TC-1 observations of flux pileup and dipolarization-associated expansion in the near-Earth magnetotail during substorms

Fifty-three substorms measured by Double Star/TC-1 in the near-Earth magnetotail from July to October, 2004 are studied. The main features of these events are: (a) Magnetic flux pileup characterized by continuous enhancement of B z is observed, which starts almost simultaneously with aurora breakup within 1–3 minutes, indicating that substorm onset is in close relation to flux pileup. (b) Sudden plasma sheet expansion with sharp increases in ion temperature and density is seen in all events, which occurs typically ∼11 minutes after the beginning of pileup. The plasma sheet expansion is shown to be in close relation with the primary substorm dipolarization and, hence, can be referred to as ‘dipolarization-associated expansion’. (c) Evidence indicates that the substorm current wedge first forms earthward of TC-1 position and, hence, inward of the flow braking region, and then propagates tailward with an expansion in the Z-direction. Possible implications of these observations are briefly discussed

Pan-cancer analysis of whole genomes

Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe

Influence of Hypericum perforatum Extract on Piglet Infected with Porcine Respiratory and Reproductive Syndrome Virus

To study the influence of Hypericum perforatum extract (HPE) on piglets infected with porcine respiratory and reproductive syndrome virus (PRRSV), enzyme-labeled immunosorbent assay (ELISA) and cytopathic effect (CPE) were used to determine in vitro whether HPE could induce swine pulmonary alveolar macrophages (PAMs) to secrete IFN-gamma, and whether PRRSV titers in PAMs were affected by the levels of HPE-induced IFN-gamma. HPE (200 mg kg(-1)) was administrated by oral gavage to piglets infected with the PRRSV in vivo to observe whether HPE affected the viremia, lung viral titers, and weight gain of piglets infected with PRRSV. The results showed that HPE was capable of inducing PAMs to produce IFN-gamma in a dose dependent manner and HPE pretreatment was capable of significantly reducing PRRSV viral titers in PAMs (P<0.01). Administration of HPE to the PRRSV-infected animals significantly (P<0.05) reduced viremia over time as compared with the PRRSV-infected animals. But there was not significant decrease in lung viral titers at day 21 post-infection between the HPE-treated animals and the PRRSV-infected control piglets. There were no significant differences in weight gain over time among the HPE-treatment animals, the normal control, and the HPE control animals. The PRRSV-infected animals caused significant (P<0.01) growth retardation as compared with the HPE controls and the normal piglets. It suggested that HPE might be an effective novel therapeutic approach to diminish the PRRSV-induced disease in swine

Water–sediment flow modeling for field case studies in Southwest China

This paper presents a highly robust numerical model to simulate water–sediment mixture flows in practical field studies. The model is composed of an integrated algorithm combining the finite element characteristic splitting method and finite volume Godunov scheme. The former maintains the generality and stability of the numerical algorithm, while the latter ensures the conservation and accuracy of the model. The proposed model is first tested by three benchmark flow problems including flood flow in a pool, dam break over a mobile bed, and morphological process of a dam removal. Then, the model is applied to two practical field case studies to demonstrate its potential engineering values. The first case study is related to the damage of the Polo Hydropower Plant by a sediment flooding event. The second one is the investigation of a well-known 2013 dam-break flooding that happened in the Tangjiashan Mountain. It is shown that the simulated water and sediment flows are in good agreement with the documented laboratory and field data, and the numerical model is capable of providing useful information on the flow predictions, thus making further engineering measures to mitigate these disasters