108 research outputs found
On the Schoenberg Transformations in Data Analysis: Theory and Illustrations
- Author
- AN KOLMOGOROV
- B Schölkopf
- BENZĂCRI J-P, and collaborators
- C Berg
- C Micchelli
- CH Fitzgerald
- CKI WILLIAMS
- CM CUADRAS
- CR RAO
- D Alpay
- D Chen
- F BAVAUD
- F Bavaud
- F CRITCHLEY
- FR HAMPEL
- François Bavaud
- G Christakos
- G Young
- I Borg
- IJ SCHOENBERG
- IJ SCHOENBERG
- IJ SCHOENBERG
- J Neumann von
- JC GOWER
- JC GOWER
- KV Mardia
- L Lebart
- LM BLUMENTHAL
- M Greenacre
- ML STEIN
- N Cristianini
- NA CAMPBELL
- R Bhatia
- R SCHILLING
- RA FISHER
- RA HORN
- S Bernstein
- S Joly
- S Verboven
- T Hofmann
- VN VAPKNIK
- W HĂ€rdle
- WS TORGESON
- Publication venue
- Publication date
- 01/04/2010
- Field of study
The class of Schoenberg transformations, embedding Euclidean distances into
higher dimensional Euclidean spaces, is presented, and derived from theorems on
positive definite and conditionally negative definite matrices. Original
results on the arc lengths, angles and curvature of the transformations are
proposed, and visualized on artificial data sets by classical multidimensional
scaling. A simple distance-based discriminant algorithm illustrates the theory,
intimately connected to the Gaussian kernels of Machine Learning
Termination of the leprosy isolation policy in the US and Japan : Science, policy changes, and the garbage can model
- Author
- Anonymous
- Anonymous
- Anonymous
- B Campbell
- B Latour
- C Londblom
- C Weiss
- CE Lindblom
- CE Lindblom
- CE Snare
- CO Jones
- D Collingridge
- D Miller
- D Nelkin
- DM Hart
- E Bardach
- E Bardach
- E Riddell-Dixon
- F Otani
- F Otani
- F Otani
- F Otani
- FC Lendrum
- Federation of National LeprosariumPatients [Zenkoku Kokuritsu Rai Ryoyojo Kanja Kyogikai] (FNLP)
- FNLP
- FNLP
- FNLP
- FNLP
- FNLP
- FNLP
- G Walt
- GA Ryrie
- GH Faget
- GH Faget
- GH Faget
- GW McCoy
- GW McCoy
- H Sato
- H Sato
- HD Lasswell
- HD Lasswell
- HS Cumming
- J Brandl
- J Lowe
- J Moon
- J van der Sluijs
- J van Eijndhoven
- Japan Medical Abstracts Society
- Japan Ministry of Health Labpr and Welfare, Minister's Secretariat, Statistics and Information Department
- Japanese Leprosy Association Committee on Leprosy Prevention Law
- JB Richmond
- JE Frantz
- JE Frantz
- JL Walker
- JW Doig
- JW Kingdon
- K Inoue
- K Mitsuda
- K Saikawa
- K Saikawa
- KJ Mueller
- LB Valencia
- LM Balina
- LM Bechelli
- LM Irgens
- M Cohen
- M Mulkay
- M Narita
- M Nishiura
- M Schneider
- M Terris
- MA Peterson
- MA Peterson
- MG Hermann
- MJ Goodman
- MR Daniels
- National Library of Medicine
- NC Roberts
- NE Wayson
- NW Polsby
- OE Denney
- OW Hasselblad
- P Applebome
- P DeLeon
- P DeLeon
- P Mindes
- P Starr
- P Thomas
- Plaintiff Group for Apology and Compensation
- PT Erickson
- R von Schomberg
- R Yin
- RD Behn
- RD Behn
- RG Reilly
- RP Biller
- RR Nelson
- S Jasanoff
- S Jasanoff
- S Stein
- S Stein
- S Stein
- S Stein
- S Yamamoto
- S Yamamoto
- S Yamamoto
- SR Hanney
- T Yoshinaga
- TF Davey
- The Japanese Leprosy Association
- TR Oliver
- TR Oliver
- TR Oliver
- US Code of Federal Regulations 40 FR 25816 (Part 32)
- US Committee on Public Health and National Quarantine
- US House of Representatives
- US House of Representatives
- US House of Representatives
- US House of Representatives
- US House of Representatives
- US House of Representatives
- US Public Health Service
- US Public Health Service
- US Public Health Service Hospital Carville, Louisiana
- US Public Law 105-78
- US Public Law 107-220
- US Public Law 64-299
- US Public Law 78-410
- US Public Law 80-781
- US Public Law 97-35 Subtitle J
- US Public Law 98-525
- US Public Law 99-117
- US Senate
- US Senate
- US Senate
- WH Jopling
- WHO Expert committee on leprosy
- WHO Expert committee on leprosy
- WHO Expert Committee on Leprosy
- World Health Organization (WHO) Expert committee on leprosy
- Y Hayashi
- Z Gussow
- Z Gussow
- Publication venue
- BioMed Central
- Publication date
- 01/01/2005
- Field of study
BACKGROUND: In both the US and Japan, the patient isolation policy for leprosy /Hansen's disease (HD) was preserved along with the isolation facilities, long after it had been proven to be scientifically unnecessary. This delayed policy termination caused a deprivation of civil liberties of the involuntarily confined patients, the fostering of social stigmas attached to the disease, and an inefficient use of health resources. This article seeks to elucidate the political process which hindered timely policy changes congruent with scientific advances. METHODS: Examination of historical materials, supplemented by personal interviews. The role that science played in the process of policy making was scrutinized with particular reference to the Garbage Can model. RESULTS: From the vantage of history, science remained instrumental in all period in the sense that it was not the primary objective for which policy change was discussed or intended, nor was it the principal driving force for policy change. When the argument arose, scientific arguments were employed to justify the patient isolation policy. However, in the early post-WWII period, issues were foregrounded and agendas were set as the inadvertent result of administrative reforms. Subsequently, scientific developments were more or less ignored due to concern about adverse policy outcomes. Finally, in the 1980s and 1990s, scientific arguments were used instrumentally to argue against isolation and for the termination of residential care. CONCLUSION: Contrary to public expectations, health policy is not always rational and scientifically justified. In the process of policy making, the role of science can be limited and instrumental. Policy change may require the opening of policy windows, as a result of convergence of the problem, policy, and political streams, by effective exercise of leadership. Scientists and policymakers should be attentive enough to the political context of policies
Pan-cancer analysis of whole genomes
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- The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium View Correspondence (jump link)
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- Publication venue
- Publication date
- 11/12/2019
- Field of study
Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe
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- Aarrestad TK
- Aarup Petersen H
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- Publication venue
- Elsevier
- Publication date
- 02/02/2024
- Field of study
Data availability:
Release and preservation of data used by the CMS Collaboration as the basis for publications is guided by the CMS policy as stated in âCMS data preservation, re-use and open access policyâ available online at: https://cms-docdb.cern.ch/cgi-bin/PublicDocDB/RetrieveFile?docid=6032&filename=CMSDataPolicyV1.2.pdf&version=2 .A preprint of this article is available online at arXiv:2311.03261v2 [hep-ex] https://arxiv.org/abs/2311.03261v2 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/TOP-22-010 (CMS Public Pages)A search is presented for new Higgs bosons in proton-proton (pp) collision events in which a same-sign top quark pair is produced in association with a jet, via the pp â tH/A â ttÂŻc and pp â tH/A â ttÂŻu processes. Here, H and A represent the extra scalar and pseudoscalar boson, respectively, of the second Higgs doublet in the generalized two-Higgs-doublet model (g2HDM). The search is based on pp collision data collected at a center-of-mass energy of 13 TeV with the CMS detector at the LHC, corresponding to an integrated luminosity of 138 fbâ1. Final states with a same-sign lepton pair in association with jets and missing transverse momentum are considered. New Higgs bosons in the 200-1000 GeV mass range and new Yukawa couplings between 0.1 and 1.0 are targeted in the search, for scenarios in which either H or A appear alone, or in which they coexist and interfere. No significant excess above the standard model prediction is observed. Exclusion limits are derived in the context of the g2HDM.SCOAP3
Recommended from our members
Measurement of the Higgs boson production via vector boson fusion and its decay into bottom quarks in proton-proton collisions at sâ = 13 TeV
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- Publication venue
- Springer Nature on behalf of SISSA
- Publication date
- 30/01/2024
- Field of study
A preprint version of the article is available at arXiv:2308.01253v2 [hep-ex], https://arxiv.org/abs/2308.01253v2 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/HIG-22-009 (CMS Public Pages). Report number: CMS-HIG-22-009, CERN-EP-2023-110.A measurement of the Higgs boson (H) production via vector boson fusion (VBF) and its decay into a bottom quark-antiquark pair (bbÂŻ) is presented using proton-proton collision data recorded by the CMS experiment at sâ = 13 TeV and corresponding to an integrated luminosity of 90.8 fbâ1. Treating the gluon-gluon fusion process as a background and constraining its rate to the value expected in the standard model (SM) within uncertainties, the signal strength of the VBF process, defined as the ratio of the observed signal rate to that predicted by the SM, is measured to be ÎŒqqHHbbÂŻ = 1.01 +0.55â0.46. The VBF signal is observed with a significance of 2.4 standard deviations relative to the background prediction, while the expected significance is 2.7 standard deviations. Considering inclusive Higgs boson production and decay into bottom quarks, the signal strength is measured to be ÎŒincl.HbbÂŻ = 0.99 +0.48â0.41, corresponding to an observed (expected) significance of 2.6 (2.9) standard deviations.SCOAP3, STFC; Marie-Curie program and the European Research Council and Horizon 2020 Gran
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Search for direct production of GeV-scale resonances decaying to a pair of muons in proton-proton collisions at sâ = 13 TeV
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- Aarup Petersen H
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- Publication venue
- Springer Nature on behalf of SISSA
- Publication date
- 30/11/2023
- Field of study
A preprint version of the article is available at arXiv:2309.16003v2 [hep-ex], https://arxiv.org/abs/2309.16003v2 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables, including additional supplementary figures, can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/EXO-21-005 (CMS Public Pages). Report number: CMS-EXO-21-005, CERN-EP-2023-165.A search for direct production of low-mass dimuon resonances is performed using sâ = 13 TeV proton-proton collision data collected by the CMS experiment during the 2017-2018 operation of the CERN LHC with an integrated luminosity of 96.6 fbâ1. The search exploits a dedicated high-rate trigger stream that records events with two muons with transverse momenta as low as 3 GeV but does not include the full event information. The search is performed by looking for narrow peaks in the dimuon mass spectrum in the ranges of 1.1-2.6 GeV and 4.2-7.9 GeV. No significant excess of events above the expectation from the standard model background is observed. Model-independent limits on production rates of dimuon resonances within the experimental fiducial acceptance are set. Competitive or world's best limits are set at 90% confidence level for a minimal dark photon model and for a scenario with two Higgs doublets and an extra complex scalar singlet (2HDM+S). Values of the squared kinetic mixing coefficient Δ2 in the dark photon model above 10â6 are excluded over most of the mass range of the search. In the 2HDM+S, values of the mixing angle sin(ΞH) above 0.08 are excluded over most of the mass range of the search with a fixed ratio of the Higgs doublets vacuum expectation tanÎČ = 0.5.SCOAP3
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- Zuolo D
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 17/07/2023
- Field of study
A preprint version of the article is available at arXiv - https://arxiv.org/abs/2210.08325The path-length dependent parton energy loss within the dense partonic
medium created in lead-lead collisions at a nucleon-nucleon center-of-mass energy of
âsNN = 5.02TeV is studied by determining the azimuthal anisotropies for dijets with
high transverse momentum. The data were collected by the CMS experiment in 2018
and correspond to an integrated luminosity of 1.69nbâ1. For events containing back-to
back jets, correlations in relative azimuthal angle and pseudorapidity (η) between jets and
hadrons, and between two hadrons, are constructed. The anisotropies are expressed as the
Fourier expansion coefficients vn, n = 2â4 of these azimuthal distributions. The dijet vn
values are extracted from long-range (1.5 < |âη| < 2.5) components of these correlations,
which suppresses the background contributions from jet fragmentation processes. Positive
dijet v2 values are observed which increase from central to more peripheral events, while
the v3 and v4 values are consistent with zero within experimental uncertainties.SCOAP
Recommended from our members
Search for WâČ bosons decaying to a top and a bottom quark in leptonic final states in proton-proton collisions at sâ = 13 TeV
- Author
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- Publication venue
- Springer Nature
- Publication date
- 05/04/2024
- Field of study
A preprint version of the article is available at arXiv:2310.19893v1 [hep-ex], https://arxiv.org/abs/2310.19893v1 . Comments: Submitted to the Journal of High Energy Physics. All figures and tables can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/B2G-20-012 (CMS Public Pages). Report number: CMS-B2G-20-012, CERN-EP-2023-213.A search for W' bosons decaying to a top and a bottom quark in final states including an electron or a muon is performed with the CMS detector at the LHC. The analyzed data correspond to an integrated luminosity of 138 fb^{-1} of proton-proton collisions at a center-of-mass energy of 13 Tev. Good agreement with the standard model expectation is observed and no evidence for the existence of the W' boson is found over the mass range examined. The largest observed deviation from the standard model expectation is found for a W' boson mass (mWâČ) hypothesis of 3.8 TeV with a relative decay width of 1%, with a local (global) significance of 2.6 (2.0) standard deviations. Upper limits on the production cross sections of W' bosons decaying to a top and a bottom quark are set. Left- and right-handed W' bosons with mWâČ below 3.9 and 4.3 TeV, respectively, are excluded at the 95% confidence level, under the assumption that the new particle has a narrow decay width. Limits are also set for relative decay widths up to 30%. These are the most stringent limits to date on this W' boson decay channel.SCOAP3
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- Yao Y
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- Yockey H
- Yohay R
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- Yoo J
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- Yumiceva F
- Yusuff I
- Zabi A
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- Zalewski P
- Zanetti M
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- Zeinali M
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- Zghiche A
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- Zhizhin I
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- Zimermmane Castro Santos A
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- Zygala L
- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 27/07/2023
- Field of study
A search for long-lived particles decaying in the outer regions of the CMS silicon tracker or in the calorimeters is presented. The search is based on a data sample of proton-proton collisions at âs = 13 TeV recorded with the CMS detector at the LHC in 2016â2018, corresponding to an integrated luminosity of 138 fbâ1. A novel technique, using nearly trackless and out-of-time jet information combined in a deep neural network discriminator, is employed to identify decays of long-lived particles. The results are interpreted in a simplified model of chargino-neutralino production, where the neutralino is the next-to-lightest supersymmetric particle, is long-lived, and decays to a gravitino and either a Higgs or Z boson. This search is most sensitive to neutralino proper decay lengths of approximately 0.5 m, for which masses up to 1.18 TeV are excluded at 95% confidence level. The current search is the best result to date in the mass range from the kinematic limit imposed by the Higgs boson mass up to 1.8 TeV.SCOAP
Recommended from our members
Search for long-lived heavy neutral leptons with lepton flavour conserving or violating decays to a jet and a charged lepton
- Author
- Aarrestad TK
- Aarup Petersen H
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- Abbiendi G
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- Publication venue
- Springer Nature on behalf of SISSA
- Publication date
- 19/03/2024
- Field of study
A preprint version of the article is available at arXiv:2312.07484v3 [hep-ex], https://arxiv.org/abs/2312.07484 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/EXO-21-013 (CMS Public Pages)A search for long-lived heavy neutral leptons (HNLs) is presented, which considers the hadronic final state and coupling scenarios involving all three lepton generations in the 2-20 GeV HNL mass range for the first time. Events comprising two leptons (electrons or muons) and jets are analyzed in a data sample of proton-proton collisions, recorded with the CMS experiment at the CERN LHC at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 138 fbâ1. A novel jet tagger, based on a deep neural network, has been developed to identify jets from an HNL decay using various features of the jet and its constituent particles. The network output can be used as a powerful discriminating tool to probe a broad range of HNL lifetimes and masses. Contributions from background processes are determined from data. No excess of events in data over the expected background is observed. Upper limits on the HNL production cross section are derived as functions of the HNL mass and the three coupling strengths VâN to each lepton generation â and presented as exclusion limits in the coupling-mass plane, as lower limits on the HNL lifetime, and on the HNL mass. In this search, the most stringent limit on the coupling strength is obtained for pure muon coupling scenarios; values of |VÎŒN|2 > 5 (4) Ă 10â7 are excluded for Dirac (Majorana) HNLs with a mass of 10 GeV at a confidence level of 95% that correspond to proper decay lengths of 17 (10) mm.SCOAP3
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