11 research outputs found
Institutional capacity and multiple conditionality in ACP-EU development cooperation.
- Publication venue
- Publication date
- 01/01/1997
- Field of study
The negotiations for the Mid-Term Review of the Fourth Lome Convention marked the introduction of multiple conditionality - economic adjustment and good governance - into the Lome relationship. It placed additional demands on the two parties, giving rise to the essential concern of this thesis: do the two sides possess the requisite institutional capacity to meet those demands. The introduction was not a sudden development. The origins of multiple conditionality lay in the Pisani Memorandum and its proposal of policy dialogue. The path from the proposal to multiple conditionality was assisted by developments within the Lome relationship, including the unintended effects of ACP initiatives. This thesis is thus, in one sense, the history of the Memorandum's legacy of inverted conditionality through policy dialogue. It is also an analysis of the capacities generated by the Convention and their applicability to multiple conditionality. My analysis of bargaining, operational and instrumental capacities demonstrates a weak ACP capacity and an asymmetrically greater EU capacity. My initial conclusion is that the EU is much more capable of meeting the demands of multiple conditionality. However, it too faces limits on its capacity, especially in dealing with the sociopolitical aspects of governance. This recognition highlights an ignored factor: there is a second legacy of the Pisani Memorandum. In addition to the instrument of policy dialogue, the Memorandum identified institutional capacity as the means to help overcome the problems of development. The new tale of two legacies illustrates an EU emphasis on policy control at the expense of capacity building. It has failed to perceive the importance of the link, in the Pisani Memorandum, between the instrument and the means. It forces me to amend my initial conclusion: neither side is adequately prepared for the demands of multiple conditionality
Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries
- Author
- Aamir Faiqa Binte
- Aamir Syed Roohan
- Ababneh Adnan
- Abbal Muhammad Anas
- Abbas Ahmed M
- Abbas Mostafa
- Abd-Albain Montasir A
- Abdalei Abdulwahab
- Abdalla Ahmed
- Abdalla Ahmed Yassir
- Abdalla Mohamed Galal Ali
- Abdalla Zainab
- Abdallah Mohamed M
- Abdalmahmoud Noon Ezzeldien
- Abdalsadeg Rowa
- Abdelaal Ahmed M
- Abdelbagi Alnazeer Y
- Abdelbaky Mostafa
- Abdelbaset Doaa
- AbdElbaset Esraa
- Abdelbast Menhag
- Abdelfatah Mohammed Abdelnasser
- Abdelgawad Samia
- Abdelhamid Mohamed M
- Abdeljaber Mahmoud
- Abdelkhalig Mubarak
- Abdelmaksoud Mohamed
- Abdelmeguid Rana
- Abdelmelek Dhia Errahmane
- Abdelnaeam Samah
- Abdelnasser Mohammad K
- Abdelrahim Najwa
- Abdelrahman Amira
- Abdelrahman Ayman
- Abdelsalam Hebatalla
- Abdelsamed Enas Abdelbaset
- Abdelwahab Khaled
- Abdoun Meriem
- Abdulali Fatima
- Abdulaziz Mohamed
- Abdulla Dheba Almukhtar
- Abdullah Bahiyah
- Abdullah Bahiyah
- Abdullah Walaa
- Abdullahi Habiba Ibrahim
- Abdulrahman Ahmed
- Abdulrasheed Lubabatu
- Abdulwahed Eman
- Abdulwahed Eman
- Abeysirigunawardana Dewmi
- Abidin Muhammad Fihmi Zainal
- Abiola Olukayode
- Abiyere Henry
- Abodina Ahmed Mohammed
- Aboelela Reham
- AboElfarh Hadeer Elsaeed
- Aboudlal Husein
- AbouHiekal Osama
- Aboulfotouh Ahmed
- Abozid Anwaar
- Abubaker Noora
- Abubaker Noora
- Abufanas Asma
- Abughanima Mahmoud
- Abuhashem Shehab
- Abulafia Daniel
- Abushaala Fatima
- Abushanab Khaled
- AbuShawareb Issa
- Abuuqteish Hamza
- Abuzaho Amany
- Achem Arome
- Adam Eithar
- Adam Mohammed
- Adam Mohammed A
- Addalla Mohamed
- Addley Jordan
- Adeleye Gbadebo
- Adeniyi Adebayo
- Adewole Nathaniel
- Adeyemo Olabisi
- Adeyeye Ademola
- Adeyeye Ademola
- Adly Michael
- Adnan Siti Nasyirah Nisya
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adze Joel Amwe
- Afeikhena Ehis
- Agida Teddy
- Agilla Hamza
- Agnew Emilie
- Agu Joy Onyekachi
- Ahmad Zatul Akmar
- Ahmed Abdalla
- Ahmed Ahmed
- Ahmed Ahmed
- Ahmed Alaaaldeen
- Ahmed Entisar
- Ahmed Habeeba
- Ahmed Hatem
- Ahmed Reem
- Ahmed Rehab
- Ahmed Rihab
- Ahmed Rogia Ahmed Abdalla
- Ahmed Ruaa
- Ahmed Sharwany
- Ahmed Uzair
- Ahmed Wahiba
- Ahmeed Sultan
- Airede Lydia Regina
- Aitchison Lori
- Ajredini Mirac
- Ajulo Adeshina A
- Akaba Godwin
- Akasha Mazin
- Akbar Maha Ghulam
- Akbuz Seyma Orcan
- Akdere Hakan
- Akın Bilge
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- Al Hammoud Amr
- Al Rawashdeh Toka
- Al-Baw Mahmoud
- Al-Dahdouh Mosheer
- Al-Haek Safa’
- Al-Hazaimeh Mo'ath
- Al-issawi Dima
- Al-Issawi Subhi
- Al-jammal Maryam
- Al-Juaifari Maytham A
- Al-Mwajeh Tesneem
- Al-Omary Sohaib
- Al-Quossi Mohammed
- Al-Shambaty Yasir Babkir Ali
- Al-Shami Qotadah
- Al-Smirat Heba
- Al-Tahayneh Sief-Addeen
- Al-Touny Aiman
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- Al-zawaydeh Alia
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- Yassin Mohamed
- Yavuz Dogancan
- Yavuz Ikranur
- Yaytokgil Muhammet
- Yazgan Yasemin
- Yee Su-Ann
- Yeung Justin
- Yeung Kar Long
- Yew Anthea
- Yi Kevin
- Yiannakopoulos Christos
- Yildirim Yasemin
- Yildiz Ahmet
- Yıldız Berkay
- Yilmaz Hakan
- Yin Chonghao
- Ying Geoffrey
- Yodkitydomying Chatnapa
- Yong Nathania
- Yoon Si Woo
- You Ha Seong
- Young Simon
- Young Stevie
- Younus Khadijah
- Yousif Fatima Imad
- Yousri Mohamed
- Youssef Ahmed A
- Youssef Arkan
- Yu Hoi Hang
- Yu Victor
- Yuan Grace
- Yue Bosco
- Yue Tiffany
- Yunos Mohamed Haseef Mohamed
- Yusuf Stephen
- Yuzgec Ayse Nilufer
- Zachomitros Fotios
- Zaed Moahmed
- Zafar Fatima
- Zaghloul Ahmed
- Zaheer Adil
- Zaidi Faseeh
- Zain Ahmad
- Zakaria Ahmed
- Zakaria Andee Dzulkarnaen
- Zakaria Mohd Zaim
- Zalloum Jihad
- Zamanbandhon Bushra
- Zambon Mattia
- Zapsalis Konstantinos
- Zargar Kamran
- Zarzour Mohamed A
- Zeng Raymond
- Zeng Raymond
- Zengin Kagan
- Zertuche Juventino Tadeo Guerrero
- Zhang Caitlin
- Zhang Edward
- Zhang Shane
- Zhang Yichi
- Zhao Hailin
- Zheng Helen
- Zhou Karen
- Zhou Yida
- Ziergiebel Felix
- Zou Peishan
- Zuylekom Kate Van
- Zuylekom Katie Van
- Zwain Yasir Adnan
- Zyul'korneeva Sof'ya
- Aladna Abdallah
- Aljoumaa Abdullah
- Nawfal Hamdi
- Niazi Ammar
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely
Beginning with Albina: Remembering the Nation
- Author
- Anke Bernau
- Bernau Anke
- Brereton Georgine de
- Burton Tim L.
- Carley James P
- Carruthers Mary J
- Carruthers Mary J
- Carruthers Mary J
- Carruthers Mary J
- Chadwick Henry
- Cohen Jeffrey Jerome
- Desmet Christy
- Eckhardt Caroline D.
- Elliott Dyan
- Evans Ruth
- Evans Ruth
- Evans Ruth
- Evans Ruth
- Evans Ruth
- Field Rosalind
- Finke Laurie A
- Furnivall Frederick J.
- Geary Patrick J
- Geary Patrick J
- Geoffrey of Monmouth
- Given-Wilson Chris
- Green Richard Firth
- Hanawalt Barbara A
- Henry of Huntingdon
- Hiatt Alfred
- Hugh of St Victor
- Johnson Lesley
- Lavezzo Kathy
- Lupack Alan
- Lydgate John
- Marvin Julia
- Matheson Lister M
- Park Katharine
- Patterson Lee
- Ruch Lisa M
- Said Edward W
- Silvester Bernard
- Smith D. Vance
- Spiegel Gabrielle M
- van Houts Elisabeth
- Warner William
- Yates Frances A
- Publication venue
- 'Maney Publishing'
- Publication date
- Field of study
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- KILBY.
- KRISHNA.
- KSIEZYK
- KUNIHIKO.
- KYUNGSAN.
- LEE.
- LEMVIGH.
- LEO.
- LEORA.
- LESLIE.
- LOTFY.
- LUO.
- MARK.
- MARTIN.
- MATHESON.
- MCLEAN.
- MEI.
- MICHAEL.
- MICHAEL.
- MILTON.
- MINEHARU.
- MOJGAN.
- MOU.
- NENG.
- NICKOLAS.
- NORRIS.
- NORRIS.
- PAUL.
- PAUL.
- PENG.
- PERRY.
- PETER.
- PIERRE.
- PIN.
- QING.
- RANDOLF.
- RAYMOND.
- REED.
- RICHARD.
- RUKMINI.
- SHING.
- SOTERIA.
- STANLEY.
- Susanne M. Humphrey
- TAL.
- TANIOS.
- THMAR.
- TIEN.
- University of South Florida Ph.D.
- WALFRED. University of 'Washington Ph.D.
- Washington Ph D.
- WAYNE.
- WLADYSLAW.
- YITONG.
- YOO.
- YUEHWERN.
- YULUN.
- YVES.
- Publication venue
- 'Association for Computing Machinery (ACM)'
- Publication date
- Field of study
Historic preservation: A comparative analyses
- Author
- Alan Axelrod
- Albert Hunter
- Alfred Runte
- Ann Douglas
- Ann MacEwen
- Arthur Vidich
- Barry Schwartz
- C. Wright Mills
- Charles B. Hosmer Jr.
- Charles Dellheim
- Craig Jackson Calhoun
- César Graña
- D. M. Matheson
- David Lowenthal
- David Shi
- Diane Barthel
- Diane Barthel
- Edward Shils
- Eugene Rochberg-Halton
- Fiona MacCarthy
- Geoffrey Scott
- Gerald Suttles
- Gilbert Durand
- Henry Nash Smith
- Herbert Gans
- Hervé Varenne
- Jacques Donzelot
- James Marston Fitch
- Janet Wolff
- John Brinckerhoff Jackson
- John Ruskin
- Joshua C. Taylor
- Kenneth Burke
- Michael DeHaven Newsom
- Mihaly Csikszentmihalyi
- National Trust for Historic Preservation
- National Trust for Historic Preservation
- Patrick Wright
- Paul DiMaggio
- Paul Thompson
- Peter Maris
- Pierre Bourdieu
- Raymond Williams
- Raymond Williams
- Richard Hofstadter
- Robert H. Wiebe
- Robin Fedden
- Roland Barthes
- Samuel Hays
- T. J. Jackson Lears
- Walter Karp
- Walter Karp
- William Butler
- William Cobbett
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Translation from Latin and French as a Source of New Medical Terms in Late Medieval England
- Author
- Adams James Noel
- Adams Valerie
- Adams Valerie
- André Jacques
- Anglicus Bartholomaeus
- Anglicus Gilbertus
- Boorde Andrew
- Cameron Angus
- Cameron Malcolm Laurence
- Cruse Alan
- Dawson Warren R
- Du Cange Charles Du Fresne
- Eldredge Laurence M.
- Fleischhacker Robert von
- Fonahn Adolf
- French Roger K.
- Getz Faye Marie
- Getz Faye Marie
- Glare Peter G. W.
- Gneuss Helmut
- Grattan John Henry Grafton
- Green Monica H.
- Gregory Stewart
- Grothé Richard
- Gustafsson Marita
- Hanna Ralph
- Haubrich William S.
- Hibbott Yvonne
- Hunt Tony
- Hunt Tony
- Hunt Tony
- Hunt Tony
- Hunt Tony
- Hunt Tony
- Hunt Tony
- Hunt Tony
- Hunt Tony
- Hyrtl Joseph
- Johannitius
- John
- John
- Jones Peter Murray
- Jones Peter Murray
- Jones Peter Murray
- Keiser George R.
- Koskenniemi Inna
- Kurath Hans
- Kurtz Patricia Deery
- Landau Sidney
- Lanfrank
- Langslow David R.
- Latham Ronald Edward
- Leonhardi Günther
- Linares Carrillo
- Lipka Leonhard
- Löweneck Max
- Marchand Hans
- Matheson Lister M.
- Mcvaugh Michael R.
- Mcvaugh Michael R.
- Mooney Linne R
- Müller Gottfried
- Norri Juhani
- Norri Juhani
- Norri Juhani
- of Cervia Theodoric
- of Gaddesden John
- of Gordon Bernard
- of Saliceto William
- Ogden Margaret S.
- Ogden Margaret S.
- Pagel Julius Leopold
- Pahta Päivi
- Pahta Päivi
- Pettit Edward
- Picht Heribert
- Platearius Joannes
- Pollard Alfred William
- Power D’Arcy
- Rhodes Dennis E.
- Rhodes Dennis E.
- Roesslin Eucharius
- Roesslin Eucharius
- Rubin Stanley
- Rydén Mats
- Sager Juan C
- Schauman Bella
- Schöffler Herbert
- Seymour Michael C.
- Simpson John
- Stone Howard
- Sudhoff Karl
- Sudhoff Karl
- Taavitsainen Irma
- Tavormina M. Teresa
- Torkar Roland
- Ullmann Stephen
- Vigo Joannes De
- Vigo Joannes De
- Voigts Linda Ehrsam
- Voigts Linda Ehrsam
- Voigts Linda Ehrsam
- Voigts Linda Ehrsam
- Voigts Linda Ehrsam
- Voigts Linda Ehrsam
- Voigts Linda Ehrsam
- Voigts Linda Ehrsam
- Vriend Hubert Jan De
- Wallis Faith
- Wallner Björn
- Wallner Björn
- Wartburg Walther von
- Publication venue
- 'Brepols Publishers NV'
- Publication date
- Field of study
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- Weiner
- Weiner
- Weiner
- Weiner
- Weiner
- Weiner
- Weintraub
- Weintraub
- Weishaupt
- Weisman
- Weisz
- Weisz
- Wells
- Wells
- Welsh
- Wenchen
- Wenchen
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- Wherrett
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- White
- White
- White
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- Wiberg
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- Wichterle
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- Wicks
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- Wiener
- Wiener
- Wiener
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- Wilcox
- Wilding
- Wilding
- Wilhoit
- Wilhoit
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- Willard
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- Willett
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- Willman
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- Wingefors
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- Wisniak
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- Wisniak
- Wisniak
- Wisniak
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- Wiswesser
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- Wooldridge
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- Woolf
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- Yalkowsky
- Yalkowsky
- Yalkowsky
- Yalkowsky
- Yamada
- Yan
- Yates
- Yaws
- Yaws
- Yaws
- Yaws
- Yee
- Yen
- Yi-Jing
- Yoon
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- Yoshimoto
- Young
- Young
- Yuan
- Yuta
- Zabetakis
- Zainulin
- Zandler
- Zapp
- Zatsepin
- Zatz
- Zemaitis
- Zhang
- Zhao
- Zhdanov
- Zhihong
- Zhihong
- Zhihong
- Zhihong
- Zhu
- Zudkevitch
- Zudkevitch
- Zudkevitch
- Zudkevitch
- Zupan
- Zupan
- Zurer
- Zurer
- Zurer
- Zurer
- Zwikker
- Zykov
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/1992
- Field of study
A Bayesian reanalysis of the Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial
- Author
- Abrams Judith
- Adda Mireille
- Adderley Jane
- Adhikari Neill K. J.
- Adhikari Neill K. J.
- Aissaoui Nadia
- Alam Ahsan
- Albrett Jonathan
- Albright Robert C.
- Alcuaz Victoria
- Allam Hayat
- Altarelli Marco
- Amaral Andre
- Amsbaugh Amy
- Anderson Felicity
- Andreu Pascal
- Antunes Veronica
- Arbane Gill
- Argaud Laurent
- Arias Castro
- Asehnoune Karim
- Attwood Ben
- Auld Fiona
- Ayas Najib
- Aycinena Juan Carlos
- Azais Marie-Ange
- Bachler Mirjam
- Backhouse Felicity
- Bagshaw Sean M.
- Bagshaw Sean M.
- Bagshaw Sean M.
- Bagshaw Sean M.
- Baharlo Behrad
- Bai Guoqiang
- Bai Jing
- Baig Nadia
- Baig Nadia
- Bailey Matthew
- Baker Nerilee
- Ball Ian M.
- Ball Jonathan
- Barbar Saber Davide
- Barbier François
- Barchard Jennifer
- Bass Frances
- Bates Samantha
- Baudry Thomas
- Beck James
- Beehre Nina
- Bellemare David
- Belley-Cote Emilie
- Bellmann Romuald
- Bellomo Rinaldo
- Bellomo Rinaldo
- Benettaib Fatna
- Benoit Luc
- Benton Jane
- Benzekri Dalila
- Bergin Colin
- Bihari Shailesh
- Bihorac Azra
- Bird Sarah
- Bitker Laurent
- Board Jasmin
- Bociek Aneta
- Bohé Julien
- Boisrame-Helms Julie
- Boivin Annick
- Bojic Andja
- Bone Allison
- Boschert Catherine
- Bouisse Camille
- Boulain Thierry
- Boulet Éric
- Boumahni Dounia
- Bourchard Pierre-Alexandre
- Bowman Katie
- Bracke Stephanie
- Bradford Celia
- Brailsford Jane
- Brandtner Anna
- Bretagnol Anne
- Brickell Kathy
- Broadfield Emma
- Brodutch Shira
- Brooks Jenny
- Brown Gillian
- Brown Sherry
- Browne Troy
- Buehner Ulrike
- Buhr Heidi
- Burke Tara
- Burns Karen
- Buscher Hergen
- Butler Magdalena
- Butler Susie
- Cahill Hazel
- Cailhier Jean-François
- Callahan Jean Christophe
- Callender Owen
- Campbell Eileen
- Campbell Troy
- Campbell Victoria
- Campisi Josie
- Camporota Luigi
- Campos Sara
- Canet Emmanuel
- Cantien Marie
- Carbonnaeu Élaine
- Carles Michel
- Carney Dominic
- Carney Gayle
- Carpentier Dorothée
- Carrera Ron
- Carrier François-Martin
- Carson Joshua
- Carter Joseph
- Carungcong Jaime
- Carvelli Paula
- Cegarra Santiago
- Cennamo Armando
- Chadbourn Indra
- Chadwick Lesley
- Chan Peter
- Chee Nigel
- Chen Man
- Chen Yan
- Chen Zhenzhen
- Chenaf Samir
- Cheung Winston
- Chevrel Guillaume
- Chiella Bianca
- Chimunda Tim
- Chudeau Nicolas
- Cinotti Raphaël
- Cirone Robert
- Clarey Emma
- Clark Amy
- Clark Edward
- Clark Michele
- Clarke France
- Cleophax Cedric
- Clere-Jehl Raphael
- Cloutier Eve
- Cohen Yves
- Cole Jade
- Cole Louise
- Coles Jennifer
- Colin Gwenhaël
- Collins Amy
- Combes Alain
- Commeureuc Morgane
- Condin Christopher
- Conner Louise
- Cooper Lauren
- Corcoran Eleanor
- Costa Patricia
- Costerousse Olivier
- Coupez Elisabeth
- Cour Martin
- Cowdrey Keri-Anne
- Creary Thais
- Crosby Laura
- Cross Rosalba
- Cunningham Mishell
- Cupka Julie
- da Costa Bruno R.
- Daniels Alison
- Dargent Auguste
- Davies Tracy Michelle
- De Crop Luc
- De La Salle Sylvie
- De Prost Nicolas
- De Watteville Aude
- Decalvele Maxens
- Dechanet Aline
- Dekeyser Thibault
- Delabranche Xavier
- Delaney Anthony
- Delecolle Lucie
- Delgado Carlos Castro
- Delisle-Thibault Charles
- Demeure Dominique
- Demiri Suela
- Demoule Alexandre
- Deng Fuxing
- Derrien Benoit
- Despy Liesl
- Dessap Armand Mekontso
- Devereaux Kelson
- Di Nella Michelle
- Diehl Jean-Luc
- Diel Naomi
- Dignam Gemma
- Dilawershah Maria
- Ding Lili
- Ding Ruiqi
- Ditlbacher Adelheid
- Dodek Peter
- Dominy Clive
- Dong Lei
- Dong Xin
- Dooley Natalie
- Doran Peter
- Dorfman Robert
- Dos Santos Sandra
- Dres Martin
- Dreyfuss Didier
- Dreyfuss Didier
- Drover John
- Du Bin
- Du Bin
- Duan Meili
- Duffy Jane
- Duffy Karina
- Dufour Nicolas
- Duggan Shelley
- Duke Graeme
- Dun Shijuan
- Dyett John
- D’Aragon Frédérick
- Eastwood Glenn M.
- Eckert Philippe
- Efron Philip
- Elderkin Tania
- Elias Madona
- Elizabeth Wilcox M.
- Eller Philipp
- Ellis Karen
- Emery Malo
- Endre Zoltan
- Ensenyat-Martin Luis
- Eraldi Jean-Pierre
- Fadel Fouad
- Fan Jingqun
- Farnell-Ward Sarah
- Farrah Helen
- Faure Morgane
- Felix Luis
- Fellows Emma
- Fendt Lucia
- Fennessy Gerard
- Fiancette Maud
- Finfer Simon
- Finkenstedt Armin
- Finney Clare
- Fletcher Jason
- Forbes Loretta
- Forni Lui G.
- Forshaw Greg
- Foulkes Stephen
- Francoeur Charles Langis
- Franja Vincenta
- Freebairn Ross
- French Craig
- Friedrich Jan
- Fries Dietmar
- Fu Lijuan
- Fu Yongjian
- Fusco Kelly
- Gallagher Martin P.
- Gallagher Martin P.
- Gangopadhyay Himangsu
- Gantner Dashiell
- Gao Lan
- Garg Amit
- Gattas David
- Gatward Jonathan
- Gaudry Stéphane
- Gaudry Stéphane
- George Aparna
- Georgescu Ilinca
- Gernez Coralie
- Ghamraoui Ali
- Ghate Taneera
- Ghosh Angaj
- Giannakouros Panagiota
- Gibson Neil
- Giebel Shelley
- Gilder Eileen
- Glybina Anna
- Gomes Brigette
- Gomez Raquel
- Goodson Jennifer
- Gordon Boyd J.
- Goulart Joyce McKenney
- Goulart Joyce McKenney
- Goundry Stephanie
- Grainger Lia
- Grangé Steven
- Grant Alice
- Grant Caroline
- Gray Geraldine
- Grenier Stéphanie
- Gresham Rebecca
- Grillot Nicolas
- Guerot Emmanuel
- Guery Aurore
- Guilbault Gabrielle
- Guitton Christophe
- Guo Dongchen
- Guo Litao
- Gurung Babita
- Gutierrez David
- Guy Zoe
- Haljan Gregory
- Hall Adam
- Hallion Jane
- Haltia Paivi
- Hambrook Geraldine
- Hammond Naomi
- Hamshere Alexandra
- Hang Lele
- Harasemiw Oksana
- Harkett Samanth
- Harkins Margaret
- Harmon John
- Harris Claire-Louise
- Harrop Clare
- Hartig Frank
- Harvey Dan
- Hashemighouchani Haleh
- Haslam Nicole
- Hasslacher Julia
- Hauschild Caroline
- Hazelton Tracy
- He Xiandi
- He Xiaona
- Heidegger Claudia
- Heinonen Jonna
- Henderson Seton
- Henderson Steven
- Hendry Deborah
- Hernandez Clara
- Hernu Romain
- Herridge Margaret S.
- Higson Vicki
- Hill Dianne
- Hill Helen
- Hindle Julia
- Hiremath Swapnil
- Hirst Claire
- Hodder Jennifer
- Hodgson Luke E.
- Hopkins Philip
- Hoppu Sanna
- Hoste Eric
- Hou Guo
- Houghton James
- Howard Kate
- Howcroft Clare
- Howe Elizabeth
- Howlett Luisa
- Hu Chenghuan
- Hu Tingting
- Hu Xiaobo
- Huang Lili
- Huang Yingzi
- Hunt Anna
- Hunt Miranda
- Hunter Stephanie
- Hussain Nauman
- Hutch Debra
- Inkinen Outi
- Investigators STARRT-AKI
- Jackson Carolyn
- Jackson David
- Jagannathan Vijay
- Jalkanen Ville
- Jang Ryan
- Janin Pierre
- Ji Xiaojun
- Jim Kym
- Jin Xia
- Joannidis Michael
- Joannidis Michael
- Johnson Emily
- Johnston Andy
- Joseph Gipsy
- Judd Harriet
- Junge Andrea
- Järvisalo Mikko J.
- Kamel Toufik
- Kapoor Ritoo
- Karachi Tim
- Karlsson Sari
- Kashani Kianoush B.
- Kaufman Melissa
- Kaur Navjot
- Kavikondala Kanthi
- Kaye Callum
- Keet Owen
- Kentala Satu
- Kerr Deborah
- Khalid Imrana
- Ki Vincent
- Kiley Sean
- Kirkham Simon
- Kissling Sébastien
- Klein David
- Klein Sebastian
- Knight David
- Knott Cameron
- Koglberger Paul
- Kokotsis Nicos
- Kol Mark
- Koottayi Sathyajith
- Korhonen Anna-Maija
- Kruger Peter
- Kuitunen Anne
- Kummerlen Christine
- Kutsogiannis Demetrios J.
- Küllmar Mira
- Lacave Guillaume
- Lacherade Jean Claude
- Ladouceur Marilène
- Lafrance Jean-Philippe
- Lagarrigue Matthieu Henry-
- Lakatos Louis
- Lakhal Karim
- Lambert Bridget
- Lamontagne François
- Lamontagne François
- Lamontagne François
- Landais Mickael
- Landoni Giovanni
- Lapinsky Stephen
- Lappi Eliria
- Large Audrey
- Latimer-Bell Charlotte
- Latta Laura
- Laurie Gordon
- Lauzier François
- Lawrence Cassie
- Le Moal Charlène
- Leaver Susannah
- Lebert Christine
- LeBlanc Guillaume
- Lebrasseur Martine
- Lee Sandra
- Leivo Keijo
- Lellouche Francois
- Lembo Rosalba
- Lenga Ilan
- Lesona Eden
- Levoranta Markus
- Li Hao
- Li Jian
- Li Jianquan
- Li Jing
- Li Min
- Li Nan
- Li Rui
- Lian Yingtao
- Liangos Orfeas
- Licari Elisa
- Lim Rosario
- Lin Jin
- Lin Jincan
- Liu Airan
- Liu Cheng
- Liu Hongjuan
- Liu Jingfeng
- Liu Kathleen D.
- Liu Manli
- Liu Pei
- Liu Xingang
- Liu Yu
- Liu Zhongmin
- Liu Zhou
- Liu Zhuang
- Lizotte Patricia
- Lobaz Steve
- Lombardi Gaetano
- Long Dali
- Long Stephanie
- Lord Jenny
- Lowrey Julie
- Lu Kun
- Lu Liping
- Lyas Claretha
- Lynch Matthew
- Lynch Matthew
- Långsjö Jaakko
- Ma Hongye
- MacIntyre Erika
- Magder Sheldon
- Maguire Teena
- Maizel Julien
- Malila Kaisa
- Mallaird Samia Abed
- Mallet Maxime
- Manns Braden J.
- Manso Katarina
- Marceron Alina
- Marchalot Antoine
- Marchand Joannie
- Margalef Jordi
- Margarson Michael
- Marinoff Nicole
- Marios Clémence
- Marotti Martina
- Marque Sophie
- Martin Emma
- Martin-Lefevre Laurent
- Martino Frédéric
- Martins Laura
- Marzaroli Matteo
- Marzouk Mehdi
- Masi Paul
- Maslove David
- Mason Chris
- Mason Sophie
- Mason Tracy
- Masse Marie-Hélène
- Masters Kristy
- Matheson Elisha
- Mathonnet Armelle
- Mayaux Julien
- Mayette Michael
- Mazer David
- McArthur Colin
- McAuley Daniel F.
- McAuley Danny F.
- McCall Philip
- McClure Jason
- McConnochie Rachael
- McCoshen Lorena
- McCracken Phoebe
- McGain Forbes
- McGlone Philip
- McGloughlin Steve
- McGonigal Elizabeth
- McGuinness Shay
- McGuinness Shay
- McGuinness Shay P.
- McIntyre Lauralyn
- Mckay-Vucago Agnes
- McKerrow Elizabeth
- McLaughlan Derek
- Meehan Sharon
- Mehrtens Jan
- Mehta Navdeep
- Mehta Sangeeta
- Mei Huaxian
- Mei Jing
- Meng Zhaoli
- Merdji Hamid
- Meredith Megan
- Messika Jonathan
- Mew Louise
- Meyer Jason
- Meziani Ferhat
- Millen Tina
- Mitchell Wendy
- Mo Min
- Monnier Alexandra
- Monti Giacomo
- Montillier Philippe
- Moon Angela
- Mooney Owen
- Morawiec Elise
- Moreland Gayle
- Morgan Matt
- Morgan Rebecca
- Morgan Stacey
- Morizot Laura
- Morris Anna
- Moser Max
- Mu Sijie
- Mulder John
- Muller Grégoire
- Muller Lucie
- Murray Lauren
- Murray Patrick T.
- Muscedere John
- Musselwhite Janine
- Mwaura Esther
- Naeem Syed
- Naeem Syed
- Naud Jean-François
- Navarra Leanlove
- Nay Mai-Anh
- Neal Philippa
- Needham Matthew
- Neils Seigenthaller
- Newby Lynette
- Neyra Javier A.
- Nichol Alistair
- Nichol Alistair D.
- Nichol Alistair D.
- Nichol Alistair D.
- Nicholson Alice
- NiChonghaile Martina
- Nicolet Laurent
- Nieszkowska Ania
- Niven Alexander S.
- Niven Daniel J.
- Noble Harriet
- Noel Gibney R. T.
- Norris Sean
- Novellas Neus Grau
- Ogg Bethan
- Okubanjo Maryanne
- Olatunji Shaanti
- Omalay George
- Ordon Marie Amélie
- Orford Neil
- Ortiz-Soriano Victor M.
- Ostermann Marlies
- Ostermann Marlies
- Ostermann Marlies
- Ovakim Daniel
- Ovsenek Athena
- Oxtoby Kerry
- Oziemski Peter
- O’Mara AnnMarie
- O’Mara AnnMarie
- Padayachee Laven
- Palevsky Paul M.
- Pan Chun
- Pan Yu
- Park Penelope
- Parke Rachael
- Parsons Penny
- Patel Alpesh
- Paternoster Gianluca
- Patrick-Heselton Julie
- Paunovic Bojan
- Peck Leah
- Peer Andreas
- Pelletier Celine
- Perez Adic
- Perret Aurelie
- Peters Cecilia
- Pettilä Leena
- Pettilä Ville
- Pettilä Ville
- Phull Mandeep-Kaur
- Pitts Sally
- Pogreban Tatiana
- Poirson Florent
- Poli Elettra
- Polychronopoulos Erietta
- Pons Bertrand
- Porteous Rebecca
- Porwal Sanjay
- Pouplet Caroline
- Pousset François
- Pradet Amandine
- Prasad Bhanu
- Prendergast Clara
- Pretorius Rinus
- Purv Sarah
- Qi Guoqing
- Qi Zhili
- Qin Bingyu
- Qin Suhui
- Qiu Haibo
- Qiu Yu
- Quenot Jean-Pierre
- Qui Haibo
- Rabouel Yannick
- Rahmani Hassene
- Rahmani Imen
- Raithatha Ajay
- Ramsey Judith
- Rao Jag
- Rattray Austin
- Razazi Keyvan
- Reece-Anthony Rosie
- Reignier Jean
- Rewa Oleksa
- Rewa Oleksa
- Reynolds Claire
- Ricard Jean-Damien
- Richard Régine
- Richardson Angus
- Richardson Max
- Rigatto Claudio
- Ristimäki Sanna
- Robert Alain
- Robertson Yvonne
- Robine Adrien
- Robinson Chelsea
- Robinson Francesca
- Robinson Holly
- Rochwerg Bram
- Rochwerg Bram
- Rogers Paula
- Rokosh Ella
- Rolls Christine
- Romano Martin
- Romanovsky Adam S.
- Roodenburg Owen
- Rose Bernd Oliver
- Rosenberg Alex
- Rosenow Nadine
- Roshdy Ashraf
- Rossi Julie
- Roux Damien
- Roux Sylvie
- Roy Isabelle
- Rozec Bertrand
- Ruddell Stacey
- Ruddell Stacey
- Ruddy Jim
- Ruppert Matthew
- Russell Michael
- Ryan Lucy
- Sabev Alexandra
- Said Simone
- Salamé Maya
- Salerno Tania
- Salva Juvy
- Sandhu Gyan
- Sangla Frederic
- Santos Marlene
- Savija Nevena
- Saylor Emma
- Schellongowski Peter
- Schenk Bettina
- Scherr Kimberly
- Schneider Antoine G.
- Schneider Antoine G.
- Schnorf Madeleine
- Schwartz Kate
- Scott Teresa
- Sedillot Nicholas
- Seguin Amélie
- Sejourne Caroline
- Shah Asim
- Shah Sumesh
- Shami Aysha
- Shanmugasundaram Pradeep
- Sharif Sairah
- Sharif Sairah
- Sharman Andrew
- Sharman Asheer
- Shaw David
- Shelley Ben
- Sheng Lulu
- Shi Qindong
- Shi Xianqing
- Shrestha Tapaswi
- Shuker Karen
- Sia Ying Tung
- Sibley Stephanie
- Sim Malcolm
- Simmonds Catherine
- Simon Marie
- Simon Mathieu
- Singh Gurmeet
- Skarzynski Marie
- Slack Andrew
- Smith John
- Smith Julie
- Smith Orla M.
- Snelson Catherine
- Sokolowski Colleen
- Soth Mark
- Souweine Bertrand
- Sparkes Simon
- Spruce Elaine
- Sridhar Kavita
- St-Arnaud Charles
- Staudinger Thomas
- Steele Andrew
- Stelfox Henry T.
- Stelfox Henry T.
- Stewart Richard
- Stoltenberg Anita
- Suen Gabriel
- Suhonen Taria
- Sun Jingjing
- Sutherland Sara-Beth
- Sutinen Sari
- Takaoka Alyson
- Tamion Fabienne
- Taneja Ravi
- Tchenio Xavier
- Thevenin Didier
- Thevenin Fabienne
- Thibault Michel
- Thiéry Guillaume
- Thomas Emma
- Thomas Liz
- Thome Fernando
- Thompson Patricia
- Thompson Tayne
- Thuong Marie
- Tiagarajah Abirami
- Tiller Esther
- Tilley Rosalinde
- Tippett Anna
- Titeca-Beauport Dimitri
- Tolibas Michael
- Tolwani Ashita
- Towns Miriam
- Tozzi Margherita
- Tridente Ascanio
- Trusson Rémi
- Tung Ying
- Turgeon Alexis F.
- Törnblom Sanna
- Udy Andrew
- Vaara Suvi
- Vaara Suvi T.
- Vaara Suvi T.
- Vallance Shirley
- Vamplew Luke
- van Diepen Sean
- van Waegeningh Thomas
- Van Hoa Dang
- Vander Hayden Kymbalee
- Varila Simo
- Veenith Tonny
- Velez Laura
- Venz Ellen
- Verlay Mélanie
- Vermeiren Daisy
- Vetro Joseph
- Vimpere Damien
- Vinatier Isabelle
- Vinsonneau Christophe
- Vitiello Michelangelo
- Vizcaychipi Marcela
- Vladic Chelsey
- Wagner Martin
- Walczak Karolina
- Wald Ron
- Wald Ron
- Wald Ron
- Wallace Samantha
- Wang Amanda Y.
- Wang Chuanyao
- Wang Chunting
- Wang Cunzhen
- Wang Dongxin
- Wang Haibo
- Wang Haiman
- Wang Jane
- Wang Jinlong
- Wang Kaiwu
- Wang Peng
- Wang Qizhi
- Wang Quihui
- Wang Xue
- Wang Yifeng
- Ward Geraldine
- Watpool Irene
- Watson Hayley
- Waugh Victoria
- Wax Randy
- Weir Matthew
- Weir Matthew A.
- Welsh Deborah
- Welters Ingeborg
- Wen Mingxiang
- Wetzig Krista
- White Peggy
- Whitehead Christina
- Whitehouse Tony
- Whitlock Richard P.
- Wilby Elizabeth
- Williams Erin
- Williams Karen
- Willox Fiona
- Wise Matthew
- Wittig Monika
- Wolverson Adam
- Wong Helen
- Wood Gordon
- Woolett Melissa
- Wootten Anna
- Wren Lynn
- Wu Changde
- Wu Jing
- Wun James
- Wyncoll Duncan
- Xu Hao
- Xu Song
- Yan Jie
- Yan Jinqi
- Yang Enyu
- Yang Jianxu
- Yang Juan
- Yang Yang
- Yang Yi
- Yang Ziqi
- Yao Han
- Yao Lan
- Yarad Elizabeth
- Ye Baning
- Yehia Aihem
- Young Helen
- Young Meredith
- Young Paul
- Youngs Nora
- Yu Zhui
- Zahirieh Alireza
- Zampieri Fernando G.
- Zangrillo Alberto
- Zarbock Alexander
- Zeng Qinjing
- Zhang Jichen
- Zhang Lei
- Zhang Meng
- Zhang Minwei
- Zhang Songsong
- Zhao Dan
- Zhao Mengya
- Zhao Shibing
- Zhao Shuangping
- Zhi Deyuan
- Zhou Qi
- Zhou Xiao
- Zhuang Haizhou
- Zotter Klemens
- Zuber Benjamin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Background
Timing of initiation of kidney-replacement therapy (KRT) in critically ill patients remains controversial. The Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial compared two strategies of KRT initiation (accelerated versus standard) in critically ill patients with acute kidney injury and found neutral results for 90-day all-cause mortality. Probabilistic exploration of the trial endpoints may enable greater understanding of the trial findings. We aimed to perform a reanalysis using a Bayesian framework.
Methods
We performed a secondary analysis of all 2927 patients randomized in multi-national STARRT-AKI trial, performed at 168 centers in 15 countries. The primary endpoint, 90-day all-cause mortality, was evaluated using hierarchical Bayesian logistic regression. A spectrum of priors includes optimistic, neutral, and pessimistic priors, along with priors informed from earlier clinical trials. Secondary endpoints (KRT-free days and hospital-free days) were assessed using zero–one inflated beta regression.
Results
The posterior probability of benefit comparing an accelerated versus a standard KRT initiation strategy for the primary endpoint suggested no important difference, regardless of the prior used (absolute difference of 0.13% [95% credible interval [CrI] − 3.30%; 3.40%], − 0.39% [95% CrI − 3.46%; 3.00%], and 0.64% [95% CrI − 2.53%; 3.88%] for neutral, optimistic, and pessimistic priors, respectively). There was a very low probability that the effect size was equal or larger than a consensus-defined minimal clinically important difference. Patients allocated to the accelerated strategy had a lower number of KRT-free days (median absolute difference of − 3.55 days [95% CrI − 6.38; − 0.48]), with a probability that the accelerated strategy was associated with more KRT-free days of 0.008. Hospital-free days were similar between strategies, with the accelerated strategy having a median absolute difference of 0.48 more hospital-free days (95% CrI − 1.87; 2.72) compared with the standard strategy and the probability that the accelerated strategy had more hospital-free days was 0.66.
Conclusions
In a Bayesian reanalysis of the STARRT-AKI trial, we found very low probability that an accelerated strategy has clinically important benefits compared with the standard strategy. Patients receiving the accelerated strategy probably have fewer days alive and KRT-free. These findings do not support the adoption of an accelerated strategy of KRT initiation
Regional Practice Variation and Outcomes in the Standard Versus Accelerated Initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) Trial: A Post Hoc Secondary Analysis.
- Author
- Abed Mallaird Samia
- Abrams Judith
- Adda Mireille
- Adderley Jane
- Adhikari Neill KJ
- Adhikari Neill KJ
- Adhikari Neill KJ
- Aissaoui Nadia
- Alam Ahsan
- Albrett Jonathan
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- Wald Ron
- Wald Ron
- Wallace Samantha
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- Wang Amanda Y
- Wang Chuanyao
- Wang Chunting
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- Wang Haibo
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- Wang Jane
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- Wang Kaiwu
- Wang Peng
- Wang Qizhi
- Wang Quihui
- Wang Xue
- Wang Yifeng
- Ward Geraldine
- Watpool Irene
- Watson Hayley
- Waugh Victoria
- Wax Randy
- Weir Matthew
- Weir Matthew A
- Welsh Deborah
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- Wetzig Krista
- White Peggy
- Whitehead Christina
- Whitehouse Tony
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- Wilby Elizabeth
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- Williams Karen
- Willox Fiona
- Wise Matthew
- Wittig Monika
- Wolverson Adam
- Wong Helen
- Wood Gordon
- Woolett Melissa
- Wootten Anna
- Wren Lynn
- Wu Changde
- Wu Jing
- Wun James
- Wyncoll Duncan
- Xu Hao
- Xu Song
- Yan Jie
- Yan Jinqi
- Yang Enyu
- Yang Jianxu
- Yang Juan
- Yang Yang
- Yang Yi
- Yang Ziqi
- Yao Han
- Yao Lan
- Yarad Elizabeth
- Ye Baning
- Yehia Aihem
- Young Helen
- Young Meredith
- Young Paul
- Youngs Nora
- Yu Zhui
- Zahirieh Alireza
- Zangrillo Alberto
- Zarbock Alexander
- Zeng Qinjing
- Zhang Jichen
- Zhang Lei
- Zhang Meng
- Zhang Minwei
- Zhang Songsong
- Zhao Dan
- Zhao Mengya
- Zhao Shibing
- Zhao Shuangping
- Zhi Deyuan
- Zhou Qi
- Zhou Xiao
- Zhuang Haizhou
- Zotter Klemens
- Zuber Benjamin
- Publication venue
- Ovid Technologies (Wolters Kluwer Health)
- Publication date
- 01/02/2024
- Field of study
ObjectivesAmong patients with severe acute kidney injury (AKI) admitted to the ICU in high-income countries, regional practice variations for fluid balance (FB) management, timing, and choice of renal replacement therapy (RRT) modality may be significant.DesignSecondary post hoc analysis of the STandard vs. Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial (ClinicalTrials.gov number NCT02568722).SettingOne hundred-fifty-three ICUs in 13 countries.PatientsAltogether 2693 critically ill patients with AKI, of whom 994 were North American, 1143 European, and 556 from Australia and New Zealand (ANZ).InterventionsNone.Measurements and main resultsTotal mean FB to a maximum of 14 days was +7199 mL in North America, +5641 mL in Europe, and +2211 mL in ANZ (p p p p p p p p = 0.007).ConclusionsAmong STARRT-AKI trial centers, significant regional practice variation exists regarding FB, timing of initiation of RRT, and initial use of continuous RRT. After adjustment, such practice variation was associated with lower ICU and hospital stay and 90-day mortality among ANZ patients compared with other regions