DNA replication licensing in stem cells: Gatekeeping the commitment to proliferation.

Carroll et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201708023) developed a method to assess DNA replication licensing in tissues. They show that intestinal stem cells within wild-type crypts, but not in crypts with cancer-causing mutations, are largely unlicensed, suggesting that licensing may represent a rate-limiting step in the commitment to proliferation

Political Elites in Federalized Countries: The Case of Spain (1980-2005). CES Working Paper, no. 146, 2008

This paper explores the social profile of the regional elite that has emerged in Spain since the de-mocratization and federalization of the country. For the first time, researchers present data about crucial variables like gender, place of birth, age, education, and profession. They make inter-regional comparisons, put their data on an international perspective, and try to explain some un-expected findings, such as the behavior of political elites in Catalonia and Castile-La Mancha. The authors compare also the social profile of MPs of the two largest parties and show that the gap between society and political elite has been reduced over the years. The paper offers a research agenda

Integrative analysis of the inter-tumoral heterogeneity of triple-negative breast cancer.

Triple-negative breast cancers (TNBC) lack estrogen and progesterone receptors and HER2 amplification, and are resistant to therapies that target these receptors. Tumors from TNBC patients are heterogeneous based on genetic variations, tumor histology, and clinical outcomes. We used high throughput genomic data for TNBC patients (n = 137) from TCGA to characterize inter-tumor heterogeneity. Similarity network fusion (SNF)-based integrative clustering combining gene expression, miRNA expression, and copy number variation, revealed three distinct patient clusters. Integrating multiple types of data resulted in more distinct clusters than analyses with a single datatype. Whereas most TNBCs are classified by PAM50 as basal subtype, one of the clusters was enriched in the non-basal PAM50 subtypes, exhibited more aggressive clinical features and had a distinctive signature of oncogenic mutations, miRNAs and expressed genes. Our analyses provide a new classification scheme for TNBC based on multiple omics datasets and provide insight into molecular features that underlie TNBC heterogeneity

Roles familiares y mercado de trabajo

La diferent posició dels individus en el mercat de treball sembla convertir-se en una variable (no l'única) amb un fort pes explicatiu de determinades pràctiques familiars que s'analitzen en aquest article. Així, les desigualtats viscudes a la família per raó de sexe poden explicar-se per la desigual situación d'homes i dones en l'esfera laboral; unes desigualtats a les quals donen suport discursos diferenciats que, a la vegada, determinen unes pràctiques socials que ens permeten distingir (en un pla teòric) tres models de família: la tradicional-segregacionista, la rupturista-modernitzadora i la mixtaLa posición diferente de los individuos en el mercado de trabajo puede convertirse en una variable (no única) con fuerte peso explicativo de determinadas prácticas familiares que se analizan en este artículo. Así, las desigualdades vividas en la familia por razón de sexo pueden explicarse por la desigual situación de hombres y mujeres en la esfera laboral; unas desigualdades que están respaldadas por discursos diferenciados que, a su vez, determinan unas prácticas sociales que nos permitirán distinguir (en un plano teórico) tres modelos de familia: tradicional-segregacionista, la rupturista-modernizadora y la mixta.The different position of individuals in the labour market seems to become a variable-not unique, though-with heavy explanatory weight of specific family practices which are analysed in this article. Thus, the family inequalities are backed b differentiated reasoning powers, wich at the same time settle certain social practices that will alow us to distinguish-on a theoretical level-three patterns of family: the traditional-segregationist, the rupturist-modernizing and the mixed one

Latent Process Heterogeneity in Discounting Behavior

We show that observed choices in discounting experiments are consistent with roughly one-half of the subjects using exponential discounting and one-half using quasi-hyperbolic discounting. We characterize the latent data generating process using a mixture model which allows different subjects to behave consistently with each model. Our results have substantive implications for the assumptions made about discounting behavior, and also have significant methodological implications for the manner in which we evaluate alternative models when there may be complementary data generating processes.

Is Cancer a Metabolic Disease?

Although cancer has historically been viewed as a disorder of proliferation, recent evidence has suggested that it should also be considered a metabolic disease. Growing tumors rewire their metabolic programs to meet and even exceed the bioenergetic and biosynthetic demands of continuous cell growth. The metabolic profile observed in cancer cells often includes increased consumption of glucose and glutamine, increased glycolysis, changes in the use of metabolic enzyme isoforms, and increased secretion of lactate. Oncogenes and tumor suppressors have been discovered to have roles in cancer-associated changes in metabolism as well. The metabolic profile of tumor cells has been suggested to reflect the rapid proliferative rate. Cancer-associated metabolic changes may also reveal the importance of protection against reactive oxygen species or a role for secreted lactate in the tumor microenvironment. This article reviews recent research in the field of cancer metabolism, raising the following questions: Why do cancer cells shift their metabolism in this way? Are the changes in metabolism in cancer cells a consequence of the changes in proliferation or a driver of cancer progression? Can cancer metabolism be targeted to benefit patients