Twisting of light around rotating black holes

Kerr black holes are among the most intriguing predictions of Einstein's general relativity theory. These rotating massive astrophysical objects drag and intermix their surrounding space and time, deflecting and phase-modifying light emitted nearby them. We have found that this leads to a new relativistic effect that imposes orbital angular momentum onto such light. Numerical experiments, based on the integration of the null geodesic equations of light from orbiting point-like sources in the Kerr black hole equatorial plane to an asymptotic observer, indeed identify the phase change and wavefront warping and predict the associated light-beam orbital angular momentum spectra. Setting up the best existing telescopes properly, it should be possible to detect and measure this twisted light, thus allowing a direct observational demonstration of the existence of rotating black holes. Since non-rotating objects are more an exception than a rule in the Universe, our findings are of fundamental importance.Comment: Article: 18 pages (11 pages in form of an Appendix). Total number of figures:

Pan-cancer analysis of whole genomes

Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe

Multidecadal variability of summer temperature over Romania and its relation with Atlantic Multidecadal Oscillation

We investigate the multidecadal variability of summer temperature over Romania as measured at 14 meteorological stations with long term observational records. The dominant pattern of summer temperature variability has a monopolar structure and shows pronounced multidecadal variations. A correlation analysis reveals that these multidecadal variations are related with multidecadal variations in the frequency of four daily atmospheric circulation patterns from the North Atlantic region. It is found that, on multidecadal time scales, negative summer mean temperature (TT) anomalies are associated with positive sea level pressure (SLP) anomalies centered over the northern part of the Atlantic Ocean and Scandinavia and negative SLP anomalies centered over the northern part of Africa. It is speculated that a possible cause of multidecadal fluctuations in the frequency of these four patterns are the sea surface temperature anomalies associated to the Atlantic Multidecadal Oscillation. These results have implications for predicting the evolution of summer temperature over Romania on multidecadal time scales

Facilitating students’ proactive recipience of feedback with feedback portfolios

Feedback is most effective when students are active participants in the feedback process. However, students may need to be supported to become proactive recipients of feedback. This chapter discusses how feedback portfolios are potentially useful interventions that may facilitate students’ recipience skills of self-appraisal, goal-setting and self-regulation, and engagement and motivation. After reviewing the ways in which feedback portfolios appear to target recipience processes, we present a qualitative case study of students’ perceptions of a VLE-embedded feedback e-portfolio to understand more about the ways in which portfolios actually facilitate recipience skills, and whether any barriers are experienced by students. We also reflect on our student-staff partnership approach, particularly in relation to how this benefitted our case study data collection