar S
- Yin ZZ
- Yin ZZ
- Yiotakis I
- Yonezawa K
- Yoo F
- Yoshida E
- Yoshizaki T
- You R
- Youssef AS
- Youssef S
- Yunoue S
- Yu‐Wai‐Man P
- Zacharia BE
- Zada G
- Zaidi HA
- Zanation AM
- Zanation AM
- Zanation AM
- Zanation AM
- Zanation AM
- Zhan R
- Zhang C
- Zhang H
- Zhang HK
- Zhang L
- Zhang M
- Zhang Q
- Zhang Q
- Zhang Q
- Zhang Q
- Zhou Q
- Zhou Q
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- Zoli M
- Zoli M
- Zou X
- Zrebeet HA
- Zuccaro G.
- Zuniga MG
- Zwagerman NT
- Publication venue
- Publication date
- 01/07/2019
- Field of study
n/
Pan-cancer analysis of whole genomes
- Author
- A. -L. rv
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- The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium View Correspondence (jump link)
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- Zou
- zt Kim
- zw Lewis
- Ó. A. th
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- Publication venue
- Publication date
- 11/12/2019
- Field of study
Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe
Comprehensive molecular characterization of the hippo signaling pathway in cancer
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- Abdel-Rahman MH
- Abeshouse A
- Adebamowo C
- Adebamowo SN
- Agnew K
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- Ajani JA
- Akbani R
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Hippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform a comprehensive molecular characterization of 19 Hippo core genes in 9,125 tumor samples across 33 cancer types using multidimensional “omic” data from The Cancer Genome Atlas. We identify somatic drivers among Hippo genes and the related microRNA (miRNA) regulators, and using functional genomic approaches, we experimentally characterize YAP and TAZ mutation effects and miR-590 and miR-200a regulation for TAZ. Hippo pathway activity is best characterized by a YAP/TAZ transcriptional target signature of 22 genes, which shows robust prognostic power across cancer types. Our elastic-net integrated modeling further reveals cancer-type-specific pathway regulators and associated cancer drivers. Our results highlight the importance of Hippo signaling in squamous cell cancers, characterized by frequent amplification of YAP/TAZ, high expression heterogeneity, and significant prognostic patterns. This study represents a systems-biology approach to characterizing key cancer signaling pathways in the post-genomic era
Persistent SR: Adding Persistence to Concurrency
- Publication venue
- Publication date
- 01/01/1995
- Field of study
Persistent SR: Adding Persistence to Concurrency
- Publication venue
- Publication date
- 01/01/1995
- Field of study
Microelectronics of Artificial Neural Networks
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1989
- Field of study
Would the Elimination of the Capacity to Suffer Solve Ethical Dilemmas in Experimental Animal Research?
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Advanced polyurethanes for blood contacting applications containing PIME as “smart” heparin-adsorbing moieties
- Author
- Publication venue
- Kluwer Acad. Pub.
- Publication date
- 01/01/2004
- Field of study
Firmware Engineering: An Extensive Update
- Author
- AV Aho
- BC Hodges
- BD Shriver
- BD Shriver
- BW Boehm
- C Vickery
- CG Bell
- CL Braun
- CL McGowan
- CV Ramamoorthy
- CV Ramamoorthy
- CV Ramamoorthy
- D Martin
- D Teichroew
- DA Patterson
- DA Patterson
- DA Patterson
- DJ DeWitt
- FT Baker
- G Wood
- GB Leeman
- H Bratman
- HJ Farber
- HK Berg
- HK Berg
- HK Berg
- HK Berg
- J Stockenburg
- JB Goodenough
- JE Urban
- JF Sommerville
- M Barbacci
- M Persson
- M Persson
- M Richards
- ME Fagan
- MV Wilkes
- N Wirth
- P Marwedel
- PA Boudreaux
- PW Mallett
- RG Turner
- RH Eckhouse
- RL Kleir
- RL London
- S Dasgupta
- S Dasgupta
- S Dasgupta
- S Davidson
- S Davidson
- S Davidson
- S Davidson
- S Menchard
- SG Tucker
- SS Husson
- T Agerwala
- T Gilb
- TG Rauscher
- VM Powers
- WC Carter
- WC Carter
- WC Carter
- WM McKeeman
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1980
- Field of study