59 research outputs found
Pan-cancer analysis of whole genomes
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- Yachida
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- yj Baylin
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- z ah
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- Z. ep
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- Z. jq
- Z. kt
- Z. oe
- Zaikova
- Zapatka
- zd Gershenwald
- Zenklusen
- Zeps
- zf Ghossein
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang H. b
- Zhao
- Zheng
- Zhou
- Zhou
- Zhu
- Zhu
- zi zj
- zm Jayaseelan
- Zou
- Zou
- zt Kim
- zw Lewis
- Ó. A. th
- Ø. sk
- Publication venue
- Publication date
- 11/12/2019
- Field of study
Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe
International Consensus Statement on Rhinology and Allergy: Rhinosinusitis
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- Abadie WM
- Abi Najm S
- Abigail P
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- Josephson GD
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- Jung JH
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- Keswani A
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- Kim JH
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- Kim JY
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- Koskinen A
- Koteswara CM
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- Nyenhuis SM
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- Ostovar A
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- Parma V
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- Pasaje CF
- Pasaje CF
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- Passali D
- Passali D
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- Passàli D
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- Patel NA
- Patel NN
- Patel VS
- Patel ZM
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- Payne SJ
- Pearlman AN
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- Peng Y
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- Penttila M
- Perez‐Novo CA
- Peric A
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- Perica A
- Perić A
- Perkasa MF
- Perloff JR
- Persson EK
- Peters AT
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- Pfaar O
- Pfaar O
- Pfaar O
- Pham V
- Phillips KM
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- Philpott C
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- Poachanukoon O
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- Prajapati DP
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- Quintanilla‐Dieck L
- Quinti I
- Qvarnberg Y
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- Ramakrishnan V
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- Ramanathan M
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- Reh DD
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- Ricciardolo FLM
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- Rostkowska‐Nadolska B
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- Rostkowska‐Nadolska BLM
- Rotenberg BW
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- Roxbury CR
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- Scangas GA
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- Schreiber CP
- Schubert MS
- Schwartz HJ
- Schwartz JS
- Schwarzbach HL
- Schwitzguébel AJ‐P
- Scott JR
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- Sedaghat AR
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- Sedaghat AR
- Seiberling K
- Seiberling KA
- Seiberling KA
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- Sejima T
- Sella GCP
- Sener M
- Senior BA
- Senior BA
- Senturk M
- Seppanen M
- Seresirikachorn K
- Servat JJ
- Seshadri S
- Sethi DS
- Sethi N
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- Setzen G
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- Shah GB
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- Shaikh N
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- Shaikh N
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- Shamji MH
- Shanbhag S
- Shapiro AJ
- Shapiro GG
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- Sharif‐Askari FS
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- Sharp HJ
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- Siedek V
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- Siegel GJ
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- Silveira MLC
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- Sirikci A
- Sitarek P
- Siu J
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- Sjogren PP
- Slavin RG
- Sleigh MA
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- Small CB
- Smith A
- Smith KA
- Smith KA
- Smith KA
- Smith KA
- Smith KA
- Smith KA
- Smith SS
- Smith SS
- Smith T
- Smith TL
- Smith TL
- Smith TL
- Smith TL
- Smith TL
- Smith TL
- Smith TL
- Snidvongs K
- Snidvongs K
- Snidvongs K
- Snidvongs K
- Snidvongs K
- Snidvongs K
- Snidvongs K
- Snidvongs K
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- Snow DG
- Snyderman CH
- Sohn HG
- Sohn JH
- Soler ZM
- Soler ZM
- Soler ZM
- Soler ZM
- Soler ZM
- Soler ZM
- Soler ZM
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- Song W
- Sonnet MH
- Soteres DF
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- Southwood JE
- Sowerby LJ
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- Steelant B
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- Steinke JW
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- Stelter K
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- Stentzel S
- Stern‐Shavit S
- Stevens PR
- Stevens WW
- Stevens WW
- Stevens WW
- Stevens WW
- Stevens WW
- Stevens WW
- Stevenson DD
- Stevenson DD
- Stewart RA
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- Stjarne P.
- Stokken J
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- Stolovitzky JP
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- Strauss G
- Stringer SP
- Stryjewska‐Makuch G
- Su MC
- Subramanian HN
- Succar EF
- Sugimoto I
- Sugino T
- Suh JD
- Sullivan PW
- Sultan B
- Sunadome H
- Sundaresan AS
- Sunkaraneni VS
- Suzuki S
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- Sykes DA
- Sylvester DC
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- Szczeklik A
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- Tabrizi R
- Taccariello M
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- Tahkokallio O
- Tait S
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- Takabayashi T
- Takabayashi T
- Takabayashi T
- Takahashi T
- Takeda K
- Takeuchi K
- Talat R
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- Tammemagi CM
- Tan BK
- Tan BK
- Tan BK
- Tan BK
- Tan BK
- Tan BK
- Tan KS
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- Tan NC
- Tan NC
- Tan NC
- Tanaka S
- Tang C
- Tanner SB
- Tarrant BJ
- Tas M
- Taschieri S
- Taulu R
- Taulu R
- Tay TR
- Taylor MJ
- Telmesani LM
- Tesche S
- Teufelberger AR
- Tewfik MA
- Thacker NM
- Thamboo A
- Thamboo A
- Thamboo A
- Tharakan A
- Theodoraki MN
- Thilsing T
- Thomas AJ
- Thomas JK
- Thomas M
- Thomas WW
- Thulasidas P
- Tieu DD
- Tipirneni KE
- Tipirneni KE
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- Tirelli G
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- Tirumandas M
- Tizzano M
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- Todman MS
- Tomassen P
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- Tomassen P
- Tomassen P
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- Tos M
- Tosca MA
- Tosca MA
- Toskala E
- Tosun F
- Tournas A
- Tran Khai Hoan N
- Tripathi A
- Trompette A
- Tscopp KP
- Tsetsos N
- Turan A
- Turan A
- Turfe Z
- Turner JH
- Turner JH
- Turner JH
- Turner JH
- Turner JH
- Tyler MA
- Tyler MA
- Tyler MA
- Tyler MA
- Tzelnick S
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- Ueda D
- Ulualp SO
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- Unlu HH
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- Uri N
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- Vaezi MF
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- Vaira LA
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- Valdes CJ
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- Zielinska‐Blizniewska H
- Zou L
- Zuckerman JD
- Zurlo JJ
- Zuskin E
- Čulig J
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2021
- Field of study
Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICAR‐RS‐2021 as well as updates to the original 140 topics. This executive summary consolidates the evidence‐based findings of the document. Methods: ICAR‐RS presents over 180 topics in the forms of evidence‐based reviews with recommendations (EBRRs), evidence‐based reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results: ICAR‐RS‐2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidence‐based management algorithm is provided. Conclusion: This ICAR‐RS‐2021 executive summary provides a compilation of the evidence‐based recommendations for medical and surgical treatment of the most common forms of RS
Global variation in anastomosis and end colostomy formation following left-sided colorectal resection
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- Depalma N
- Deputy M
- Der Y
- Dervenis C
- Despotidis V
- Desta S
- Deutschmann P
- Devadasar Gh
- Dharamshi Ha
- Dhillon D
- Di Franco F
- Di Martino N
- Di Saverio S
- Di Saverio S
- Diab A
- Diaconescu B
- Diaconescu Ib
- Dias S
- Diaz-Jover P
- Diaz-Zorrilla C
- Dick L
- Dickfos M
- Dickson L
- Dijan E
- Dimech T
- Din F
- Dindyal S
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- Dissanayake T
- Djivoh F
- Domini E
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- Donnelly P
- Donoghue D
- Dorani Rmnr
- Dorismé
- Dos Santos DV
- Dossou F
- Doughan S
- Doughty J
- Dousset B
- Dragatas D
- Drake Tm
- Drake Tm
- Driscoll A
- Drungilas M
- Du Plessis D
- du Plooy F
- Du Toit F
- Duane T
- Dubois A
- Dueñ
- Duffy L
- Duhoranenayo D
- Duinhouwer L
- Dulskas A
- Durand Sya
- Dwydar A
- Ebdewi H
- Ebidy M
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- Ebrahim Os
- Eduard P
- Edwards J
- Edye M
- Eid Mm
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- Ekow M
- El Ashal G
- El Dahab AA
- El Deen KN
- El Galeel AA
- El Gendy NH
- El Gendy A
- El Halawany M
- El Hameed OSA
- El Hamid NA
- El Jamassi A
- El Kashash A
- El Kholy A
- El Magd AA
- El Mesery S
- El Salam YA
- El Sayed GS
- El Sayed IM
- El Shoura Y
- El Slam MA
- El-Badawy Ha
- El-Dien Ks
- El-Dien Ks
- El-Din Ra
- El-Din Sa
- El-Gizawy E
- El-Hamouly As
- El-Kashef H
- El-Latif Nka
- El-Ma&apos
- El-Rabaa S
- El-Sagheer N
- El-Salam Fa
- El-Sawy A
- El-Sehily A
- El-Shahat Ns
- El-Sheemy H
- El-Taher E
- Elabdin Hz
- Elashmawy M
- Elashry R
- Elazab A
- Elazayem Aa
- Elazoul M
- Elbanby E
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- Elbatahgy A
- Elbe P
- Elbermawy M
- Elbisomy Kh
- Eldafrawy M
- Eldamaty L
- Eldeeb Az
- Eldeen Ea
- Eldin Mab
- Elebute O
- Elebute O
- Elena G
- Elfarargy A
- Elfeki H
- Elfeki H
- Elfiky M
- Elfil M
- Elfouly N
- Elfouly N
- Elfouly Y
- Elfouly Y
- Elgebaly A
- Elgendy Ah
- Elgendy Fi
- Elgheriany M
- Elhadad A
- Elhadary Nm
- Elhadry S
- Elhalawany E
- Elhamouly S
- Elhelbawy Ms
- Elhendawy A
- Elhendawy Aoa
- Elhoseny G
- Elhusseiny Aae
- Elkadsh I
- Elkady F
- Elkelany A
- Elkelany A
- Elkelany A
- Elkelany A
- Elkhadrawi M
- Elkhalek Ea
- Elkholy A
- Elkholy Ss
- Elkolaly Ss
- Elkorashy Am
- Ellison Q
- Elmashala A
- Elmasry M
- Elmelegy R
- Elmihy S
- Elnagar A
- Elnajjar Ma
- Elnemr Ae
- Elrasoul Ya
- Elrazek Aa
- Elsabbagh N
- Elsameea Aa
- Elsawahly Dme
- Elsawy A
- Elsayed M
- Elsayed M
- Elsayed N
- Elsayed Nar
- Elsayed Zm
- Elsebaaye Ao
- Elsehimy M
- Elsemelawy R
- Elshaar M
- Elshaer K
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- Elshaer M
- Elshafay Ae
- Elshami M
- Elshanwany S
- Elsharkawy Aa
- Elsheikh S
- Elsherbiney S
- Elsherbiny As
- Elsherif Fa
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy Deaa
- Elwaey A
- Elwakil H
- Elwan A
- Elwan A
- Elwy E
- Elzahed N
- Elzayat I
- Elzayat M
- Elzayyat I
- Elzowawi F
- Emadeldin D
- Emadeldin H
- Emara E
- Emile S
- Eng C
- English W
- Esam A
- Escobar Eg.
- Espin-Basany E
- Espinoza F
- Espinoza Kt
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- Essam A
- Essam Aa
- Essam M
- Essoun S
- Esteban E
- Estee Mm
- Estupinian S
- Etchill E
- Etchill E
- Etienne S
- Etman M
- Etwire V
- Evajelista Cv
- Evans D
- Evans E
- Eysa A
- Eyssartier E
- Ezzat E
- Ezzat T
- Faboya O
- Faccincani R
- Fadel A
- Fahiem A
- Fahim M
- Fahy C
- Fairfield C
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- Fairfield C
- Fakher R
- Falaschi F
- Falco N
- Falzon M
- Farag A
- Farag S
- Farah A
- Farahat Mm
- Faraz A
- Fares M
- Farfan Esf
- Farhad M
- Farhan-Alanie Mmh
- Farhangmehr N
- Farinella E
- Farmakis K
- Farooq T
- Farouk Sam
- Farquharson A
- Farrugia A
- Farrugia A
- Faruq A
- Fathy Am
- Fattah Aa
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
- Favero A
- Fawzy A
- Feidantsis T
- Felipe Co
- Fergany A
- Fergusson Sj
- Fergusson Sj
- Fergusson Sj
- Fermani C
- Fermani Cg
- Ferná
- Fernandes C
- Fernandez-Bueno F
- Fernandez-Vega L
- Ferousis C
- Ferreira Sak
- Ferrero E
- Fievet L
- Filatau A
- Findlay-Cooper K
- Firdouse M
- Firdouse M
- Firdouse M
- Firwana A
- Fitsum A
- Fitzgerald Je
- Florez Ljg
- Foco M
- Fok Cyj
- Fontana T
- Foo Cc
- Forlin L
- Forno W
- Fouad A
- Fouad D
- Fouad D
- Fourcade L
- Fowler Aj
- Fozard T
- Fozard T
- Frade F
- Fraga Gp
- Franco H
- Francois P
- Francois-Coridon H
- Francone E
- Freitas Av
- Frey D
- Frisk B
- Fuentes-Rivera L
- Fujii F
- Furqan Mm
- Gü
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- Gaafar S
- Gaarder T
- Gad A
- Gad Mo
- Gadelkarim M
- Gadhvi V
- Gado A
- Gaiž
- Gaignard E
- Gaignard E
- Gala T
- Gala T
- Galiqi G
- Galleano R
- Gallo G
- Galloway S
- Galvez Cp
- Gamal D
- Gamal E
- Gamal H
- Gamal S
- Gamaly E
- Gamil D
- Gan C
- Gan Yy
- Gani Ma
- Garaycochea O
- Garcí
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- Garcia-Marin Ja
- Garcia-Perez Jm
- Garland A
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- Gasteratos K
- Gaujoux S
- Gavagna L
- Gbessi Dg
- Gemeah M
- Gemenetzis G
- Gemenetzis G
- George R
- Germanos S
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- Gerosa A
- Gerosa A
- Geuoshy A
- Ghaben A
- Ghandora N
- Ghanem A
- Ghanem E
- Ghanem S
- Ghanem S
- Ghannam M
- Gharib A
- Gharib A
- Ghazy Aa
- Gheith A
- Ghetia M
- Ghetia M
- Ghonaim Ma
- Ghoneem M
- Ghoneim O
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- Giardino Fr
- Giavarini L
- Giglio Mc
- Gilbert R
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- Giuriato Tf
- Gkiokas G
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- Glynn M
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- Gohar Meam
- Gokani S
- Goldin E
- Golding D
- Gomaa A
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- Grant A
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- Grassi V
- Gratton R
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- Grella Mg
- Gribauskaite J
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- Grima T
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- Grizhja B
- Grobler Dc
- Grosos C
- Grossart C
- Guasti Bpsj
- Gudal A
- Gudal A
- Gudal A
- Gudlaugsdottir K
- Guevara R
- Guglielmo V
- Gui D
- Gulbinas A
- Gulcicek Ob
- Gulielmi A
- Gultom Pa
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- Gunawan R
- Guner A
- Gunnarsson U
- Guo W
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- Gustafsson U
- Gyamfi Fe
- Gyanchandani N
- Gyedu A
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- Habeeb O
- Habeebullah A
- Hache-Marliere M
- Haddad N
- Hafez At
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- Hafez M
- Hafez S
- Haffreingue A
- Hafiz S
- Hagan R
- Hagar A
- Haines M
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- Hajeh H
- Hakim H
- Halhouli O
- Halhouli O
- Halicioglu I
- Hall E
- Hall N
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- Hall Tf
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- Haloho A
- Hamad Mgm
- Hamaguchi Jlh
- Hamarshi A
- Hamasaki J
- Hamdan A
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- Hamill D
- Hammad A
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- Hamsho W
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- Hanley I
- Hanoun S
- Hanrahan M
- Hanrahan M
- Hanrahan M
- Hanrahan M
- Hantour U
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- Hany E
- Haque M
- Har Pa
- Haraux E
- Harbord P
- Haroun A
- Harper E
- Harrison Em
- Harrison Em
- Harrison N
- Harrison P
- Harrison R
- Hartford L
- Harvey N
- Hasan A
- Hasan A
- Hasan D
- Hasanah A
- Hasanain D
- Hascoet J
- Hashad E
- Hasheminia A
- Hashim A
- Hashish A
- Hashish M
- Haslegrave A
- Hasnan Mb
- Hassaan A
- Hassaan A
- Hassan A
- Hassan A
- Hassan A
- Hassan Ata
- Hassan I
- Hassan M
- Hassan Omm
- Hassan S
- Hassan Z
- Hassanain M
- Hassanain M
- Hassanein Ab
- Havemann I
- Hawkins W
- Heard R
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- Heffernan D
- Hegazy Em
- Hegazy Y
- Helene Fc
- Helguero-Santin Lm
- Hemeda D
- Hemingway D
- Hemmila M
- Hemmila M
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- Henderson L
- Heng He
- Henric N
- Henry F
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- Herebat A
- Herikstad R
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- Hervieux E
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- Hesham O
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- Hewage K
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- Hilal K
- Hinojosa C
- Hjertberg M
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- Ho A
- Ho Cw
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- Hodonou F
- Hogea M
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- Homeida A
- Hoogakker E
- Horobjowsky A
- Hosein Sp
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- Hossameldin A
- Houlden C
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- Howie Ee
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- Huaman E
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- Huwait A
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- Iacono C
- Iannone I
- Ibraheem Aa
- Ibraheem Hi
- Ibrahem Aa
- Ibrahem Aa
- Ibrahim A
- Ibrahim A
- Ibrahim A
- Ibrahim Am
- Ibrahim E
- Ibrahim Em
- Ibrahim I
- Ibrahim K
- Ibrahim M
- Ibrahim Mh
- Ibrahim Y
- Idress T
- Idris F
- Idris Sai
- Iftekhar F
- Iftikhar Z
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- Ignatavicius P
- Ihediwa G
- Imoro O
- Ingabire Jca
- Ingabire Jca
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- Ioannidis O
- Iordache Fm
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- Iqbal Mr
- Ireland P
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- Irwin G
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- Kamarajah Sk
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- Karabelias G
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- Kasputyte S
- Kaul A
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- Loaloa Mr
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- Mentula P
- Meqbil J
- Mericliler M
- Merlini D
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- Mesbah N
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- Metwally Mm
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- Mihaljevic Al
- Mihanovic J
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- Miranda C
- Mircea H
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- Mironescu A
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- Mirza A
- Mirza S
- Mistry A
- Mitrasinovic S
- Mitroudi M
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- Mizzi C
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- Mlotshwa M
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- Modolo Mm
- Modolo Mm
- Modolo Mm
- Moe Tt
- Mogan Yp
- Moghazy Me
- Mohamed A
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- Mohamed Am
- Mohamed Ar
- Mohamed B
- Mohamed F
- Mohamed I
- Mohamed M
- Mohamed Ma
- Mohamed Maeh
- Mohamed Mm
- Mohamed O
- Mohamed Sr
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- Mohammad A
- Mohammad A
- Mohammed A
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- Mohammed Ae
- Mohammed Ar
- Mohammed H
- Mohammed Mm
- Mohammed Mmh
- Mohammed S
- Mohan H
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- Molina G
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- Monrad-Hansen Pw
- Montejo Msg
- Monteleone M
- Monteleone M
- Montes I
- Montes I
- Montrimaite M
- Montrimaite M
- Moodley Y
- Moore R
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- Mora Jjv
- Morais Pab
- Morales C
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- Morandi E
- Moreira G
- Moreno Sc
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- Morsi A
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- Mosad A
- Mosalum O
- Mostafa Ha
- Mostafa M
- Mostafa M
- Mousa M
- Moussa O
- Moustafa A
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- Mowafy B
- Mphatsoe Am
- Mshelbwala P
- Msiska N
- Msosa V
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- Muddebihal U
- Mukin Adf
- Muktar U
- Mukuzunga C
- Muller C
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- Munera A
- Munhoz Mm
- Munipalle Pc
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- Muralha N
- Murphy J
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- Musa Aek
- Musleh A
- Musowoya J
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- Musyoka Ck
- Mutabazi Az
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- Mutlu D
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- Muzio E
- Myers J
- Mykoniatis I
- Næ
- Nabawi A
- Nada F
- Nadeem N
- Nadkarni S
- Nagy Gs
- Nahar Sn
- Nair H
- Nanthakumaran S
- Napolitano L
- Napolitano L
- Naqvi Sa
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- Naranjo Aristizã
- Narayanan R
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- Narvestad Jk
- Nashaat A
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- Nasher O
- Nashidengo P
- Nasir A
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- Nassif D
- Nastri G
- Natalie H
- Nataraja R
- Natili A
- Navarro A
- Nawara C
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- Nazir M
- Ndajiwo A
- Ndajiwo A
- Ndegwa W
- Ndlovu Sr
- Ndwambi P
- Ne&apos
- Negida A
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- Nel D
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- Neo Yn
- Neo Yt
- Neophytou C
- Nepogodiev D
- Nepogodiev D
- Nepogodiev D
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- Nesaratnam A
- Nessa A
- Nestorovic M
- Nevieraite V
- Newton T
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- Nikoloudis N
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- Njokanma I
- Nnajiuba H
- Nocito A
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- Nofal E
- Noor F
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- Notarnicola M
- Nouh T
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- Novak A
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- Nsengimana Vjp
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- Ntirenganya F
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- Nurqistan Hd
- Nwabuoku E
- Nwinee V
- Nwokoro C
- Nyberg J
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- O&apos
- O&apos
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- Obute Rd
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- Odeyemi B
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- Odutola O
- Ogunsua O
- Ogunyemi A
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- Olaolorun A
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- Ortiz N
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- Oshati O
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- Ozben V
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- Padmore G
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- Palma Af
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- Papaskarlatos Ia
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- Parseliunas A
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- Pasquali S
- Pastora J
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- Patoulias I
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- Poskus T
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- Preckailaite E
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- Razmdjou S
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- Razzaque J
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- Redota Map
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- Sabour Fa
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- Ukwenya Y
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- Urbanavicius L
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- Urniež
- Urniezius Z
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- Yang J
- Yap S
- Yaseen T
- Yaseen Tm
- Yau Jd
- Yavuz Ma
- Ye J
- Yeang Lj
- Yee J
- Yeo Ls
- Yeung En
- Yeung Mha
- Yifieyeh A
- Yildirim R
- Yip C
- Yip Sbs
- Ymeri S
- Yoganathan P
- Yolcu S
- Yong Co
- Yong Gl
- Younis A
- Youssef D
- Youssef H
- Youssef M
- Youssif Jh
- Yuksek Ma
- Yusufali T
- Zaa&apos
- Zachariades Dc
- Zadoroznas A
- Zahran D
- Zakaria E
- Zakaria M
- Zakaria Y
- Zaki A
- Zakir M
- Zalabia Mf
- Zamarin K
- Zammit S
- Zampitis N
- Zani A
- Zani A
- Zani A
- Zanini N
- Zanini N
- Zapata F
- Zarb C
- Zardab A
- Zegarra S
- Zeidan S
- Zerihun Ab
- Zhang Z
- Zheng F
- Zidan H
- Zidan H
- Zidan M
- Zielinski M
- Ziff O
- Zikry M
- Zil-E-Ali A
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskiene R
- Zimmermann Ef
- Zohair A
- Zorrilla Cd
- Zuber M
- Zuber M
- Zuk G
- Zulkifli A
- Zumbü
- Publication venue
- 'Wiley'
- Publication date
- 27/11/2018
- Field of study
Background
End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection.
Methods
This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model.
Results
In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6·9 per cent) from low-HDI, 254 (15·5 per cent) from middle-HDI and 1268 (77·6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57·5, 40·9 and 35·4 per cent; P < 0·001) and subsequent use of end colostomy (52·2, 24·8 and 18·9 per cent; P < 0·001) in low- compared with middle- and high-HDI settings. The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3·20, 95 per cent c.i. 1·35 to 7·57; P = 0·008) after risk adjustment for malignant disease (OR 2·34, 1·65 to 3·32; P < 0·001), emergency surgery (OR 4·08, 2·73 to 6·10; P < 0·001), time to operation at least 48 h (OR 1·99, 1·28 to 3·09; P = 0·002) and disease perforation (OR 4·00, 2·81 to 5·69; P < 0·001).
Conclusion
Global differences existed in the proportion of patients receiving end stomas after left-sided colorectal resection based on income, which went beyond case mix alone
Cranial Arteritis With Liver Involvement
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- Field of study
Expression of a glycoprotein of the carcinoembryonic antigen family in normal and neoplastic sebaceous glands - Limited role of carcinoembryonic antigen as a sweat gland marker
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/05/1996
- Field of study
Background: Carcinoembryonic antigen (CEA) is a well-known marker for sweat gland differentiation in adnexal neoplasms
Long-term intracranial pressure recording in the management of pseudotumor cerebri
- Author
- Publication venue
- 'Journal of Neurosurgery Publishing Group (JNSPG)'
- Publication date
- Field of study
Pattern-reversal visual evoked potentials in patients with hydrocephalus
- Author
- Publication venue
- 'Journal of Neurosurgery Publishing Group (JNSPG)'
- Publication date
- Field of study
Childhood Optic Gliomas. Microsurgical Treatment
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1981
- Field of study
Ophthalmologic Findings as Predictors of Carotid Artery Disease
- Author
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
- …