Knowing What, Knowing How, or Knowing Where? How Technology Challenges Concepts of Knowledge

When bringing innovative technology into school education it has been challenging to get full benefits from the technology. Instead of seeking new ways of teaching we tend to adapt the use of technology to traditional ways of teaching. This can relate to the fact that we lack theoretical concepts that help us rethink and revise our practices. In Norwegian curriculum we see different learning discourses represented, that makes it difficult to change our concept of knowledge. It is therefore time to look for new ways of understanding the concept of knowledge, to be able to build new perspective on learning and teaching that opens for a more innovate way of using technology in education. George Siemens’ connectivism gives interesting contributions to this transformative process, and may inspire to new concepts of knowledge

Digital Natives and Educational Traditions. What Changes When Exchanging Textbook Content with Internet Search?

Use of technology challenge traditional concepts of learning in school. But what is actually changing? The paper shows result from a study that finds that the shift from textbook to internet content implicates significant changes. Textbooks present qualified content that is well adapted to the cognitive development of students of certain ages. Using internet content gives no such guarantees. The content validation has to be taken care of by the students. The internet search demands more complex skills than accessing content through the textbook. The students have to find relevant search terms, review and validate the results they find, select relevant content, use relevant strategies for storing and retrieving content and having the ability to present abstracts of their findings that are adapted to their learning purpose. Collaboration works well for searching for content online because the students can benefit from each other’s prior knowledge when discussing and reflecting during the learning work. Communicative and collaborative skills are important. So are good relations, to able students to work through obstacles and keep focus on the task even when internet searching takes them everywhere. Internet content has a flexibility that makes it easy adaptable to all students’ learning prerequisites. Student collaboration between heterogeneous peers can work well because the complexity of the task involves a lot of different tasks to manage and are easy to distribute. It also makes possible for high performing students to find engaging content that will motivate and nourish the learning motivation

Pan-cancer analysis of whole genomes

Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe

Non-affirmative Theory of Education as a Foundation for Curriculum Studies, Didaktik and Educational Leadership

This chapter presents non-affirmative theory of education as the foundation for a new research program in education, allowing us to bridge educational leadership, curriculum studies and Didaktik. We demonstrate the strengths of this framework by analyzing literature from educational leadership and curriculum theory/didaktik. In contrast to both socialization-oriented explanations locating curriculum and leadership within existing society, and transformation-oriented models viewing education as revolutionary or super-ordinate to society, non-affirmative theory explains the relation between education and politics, economy and culture, respectively, as non-hierarchical. Here critical deliberation and discursive practices mediate between politics, culture, economy and education, driven by individual agency in historically developed cultural and societal institutions. While transformative and socialization models typically result in instrumental notions of leadership and teaching, non-affirmative education theory, previously developed within German and Nordic education, instead views leadership and teaching as relational and hermeneutic, drawing on ontological core concepts of modern education: recognition; summoning to self-activity and Bildsamkeit. Understanding educational leadership, school development and teaching then requires a comparative multi-level approach informed by discursive institutionalism and organization theory, in addition to theorizing leadership and teaching as cultural-historical and critical-hermeneutic activity. Globalisation and contemporary challenges to deliberative democracy also call for rethinking modern nation-state based theorizing of education in a cosmopolitan light. Non-affirmative education theory allows us to understand and promote recognition based democratic citizenship (political, economical and cultural) that respects cultural, ethical and epistemological variations in a globopolitan era. We hope an American-European-Asian comparative dialogue is enhanced by theorizing education with a non-affirmative approach