Experimental Study on a Metal Hydride Tank for the Totalized Hydrogen Energy Utilization System

AbstractWe have been performing research on a Totalized Hydrogen Energy Utilization System (THEUS) which is composed of a Unitized Reversible Fuel Cell (URFC) and metal hydride tanks. THEUS is very similar to the regenerative fuel cell system located at the Savannah River National Laboratory (SRNL) but it utilizes the thermal energy from the system to improve the total system efficiency. AIST and SRNL started a collaborative research program on THEUS in 2010 under the Clean Energy Partnership Technology Program between METI and DOE. To initiate the project, a horizontal type metal hydride tank was developed. It had a double coil type heat exchanger and contained 50kg of AB5 type metal hydride alloy. Absorption and desorption of 6,350 NL of hydrogen was successfully attained at an absorption rate of 11.8 NL/min and a desorption rate of 8.1 NL/min. The experimental results of the heat exchanging performance were compared with the results of a vertical type metal hydride tank which was developed in AIST in 2008. This paper introduces the experimental results of the metal hydride tank which is tested in SRNL

Selection of Psyllid-Resistant Forage Varieties from an Inter-Specific Breeding Program of \u3cem\u3eLeucaena leucocephala\u3c/em\u3e with \u3cem\u3eL. pallida\u3c/em\u3e

Leucaena (Leucaena leucocephala) pastures for beef cattle production are productive and sustainable; however, susceptibility to the psyllid insect (Heteropsylla cubana) has limited expansion of current commercial cultivars into more humid areas (\u3e 800 mm/yr) (Shelton and Dalzell 2007). Psyllids can also cause intermittent damage in lower rainfall regions during humid periods. The psyllid, which arrived in Australia in 1986, is a leaf-sucking insect specific to the Leucaena genus, feeding on the growing tips of susceptible cultivars (Bray 1994). Psyllid damage can reduce production by as much as 50-70% in humid regions and 20-50% in subhumid environments (Bray 1994; Mullen and Shelton 2003). Work on psyllid resistance in the Leucaena genus through the 1990s showed that several Leucaena species, including the tetraploid L. pallida, had good levels of resistance (Mullen et al. 2003). A breeding program to develop psyllid-resistant varieties began in 2002 at The University of Queensland (UQ) based on the F1 inter-specific hybrids between L. leucocephala and L. pallida (known as ‘KX2’), developed at the University of Hawaii (Brewbaker 2008). Between 2002 and 2005, UQ initiated a program of recurrent selection in an attempt to produce stable outcrossed KX2-derived lines but inbreeding depression for yield and poor forage quality led to a change in the breeding strategy, and a backcrossing program was implemented between 2005 and 2008. Two cycles of backcrossing to elite L. leucocephala ssp. glabrata material were completed followed by 2 cycles of progeny testing and selection for self-compatibility to achieve stability and uniformity (2009 - 2012). Forty elite psyllid-resistant lines were then evaluated to identify the most suitable lines for release to industry. This paper describes the results of these trials

Leptin mediates the increase in blood pressure associated with obesity.

Obesity is associated with increased blood pressure (BP), which in turn increases the risk of cardiovascular diseases. We found that the increase in leptin levels seen in diet-induced obesity (DIO) drives an increase in BP in rodents, an effect that was not seen in animals deficient in leptin or leptin receptors (LepR). Furthermore, humans with loss-of-function mutations in leptin and the LepR have low BP despite severe obesity. Leptin's effects on BP are mediated by neuronal circuits in the dorsomedial hypothalamus (DMH), as blocking leptin with a specific antibody, antagonist, or inhibition of the activity of LepR-expressing neurons in the DMH caused a rapid reduction of BP in DIO mice, independent of changes in weight. Re-expression of LepRs in the DMH of DIO LepR-deficient mice caused an increase in BP. These studies demonstrate that leptin couples changes in weight to changes in BP in mammalian species

Examining the social construction of surveillance: a critical issue for health visitors and public health nurses working with mothers and children

Aims and objectives In this paper we will critically examine surveillance practices of health visitors (HV) in the UK and public health nurses (PHNs) in Canada. Background The practice and meaning of surveillance shifts and changes depending on the context and intent of relationships between mothers and HVs or PHNs. Design We present the context and practice of HVs in the UK and PHNs in Canada and provide a comprehensive literature review regarding surveillance of mothers within public health systems. We then present our critique of the meaning and practice of surveillance across different settings. Methods Concepts from Foucault and discourse analysis are used to critically examine and discuss the meaning of surveillance Results Surveillance is a complex concept that shifts meaning and is socially and institutionally constructed through relations of power Conclusions Health care providers need to understand the different meanings and practices associated with surveillance to effectively inform practice. Relevance to clinical practice Health care providers should be aware of how their positions of expert and privilege within health care systems affect relationships with mothers. A more comprehensive understanding of personal social and institutional aspects of surveillance will provide opportunities to reflect upon and change practices that are supportive of mothers and their families

Writing in Britain and Ireland, c. 400 to c. 800

No abstract available

The view from everywhere: Disciplining diversity in post–World War II international social science

This paper explores the attempt of social scientists associated with Unesco to create a system of knowledge production to provide the international perspective necessary for democratic governance of a world community. Social scientists constructed a federal system of international associations that institutionalized American disciplines on an international scale. An international perspective emerged through the process of interdisciplinary international research. I call this ideal of coordinating multiple subjectivities to produce objectivity the “view from everywhere.” Influenced by social psychological “action-research,” collaborative research was group therapy. The attempt to operationalize internationalists' rallying slogan, “unity in diversity,” illuminated tensions inherent in the mobilization of science for social and political reform. © 2009 Wiley Periodicals, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/64294/1/20394_ftp.pd

Plants as river system engineers

I would like to acknowledge three research grants/contracts that are supporting my current research on this theme: Grant F/07 040/AP from the Leverhulme Trust; Grant NE/F014597/1 from the Natural Environment Research Council, UK, and the REFORM collaborative project funded by the European Union Seventh Framework Programme under grant agreement 282656

3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial

Background: Liraglutide 3·0 mg was shown to reduce bodyweight and improve glucose metabolism after the 56-week period of this trial, one of four trials in the SCALE programme. In the 3-year assessment of the SCALE Obesity and Prediabetes trial we aimed to evaluate the proportion of individuals with prediabetes who were diagnosed with type 2 diabetes. Methods: In this randomised, double-blind, placebo-controlled trial, adults with prediabetes and a body-mass index of at least 30 kg/m2, or at least 27 kg/m2 with comorbidities, were randomised 2:1, using a telephone or web-based system, to once-daily subcutaneous liraglutide 3·0 mg or matched placebo, as an adjunct to a reduced-calorie diet and increased physical activity. Time to diabetes onset by 160 weeks was the primary outcome, evaluated in all randomised treated individuals with at least one post-baseline assessment. The trial was conducted at 191 clinical research sites in 27 countries and is registered with ClinicalTrials.gov, number NCT01272219. Findings: The study ran between June 1, 2011, and March 2, 2015. We randomly assigned 2254 patients to receive liraglutide (n=1505) or placebo (n=749). 1128 (50%) participants completed the study up to week 160, after withdrawal of 714 (47%) participants in the liraglutide group and 412 (55%) participants in the placebo group. By week 160, 26 (2%) of 1472 individuals in the liraglutide group versus 46 (6%) of 738 in the placebo group were diagnosed with diabetes while on treatment. The mean time from randomisation to diagnosis was 99 (SD 47) weeks for the 26 individuals in the liraglutide group versus 87 (47) weeks for the 46 individuals in the placebo group. Taking the different diagnosis frequencies between the treatment groups into account, the time to onset of diabetes over 160 weeks among all randomised individuals was 2·7 times longer with liraglutide than with placebo (95% CI 1·9 to 3·9, p<0·0001), corresponding with a hazard ratio of 0·21 (95% CI 0·13–0·34). Liraglutide induced greater weight loss than placebo at week 160 (–6·1 [SD 7·3] vs −1·9% [6·3]; estimated treatment difference −4·3%, 95% CI −4·9 to −3·7, p<0·0001). Serious adverse events were reported by 227 (15%) of 1501 randomised treated individuals in the liraglutide group versus 96 (13%) of 747 individuals in the placebo group. Interpretation: In this trial, we provide results for 3 years of treatment, with the limitation that withdrawn individuals were not followed up after discontinuation. Liraglutide 3·0 mg might provide health benefits in terms of reduced risk of diabetes in individuals with obesity and prediabetes. Funding: Novo Nordisk, Denmark

Incisional hernia following colorectal cancer surgery according to suture technique: Hughes Abdominal Repair Randomized Trial (HART).

BACKGROUND: Incisional hernias cause morbidity and may require further surgery. HART (Hughes Abdominal Repair Trial) assessed the effect of an alternative suture method on the incidence of incisional hernia following colorectal cancer surgery. METHODS: A pragmatic multicentre single-blind RCT allocated patients undergoing midline incision for colorectal cancer to either Hughes closure (double far-near-near-far sutures of 1 nylon suture at 2-cm intervals along the fascia combined with conventional mass closure) or the surgeon's standard closure. The primary outcome was the incidence of incisional hernia at 1 year assessed by clinical examination. An intention-to-treat analysis was performed. RESULTS: Between August 2014 and February 2018, 802 patients were randomized to either Hughes closure (401) or the standard mass closure group (401). At 1 year after surgery, 672 patients (83.7 per cent) were included in the primary outcome analysis; 50 of 339 patients (14.8 per cent) in the Hughes group and 57 of 333 (17.1 per cent) in the standard closure group had incisional hernia (OR 0.84, 95 per cent c.i. 0.55 to 1.27; P = 0.402). At 2 years, 78 patients (28.7 per cent) in the Hughes repair group and 84 (31.8 per cent) in the standard closure group had incisional hernia (OR 0.86, 0.59 to 1.25; P = 0.429). Adverse events were similar in the two groups, apart from the rate of surgical-site infection, which was higher in the Hughes group (13.2 versus 7.7 per cent; OR 1.82, 1.14 to 2.91; P = 0.011). CONCLUSION: The incidence of incisional hernia after colorectal cancer surgery is high. There was no statistical difference in incidence between Hughes closure and mass closure at 1 or 2 years. REGISTRATION NUMBER: ISRCTN25616490 (http://www.controlled-trials.com)

Improved functionalization of oleic acid-coated iron oxide nanoparticles for biomedical applications

Superparamagnetic iron oxide nanoparticles can providemultiple benefits for biomedical applications in aqueous environments such asmagnetic separation or magnetic resonance imaging. To increase the colloidal stability and allow subsequent reactions, the introduction of hydrophilic functional groups onto the particles’ surface is essential. During this process, the original coating is exchanged by preferably covalently bonded ligands such as trialkoxysilanes. The duration of the silane exchange reaction, which commonly takes more than 24 h, is an important drawback for this approach. In this paper, we present a novel method, which introduces ultrasonication as an energy source to dramatically accelerate this process, resulting in high-quality waterdispersible nanoparticles around 10 nmin size. To prove the generic character, different functional groups were introduced on the surface including polyethylene glycol chains, carboxylic acid, amine, and thiol groups. Their colloidal stability in various aqueous buffer solutions as well as human plasma and serum was investigated to allow implementation in biomedical and sensing applications.status: publishe