106 research outputs found
Rapid Global Expansion of Invertebrate Fisheries: Trends, Drivers, and Ecosystem Effects
- Author
- AK Salomon
- B Worm
- B Worm
- BF Phillips
- CH Peterson
- D Pauly
- D Pauly
- F Berkes
- F Ferdouse
- G Jamieson
- G Leiva
- H Tillin
- Heike K. Lotze
- HK Lotze
- J Castilla
- J Hiddink
- JBC Jackson
- Joanna Mills Flemming
- K Kelleher
- L Botsford
- M Kaiser
- MJ Tegner
- MX Kirby
- NL Andrew
- P Breen
- R Froese
- R Hilborn
- R Watson
- Reg Watson
- RI Perry
- RIE Newell
- S Shepherd
- S Uthicke
- SA Sethi
- SC Anderson
- SC Anderson
- Sean C. Anderson
- Steven J. Bograd
- TE Essington
- Publication venue
- Public Library of Science
- Publication date
- 08/03/2011
- Field of study
BACKGROUND: Worldwide, finfish fisheries are receiving increasing assessment and regulation, slowly leading to more sustainable exploitation and rebuilding. In their wake, invertebrate fisheries are rapidly expanding with little scientific scrutiny despite increasing socio-economic importance. METHODS AND FINDINGS: We provide the first global evaluation of the trends, drivers, and population and ecosystem consequences of invertebrate fisheries based on a global catch database in combination with taxa-specific reviews. We also develop new methodologies to quantify temporal and spatial trends in resource status and fishery development. Since 1950, global invertebrate catches have increased 6-fold with 1.5 times more countries fishing and double the taxa reported. By 2004, 34% of invertebrate fisheries were over-exploited, collapsed, or closed. New fisheries have developed increasingly rapidly, with a decrease of 6 years (3 years) in time to peak from the 1950s to 1990s. Moreover, some fisheries have expanded further and further away from their driving market, encompassing a global fishery by the 1990s. 71% of taxa (53% of catches) are harvested with habitat-destructive gear, and many provide important ecosystem functions including habitat, filtration, and grazing. CONCLUSIONS: Our findings suggest that invertebrate species, which form an important component of the basis of marine food webs, are increasingly exploited with limited stock and ecosystem-impact assessments, and enhanced management attention is needed to avoid negative consequences for ocean ecosystems and human well-being
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Infant Outcomes Following Maternal Infection With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): First Report From the Pregnancy Coronavirus Outcomes Registry (PRIORITY) Study.
- Author
- Publication venue
- Jefferson Digital Commons
- Publication date
- 18/09/2020
- Field of study
Infant outcomes after maternal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are not well described. In a prospective US registry of 263 infants, maternal SARS-CoV-2 status was not associated with birth weight, difficulty breathing, apnea, or upper or lower respiratory infection through 8 weeks of age
Effects of peripheral nerve injury on parvalbumin expression in adult rat dorsal root ganglion neurons
- Author
- A Parekh
- AD Gaudet
- AJ Reid
- C Duc
- C Molander
- C O’Brien
- CN Honda
- CN Liu
- D Welin
- DE Wright
- DL Hammond
- EV Pitts
- FC Yang
- GJ Michael
- H Ichikawa
- H Ichikawa
- H Ichikawa
- H Kashiba
- H Tsujino
- HA Lekan
- I Kirillova
- IJ Lever
- J Pavel
- J Yuan
- JA Rall
- JC Copray
- JC Nooij de
- JL Elliot
- JM Peyronnard
- K Kataoka
- K Miki
- K Noguchi
- L Bosch Van Den
- LJ Zhou
- LS Sorkin
- M Colleoni
- M Costigan
- M Dobretsov
- M Ikura
- M Michaelis
- M Millan
- M Tsukagoshi
- M Zimmermann
- ME Alexianu
- MF Antal
- MH Cao
- MJ Perry
- MJ Szabolcs
- MR Celio
- MR Celio
- ND Fagoe
- P Hu
- P Ince
- P Shortland
- P Shortland
- PA Carr
- PA Carr
- PA Carr
- PC Englezou
- Peter J. Shortland
- PJ Shortland
- RR Cruz De La
- S Averill
- S Iino
- S Iino
- S Pezet
- S Wakisaka
- S Wakisaka
- SA Shehab
- SH Kim
- SM Jamieson
- SN Lawson
- T Fukuoka
- T Fukuoka
- T Fukuoka
- T Gordon
- T Hökfelt
- T Tandrup
- TD Patel
- Tom Medici
- VLH Leinster
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Background: Parvalbumin (PV) is a calcium binding protein that identifies a subpopulation of proprioceptive dorsal root ganglion (DRG) neurons. Calcitonin gene-related peptide (CGRP) is also expressed in a high proportion of muscle afferents but its relationship to PV is unclear. Little is known of the phenotypic responses of muscle afferents to nerve injury. Sciatic nerve axotomy or L5 spinal nerve ligation and section (SNL) lesions were used to explore these issues in adult rats using immunocytochemistry. Results: In naive animals, the mean PV expression was 25 % of L4 or L5 dorsal root ganglion (DRG) neurons, and this was unchanged 2 weeks after sciatic nerve axotomy. Colocalization studies with the injury marker activating transcription factor 3 (ATF3) showed that approximately 24 % of PV neurons expressed ATF3 after sciatic nerve axotomy suggesting that PV may show a phenotypic switch from injured to uninjured neurons. This possibility was further assessed using the spinal nerve ligation (SNL) injury model where injured and uninjured neurons are located in different DRGs. Two weeks after L5 SNL there was no change in total PV staining and essentially all L5 PV neurons expressed ATF3. Additionally, there was no increase in PV-ir in the adjacent uninjured L4 DRG cells. Co-labelling of DRG neurons revealed that less than 2 % of PV neurons normally expressed CGRP and no colocalization was seen after injury. Conclusion: These experiments clearly show that axotomy does not produce down regulation of PV protein in the DRG. Moreover, this lack of change is not due to a phenotypic switch in PV immunoreactive (ir) neurons, or de novo expression of PV-ir in uninjured neurons after nerve injury. These results further illustrate differences that occur when muscle afferents are injured as compared to cutaneous afferents
Heart Valve Tissue Engineering: Concepts, Approaches, Progress, and Challenges
- Author
- A. B. Pratt
- A. C. Grayson
- A. Deb
- A. Lendlein
- A. Leri
- A. Mol
- A. Mol
- A. Ramamurthi
- A. Saiura
- A. Schmitt-Graff
- B. Bertipaglia
- B. C. Isenberg
- B. D. Ratner
- B. Dawn
- B. K. Mann
- C. A. Fernandez
- C. A. Simmons
- C. B. Weinberg
- C. K. Breuer
- C. Liu
- C. Urbich
- C. Urbich
- C. Williams
- D. Beis
- D. C. Radisky
- D. Fukuda
- D. G. Anderson
- D. J Ceradini
- D. J. Prockop
- D. L. Mulholland
- D. Orlic
- D. Simper
- D. Srivastava
- E. Aikawa
- E. Erez
- E. Eybl
- E. J. Armstrong
- E. N. Olson
- E. Rabkin
- E. Rabkin
- E. Rabkin
- E. Rabkin-Aikawa
- E. Rabkin-Aikawa
- E. Rabkin-Aikawa
- E. Rieder
- E. Tamariz
- F. A. Jaffer
- F. A. Jaffer
- F. Della Rocca
- F. J. Schoen
- F. J. Schoen
- F. Mouquet
- F. S. Apple
- F. Sayk
- F. W. H. Sutherland
- Frederick J. Schoen
- G Zund
- G. A. Silva
- G. A. Walker
- G. C. Engelmayr
- G. F. Muschler
- G. Genove
- G. H. Borschel
- G. Paranya
- G. Steinhoff
- H. B. Grossman
- H. M. Nugent
- I. E. Blom
- I. Ott
- I. Vesely
- J. Aoki
- J. Chen
- J. D. Wood
- J. G. Emsley
- J. George
- J. J. Ross
- J. Lahann
- J. Leor
- J. M. Hill
- J. P. Basilion
- J. P. Stegemann
- J. R. Mauney
- J. T. Butcher
- J. T. Butcher
- J. Yang
- J.-O. Deguchi
- K. A. Robinson
- K. Hammermeister
- K. Marron
- K. R. Kanter
- K. S. Masters
- K. Schenke-Layland
- K. Tanaka
- Karen Mendelson
- L. E. Freed
- L. E. Niklason
- L. M. Eisenberg
- L. M. Eisenberg
- M. A. Laflamme
- M. Deutsch
- M. E. Brezinski
- M. F. Pittenger
- M. H. Yacoub
- M. Hristov
- M. J. Van den Hoff
- M. O. Hoque
- M. P. Lutolf
- M. Poh
- M. Radisic
- M. Sata
- M. Sata
- M. Spina
- N. A. Patel
- N. Werner
- O. H. Frazier
- P. E. Szmitko
- P. F. Davies
- P. M. Dohmen
- P. M. Dohmen
- P. M. Taylor
- P. M. Taylor
- P. Simon
- P. V. Giannoudis
- P. W. M. Fedak
- Q. Shi
- Q. Ye
- R. A. Hopkins
- R. A. Roeder
- R. C. Elkins
- R. G. Matheny
- R. Langer
- R. Langer
- R. M. Nerem
- R. N. Mitchell
- R. Roy
- R. Sodian
- R. T. Tranquillo
- R. Weinshilboum
- S. Dimmeler
- S. F. Badylak
- S. F. Badylak
- S. H. Rahimtoola
- S. H. Rahimtoola
- S. Iwai
- S. J. Hollister
- S. Jockenhoevel
- S. Kaushal
- S. P. Hoerstrup
- S. Rafii
- S. Rafii
- T. E. Perry
- T. Eschenhagen
- T. Ichikawa
- T. Ishihara
- T. Ogata
- T. Ota
- T. S. Van Le
- T. Shinoka
- T. Shinoka
- U. A. Stock
- V. Garg
- V. Karageorgiou
- W. Boecker
- W. D. Merryman
- W. Konertz
- W. R. Jamieson
- W. Schurch
- X. Liu
- X. Wu
- X. Wu
- Y. Iwami
- Y. Jiang
- Y. M. Lee
- Y. Narita
- Y. Shi
- Y. Shi
- Publication venue
- Kluwer Academic Publishers-Plenum Publishers
- Publication date
- 01/01/2006
- Field of study
Potential applications of tissue engineering in regenerative medicine range from structural tissues to organs with complex function. This review focuses on the engineering of heart valve tissue, a goal which involves a unique combination of biological, engineering, and technological hurdles. We emphasize basic concepts, approaches and methods, progress made, and remaining challenges. To provide a framework for understanding the enabling scientific principles, we first examine the elements and features of normal heart valve functional structure, biomechanics, development, maturation, remodeling, and response to injury. Following a discussion of the fundamental principles of tissue engineering applicable to heart valves, we examine three approaches to achieving the goal of an engineered tissue heart valve: (1) cell seeding of biodegradable synthetic scaffolds, (2) cell seeding of processed tissue scaffolds, and (3) in-vivo repopulation by circulating endogenous cells of implanted substrates without prior in-vitro cell seeding. Lastly, we analyze challenges to the field and suggest future directions for both preclinical and translational (clinical) studies that will be needed to address key regulatory issues for safety and efficacy of the application of tissue engineering and regenerative approaches to heart valves. Although modest progress has been made toward the goal of a clinically useful tissue engineered heart valve, further success and ultimate human benefit will be dependent upon advances in biodegradable polymers and other scaffolds, cellular manipulation, strategies for rebuilding the extracellular matrix, and techniques to characterize and potentially non-invasively assess the speed and quality of tissue healing and remodeling
Track E Implementation Science, Health Systems and Economics
- Author
- Abolarin O.
- Ackers M.
- Ackers M.
- Adouko S.
- Adungosi J.
- Afolayan F.
- Aghokeng A.
- Agot K.
- Ahimbisibwe A.
- Ahmed Y.
- Akwei Addo N.
- Alary M.
- Alexander G.
- Ali S.A.
- Allman D.
- Alumando E.S.
- Alves J.
- Amanyire G.
- Amenyah R.
- Angela A.
- Anthony G.
- Anthony J.
- Ardura Garcia C.
- Arrighi Y.
- Asante F.
- Asante K.
- Ashigbie P.
- Assouan I.
- Atibu J.
- Atuahene K.
- Avafia T.
- Avalos A.
- Ayieko B.
- Ayuaya T.
- Babu R.
- Barros H.
- Barry M.
- Behets F.
- Bertrand J.
- Bertrand J.
- Bhardwaj K.
- Bhende A.
- Bilguissa D.
- Birdthistle I.
- Birger R.
- Black D.
- Bogart L.
- Bogg L.
- Bollinger T.
- Bor J.
- Bor J.
- Boulet P.
- Boyer S.
- Brink B.
- Brockington S.
- Buhendwa L.
- Burrone E.
- Byonanebye D.
- Bärnighausen T.
- Bärnighausen T.
- Bärnighausen T.
- Carrieri M.P.
- Castor D.
- Castor D.
- Chabikuli O.
- Chadambuka A.
- Chamie G.
- Chamie G.
- Chamie G.
- Chandisarewa W.
- Chandrashekar S.
- Charlebois E.
- Charlebois E.
- Charlebois E.D.
- Chasela C.S.
- Chavez J.
- Cheng X.
- Chetty S.
- Chidarikire T.
- Chikwinya B.
- Chileshe C.
- Chimbindi N.Z.
- Chipimo M.
- Chisoko C.
- Churchman E.
- Churchyard G.
- Ciccacci F.
- Clark T.
- Clark T.
- Clark T.
- Cockburn J.
- Cohn J.
- Coleman S.
- Cornier N.
- Cummiskey C.
- Dagunduro T.
- Damisoni H.
- Dancel E.
- Davidovich U.
- De Costa A.
- Delaporte E.
- Des Jarlais D.C.
- Desinor O.
- Dhaliwal M.
- Dilorenzo M.A.
- Diseko L.
- Ditmore M.
- Dixon M.
- Dongmo Nguimfack B.
- Dorman S.
- Doumbouya B.
- Dowdy D.
- Drain P.
- Dringus S.
- Dryden‐peterson S.
- Dutta A.
- Edmonds A.
- Egger M.
- Ehmer J.
- El‐adas A.
- Escaleira F.
- Evi J.B.
- Fahim S.K.
- Fatti G.
- Feinstein L.
- Feldacker C.
- Feleke G.
- Fennema H.
- Ferreyra C.
- Fidler S.
- Ford N.
- Formson C.
- Forsythe S.
- Foso M.
- Frade S.
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- Francis Munjattu J.
- Freedberg K.
- Freedberg K.A.
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- Freeman A.
- Fulwood Wood A.
- Gadisa T.
- Gaikwad D.S.S.
- Geng E.
- Geng E.
- Geng E.
- Gennaro E.
- Germano P.
- Gervas S.
- Ghosh S.C.
- Gibb D.M.
- Gichanga B.
- Gichangi A.
- Giddy J.
- Glandon D.
- Gotsadze G.
- Gounongbe M.
- Graham B.
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- Grimwood A.
- Grote S.
- Guidotti G.
- Gunguwo H.
- Gupta I.
- Guthrie T.
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- Gyarappagari S.
- Hallett T.
- Hamangaba F.
- Harris J.
- Hasselberg E.
- Hatwiinda S.
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- Hemingway‐foday J.
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- Herbst A.J.
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- Holtgrave D.
- Hosseinipour M.
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- Jain V.
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- Kamya M.
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- Katz I.
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- Kayira D.
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- Khamofu H.
- Khoshnood K.
- Kimuli R.
- King C.K.
- Kioko U.
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- Kizito H.
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- Labhardt N.D.
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- Mensah‐maïka B.
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- Merry C.
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- Mgugu D.
- Middleton‐lee S.
- Milani B.
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- Miruka F.
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- Mondal S.
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- Morse J.
- Moss W.J.
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- Muchedzi A.
- Mueller O.
- Mugume A.
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- Muirhead D.
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- Mulema V.S.
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- Mumbe L.
- Murugan S.K.
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- Neuhann H.W.F.
- Nevhutalu Z.
- Newell M.‐l.
- Newell M.‐l.
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- Palchaudhuri S.
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- Paltiel A.D.
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- Panessa C.
- Park C.
- Park J.‐e.
- Parris D.
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- Perelman J.
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- Shet A.
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- Shetty G.
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- Thirumurthy H.
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- Thirumurthy H.
- Thompson D.
- Tiam A.
- Tirumalasetti V.R.
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- van der Helm J.
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- van Widenfelt E.
- van Zyl A.
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- Waiswa P.
- Walensky R.
- Walensky R.P.
- Walensky R.P.
- Walker S.
- Wallace N.
- Wandeler G.
- Wanjiku L.
- Watts C.
- Watts C.
- Weigel R.
- Weinstein M.C.
- Weir B.W.
- Whiddon L.
- Wolde A.
- Wondergem P.
- Wong W.
- Wu Z.
- Xiong K.
- Yankah E.
- Yazdanpanah Y.
- Yekeye R.
- Yiweza Tshipala D.
- Zaho M.
- Zeh C.
- Zeng G.
- Zewdu S.
- Zhyhinas O.
- Zuure F.
- ’t Hoen E.
- Publication venue
- 'International AIDS Society'
- Publication date
- 01/10/2012
- Field of study
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138412/1/jia218443.pd
Pan-cancer analysis of whole genomes
- Author
- A. -L. rv
- A. -M. ma
- A. A. qj
- A. abp
- A. ak
- A. ak
- A. am
- A. am
- A. am
- A. av
- A. B. ry
- A. bb
- A. bg
- A. br
- A. bu
- A. cb
- A. cb
- A. ch
- A. ch
- A. ck
- A. D. b ey
- A. dg
- A. dg
- A. dg
- A. dy
- A. ev
- A. G. lo
- A. G. ni
- A. G. yc
- A. gl
- A. gt
- A. gt
- A. gz
- A. hy
- A. hy
- A. I. gg
- A. ik
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- X. k Mbabaali
- X. oi
- X. S. wd
- X. tc
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- xb Danilova
- xb Felau
- xc Lovat
- xh Curley
- xh Fulton
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- Xiang
- Xiong
- xo Abeshouse
- xp Benz
- xp Edwards
- xr Ghori
- xs Gundem
- Xue
- xv Luxton
- xw McDermott
- xy Visakorpi
- xz Whitaker
- Y. -E. ot
- Y. -J. k
- Y. -J. xn
- Y. abp
- Y. ae
- Y. ae
- Y. ae
- Y. ae
- Y. ai
- Y. aj
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- Y. rj
- Y. rm
- Y. S. jf
- Y. uz
- Y. vr
- Y. wt
- Y. yc
- ya Al-Ahmadie
- Yachida
- Yamaguchi
- Yamaguchi T. N. k
- Yamamoto
- Yamaue
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- Yang
- Yang
- Yang
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- Yugawa
- z ah
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- Zapatka
- zd Gershenwald
- Zenklusen
- Zeps
- zf Ghossein
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang H. b
- Zhao
- Zheng
- Zhou
- Zhou
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- zi zj
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- zt Kim
- zw Lewis
- Ó. A. th
- Ø. sk
- Publication venue
- Publication date
- 11/12/2019
- Field of study
Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe
The James Webb Space Telescope Mission
- Author
- Abbott Randy
- Abell James S.
- Abernathy Mark
- Abney Faith E.
- Abraham John G.
- Abraham Roberto
- Abul-Huda Yasin M.
- Acton Scott
- Adams Cynthia K.
- Adams Evan
- Adler David S.
- Adriaensen Maarten
- Aguilar Jonathan Albert
- Ahmed Mansoor
- Ahmed Nasif S.
- Ahmed Tanjira
- Alarcon Rafael Ramos
- Albat Rüdeger
- Albert Loïc
- Alberts Stacey
- Aldridge David
- Allen Mary Marsha
- Allen Shaune S.
- Altenburg Martin
- Altunc Serhat
- Alvarez Jose Lorenzo
- Ambrose Leslie L.
- Anandakrishnan Satya M.
- Andersen Gregory C.
- Anderson Harry James
- Anderson Jay
- Anderson Kristen
- Anderson Sara M.
- Aprea Julio
- Archer Benita J.
- Arenberg Jonathan W.
- Argyriou Ioannis
- Arribas Santiago
- Artigau Étienne
- Arvai Amanda Rose
- Atcheson Paul
- Atkinson Charles B.
- Averbukh Jesse
- Aymergen Cagatay
- Bacinski John J.
- Baggett Wayne E.
- Bagnasco Giorgio
- Baker Lynn L.
- Balzano Vicki Ann
- Banks Kimberly A.
- Baran David A.
- Barker Elizabeth A.
- Barrett Larry K.
- Barringer Bruce O.
- Barto Allison
- Bast William
- Baudoz Pierre
- Baum Stefi
- Beatty Thomas G.
- Beaulieu Mathilde
- Bechtold Kathryn
- Beck Tracy
- Beddard Megan M.
- Beichman Charles
- Bellagama Larry
- Bely Pierre
- Berger Timothy W.
- Bergeron Louis E.
- Bertch Maria D.
- Beskow Charlotte
- Betz Laura E.
- Biagetti Carl P.
- Birkmann Stephan
- Bjorklund Kurt F.
- Blackwood James D.
- Blazek Ronald Paul
- Blossfeld Stephen
- Bluth Marcel
- Boccaletti Anthony
- Boegner Jr. Martin E.
- Bohlin Ralph C.
- Boia John Joseph
- Bonaventura N.
- Bond Nicholas A.
- Bosley Kari Ann
- Boucarut Rene A.
- Bouchet Patrice
- Bouwman Jeroen
- Bower Gary
- Bowers Ariel S.
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- Brennan David
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- Bunker A. J.
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- Canipe Alicia M.
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- Cara Mihai
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- Case Michael Eli
- Cesari Thaddeus
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- Clampin Mark
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- Coulais Alain
- Cox Colin R.
- Coyle Ray T.
- Cracraft Misty M.
- Crew Keith A.
- Curtis Gary J.
- Cusveller Bianca
- Dailey Christopher T.
- Darveau-Bernier Antoine
- Daugeron Frédéric
- Davidson Greg S.
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- de Chambure Daniel
- de Jong Pauline
- De Marchi Guido
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- Deschenes Jeremy
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- Dixon William V.
- Doggett Jesse B.
- Dominguez Keisha L.
- Donaldson Thomas S.
- Doria-Warner Cristina M.
- Doty Heather
- Douglas Jr. Robert E.
- Doyon René
- Dressler Alan
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- Dupuis Jean
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- Etienne Odessa
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- Evans Leah
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- Krause Oliver
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- Labador Aurora Gadiano
- Labiano Álvaro
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- Such Miguel
- Sukhatme Kalyani
- Sullivan Joseph F.
- Sullivan Pamela C.
- Sumner Sandra M.
- Sun Fengwu
- Sunnquist Benjamin Dale
- Swade Daryl Allen
- Swam Michael S.
- Swenton Diane F.
- Swoish Robby A.
- Tamas Laszlo
- Tao Andrew
- Taylor David K.
- Taylor Joanna M.
- Teague Kelly K.
- Telfer Randal C.
- Temim Tea
- Texter Scott C.
- Thatte Deepashri G.
- Thompson Christopher Lee
- Thompson Linda M.
- Thomson Shaun R.
- Thronson Harley
- Tierney C. M.
- Tikkanen Tuomo
- Tinnin Lee
- Tippet William Thomas
- Todd Connor William
- Tran Hien D.
- Trauger John
- Trejo Edwin Gregorio
- Truong Justin Hoang Vinh
- Tsukamoto Christine L.
- Tufail Yasir
- Tumlinson Jason
- Tustain Samuel
- Tyra Harrison
- Ubeda Leonardo
- Underwood Kelli
- Uzzo Michael A.
- Vaclavik Steven
- Valenduc Frida
- Valenti Jeff A.
- Van Campen Julie
- van de Wetering Inge
- Van Der Marel Roeland P.
- van Dishoeck Ewine F.
- van Haarlem Remy
- Van Tea Mason
- Vandenbussche Bart
- Vanterpool Dona D.
- Vernoy Michael R.
- Volk Kevin
- Voorzaat Piet
- Voyton Mark F.
- Vydra Ekaterina
- Waddy Darryl J.
- Waelkens Christoffel
- Wahlgren Glenn Michael
- Walker Jr. Frederick E.
- Wander Michel
- Warfield Christine K.
- Warner Gerald
- Wasiak Francis C.
- Wasiak Matthew F.
- Wehner James
- Weiler Kevin R.
- Weilert Mark
- Weiss Stanley B.
- Wells Martyn
- Welty Alan D.
- Wheate Lauren
- Wheeler Thomas P.
- White Christy L.
- Whitehouse Paul
- Whiteleather Jennifer Margaret
- Whitman William Russell
- Williams Christina C.
- Willmer Christopher N. A.
- Willott Chris J.
- Willoughby Scott P.
- Wilson Andrew
- Wilson Debra
- Wilson Donna V.
- Windhorst Rogier
- Wislowski Emily Christine
- Wolfe David J.
- Wolfe Michael A.
- Wolff Schuyler
- Wondel Amancio
- Woo Cindy
- Woods Robert T.
- Worden Elaine
- Workman William
- Wright Gillian S.
- Wu Carl
- Wu Chi-Rai
- Wun Dakin D.
- Wymer Kristen B.
- Yadetie Thomas
- Yan Isabelle C.
- Yang Keith C.
- Yates Kayla L.
- Yeager Christopher R.
- Yerger Ethan John
- Young Erick T.
- Young Gary
- Yu Gene
- Yu Susan
- Zak Dean S.
- Zeidler Peter
- Zepp Robert
- Zhou Julia
- Zincke Christian A.
- Zonak Stephanie
- Zondag Elisabeth
- Álvarez-Márquez Javier
- Östlin Göran
- Publication venue
- Publication date
- 10/04/2023
- Field of study
Twenty-six years ago a small committee report, building on earlier studies,
expounded a compelling and poetic vision for the future of astronomy, calling
for an infrared-optimized space telescope with an aperture of at least 4m.
With the support of their governments in the US, Europe, and Canada, 20,000
people realized that vision as the 6.5m James Webb Space Telescope. A
generation of astronomers will celebrate their accomplishments for the life of
the mission, potentially as long as 20 years, and beyond. This report and the
scientific discoveries that follow are extended thank-you notes to the 20,000
team members. The telescope is working perfectly, with much better image
quality than expected. In this and accompanying papers, we give a brief
history, describe the observatory, outline its objectives and current observing
program, and discuss the inventions and people who made it possible. We cite
detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space
Telescope Overview, 29 pages, 4 figure
Recommended from our members
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 02/03/2020
- Field of study
Chromothripsis is a mutational phenomenon characterized by massive, clustered genomic rearrangements that occurs in cancer and other diseases. Recent studies in selected cancer types have suggested that chromothripsis may be more common than initially inferred from low-resolution copy-number data. Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA), we analyze patterns of chromothripsis across 2,658 tumors from 38 cancer types using whole-genome sequencing data. We find that chromothripsis events are pervasive across cancers, with a frequency of more than 50% in several cancer types. Whereas canonical chromothripsis profiles display oscillations between two copy-number states, a considerable fraction of events involve multiple chromosomes and additional structural alterations. In addition to non-homologous end joining, we detect signatures of replication-associated processes and templated insertions. Chromothripsis contributes to oncogene amplification and to inactivation of genes such as mismatch-repair-related genes. These findings show that chromothripsis is a major process that drives genome evolution in human cancer
The Bioarchaeological Investigation of Childhood and Social Age: Problems and Prospects
- Author
- A. A. Saxe
- A. Gottlieb
- A. H. Goodman
- A. H. Goodman
- A. H. Goodman
- A. H. Goodman
- A. H. Goodman
- A. Ingvarsson-Sundström
- A. James
- A. Prentice
- A. Prout
- A. Prout
- A. S. Wiley
- B. A. Hanawalt
- B. A. Hanawalt
- B. Bogin
- B. Bogin
- B. Bogin
- B. Bogin
- B. E. Roveland
- B. L. Turner
- C. Jenks
- C. M. Beall
- C. O. Lovejoy
- C. Panter-Brick
- C. Ruff
- C. S. Larsen
- C. Shilling
- D. A. Herring
- D. Boric
- D. C. Welten
- D. J. Ortner
- D. P. Gerven Van
- D. W. Sellen
- E. A. Hooton
- E. C. Scott
- E. C. Scott
- E. C. Scott
- E. Messer
- E. Rega
- E. Said
- F. E. Johnston
- F. E. Johnston
- F. E. Johnston
- G. Ascádi
- G. G. Politis
- G. Lillehammer
- H. Barry
- H. Cunningham
- H. R. Buckley
- J. A. Tainter
- J. B. Ritchie
- J. Benthall
- J. E. Baxter
- J. E. Buikstra
- J. E. Buikstra
- J. E. Ericson
- J. G. D. Clark
- J. Ginn
- J. L. Scheuer
- J. L. Scheuer
- J. L. Scheuer
- J. P. Bocquet-Appel
- J. Qvortrup
- J. R. Sofaer
- J. R. Sofaer Derevenski
- J. R. Sofaer Derevenski
- J. Robb
- J. Robb
- J. W. Wood
- J. Wileman
- J. Winberg
- K. A. Kamp
- K. A. Kamp
- K. A. Kamp
- K. A. Kamp
- K. A. Kamp
- K. L. Kramer
- K. L. Kramer
- K. M. Domett
- K. M. Weiss
- K. O. Lorentz
- K. O. Lorentz
- K. S. Lesick
- L. E. Wright
- L. Meskell
- L. T. Humphrey
- L. Wilkie
- M. A. Katzenberg
- M. A. Perry
- M. Bluebond-Langner
- M. Cain
- M. Cox
- M. D. Hamilton
- M. E. Lewis
- M. E. Lewis
- M. E. Lewis
- M. E. Lewis
- M. E. Lewis
- M. E. Lewis
- M. Fortes
- M. Harman
- M. Nag
- M. P. Richards
- M. R. Schurr
- M. S. Kuefler
- N. A. Rothschild
- N. Finlay
- N. Scheper-Hughes
- N. Scheper-Hughes
- N. Stoodley
- Nancy Tayles
- O. Nieuwenhuys
- P. Ariès
- P. Bennike
- P. J. Brown
- P. J. Ucko
- P. Murail
- P. N. Stearns
- P. Wason
- R. A. Bentley
- R. A. Bentley
- R. A. Joyce
- R. D. Hoppa
- R. L. Gowland
- R. L. Gowland
- R. L. Tompkins
- R. Martin
- R. W. Jamieson
- R. W. Park
- S. A. Mays
- S. A. Mays
- S. A. Mays
- S. Beauvoir de
- S. Crawford
- S. E. Halcrow
- S. H. Katz
- S. J. Gould
- S. R. Saunders
- S. R. Saunders
- S. Shahar
- S. Voutsaki
- S. Washburn
- Siân E. Halcrow
- T. W. McDade
- T. Waldron
- UNICEF
- V. Caputo
- V. Maher
- W. A. Corsaro
- W. R. Trevathan
- Y. Heuzé
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
- Author
- A Gordon Robertson
- Abdullah Kahraman
- Abel Gonzalez-Perez
- Adam A Margolin
- Adam Abeshouse
- Adam Grundhoff
- Adam J Struck
- Adam J Struck
- Adam J Wright
- Adam Lambert
- Adam P Butler
- Adam P Butler
- Adel El-Naggar
- Adnan M Nagrial
- Adrian Ally
- Adrian Baez-Ortega
- Adrian Thorogood
- Adriana Salcedo
- Adrienne M Flanagan
- Ake Borg
- Akihiro Fujimoto
- Akihiro Suzuki
- Akinyemi I Ojesina
- Alain Viari
- Alan J Robertson
- Alan P Hoyle
- Alan Thompson
- Alasdair Stenhouse
- Alastair M Thompson
- Aldo Scarpa
- Alessandro Pastore
- Alex Buchanan
- Alex Buchanan
- Alexander Claviez
- Alexander J Lazar
- Alexander Martinez-Fundichely
- Alfonso Muñoz
- Alfonso Valencia
- Aliaksei Z Holik
- Alice Meng
- Alicia L Bruzos
- Allison Creason
- Allison P Heath
- Alvin Wei Tian Ng
- Alvis Brazma
- Amaro Taylor-Weiner
- Amber L Johns
- Amie Radenbaugh
- Amit G Deshwar
- Ana Dueso-Barroso
- Ana Mijalkovic Mijalkovic-Lazic
- Ana Milovanovic
- Ana Milovanovic
- Andre Kahles
- Andrea Haake
- Andrea Holbrook
- Andrea L Richardson
- Andrea Mafficini
- Andrea Ruzzenente
- Andreas Behren
- Andreas Rosenwald
- Andreia V Pinho
- Andrew Berchuck
- Andrew D Cherniack
- Andrew J Dunford
- Andrew J Mungall
- Andrew J Spillane
- Andrew Menzies
- Andrew Menzies
- Andrew P Barbour
- Andrew Tutt
- Andrew V Biankin
- Andrey Korshunov
- Andrés Lanzós
- Andy Cafferkey
- Andy G Lynch
- Angela Chou
- Angela N Brooks
- Angela Tam
- Angelica Ochoa
- Angelika N Christ
- Angelo P Dei Tos
- Anieta M Sieuwerts
- Anil K Sood
- Anita Langerød
- Anja Füllgrabe
- Anke K Bergmann
- Ann-Marie Patch
- Anna deFazio
- Anna Ehinger
- Anna Fitzgerald
- Anne Hamilton
- Anne Vincent-Salomon
- Anne Y Warren
- Anne-Lise Børresen-Dale
- Annegien Broeks
- Anthony DiBiase
- Anthony J Gill
- Anthony Ng
- Anthony R Green
- Antonia L Pritchard
- Antonio Pea
- Antonios Koures
- Aparna Prasad
- Apurva M Hegde
- Aquila Fatima
- Arcadi Navarro
- Arie B Brinkman
- Arif O Harmanci
- Arindam Maitra
- Armando Lopez-Guillermo
- Arndt Borkhardt
- Arnoud Boot
- Asger Hobolth
- Ashley Williams
- Ashton A Connor
- Atul J Butte
- Aurélien Chateigner
- Austin J Hepperla
- Axel Aretz
- Aya Sasaki-Oku
- Ayellet V Segre
- B F Francis Ouellette
- Bailey Matthew H
- Barbara Hutter
- Barbara Hutter
- Barbara Kremeyer
- Bartha M Knoppers
- Beifang Niu
- Beifang Niu
- Beifang Niu
- Benedikt Brors
- Benita Kiat Tee Tan
- Benjamin J Raphael
- Benjamin P Berman
- Benjamin Raeder
- Bernardo Rodriguez-Martin
- Bernhard Radlwimmer
- Bernice H Wong
- Beth Karlan
- Bin Tean Teh
- Bin Zhu
- Birgit Burkhardt
- Bishoy M Faltas
- Bodil Bjerkehagen
- Bogdan Czerniak
- Boris Winterhoff
- Borislav C Rusev
- Bradly G Wouters
- Brandi N Davis-Dusenbery
- Brian Craft
- Brian D O'Connor
- Brian Patrick O'Neill
- Brice Aminou
- Calvin Wing Yiu Chan
- Cameron M Soulette
- Carl Herrmann
- Carl Morrison
- Carlo Gambacorti-Passerini
- Carlos Caldas
- Carlos D Bustamante
- Carlos López-Otín
- Carlota Rubio-Perez
- Carmen Gomez
- Carolien H M van Deurzen
- Carolyn M Hutter
- Carolyn M Hutter
- Carrie Cibulskis
- Caterina Vicentini
- Catherine A Shang
- Catherine D Moser
- Catherine J Kennedy
- Catrina C Fronick
- Chad J Creighton
- Chandra Sekhar Pedamallu
- Chang Li
- Charles David Imbusch
- Charles M Perou
- Charles Saller
- Charles Short
- Charlie E Massie
- Chawalit Pairojkul
- Chen Hong
- Chen Ye
- Cheng-Zhong Zhang
- Chin-Lee Wu
- Chip Stewart
- Chip Stewart
- Chip Stewart
- Choon Kiat Ong
- Chris Lawerenz
- Chris Mitchell
- Chris Sander
- Christian von Mering
- Christiane Buchholz
- Christina K Yung
- Christina K Yung
- Christina Yau
- Christine A Iacobuzio-Donahue
- Christine Chomienne
- Christine Desmedt
- Christine P'ng
- Christof von Kalle
- Christoph Borst
- Christoph Plass
- Christopher A Miller
- Christopher Benz
- Christopher J Scarlett
- Christopher J Yoon
- Christopher K Wong
- Christopher M Lalansingh
- Christopher M Lalansingh
- Christopher Ogden
- Christopher S Foster
- Christopher Umbricht
- Christopher W Toon
- Christos Sotiriou
- Cindy Bell
- Cinzia Cantù
- Ciyue Shen
- Claes Wadelius
- Clare Verrill
- Clarissa Gerhauser
- Claudia Calabrese
- Claudio Bassi
- Claudio Luchini
- Claudiu Farcas
- Clemency Jolly
- Colin A Purdie
- Colin A Semple
- Colin C Collins
- Colin S Cooper
- Conrad R Leonard
- Constance H Li
- Corbin D Jones
- Craig Shriver
- Cristina López
- Cyriac Kandoth
- Cyril Fisher
- D Neil Hayes
- Dai-Ying Wu
- Daiming Fan
- Daisuke Komura
- Dale W Garsed
- Daniel A Leongamornlert
- Daniel Baumhoer
- Daniel Hübschmann
- Daniel J Turner
- Daniel J Weisenberger
- Daniel M Berney
- Daniel Rosebrock
- Daniel S Brewer
- Daniela S Gerhard
- Danielle Pasternack
- Darell Bigner
- Dariush Etemadmoghadam
- Darlene Lee
- Darrin F Taylor
- Dave Larson
- David A Wheeler
- David A Wheeler
- David C Wedge
- David Craft
- David D L Bowtell
- David E Neal
- David Haan
- David Haussler
- David Haussler
- David Hedley
- David Huntsman
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- David J Adams
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- Veronica Y Sabelnykova
- Victor Reuter
- Vikram Deshpande
- Viktoriya Korchina
- Ville Mustonen
- Vinayak Bhandari
- Vincent Ferretti
- Vincent Huang
- Vincent Huang
- Vincent J Gnanapragasam
- Vincent Khoo
- Vincenzo Corbo
- Vishal S Chandan
- Volker Hovestadt
- W Kimryn Rathmell
- W M Linehan
- Walker Hale
- Wan Choi
- Wanding Zhou
- Wang Liang-Bo
- Weerasinghe Amila
- Wei Jiao
- Wendl Michael C
- Wenyi Wang
- Wenyi Wang
- Wenyi Wang
- Wheeler David A
- William B Isaacs
- William C Faquin
- William Friedman
- William Howat
- William U Meyerson
- Willie Yu
- Winghing Wong
- Wojciech Bazant
- Wolfgang Huber
- Wolfram Klapper
- Xavier Estivill
- Xavier Pivot
- Xiao Xiao
- Xiaobo Li
- Xiaoping Su
- Xiaotong Li
- Xiaotong Yao
- Xing Hua
- Xingmin Liu
- Xinyue Li
- Xiuqing Zhang
- Xiuqing Zheng
- Xose S Puente
- Xuan Le
- Xuanping Zhang
- Xuemei Luo
- Xueqing Zou
- Yan Shi
- Yan Zhang
- Yang Wu
- Yang Yang
- Yann Joly
- Yanxun Xu
- Yao He
- Yasin Senbabaoglu
- Yassen Assenov
- Yasser Riazalhosseini
- Yasuhito Arai
- Yasushi Rino
- Yasushi Totoki
- Yeng Ang
- Yi Huang
- Yi Huang
- Yifei Men
- Yiling Lu
- Yilong Li
- Yingyan Yu
- Yiwen Chen
- Yogesh Kumar
- Yogesh Kumar
- Yoke-Eng Chiew
- Yong Hou
- Yong Zhou
- Yong-Jie Lu
- Yongzhan Nie
- Yosef E Maruvka
- Yosef E Maruvka
- Yoshiiku Kawakami
- Young Seok Ju
- Youngchoon Woo
- Youngil Koh
- Youngwook Kim
- Youyong Lu
- Yu Fan
- Yu Fan
- Yu Fan
- Yu-Jia Shiah
- Yuan Ji
- Yuan Yuan
- Yuichi Shiraishi
- Yulia Newton
- Yulia Rubanova
- Yumeng Wang
- Yupeng Cun
- Yussanne Ma
- Zachary Heins
- Zechen Chong
- Zechen Chong
- Zemin Zhang
- Zhaohong Chen
- Zhenggang Wu
- Zhenggang Wu
- Zhining Wang
- Zhongming Zhao
- Ziao Lin
- Zsofia Kote-Jarai
- Ólafur Andri Stefánsson
- Øystein Garred
- Publication venue
- Nature Communications
- Publication date
- 01/01/2020
- Field of study
Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts
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