Physiological Responses of Synechocystis sp PCC 6803 under Clinorotation

Photosystem efficiency and the characteristic on oxidative stress were examined to elucidate the metabolic responses of Synechocystis sp. PCC 6803 to short-term clinorotation. Results compiled when using clinostat to simulate microgravity for 60 h, showed that clinorotation clearly prohibited the photochemical quantum yield, but promoted the synthesis of chlorophyll and total protein. This may be a compensatory mechanism for the algal cell to maintain its normal metabolism. An increased malondialdehyde (MDA) content of algal cell upon clinorotation, together with an enhanced catalase (CAT) activity was observed during the whole period of clinorotation. One conclusion is that short-term clinorotation acts as a kind of stress, and that these physiological responses may be a special way for an algal cell to adapt itself to a different environment other than earth gravity.Photosystem efficiency and the characteristic on oxidative stress were examined to elucidate the metabolic responses of Synechocystis sp. PCC 6803 to short-term clinorotation. Results compiled when using clinostat to simulate microgravity for 60 h, showed that clinorotation clearly prohibited the photochemical quantum yield, but promoted the synthesis of chlorophyll and total protein. This may be a compensatory mechanism for the algal cell to maintain its normal metabolism. An increased malondialdehyde (MDA) content of algal cell upon clinorotation, together with an enhanced catalase (CAT) activity was observed during the whole period of clinorotation. One conclusion is that short-term clinorotation acts as a kind of stress, and that these physiological responses may be a special way for an algal cell to adapt itself to a different environment other than earth gravity

Pan-cancer analysis of whole genomes

Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe

Spin dynamics with the interplay of elasticity and radiation in hybrid systems

Originated from the electron’s intrinsic angular momentum, magnetism has endowed various manipulations in both macroscopic and microscopic setups with another degree of freedom. Beyond the traditionally developed usage such as storage and sensors, there are enormous applications based on engineering and integrating magnetism into heterostructures and their susceptibility to external stimuli. The emergent fields of nano-level spintronics and spin caloritronics with novel properties have been intensively studied both theoretically and experimentally. Within those developments, the interaction of atomic spins with electromagnetic waves (photons) and elastic dynamics (phonons) are of fundamental importance. This thesis is devoted to investigating the interplay of magnetism with electrodynamics and lattice elasticity in several hybrid systems.QN/Blaauboer Grou

Magnon Accumulation in Chirally Coupled Magnets

We report strong chiral coupling between magnons and photons in microwave waveguides that contain chains of small magnets on special lines. Large magnon accumulations at one edge of the chain emerge when exciting the magnets by a phased antenna array. This mechanism holds the promise of new functionalities in nonlinear and quantum magnonics.QN/Bauer GroupQN/Blaauboer GroupQN/Blanter Grou

Enhanced energy transfer in a Dicke quantum battery

We theoretically investigate the enhancement of the charging power in a Dicke quantum battery which consists of an array of N two-level systems (TLS)coupled to a single mode of cavity photons. In the limit of small N, we analytically solve the time evolution for the full charging process. The eigenvectors of the driving Hamiltonian are found to be pseudo-Hermite polynomials and the evolution is thus interpreted as harmonic oscillator like behaviour. Then we demonstrate the average charging power using a collective protocol is (Formula presented.) times larger than that of the parallel protocol when transferring the same amount of energy. Unlike previous studies, we point out that such quantum advantage does not originate from entanglement but is due to the coherent cooperative interactions among the TLSs. Our results provide intuitive quantitative insight into the dynamic charging process of a Dicke battery and can be observed under realistic experimental conditions.QN/Blaauboer Grou

Unidirectional Pumping of Phonons by Magnetization Dynamics

We propose a method to control surface phonon transport by weak magnetic fields based on the pumping of surface acoustic waves (SAWs) by magnetostriction. We predict that the magnetization dynamics of a nanowire on top of a dielectric films injects SAWs with opposite angular momenta into opposite directions. Two parallel nanowires form a phononic cavity that at magnetic resonances pump a unidirectional SAW current into half of the substrate. QN/Blaauboer GroupQN/Bauer Grou

Operational risk allocation in urban rail transit public–private partnership projects

Operation risk (OR) has affected sustainable development of urban rail transit (URT) public–private partnership (PPP) projects in China. Balanced distribution of operational risks among stakeholders (the public, government, and private companies) involved in URT PPP projects can maximize overall profit. Quantitative analysis of operational risk allocation of urban rail transit PPP project is the key to achieve balance. Few existing studies have quantitatively analyzed operation risk allocation (ORA) in URT PPP project. The objective of this research is to construct a quantitative risk allocation model among three participants by using cooperative game theory. The risk allocation model was modified based on the consideration of four factors affecting the allocation of operational risks: controllability, risk loss, affordability, and handling cost. A case was used as an empirical example, and possible problems were illustrated. The result shows it is necessary and feasible to let the public bear part of the operational risk of the project by raising ticket prices. The results reveal that the public will play an important role in balancing risk allocation. This study shows that an ORA model can suggest how to make the risk allocation process more reasonable, fair, and stable. Meanwhile, the quantitative approach proposed can also be used by stakeholders in achieving fairness and stability of the partnership.Integral Design and Managemen

Chiral coupling of magnons in waveguides

We theoretically investigate the collective excitations of multiple (sub)millimeter-sized ferromagnets mediated by waveguide photons. By the position of the magnets in the waveguide, the magnon-photon coupling can be tuned to be chiral, i.e., magnons only couple with photons propagating in one direction, leading to an asymmetric transfer of angular momentum and energy between the magnets. A large enhancement of the magnon number population can be achieved at an edge of a long chain of magnets. The chain also supports standing waves with low radiation efficiency that are inert to the chirality.QN/Bauer GroupQN/Blaauboer GroupQN/Blanter Grou

An indicator system for evaluating operation and maintenance management of mega infrastructure projects in China

Mega infrastructure projects provide a basic guarantee for social development, economic construction, and livelihood improvement. Their operation and maintenance (O&M) management are of great significance for the smooth operation and the realization of the value created by the projects. In order to provide an approach for effectively evaluating O&M management, this study develops a holistic indicator system using a mixed-review method from the national macro perspective in China. In this study, literature analysis, policy texts, expert interviews, and grounded theory were used to collect relevant data at home and abroad, and establish an initial evaluation indicator system with 23 indicators covering two dimensions and five aspects. Then the questionnaire survey and factor analysis were used to score and categorize the indicators, and finally an evaluation indicator system for O&M management of mega infrastructure projects was formed. The results show that social relations, environmental benefits, macro policy, and operational capacities play an important role in the evaluation of the O&M of mega infrastructure projects. This study helps the management team to avoid negative impacts in the O&M management of mega infrastructure projects and lays a theoretical foundation for future research. The indicator system in this study is based on the Chinese context, and it remains to be verified whether the indicator system is applicable to other countries due to the differences in political and cultural backgrounds in different regions.Integral Design and Managemen

Effect of porosity variation strategy on the performance of functionally graded Ti-6Al-4V scaffolds for bone tissue engineering

Functionally graded scaffold (FGS) is designed to mimic the morphology, mechanical and biological properties of natural bone closely. Porosity variation strategy between different regions in FGS plays a crucial role in influencing its mechanical and biological performance. A combination of modeling tool and scripting language can effectively enhance the ability to optimize FGS design. This study was aimed at determining the effect of porosity variation strategy on the mechanical performance and permeability of the as-built and as-heat-treated FGSs. Ti-6Al-4V FGSs with sizes of 10 × 10 × 15 mm and diamond lattice structures were designed and fabricated by means of selective laser melting. A wide range of porosities in the FGSs (38–75%) were achieved by applying six different porosity variation strategies. The elastic modulus (3.7–5.7 GPa) and yield strength (27.1–84.7 MPa) of the as-built FGSs were found to vary between the corresponding mechanical properties of cancellous bone and cortical bone. Heat treatment reduced the strengths by 13–56%. Porosity variation strategy strongly affected the deformation behavior and failure mechanisms of the FGSs. The sigmoid function-controlled FGSs showed gradual failure behavior and sample Sigk0.5b8 showed superior overall performance. The results demonstrated that porosity variation strategy is a feasible means for tailor design of FGS.Accepted Author ManuscriptBiomaterials & Tissue Biomechanic