69 research outputs found
Prevalence and architecture of de novo mutations in developmental disorders.
- Author
- Ahmed Munaza
- Aitken Stuart
- Akawi Nadia
- Alvi Mohsan
- Ambridge Kirsty
- Anjum Uruj
- Archer Hayley
- Armstrong Ruth
- Awada Jana
- Balasubramanian Meena
- Banka Siddharth
- Baralle Diana
- Barnicoat Angela
- Barrett Daniel M.
- Barrett Jeffrey C.
- Batstone Paul
- Baty David
- Bayzetinova Tanya
- Bennett Chris
- Berg Jonathan
- Bernhard Birgitta
- Bevan A. Paul
- Bitner-Glindzicz Maria
- Blair Edward
- Blyth Moira
- Bohanna David
- Bourdon Louise
- Bourn David
- Bradley Lisa
- Brady Angela
- Brent Simon
- Brewer Carole
- Brunstrom Kate
- Bunyan David J.
- Burn John
- Canham Natalie
- Castle Bruce
- Chandler Kate
- Chatzimichali Elena
- Cilliers Deirdre
- Clarke Angus
- Clasper Susan
- Clayton Stephen
- Clayton-Smith Jill
- Clowes Virginia
- Coates Andrea
- Cole Trevor
- Colgiu Irina
- Collins Amanda
- Collinson Morag N.
- Connell Fiona
- Cooper Nicola
- Cox Helen
- Cresswell Lara
- Cross Gareth
- Crow Yanick
- D'Alessandro Mariella
- Dabir Tabib
- Davidson Rosemarie
- Davies Sally
- de Vries Dylan
- Dean John
- Deshpande Charu
- Devlin Gemma
- Dixit Abhijit
- Dobbie Angus
- Donaldson Alan
- Donnai Dian
- Donnelly Carina
- Donnelly Deirdre
- Douglas Angela
- Douzgou Sofia
- Duncan Alexis
- Eason Jacqueline
- Ellard Sian
- Ellis Ian
- Elmslie Frances
- Evans Karenza
- Everest Sarah
- Fendick Tina
- Firth Helen V.
- Fisher Richard
- Fitzgerald Tomas W.
- FitzPatrick David R.
- Flinter Frances
- Foulds Nicola
- Fry Andrew
- Fryer Alan
- Gardiner Carol
- Gaunt Lorraine
- Ghali Neeti
- Gibbons Richard
- Gill Harinder
- Goodship Judith
- Goudie David
- Gray Emma
- Green Andrew
- Greene Philip
- Greenhalgh Lynn
- Gribble Susan
- Harrison Lucy
- Harrison Rachel
- Harrison Victoria
- Hawkins Rose
- He Liu
- Hellens Stephen
- Henderson Alex
- Hewitt Sarah
- Hildyard Lucy
- Hobson Emma
- Holden Simon
- Holder Muriel
- Holder Susan
- Hollingsworth Georgina
- Homfray Tessa
- Humphreys Mervyn
- Hurles Matthew E.
- Hurst Jane
- Hutton Ben
- Ingram Stuart
- Irving Melita
- Islam Lily
- Jackson Andrew
- Jarvis Joanna
- Jenkins Lucy
- Johnson Diana
- Jones Elizabeth
- Jones Philip
- Jones Wendy D.
- Josifova Dragana
- Joss Shelagh
- Kaemba Beckie
- Kaplanis Joanna
- Kazembe Sandra
- Kelsell Rosemary
- Kerr Bronwyn
- King Daniel
- Kingston Helen
- Kini Usha
- Kinning Esther
- Kirby Gail
- Kirk Claire
- Kivuva Emma
- Kraus Alison
- Krishnappa Netravathi
- Kumar Dhavendra
- Kumar V. K. Ajith
- Lachlan Katherine
- Lam Wayne
- Lampe Anne
- Langman Caroline
- Lees Melissa
- Lim Derek
- Longman Cheryl
- Lowther Gordon
- Lynch Sally A.
- Magee Alex
- Maher Eddy
- Male Alison
- Mansour Sahar
- Marks Karen
- Martin Katherine
- Mason Laura E.
- Maye Una
- McCann Emma
- McConnell Vivienne
- McEntagart Meriel
- McGowan Ruth
- McKay Kirsten
- McKee Shane
- McMullan Dominic J.
- McNerlan Susan
- McRae Jeremy F.
- McWilliam Catherine
- Mehta Sarju
- Metcalfe Kay
- Middleton Anna
- Miedzybrodzka Zosia
- Miles Emma
- Mohammed Shehla
- Montgomery Tara
- Moore David
- Morgan Sian
- Morton Jenny
- Mugalaasi Hood
- Murday Victoria
- Murphy Helen
- Naik Swati
- Nellåker Chris
- Nemeth Andrea
- Nevitt Louise
- Newbury-Ecob Ruth
- Norman Andrew
- O'Shea Rosie
- Ogilvie Caroline
- Ong Kai-Ren
- Park Soo-Mi
- Parker Michael
- Parker Michael J.
- Patel Chirag
- Paterson Joan
- Payne Stewart
- Perrett Daniel
- Phipps Julie
- Pilz Daniela T.
- Pollard Martin
- Pottinger Caroline
- Poulton Joanna
- Pratt Norman
- Prescott Katrina
- Price Sue
- Pridham Abigail
- Prigmore Elena
- Procter Annie
- Purnell Hellen
- Quarrell Oliver
- Ragge Nicola
- Rahbari Raheleh
- Rajan Diana
- Randall Josh
- Rankin Julia
- Raymond Lucy
- Rice Debbie
- Robert Leema
- Roberts Eileen
- Roberts Gillian
- Roberts Jonathan
- Roberts Paul
- Ross Alison
- Rosser Elisabeth
- Saggar Anand
- Samant Shalaka
- Sampson Julian
- Sandford Richard
- Sarkar Ajoy
- Schweiger Susann
- Scott Richard
- Scurr Ingrid
- Selby Ann
- Seller Anneke
- Sequeira Cheryl
- Shannon Nora
- Sharif Saba
- Shaw-Smith Charles
- Shearing Emma
- Shears Debbie
- Sheridan Eamonn
- Sifrim Alejandro
- Simonic Ingrid
- Singh Tarjinder
- Singzon Roldan
- Skitt Zara
- Smith Audrey
- Smith Kath
- Smithson Sarah
- Sneddon Linda
- Splitt Miranda
- Squires Miranda
- Stewart Fiona
- Stewart Helen
- Straub Volker
- Suri Mohnish
- Sutton Vivienne
- Swaminathan Ganesh Jawahar
- Sweeney Elizabeth
- Tatton-Brown Kate
- Taylor Cat
- Taylor Rohan
- Tein Mark
- Temple I. Karen
- Thomson Jenny
- Tischkowitz Marc
- Tivey Adrian R.
- Tomkins Susan
- Torokwa Audrey
- Treacy Becky
- Turner Claire
- Turnpenny Peter
- Tysoe Carolyn
- Vandersteen Anthony
- Varghese Vinod
- Vasudevan Pradeep
- Vijayarangakannan Parthiban
- Vogt Julie
- Wakeling Emma
- Wallwark Sarah
- Waters Jonathon
- Weber Astrid
- Wellesley Diana
- Whiteford Margo
- Widaa Sara
- Wilcox Sarah
- Wilkinson Emily
- Williams Denise
- Williams Nicola
- Wilson Louise
- Woods Geoff
- Wragg Christopher
- Wright Caroline F.
- Wright Michael
- Yates Laura
- Yau Michael
- Publication venue
- Nature
- Publication date
- 01/01/2017
- Field of study
The genomes of individuals with severe, undiagnosed developmental disorders are enriched in damaging de novo mutations (DNMs) in developmentally important genes. Here we have sequenced the exomes of 4,293 families containing individuals with developmental disorders, and meta-analysed these data with data from another 3,287 individuals with similar disorders. We show that the most important factors influencing the diagnostic yield of DNMs are the sex of the affected individual, the relatedness of their parents, whether close relatives are affected and the parental ages. We identified 94 genes enriched in damaging DNMs, including 14 that previously lacked compelling evidence of involvement in developmental disorders. We have also characterized the phenotypic diversity among these disorders. We estimate that 42% of our cohort carry pathogenic DNMs in coding sequences; approximately half of these DNMs disrupt gene function and the remainder result in altered protein function. We estimate that developmental disorders caused by DNMs have an average prevalence of 1 in 213 to 1 in 448 births, depending on parental age. Given current global demographics, this equates to almost 400,000 children born per year
The impact of immediate breast reconstruction on the time to delivery of adjuvant therapy: the iBRA-2 study
- Author
- Abdullah Nassreen
- Accurso Antonello
- Accurso Antonello
- Achuthan Raj
- Adam Rahma
- Adelekan Matthew
- Adwani Asha
- Aertssen Anna
- Agrawal Amit
- Agrawal Avi
- Ain Quratul
- Ainsworth Rachel
- Akerlund Malin
- Akolekar Deepika
- Alder Louise
- Alexander Susanna
- Ali Deedar
- Ali Rozina
- Allan Anna
- Allum William
- Aloraifi Fatima
- Amin Khalid
- Amorosi Vittoria
- Arif Tahera
- Armstrong Alexander
- Asaad Oubida
- Asgeirsson Kristjan
- Athanasiou Irene
- Audisio Riccardo
- Azmy Iman
- Bache Sarah
- Bains Salena
- Bajrusevic Sladana
- Balasubramanian Balapathiran
- Balata Safa Ahmed
- Bali Radhika
- Barnes Nicola
- Barnes Nicola LP
- Barrows Sara
- Barry Peter
- Barua Ellora
- Basu Naren
- Bathla Sonia
- Benyon Sarah L
- Bernaudo Lorenzo
- Bhaskar Pud
- Bibi Saira
- Biddle M
- Bignell Kym
- Biswas Bashishta
- Blazeby Jane
- Bourne Roger
- Brock Lisa
- Brown Victoria
- Bucata Claudiu
- Bucknor Alexandra
- Byrne Miriam
- Cain Henry
- Callaghan Maria
- Canny Rebecca
- Catanuto Giuseppe
- Cawthorn Simon
- Ceccarino Raffaele
- Chagla Leena
- Challoner Tom
- Chana Jagdeep
- Chand Natalie
- Chandrashekar Mysore
- Charalambous Michalis
- Charalampou-Dis Petros
- Chew Ben
- Chicken Dennis Wayne
- Chin Kian
- Chong Kelvin
- Choy Christina
- Christopoulos Petros
- Chrysafi Ada
- Clark Sarah
- Clarke Natalie
- Coco Guido
- Colizzi Livio
- Collab Breast Reconstruction Res
- Collis Nick
- Conroy Elizabeth
- Constantinou Chloe
- Critchley Adam
- Cullinane Carolyn
- Curnier Alain
- Curran Terry-Ann
- Dauria Marta
- Dave Rajiv
- Dave Rajiv V
- Dave Rajiv V
- Davey Simon
- de Sousa Emma
- Debanth Debasish
- Depasquale Ivan
- Devane Liam
- Dhooma Naseem
- Di Micco Rosa
- Dixon JM
- Dordea Matei
- Douek Michael
- Down Sue
- Downey Sarah
- Dragoumis Dimitris
- Dumitru Dorin
- Dunn Julie
- Durbar Michael
- El-Sharief Deena
- Elahi Bilal
- Elfadl Dalia
- Epurescu Daniel
- Evoy Denis
- Exarchos Georgios
- Fabio Santanelli di Pompeo
- Fafemi Oladapo
- Fage Elena
- Farrell Eric
- Ferguson Douglas
- Fiddes Roanne
- Figus Andrea
- Fopp Laura
- Foster Rachel
- Fuller Mairi
- Fustaino Loredana
- Gahir Jasdeep
- Gandamihardja Tasha
- Gandhi Ashu
- Gardiner Matthew
- Gardiner Matthew
- Garg Neeraj
- Garnsey Clare
- Geraghty James
- Geropantas Konstantinos
- Ghali Shadi
- Ghilli Matteo
- Gill Emma
- Goh Steven
- Govindarajulu Sasirekha
- Graja Tomasz
- Granger Emily
- Grassi Veronica
- Grover Kartikae
- Grp iBRA-2 Steering
- Guest Francesca
- Gui Gerald
- Gutteridge Eleanor
- Gvaramadze Anzors
- Hallam Kelly
- Hamad Ahmed
- Hamed Hisham
- Hamilton Stephen
- Hamnett Kathryn
- Hamo Ishrak
- Haq Anwar
- Harcourt Ruth
- Harding-MacKean Claudia
- Harnett Adrian
- Harnett Adrian
- Harnett Adrian
- Harris Chad
- Harris Kevin
- Harris Paul
- Harvey James
- Harvey Kate L
- Haywood Richard M
- Healy Samuel
- Henderson Julia
- Henry Francis P
- Hernan Izaro
- Heys Steven
- Hignett Susan
- Hill Arnold DK
- Hogan Brian
- Holcombe Chris
- Holcombe Chris
- Holcombe Chris
- Hollywood Ciaran
- Holt Simon
- Horgan Kieran
- Howes Rachel
- Hu Jennifer
- Humphreys Laura
- Hunter Judith
- Hussien Maged I
- Ihsan Naila
- Iqbal Azhar
- Irakleidis Foivos
- Irwin Gareth
- Irwin Michael S
- Isherwood Jennifer
- Ives Charlotte
- Jafferbhoy Sadaf
- Jafferbhoy Sadaf
- Jain Yogesh
- Jallali Navid
- James Karen
- James Ruth
- James Stuart
- Jibril Jibril A
- Jiwa Natasha
- Johns Neil
- Johnson Laura
- Johnson Richard
- Jones Ben Mancey
- Jones Robin
- Kalles Vasileios
- Kalra Loraine
- Kaushik Monika
- Kearns Marie
- Kelsall Jennett
- Kennedy Katy
- Kenny Frances
- Khalil Haitham
- Khan Mansoor
- Khan Shazia M
- Khattak Ilyas
- Khawaja Saira
- Khout Hazem
- Kirby Robert
- Kirchhoff Chris
- Kirkpatrick Katharine
- Kiruparan Pasupathy
- Kirwan Cliona C
- Kleidi Eleftheria
- Kneeshaw Peter
- Kokan Jalal
- Koris Jacob
- Kothari Ashutosh
- Kovacs Tibor
- Krupa Jaroslaw
- Krupa Katerine
- Kryjak Zbigniew
- Kulkarni Dhananjay
- Lai Lee Min
- Lambert Kelly
- Lampropoulos Pavlos
- Lane Risha
- Langlands Fiona
- Lansdown Mark
- Laurence Nicola
- Lawlor Catriona
- Laws Siobhan
- Ledwidge Serena
- Lee Jason
- Lewis Rebecca
- Li Alessandro Quattrini
- Liccardo Raffaele
- Limite Gennaro
- Lo Michelle
- Lund Jonathan
- Lymperopoulos N
- Maalo Joseph
- Mackay Iain
- MacLean Gael
- MacLennan Louise
- Macmillan Douglas
- MacNeill Fiona
- Mahapatra Tapan
- Majeed Yousef
- Malata Charles M
- Mallon Peter
- Malyon Andy
- Mansfield Lucy
- Mariniello Maria Donatella
- Marsh Daniel
- Marzia Lo Russo
- Masannat Yazan A
- Masood Mohammad
- Massey Julia
- Matey Pilar
- Mathen Vinod
- Mathew Tom
- Mazari Fayyaz
- McCartan Damian
- McCulley Stephen
- McDermott Enda
- McEvoy Kat
- McGill David
- McGuiness Caroline
- McIntosh Jamie
- McIntosh Stuart A
- Mckenzie Shireen
- McManus Penelope
- Mehmood Iftikhar
- Mehta Disha
- Michalakis Ioannis
- Michieletto Silvia
- Milligan Robert
- Misky Adam
- Mitchell Geraldine
- Monib Sherif
- Morgan Mary
- Morrison Colin
- Mortimer Caroline
- Mosahebi Afshin
- Moss Sarah
- Muhibullah Nazli
- Mullan Michelle
- Munot Kailas
- Murali Kothandaraman
- Murphy Claire
- Murphy Declan C
- Murphy John
- Mustafa Mohammed
- Mylvaganam Senthurun
- Nagachandra Geerthan
- Narayanan Sankaran
- Naseem Salma
- Nasr Rana
- Navin Channegowda
- Nguyen Dai
- Nizamoglu Metin
- O'Brien Ciara
- O'Brien Ciara
- O'Brien James
- O'Connell Rachel
- O'Connell Rachel L
- O'Donoghue Joe
- O'Leary Peter
- Okwemba Sylvia
- Oliver James
- Olsen Sisse
- Oluwajana Michael
- Otieno Charlene
- Pain Simon J
- Park Alan
- Parvanta Laila
- Patel Ashraf
- Patel Krupali
- Peel Anthony
- Pereira Bernadette
- Pereira Jerome
- Pikoulas Panagiotis
- Pilgrim Simon
- Piper Jenny
- Poonawala Shabbir
- Popa Elena
- Pope Vanessa
- Potter Shelley
- Potter Shelley
- Potter Shelley
- Power Kieran
- Prichard Ruth
- Prousskaia Elena
- Pujji Ojas
- Rainsbury Dick
- Ramakrishnan Venkat
- Ramsey Kelvin
- Rasheed Tuabin
- Rattay Tim
- Rattay Tim
- Ravichandran Duraisamy
- Ray Biswajit
- Rayter Zenon
- Refsum Sigi
- Reissis Dimitris
- Remoundos Dionysios Dennis
- Ribas Maria Dalmau
- Rizkalla Maged
- Rizki Hirah
- Rocco Nicola
- Roche Nicola
- Roncella Manuela
- Roshanlall Chandeena
- Rossetti Elena
- Rothwell Jane
- Roy Pankaj
- Rusby Jennifer
- Sahu Ajay
- Saibene Tania
- Saleem Talha
- Sami AS
- Sassoon EM
- Scott John
- Seetharam Seema
- Sethu Claire
- Seward Joanna
- Shanks Lindsay
- Shariaha Yousef
- Sherwin Liz
- Shetty Geeta
- Shokuhi Sheila
- Shrestha Deepak
- Sircar Tapan
- Sirianni Chiara
- Sirianni Chiara
- Sjokvist Olivia
- Skillman Joanna
- Skillman Joanna
- Slade-Sharman Diana
- Sloan Samantha
- Smyth Elizabeth
- Sojitra Nilesh
- Soulsby Rachel
- Soumian Soni
- Sowdi Ravi
- Stebbing Anne
- Sundaramoorthy Souganthy
- Sutton Richard
- Svenning Matilda
- Syed Farah
- Tadros Amir
- Taghizadeh Rieka
- Tansley Anne
- Tasoulis Marios
- Tayeh Salim
- Taylor Amanda
- Taylor Jevan
- Taylor Lauren
- Tebbal Sally
- Tevlin Ruth
- Thekkinkattil Dinesh
- Thomas Rachel Bright
- Thomson Simon
- Thorne Amanda
- Thrush Steven
- Tillett Rachel
- To Natalie
- Tomlins Abigail
- Trapszo Pawel
- Trickey Adam
- Turton Philip
- Udayasankar S
- Valassiadou Kalliope
- Verjee Liaquat S
- Vidya Raghavan
- Vigneswaran Natali
- Vinayagam Raman
- Vollermere Angela J
- Walker Philip
- Weiler-Mithoff Eva
- Weston-Petrides Gina
- Whisker Lisa
- Wilkins Alex
- Williamson Paula
- Wilson Rebecca
- Wilson Sherif
- Windle Rebecca
- Wintrip Dorothy
- Wood Simon
- Wooler Brendan
- Woollard Alex
- Woollard Alexander
- Yoshimura Ryo
- Young Oliver
- Younis Ibby
- Youssef Mina
- Zechmeister Katalin
- Zeidan Bashar
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Background:
Immediate breast reconstruction (IBR) is routinely offered to improve quality-of-life for women requiring mastectomy, but there are concerns that more complex surgery may delay adjuvant oncological treatments and compromise long-term outcomes. High-quality evidence is lacking. The iBRA-2 study aimed to investigate the impact of IBR on time to adjuvant therapy.
Methods:
Consecutive women undergoing mastectomy ± IBR for breast cancer July–December, 2016 were included. Patient demographics, operative, oncological and complication data were collected. Time from last definitive cancer surgery to first adjuvant treatment for patients undergoing mastectomy ± IBR were compared and risk factors associated with delays explored.
Results:
A total of 2540 patients were recruited from 76 centres; 1008 (39.7%) underwent IBR (implant-only [n = 675, 26.6%]; pedicled flaps [n = 105,4.1%] and free-flaps [n = 228, 8.9%]). Complications requiring re-admission or re-operation were significantly more common in patients undergoing IBR than those receiving mastectomy. Adjuvant chemotherapy or radiotherapy was required by 1235 (48.6%) patients. No clinically significant differences were seen in time to adjuvant therapy between patient groups but major complications irrespective of surgery received were significantly associated with treatment delays.
Conclusions:
IBR does not result in clinically significant delays to adjuvant therapy, but post-operative complications are associated with treatment delays. Strategies to minimise complications, including careful patient selection, are required to improve outcomes for patients
New genetic loci link adipose and insulin biology to body fat distribution.
- Author
- Aalto Ville
- Aasarød Knut
- Abecasis Goncalo R
- Abecasis Gonçalo
- Absher Devin
- Adair Linda S
- Adam Martin
- Adeyemo Adebowale
- Ahlqvist Emma
- Ahmadi Kourosh R
- Ahola Aila
- Ainali Chrysanthi
- Akylbekova Ermeg
- Ala-Korpela Mika
- Alavere Helen
- Albagha Omar M E
- Albrecht Eva
- Alen Markku
- Alexander Myriam
- Alhenc-Gelas François
- Alizadeh Behrooz Z
- Allison Matthew A
- Alonso Nerea
- Altshuler David
- Ambite Jose Luis
- Amin Najaf
- Amouyel Philippe
- An Ping
- Anderson Carl A
- Anderson Denise
- Anderson Garnet
- Andrews Jeanette S
- Antonella Mulas
- Antti Jula
- Aragaki Aaron K
- Arking Dan E
- Arnold Alice
- Arnold Alice M
- Arora Pankaj
- Arscott Gillian M
- Artigas Maria Soler
- Arveiler Dominique
- Asiki Gershim
- Aspelund Thor
- Assimes Themistocles L
- Atalay Mustafa
- Atkinson Elizabeth J
- Aulchenko Yurii
- Avery Christy
- Bain Stephen C
- Bakker Stephan J L
- Balcells Susana
- Balkau Beverley
- Ballantyne Christie M
- Balmforth Anthony J
- Bandinelli Stefania
- Barbalic Maja
- Barrett Amy
- Barroso Ines
- Barroso Inês
- Basart Hanneke
- Basart Hanneke V
- Bataille Veronique
- Baumert Jens
- Beckmann Jacques S
- Beekman Marian
- Been Latonya F
- Beilby John
- Beilby John P
- Bell Jordana T
- Bellis Claire
- Bennett Amanda J
- Bennett Franklyn
- Berenson Gerald S
- Bergman Richard N
- Bergmann Sven
- Berndt Sonja I
- Berne Christian
- Bidulescu Aurelian
- Bielak Lawrence F
- Bierut Laura J
- Biffar Reiner
- Bis Joshua C
- Blackburn Hannah
- Blangero John
- Blankenberg Stefan S
- Blüher Matthias
- Boban Mladen
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle Eric
- Boezen H Marike
- Bolton Jennifer L
- Bolton Judith A Hoffman
- Bonnet Fabrice
- Bonnycastle Lori L
- Boomsma Dorret I
- Borecki Ingrid
- Boright Andrew P
- Borja Judith B
- Bornstein Stefan R
- Boston Jonathan
- Bots Michiel L
- Bouatia-Naji Nabila
- Bouchard Claude
- Bovet Pascal
- Boyd Heather A
- Bragg-Gresham Jennifer L
- Brambilla Paolo
- Brand Eva
- Brand Stefan-Martin
- Brandi Maria Luisa
- Braund Peter S
- Brennan Eoin P
- Brismar Kerstin
- Brody Jennifer
- Broekmans Frank J
- Broer Linda
- Brown Matthew A
- Brown Morris J
- Brown-Gentry Kristin
- Bruinenberg Marcel
- Buchkovich Martin L
- Buckley Brendan M
- Buil Alfonso
- Bull Shelley B
- Burgdorf Christof
- Buring Julie E
- Burnett Mary S
- Burnier Michel
- Burri Andrea
- Burton Paul R
- Bush William S
- Busonero Fabio
- Buxbaum Sarah G
- Buyske Steve
- Buzkova Petra
- Byrne Enda M
- Böger Carsten A
- Böhringer Stefan
- Böttcher Yvonne
- Cambien Francois
- Campbell Harry
- Campbell Susan
- Carba Delia B
- Carlson Chris
- Carlson Olga D
- Carty Cara
- Casas Juan P
- Caspersen Ida H
- Castano-Betancourt Martha
- Cauchi Stéphane
- Cauley Jane A
- Caulfield Mark
- Cavalieri Margherita
- Cazier Jean-Baptiste
- Center Jacqueline R
- Cesana Giancarlo
- Chakravarti Aravinda
- Chambers John
- Chandak Giriraj R
- Chang Hsing-Yi
- Chang Yen-Pei C
- Chanock Stephen J
- Charchar Fadi J
- Chasman Dan
- Chaturvedi Nish
- Chen Constance
- Chen Han
- Chen Ida
- Chen Jin
- Chen Ming-Huei
- Chen Wei
- Chen Yii-Der Ida
- Cheng Iona
- Cheng Sulin
- Chines Peter S
- Cho Yoon Shin
- Choi Murim
- Chouraki Vincent
- Christiansen Claus
- Chu Audrey Y
- Cimponeriu Dan
- Ciullo Marina
- Clark Graeme R
- Clarke Robert
- Claudi-Boehm Simone
- Coassin Stefan
- Cochran Barbara
- Cole Shelley
- Colhoun Helen
- Colhoun Helen M
- Collins Francis S
- Collins Rory
- Connell John M
- Cooper Cyrus
- Cooper Jackie A
- Cooper Matthew N
- Cooper Richard S
- Coresh Josef
- Cornelis Marilyn C
- Corre Tanguy
- Corsi Anna Maria
- Couper David
- Cousminer Diana L
- Coviello Andrea D
- Cox David
- Crawford Dana
- Crisponi Laura
- Croteau-Chonka Damien C
- Cucca Francesco
- Cummings Steven R
- Cupples Adrienne L
- Cupples L Adrienne
- Curhan Gary
- d'Adamo Pio
- Dahgam Santosh
- Dailiana Zoe
- Danesh John
- Danoy Patrick
- Dastani Zari
- Davies Gail
- Daw E Warwick
- Day Felix R
- Day Ian N M
- de Andrade Mariza
- de Boer Ian H
- de Boer Rudolf A
- de Faire Ulf
- de Geus Eco J C
- Deary Ian J
- Dedoussis George
- Dedoussis George V
- Dedoussis George V Z
- Deelen Joris
- Deelman Ewa
- Dehghan Abbas
- Delgado Graciela
- Deloukas Panagiotis
- Deloukas Panos
- Demerath Ellen W
- Demirkan Ayse
- Demirkan Ayşe
- Den Hertog Heleen M
- Denniff Matthew
- Dennison Elaine M
- Dermitzakis Emmanouil T
- Deshmukh Harshal
- Deshmukh Harshal A
- Devuyst Olivier
- di Meglio Paola
- Diemert Patrick
- Dimas Antigone S
- Dimitriou Maria
- Ding Jingzhong
- Do Ron
- Dominiczak Anna F
- Doney Alex
- Dong Yanbin
- Donnelly Louise A
- Doumatey Ayo
- Dreisbach Albert W
- Drong Alexander W
- Duggan David
- Dumitrescu Logan
- Duncan Bruce B
- Duncan Emma L
- Dupuis Josee
- Dupuis Josée
- Durbin Richard
- Durda Peter
- Döring Angela
- Dörr Marcus
- Eastell Richard
- Easton Douglas F
- Ebrahim Shah
- Econs Michael J
- Edkins Sarah
- Egan Josephine
- Ehret Georg
- Eiriksdottir Gudny
- Eisman John A
- Eklund Niina
- El Mokhtari NourEddine
- Elks Cathy E
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- Eury Elodie
- Evangelou Evangelos
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- Ingle Catherine
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- van Meurs Joyve B J
- van Nierop Peter
- van Oort Floor V A
- van Pelt L Joost
- van Schoor Natasja M
- Van Vliet-Ostaptchouk Jana V
- van Wingerden Sophie
- van Wingerden Sophie W
- Van Zuydam Natalie
- Vandenput Liesbeth
- Varga Tibor V
- Vartiainen Erkki
- Vasan Ramachandran S
- Vedantam Sailaja
- Veldre Gudrun
- Verlaan Dominique
- Vernon Smith Albert
- Veronesi Giovanni
- Verweij Niek
- Verwoert Germaine
- Verwoert Germaine C
- Viigimaa Margus
- Viikari Jorma
- Vinay D G
- Vineis Paolo
- Vink Jacqueline M
- Virtamo Jarmo
- Visscher Peter M
- Visser Jenny A
- Vitart Veronique
- Vohl Marie-Claude
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- Volcik Kelly A
- Vollenweider Peter
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- Voorhuis Marlies
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- Völzke Henry
- Wadén Johan
- Waeber Gerard
- Waeber Gérard
- Wagenknecht Lynne E
- Waggott Daryl
- Wagner Peter J
- Wain Louise V
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- Waite Lindsay L
- Walker Mark
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- Wallaschofski Henri
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- Wang Jie Jin
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- Wang Xiaoling
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- Waterworth Dawn
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- Weedon Michael N
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- Wells George A
- Wennauer Roman
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- Wheeler Eleanor
- Wheeler Heather E
- Whincup Peter H
- Whitfield John B
- Wichmann H Erich
- Wichmann H-Erich
- Widen Elisabeth
- Wiggins Kerri L
- Wijmenga Cisca
- Wijnands-van Gent Colette J M
- Wild Philipp S
- Wild Sarah H
- Wilk Alicja
- Wilkens Lynne
- Willems Sara M
- Willemsen Gonneke
- Willemsvan-vanDijk Ko
- Willenborg Christina
- Willer Cristen J
- Williams Frances M K
- Williams Rasheeda
- Williams Winfred W
- Willner Dana
- Wilsgaard Tom
- Wilson James F
- Wilson James G
- Wilson Sarah
- Wilson Scott G
- Winkler Thomas
- Witteman Jacqueline C
- Witteman Jacqueline C M
- Wojczynski Mary K
- Wolffenbuttel Bruce H R
- Wong Andrew
- Wong Tien Y
- Woo Jean
- Wood Andrew R
- Wood Andy
- Workalemahu Tsegaselassie
- Wright Alan F
- Wu Chunyuan
- Wu Joseph M W
- Wu Ying
- Würtz Peter
- Xiao Su-Mei
- Yajnik Chittaranjan S
- Yang Jian
- Yang Qiong
- Yang Tsun-Po
- Yao Jie
- Yengo Loïc
- Yerges-Armstrong Laura M
- Young Alicia
- Young Elizabeth H
- Young J H
- Young Lauren
- Yuan Xin
- Zaboli Ghazal
- Zalloua Pierre A
- Zarrabeitia María T
- Zelenika Diana
- Zemunik Tatijana
- Zerbini Gianpaolo
- Zgaga Lina
- Zhai Guangju
- Zhang Feng
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng Hou-Feng
- Zheng Wei
- Zhou Yanhua
- Zhu Haidong
- Zhu Kun
- Zhu Xiaofeng
- Zhuang Wei V
- Zhuang Wei Vivian
- Ziegler Andreas
- Zillikens M Carola
- Zimmermann Martina E
- Zitting Paavo
- Zondervan Krina T
- Zukowska-Szczechowska Ewa
- Zygmunt Marek
- Ärnlöv Johan
- Österholm Anne-May
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
- Avis Terry
- Ayele Mulu
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- Bacon Joanne
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- Bailey Jonathan
- Bajorek Eva
- Baker Andrew
- Baker Dan
- Baker M.
- Baker Richard
- Bakis Michele
- Baldwin Jennifer
- Banda Michael
- Banerjee Ruby
- Bao Jingyue
- Bao Qiyu
- Bao Weidong
- Bao Weidong
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- Barbaria Joseph A.
- Barbe Valérie
- Bardill Simon
- Barker Daniel
- Barker Darren
- Barker Gary
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- Baron Laurent
- Barrett Anika
- Bartlett Rebecca
- Basham Victoria
- Bashman David
- Basu Suba
- Bateman Alex
- Bates Karen
- Battles John
- Batzer Mark
- Baumgart Cornelia
- Baumohl Jason
- Baynes Caroline
- Bayul Tashi
- Beall Keith
- Beard Lisa
- Beard Susan
- Beare David
- Beasley Alastair
- Beasley Helen
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- Beaudet Arthur
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- Bergmann Anne
- Berkowicz Nicolas
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- Bituin Aleksandr
- Black Stacey
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- Blair Jessica Anne
- Blakey Sarah
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- Chen Ray
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- Chen Yiyu
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- Chillingworth Neil
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- Hupman Matt
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- Idlebird Devincent G.
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- Imo Kelvin C.
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- Ince Michael
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- Ishibashi Akiko
- Ishikawa Sabine K.
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- Jaklevic Michael
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- Madabhushi Ramki
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- McNinch Jenny
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- Nakato Eriko
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- Nandkeshwar Richard
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- Naranjo Cleo M.
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- Nwokenkwo Stanley
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- Okumura Reina
- Okwuonu Geoffrey O.
- Okwuonu Kenneth C.
- Olarnpunsagoon Alisa
- Olivas Jason
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- Olsen Anne S.
- Olson Maynard V.
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- Ow David
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- Patel Bella Mayurkumar
- Patel Dina
- Patel Jalpa N.
- Patel Ritesh
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- Paul Shelia
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- Perez Lesette M.
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- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
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- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
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- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
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- Abdelmohsen K.
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- Publication venue
- Publication date
- 22/09/2015
- Field of study
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. For example, a key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process versus those that measure fl ux through the autophagy pathway (i.e., the complete process including the amount and rate of cargo sequestered and degraded). In particular, a block in macroautophagy that results in autophagosome accumulation must be differentiated from stimuli that increase autophagic activity, defi ned as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (inmost higher eukaryotes and some protists such as Dictyostelium ) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the fi eld understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. It is worth emphasizing here that lysosomal digestion is a stage of autophagy and evaluating its competence is a crucial part of the evaluation of autophagic flux, or complete autophagy. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. Along these lines, because of the potential for pleiotropic effects due to blocking autophagy through genetic manipulation it is imperative to delete or knock down more than one autophagy-related gene. In addition, some individual Atg proteins, or groups of proteins, are involved in other cellular pathways so not all Atg proteins can be used as a specific marker for an autophagic process. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field
Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study
- Author
- Abel K
- Adamali H.
- Adeloye D
- Adeyemi Oluwaseun
- Adrego Rita
- Aguilar Jimenez Laura A.
- Ahmad Haider N
- Ahmad Shanaz
- Ahmed R
- Ahwireng Nyarko
- Ainsworth Mark
- Al-Sheklly B.
- Alamoudi Asma
- Alfaro-Almagro Fidel
- Ali Mariam
- Aljaroof M
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- Allen R J
- Allerton Lisa
- Allsop Lynne
- Allt Ann Marie
- Almeida Paula
- Altmann Danny
- Alvarez Corral Maria
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- Arbane Gill
- Arias Ava Maria
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- Armstrong Natalie
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- Steiner Mike
- Stensel D.
- Stephens G
- Stephenson Lorraine
- Stern M
- Stewart I
- Stimpson R
- Stockdale Sue
- Stockley J
- Stoker Wendy
- Stone Roisin
- Storrar Will
- Storrie Andrew
- Storton Kim
- Stringer E
- Strong-Sheldrake Sophia
- Stroud Natalie
- Subbe Christian
- Sudlow C L
- Suleiman Z
- Summers C
- Summersgill C
- Sutherland Debbie
- Sykes D.L.
- Sykes R.
- Talbot Nick
- Tan Ai Lyn
- Tarusan Lawrence
- Tavoukjian Vera
- Taylor Abigail
- Taylor Chris
- Taylor Jessica
- Te Amelie
- Tedd H.
- Tee Caroline
- Teixeira J
- Tench Helen
- Terry Sarah
- Thackray-Nocera Susannah
- Thaivalappil Favas
- Thamu B
- Thickett D
- Thomas Andrew K.
- Thomas Caradog
- Thomas David C.
- Thomas S.
- Thomas-Woods T.
- Thompson A A Roger
- Thompson T
- Thornton T
- Thorpe M
- Thwaites Ryan S.
- Tilley Jo
- Tinker N
- Tiongson Gerlynn F
- Tobin Martin
- Tomlinson Johanne
- Tong C
- Toshner Mark
- Touyz R.
- Treibel Thomas A
- Tripp K.A.
- Tunnicliffe Elizabeth M.
- Turnbull A
- Turner E
- Turner Kim
- Turner Sarah
- Turner Victoria
- Turney Sharon
- Turtle Lance
- Turton Helena
- Ugoji Jacinta
- Ugwuoke R
- Upthegrove R
- Valabhji J.
- Ventura M
- Vere Joanne
- Vickers Carinna
- Vinson B
- Wade Elaine
- Wade Phillip
- Wain Louise V
- Wainwright Tania
- Wajero Lilian O.
- Walder S
- Walker S
- Walker S.
- Wall E
- Wallis T
- Walmsley S
- Walsh J.A.
- Walsh S.
- Warburton Louise
- Ward T J C
- Warwick Katie
- Wassall Helen
- Waterson Samuel
- Watson Ekaterina
- Watson James
- Watson L.
- Webster M
- Weir-McCall Jonathan R
- Welch C
- Welch H.
- Welsh B.
- Wessely S.
- West Sophie
- Weston Heather
- Wheeler H
- White Sonia
- Whitehead Victoria
- Whitney J.
- Whittaker S
- Whittam Beverley
- Whitworth V
- Wight A
- Wild James M
- Wilkins M.
- Wilkinson D
- Williams B
- Williams Jenny
- Williams N
- Williams Nick
- Williams-Howard S.A.
- Willicombe M.
- Willis Gemma
- Willoughby J
- Wilson Ann
- Wilson D
- Wilson Imogen
- Window Nicola
- Witham M.
- Wolf-Roberts Rebecca
- Wood Chloe
- Woodhead F
- Woods Janet
- Wootton Daniel G.
- Wormleighton J
- Worsley J.
- Wraith D
- Wrey Brown Caroline
- Wright C.
- Wright L
- Wright S.
- Wyles J.
- Wynter Inez
- Xie Cheng
- Xu M
- Yasmin Najira
- Yasmin S
- Yates Tom
- Yip K P
- Young A.
- Young B.
- Young Susan
- Yousuf A J
- Zawia Amira
- Zeidan Lisa
- Zhao Bang
- Zheng Bang
- Zongo O.
- Publication venue
- Elsevier
- Publication date
- 22/09/2023
- Field of study
Introduction:
The multiorgan impact of moderate to severe coronavirus infections in the post-acute phase is still poorly understood. We aimed to evaluate the excess burden of multiorgan abnormalities after hospitalisation with COVID-19, evaluate their determinants, and explore associations with patient-related outcome measures.
Methods:
In a prospective, UK-wide, multicentre MRI follow-up study (C-MORE), adults (aged ≥18 years) discharged from hospital following COVID-19 who were included in Tier 2 of the Post-hospitalisation COVID-19 study (PHOSP-COVID) and contemporary controls with no evidence of previous COVID-19 (SARS-CoV-2 nucleocapsid antibody negative) underwent multiorgan MRI (lungs, heart, brain, liver, and kidneys) with quantitative and qualitative assessment of images and clinical adjudication when relevant. Individuals with end-stage renal failure or contraindications to MRI were excluded. Participants also underwent detailed recording of symptoms, and physiological and biochemical tests. The primary outcome was the excess burden of multiorgan abnormalities (two or more organs) relative to controls, with further adjustments for potential confounders. The C-MORE study is ongoing and is registered with ClinicalTrials.gov, NCT04510025.
Findings:
Of 2710 participants in Tier 2 of PHOSP-COVID, 531 were recruited across 13 UK-wide C-MORE sites. After exclusions, 259 C-MORE patients (mean age 57 years [SD 12]; 158 [61%] male and 101 [39%] female) who were discharged from hospital with PCR-confirmed or clinically diagnosed COVID-19 between March 1, 2020, and Nov 1, 2021, and 52 non-COVID-19 controls from the community (mean age 49 years [SD 14]; 30 [58%] male and 22 [42%] female) were included in the analysis. Patients were assessed at a median of 5·0 months (IQR 4·2–6·3) after hospital discharge. Compared with non-COVID-19 controls, patients were older, living with more obesity, and had more comorbidities. Multiorgan abnormalities on MRI were more frequent in patients than in controls (157 [61%] of 259 vs 14 [27%] of 52; p<0·0001) and independently associated with COVID-19 status (odds ratio [OR] 2·9 [95% CI 1·5–5·8]; padjusted=0·0023) after adjusting for relevant confounders. Compared with controls, patients were more likely to have MRI evidence of lung abnormalities (p=0·0001; parenchymal abnormalities), brain abnormalities (p<0·0001; more white matter hyperintensities and regional brain volume reduction), and kidney abnormalities (p=0·014; lower medullary T1 and loss of corticomedullary differentiation), whereas cardiac and liver MRI abnormalities were similar between patients and controls. Patients with multiorgan abnormalities were older (difference in mean age 7 years [95% CI 4–10]; mean age of 59·8 years [SD 11·7] with multiorgan abnormalities vs mean age of 52·8 years [11·9] without multiorgan abnormalities; p<0·0001), more likely to have three or more comorbidities (OR 2·47 [1·32–4·82]; padjusted=0·0059), and more likely to have a more severe acute infection (acute CRP >5mg/L, OR 3·55 [1·23–11·88]; padjusted=0·025) than those without multiorgan abnormalities. Presence of lung MRI abnormalities was associated with a two-fold higher risk of chest tightness, and multiorgan MRI abnormalities were associated with severe and very severe persistent physical and mental health impairment (PHOSP-COVID symptom clusters) after hospitalisation.
Interpretation:
After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeutic stratification
Recommended from our members
The contribution of X-linked coding variation to severe developmental disorders
- Author
- Abbs Steve
- Akawi Nadia
- Albaba Shadi
- Allen Zoe
- Armstrong Ruth
- Azam Tara
- Baker Duncan
- Balasubramanian Meena
- Banka Siddharth
- Baple Emma
- Baptista Júlia
- Baralle Diana
- Barnicoat Angela
- Beleza Ana
- Bennett Christopher
- Berg Jonathan
- Bernhard Birgitta
- Blair Edward
- Blyth Moira
- Bodek Simon
- Borras Silvia
- Bourn David
- Bradley Lisa
- Bradley Therese
- Bradshaw Kirsty
- Brady Angela
- Breen Catherine
- Brewer Carole
- Briggs Tracy
- Brooks Claire
- Burkitt-Wright Emma
- Burn John
- Busby Louise
- Butler Rachel
- Callaway Alison
- Campbell Jennifer
- Canham Natalie
- Carmichael Jenny
- Cassidy Emma J.
- Castle Bruce
- Chandler Kate
- Cilliers Deirdre
- Clark Caroline
- Clarke Angus
- Clasper Susan
- Clayton-Smith Jill
- Cleary Elaine
- Clement Emma
- Clowes Virginia
- Coates Andrea
- Cole Trevor
- Comerford Joanne
- Cooper Nicola
- Cooper-Charles Lisa
- Corrin Sian
- Cox Helen
- Crosby Charlene
- Dabir Tabib
- Daniels Stacey
- Davidson Rosemarie
- Dean John
- Deshpande Charu
- Dixit Abhijit
- Dobbie Angus
- Donaldson Alan
- Donnai Dian
- Donnelly Deirdre
- Douglas Andrew
- Douzgou Sofia
- Dunn Carolyn
- Eason Jacqueline
- Eberhardt Ruth Y.
- Ellis Ian
- Elmslie Frances
- Faravelli Francesca
- Firth Helen V.
- Fisher Richard
- FitzPatrick David R.
- Flinter Frances
- Foulds Nicola
- Fry Andrew
- Gallone Giuseppe
- Gardiner Carol
- Gardner Eugene J.
- Gaunt Lorraine
- Ghali Neeti
- Gibbons Richard
- Goudie David
- Green Andrew
- Greenhalgh Lynn
- Haines Rebecca
- Harrison Rachel
- Hellens Steve
- Henderson Alex
- Hewitt Sarah
- Hills Alison
- Hobson Emma
- Holden Simon
- Holder Muriel
- Holder Susan
- Homfray Tessa
- Howard Emma
- Humphreys Mervyn
- Hunt David
- Hurles Matthew E.
- Hurst Jane
- Ibitoye Rita
- Irving Melita
- Islam Lily
- Izatt Louise
- Jackson Andrew
- Jackson Eilidh
- Jarvis Joanna
- Jenkins Lucy
- Jewell Rosalyn
- Jin Huilin
- Johnson Diana
- Jones Elizabeth
- Jones Wendy
- Josifova Dragana
- Joss Shelagh
- Kamath Arveen
- Kaplanis Joanna
- Keelagher Rebecca
- Kerr Bronwyn
- Kharbanda Mira
- Kini Usha
- Kinning Esther
- Kivuva Emma
- Kraus Alison
- Kumar V.K.Ajith
- Lachlan Katherine
- Lahiri Nayana
- Lam Wayne
- Lampe Anne
- Langley Claire
- Lees Melissa
- Lester Tracy
- Lim Derek
- Longman Cheryl
- Loughlin Sam
- Low Karen
- Lynch Sally
- Magee Alex
- Male Alison
- Mansour Sahar
- Marks Karen
- Martin Hilary C.
- Mavrak Eleni
- McCann Emma
- McConnell Vivienne
- McEntagart Meriel
- McGowan Ruth
- McKee Shane
- McLean Joanne
- McMullan Dominic
- McNerlan Susan
- McQuaid Shirley
- McRae Jeremy
- McWilliam Catherine
- Mercer Catherine
- Metcalfe Kay
- Miedzybrodzka Zosia
- Mohammed Shehla
- Molenda Aneta
- Montgomery Tara
- Moore David
- Morrison Patrick J.
- Morrogh Deborah
- Morton Jenny
- Mugalaasi Hood
- Mullaney Brendan
- Murday Victoria
- Mutch Stacey
- Naik Swati
- Nemeth Andrea
- Neville Matthew D. C.
- Newbury-Ecob Ruth
- Niemi Mari E. K.
- Norman Andrew M.
- Ong Kai-Ren
- Osio Deborah
- Owens Martina
- O’Driscoll Mary
- Park Soo-Mi
- Parker Michael
- Paterson Joan
- Pilz Daniela
- Porteous Mary
- Pottinger Caroline
- Poulton Joanna
- Prescott Katrina
- Price Sue
- Procter Annie
- Quarrell Oliver
- Ragge Nicola
- Rankin Julia
- Raymond Lucy
- Rea Gillian
- Reavey Eleanor
- Reid Evan
- Robert Leema
- Roberts Eileen
- Ross Alison
- Rosser Elisabeth
- Roworth Wendy
- Ruddy Deborah
- Ryten Mina
- Saggar Anand
- Samocha Kaitlin E.
- Sampson Julian
- Sandford Richard
- Sansbury Francis
- Sarkar Ajoy
- Scott Richard
- Scurr Ingrid
- Searle Claire
- Shannon Nora
- Sharif Abid
- Shaw-Smith Charles
- Shears Debbie
- Sheridan Eamonn
- Side Lucy
- Sifrim Alejandro
- Simonic Ingrid
- Smith Audrey
- Smithson Sarah
- Splitt Miranda
- Stewart Alison
- Stewart Fiona
- Stewart Helen
- Stinton Victoria
- Straub Volker
- Suri Mohnish
- Swale Andrew
- Tatton-Brown Kate
- Tavares Ana Lisa Taylor
- Temple I. Karen
- Tennant Stephen
- Thomson Jenny
- Tischkowitz Marc
- Tobias Edward
- Tooley Madeleine
- Turner Claire
- Turnpenny Peter
- Turton Sarah
- Tysoe Carolyn
- Varghese Vinod
- Vasudevan Pradeep
- Vogt Julie
- Wakeling Emma
- Weber Astrid
- Wellesley Diana
- Whiteford Margo
- Wilkie Andrew
- Williams Denise
- Williams Nicola
- Willoughby Josh
- Wilson Louise
- Woods Geoff
- Wright Caroline F.
- Wright Michael
- Wright Ronnie
- Yau Shu
- Zwolinski Simon
- Publication venue
- Nature Communications
- Publication date
- 27/01/2021
- Field of study
Abstract: Over 130 X-linked genes have been robustly associated with developmental disorders, and X-linked causes have been hypothesised to underlie the higher developmental disorder rates in males. Here, we evaluate the burden of X-linked coding variation in 11,044 developmental disorder patients, and find a similar rate of X-linked causes in males and females (6.0% and 6.9%, respectively), indicating that such variants do not account for the 1.4-fold male bias. We develop an improved strategy to detect X-linked developmental disorders and identify 23 significant genes, all of which were previously known, consistent with our inference that the vast majority of the X-linked burden is in known developmental disorder-associated genes. Importantly, we estimate that, in male probands, only 13% of inherited rare missense variants in known developmental disorder-associated genes are likely to be pathogenic. Our results demonstrate that statistical analysis of large datasets can refine our understanding of modes of inheritance for individual X-linked disorders
The Gothic in Victorian Poetry
- Author
- Aird
- Aird
- Alexander
- Alexander
- Alexander
- Alexander
- Allen
- Allen
- Altick
- Altick
- Altick
- Altick
- Andrew
- Andrew
- Angenot
- Angenot
- Apel
- Apel
- Appel
- Appel
- Arata
- Arata
- Arata
- Arata
- Armstrong
- Armstrong
- Ashley
- Ashley
- Atkinson
- Atkinson
- Atterbury
- Atterbury
- Ayguals de Izco
- Ayguals de Izco
- Backus
- Backus
- Baker
- Baker
- Baldick
- Baldick
- Bann
- Bann
- Barber
- Barber
- Barnes
- Barnes
- Barr
- Barr
- Barzilai
- Barzilai
- Basham
- Basham
- Bataille
- Bataille
- Bate
- Bate
- Beatty
- Beatty
- Belcher
- Belcher
- Bennett
- Bennett
- Bennett
- Bennett
- Bergland
- Bergland
- Bernheimer
- Bernheimer
- Bienstock Anolik
- Bienstock Anolik
- Birch
- Birch
- Bizup
- Bizup
- Blanco White
- Blanco White
- Bleasdale
- Bleasdale
- Bloom
- Bloom
- Bloom
- Bloom
- Boerner
- Boerner
- Boitard
- Boitard
- Booth
- Booth
- Booth
- Booth
- Booth
- Booth
- Botrel
- Botrel
- Botting
- Botting
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- Botting
- Bowen
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- Bowen
- Bowen
- Bowen
- Bown
- Bown
- Braddon
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- Braddon
- Brantlinger
- Brantlinger
- Bratton
- Bratton
- Bratton
- Bratton
- Breen
- Breen
- Brewster
- Brewster
- Brewster
- Brewster
- Bricchi
- Bricchi
- Briggs
- Briggs
- Brontë
- Brontë
- Brontë
- Brontë
- Brontë
- Brontë
- Brontë
- Brontë
- Brooker
- Brooker
- Brooks
- Brooks
- Brown
- Brown
- Browning
- Browning
- Bulfin
- Bulfin
- Burdekin
- Burdekin
- Burke
- Burke
- Butler
- Butler
- Byron
- Byron
- Byron
- Byron
- Byron
- Byron
- Bécquer
- Bécquer
- Calder
- Calder
- Calvino
- Calvino
- Camilletti
- Camilletti
- Capuana
- Capuana
- Capuana
- Capuana
- Carleton
- Carleton
- Carlyle
- Carlyle
- Carlyle
- Carlyle
- Carlyle
- Carlyle
- Carlyle
- Carlyle
- Cassuto
- Cassuto
- Castle
- Castle
- Ceserani
- Ceserani
- Chesterton
- Chesterton
- Chichester
- Chichester
- Child
- Child
- Chisholm
- Chisholm
- Clark
- Clark
- Clemens
- Clemens
- Clery
- Clery
- Cochran
- Cochran
- Cohn
- Cohn
- Colby
- Colby
- Coleridge
- Coleridge
- Coleridge
- Coleridge
- Coleridge
- Coleridge
- Coleridge
- Coleridge
- Coleridge
- Coleridge
- Coleridge
- Coleridge
- Collodi
- Collodi
- Colman
- Colman
- Colvin
- Colvin
- Conan Doyle
- Conan Doyle
- Connell
- Connell
- Connolly
- Connolly
- Connolly
- Connolly
- Connor
- Connor
- Connor
- Connor
- Conrad
- Conrad
- Cook
- Cook
- Cook
- Cook
- Courthope
- Courthope
- Cox
- Cox
- Cox
- Cox
- Cox
- Cox
- Cox
- Cox
- Croce
- Croce
- Croce
- Croce
- Crookenden
- Crookenden
- Crow
- Crow
- Crowe
- Crowe
- Curry
- Curry
- Cusack
- Cusack
- Cvetcovich
- Cvetcovich
- Dacre
- Dacre
- Daniele
- Daniele
- Darwin
- Darwin
- Darwin
- Darwin
- Darwin
- Darwin
- Darwin
- Darwin
- Darwin
- Darwin
- Davidson
- Davidson
- Davidson
- Davidson
- Davison
- Davison
- Davison
- Davison
- Davison
- Davison
- de Turris
- de Turris
- de Vega
- de Vega
- DeLamotte
- DeLamotte
- Delano
- Delano
- Deleuze
- Deleuze
- Desmond
- Desmond
- Desmond
- Desmond
- di Giacomo
- di Giacomo
- Dickens
- Dickens
- Dickens
- Dickens
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- Dickens
- Dickens
- Dickens
- Dickens
- Dickens
- Dickens
- Dickens
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- Dickens
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- Dickens
- Dickens
- Dickens
- Dickens
- Dickens
- Dickens
- Dickens
- Dickens
- Dickens
- Dickerson
- Dickerson
- Dickinson
- Dickinson
- Doherty
- Doherty
- Downey
- Downey
- Doyle
- Doyle
- Doyle
- Doyle
- Drake
- Drake
- Duggett
- Duggett
- Duncan
- Duncan
- During
- During
- Défourneaux
- Défourneaux
- Eastlake
- Eastlake
- Eckardt
- Eckardt
- Edgeworth
- Edgeworth
- Edwards
- Edwards
- Edwards
- Edwards
- Eimer
- Eimer
- Elbert
- Elbert
- Eliot
- Eliot
- Eliot
- Eliot
- Ellis
- Ellis
- Ellis
- Ellis
- Eltis
- Eltis
- Emerson
- Emerson
- Enns
- Enns
- Eyriès
- Eyriès
- Ezra
- Ezra
- Faflak
- Faflak
- Fanon
- Fanon
- Faulkner
- Faulkner
- Faulkner
- Faulkner
- Feldman
- Feldman
- Fennell
- Fennell
- Ferguson
- Ferguson
- Ferriar
- Ferriar
- Fisher
- Fisher
- Fisher
- Fisher
- Fitzball
- Fitzball
- Fitzgerald
- Fitzgerald
- Foni
- Foni
- Fontes da Costa
- Fontes da Costa
- Forster
- Forster
- Forster
- Forster
- Fosbrooke
- Fosbrooke
- Foscolo
- Foscolo
- Foucault
- Foucault
- Frangipani
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- Franklin
- Franklin
- Freeman
- Freeman
- Freud
- Freud
- Freud
- Freud
- Frith
- Frith
- Gale
- Gale
- Gallagher
- Gallagher
- Garside
- Garside
- Gaskell
- Gaskell
- Geffarth
- Geffarth
- Gerard
- Gerard
- Ghidetti
- Ghidetti
- Ghidetti
- Ghidetti
- Ghislanzoni
- Ghislanzoni
- Gianquitto
- Gianquitto
- Gilbert
- Gilbert
- Gilbert
- Gilbert
- Gillespie
- Gillespie
- Ginger
- Ginger
- Goddu
- Goddu
- Gorky
- Gorky
- Gosse
- Gosse
- Gray
- Gray
- Grierson
- Grierson
- Griffin
- Griffin
- Gruner
- Gruner
- Guerrazzi
- Guerrazzi
- Gutiérrez
- Gutiérrez
- Gómez de Avellaneda
- Gómez de Avellaneda
- Haining
- Haining
- Hale
- Hale
- Hale
- Hale
- Hall
- Hall
- Harries
- Harries
- Harris
- Harris
- Harris
- Harris
- Harson
- Harson
- Hartman
- Hartman
- Hazlitt
- Hazlitt
- Heard
- Heard
- Heard
- Heard
- Hecht
- Hecht
- Hecht
- Hecht
- Hecht
- Hecht
- Heilman
- Heilman
- Heller
- Heller
- Heller
- Heller
- Heller
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- Henry
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- Henson
- Henson
- Herr
- Herr
- Hill
- Hill
- Hill
- Hill
- Hillis Miller
- Hillis Miller
- Hoeveler
- Hoeveler
- Hoeveler
- Hoeveler
- Hoeveler
- Hoeveler
- Hoeveler
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- Hogg
- Hogg
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- Hollington
- Hollington
- Holmes
- Holmes
- Hood
- Hood
- Hooper
- Hooper
- Hopkins
- Hopkins
- Horn
- Horn
- Howe
- Howe
- Huggett
- Huggett
- Hughes
- Hughes
- Humpherys
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- Hyder
- Hyder
- Iarocci
- Iarocci
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- James
- Jarrells
- Jarrells
- Jerrold
- Jerrold
- Jewett
- Jewett
- Jewsbury
- Jewsbury
- Jones
- Jones
- Joshi
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- Kahane
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- Kaplan
- Kelly
- Kelly
- Kelvin
- Kelvin
- Kember
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- Kidd
- Kidd
- Kilgour
- Kilgour
- Killeen
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- King
- King
- Kipling
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- Kirkpatrick
- Kite
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- Koch
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- Koselleck
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- Kristeva
- Lang
- Lang
- Lang
- Lang
- Langdon
- Langdon
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- Law
- Le Fanu
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- Le Fanu
- Le Fanu
- Le Fanu
- Ledger
- Ledger
- Lee
- Lee
- Leon
- Leon
- Leopardi
- Leopardi
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- Lewis
- Lewis
- Lockhart
- Lockhart
- Logie Robertson
- Logie Robertson
- Lombroso
- Lombroso
- Lombroso-Ferrero
- Lombroso-Ferrero
- Lotman
- Lotman
- Luck
- Luck
- Luckhurst
- Luckhurst
- Luckhurst
- Luckhurst
- Lutz
- Lutz
- Lynch
- Lynch
- Lévy
- Lévy
- López Santos
- López Santos
- López Santos
- López Santos
- MacCarthy
- MacCarthy
- Machen
- Machen
- Machen
- Machen
- Mack
- Mack
- Madden
- Madden
- Mahawatte
- Mahawatte
- Makala
- Makala
- Malchow
- Malchow
- Malley
- Malley
- Malthête
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- Mangan
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- Manlove
- Manlove
- Mannoni
- Mannoni
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- Manzoni
- Manzoni
- Manzoni
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- Manzoni
- Marcus
- Marcus
- Marion
- Marion
- Marrs
- Marrs
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- Marx
- Marx
- Matthews
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- Mattioda
- Mattioda
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- Maunder
- Maunder
- Maunder
- Mayo
- Mayo
- McCarthy
- McCarthy
- McGann
- McGann
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- Meyer
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- Miller
- Miller
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- Mistrali
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- Moberly
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- Moers
- Moers
- Mogen
- Mogen
- Molina Porras
- Molina Porras
- Monnet
- Monnet
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- Moody
- Moore-Gilbert
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- Moretti
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- Morgan
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- Morley
- Morris
- Morris
- Morris
- Morris
- Morris
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- Morris
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- Morris
- Morris
- Morris
- Morris
- Morris
- Morris
- Morris
- Morrison
- Morrison
- Morton
- Morton
- Murphy
- Murphy
- Murphy
- Murphy
- Musäus
- Musäus
- Mégroz
- Mégroz
- Natale
- Natale
- Natoli
- Natoli
- Navas
- Navas
- Nayder
- Nayder
- Nead
- Nead
- Nead
- Nead
- Neiman
- Neiman
- Nesbit
- Nesbit
- Neuberg
- Neuberg
- Newton
- Newton
- Nicholson
- Nicholson
- Nordau
- Nordau
- Norman
- Norman
- North
- North
- Ofek
- Ofek
- Oliphant
- Oliphant
- Oliphant
- Oliphant
- Oliphant
- Oliphant
- Oliphant
- Oliphant
- Ollier
- Ollier
- Oppenheim
- Oppenheim
- Ortenberg
- Ortenberg
- Paravisini-Gebert
- Paravisini-Gebert
- Parker
- Parker
- Patrick
- Patrick
- Pendleton
- Pendleton
- Pevsner
- Pevsner
- Pevsner
- Pevsner
- Phillips
- Phillips
- Phillips
- Phillips
- Pick
- Pick
- Pinero
- Pinero
- Poe
- Poe
- Polidori
- Polidori
- Polidori
- Polidori
- Polidori
- Polidori
- Pollock
- Pollock
- Pope
- Pope
- Porter
- Porter
- Powell
- Powell
- Powell
- Powell
- Prichard
- Prichard
- Pugin
- Pugin
- Pugin
- Pugin
- Pykett
- Pykett
- Pérez Galdós
- Pérez Galdós
- Radcliffe
- Radcliffe
- Radcliffe
- Radcliffe
- Reynolds
- Reynolds
- Richards
- Richards
- Rider Haggard
- Rider Haggard
- Ringel
- Ringel
- Roas
- Roas
- Roas
- Roas
- Roas
- Roas
- Robertson
- Robertson
- Robinson
- Robinson
- Rodenas
- Rodenas
- Rosamaria
- Rosamaria
- Rosenman
- Rosenman
- Rossetti
- Rossetti
- Rossetti
- Rossetti
- Rubio Cremades
- Rubio Cremades
- Ruskin
- Ruskin
- Ruskin
- Ruskin
- Ruskin
- Ruskin
- Ruskin
- Ruskin
- Ruskin
- Ruskin
- Rutherford
- Rutherford
- Rymer
- Rymer
- Rymer
- Rymer
- Rymer
- Rymer
- Sabor
- Sabor
- Sage
- Sage
- Sage
- Sage
- Saglia
- Saglia
- Saglia
- Saglia
- Saglia
- Saglia
- Santiago de Alvarado de la Peña
- Santiago de Alvarado de la Peña
- Schivelbusch
- Schivelbusch
- Schotland
- Schotland
- Schulze
- Schulze
- Scott
- Scott
- Scott
- Scott
- Scott
- Scott
- Scott
- Scott
- Scott
- Scott
- Scott
- Scott
- Scott
- Scott
- Scott
- Scott
- Scott
- Scott
- Scott
- Scott
- Scott
- Scott
- Scullion
- Scullion
- Senf
- Senf
- Seymour
- Seymour
- Shanahan
- Shanahan
- Shannon-Mangan
- Shannon-Mangan
- Shaw
- Shaw
- Shelley
- Shelley
- Shelley
- Shelley
- Shelley
- Shelley
- Shelston
- Shelston
- Shenton
- Shenton
- Sherwin
- Sherwin
- Shiels
- Shiels
- Shillito
- Shillito
- Showalter
- Showalter
- Showalter
- Showalter
- Shubert
- Shubert
- Silver
- Silver
- Six
- Six
- Six
- Six
- Slater
- Slater
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Smith
- Solomon
- Solomon
- Southey
- Southey
- Southey
- Southey
- Southey
- Southey
- Southey
- Southey
- Southey
- Southey
- Speaight
- Speaight
- Speck
- Speck
- Spenser
- Spenser
- Spooner
- Spooner
- St Clair
- St Clair
- St Clair
- St Clair
- Staines
- Staines
- Stevenson
- Stevenson
- Stevenson
- Stevenson
- Stevenson
- Stevenson
- Stevenson
- Stevenson
- Stocker
- Stocker
- Stoker
- Stoker
- Stoker
- Stoker
- Stoker
- Stoker
- Stoker
- Stoker
- Stoker
- Stoker
- Storey
- Storey
- Storey
- Storey
- Stott
- Stott
- Stuart
- Stuart
- Sue
- Sue
- Summers
- Summers
- Sutcliffe
- Sutcliffe
- Sutherland
- Sutherland
- Tarchetti
- Tarchetti
- Tarchetti
- Tarchetti
- Tardiola
- Tardiola
- Tennyson
- Tennyson
- Thackeray
- Thackeray
- Thompson
- Thompson
- Thompson
- Thompson
- Thomson
- Thomson
- Tilley
- Tilley
- Tillotson
- Tillotson
- Tosh
- Tosh
- Toulmin
- Toulmin
- Toulmin
- Toulmin
- Townend
- Townend
- Townshend
- Townshend
- Townshend
- Townshend
- Trautwein
- Trautwein
- Twitchell
- Twitchell
- Uglow
- Uglow
- Utterson
- Utterson
- Van Woudenberg
- Van Woudenberg
- Verga
- Verga
- Vescovi
- Vescovi
- Von Krafft-Ebing
- Von Krafft-Ebing
- Von Sneidern
- Von Sneidern
- Walker
- Walker
- Walker
- Walker
- Walpole
- Walpole
- Walter
- Walter
- Wardrop
- Wardrop
- Warner
- Warner
- Warter
- Warter
- Warwick
- Warwick
- Watson
- Watson
- Watt
- Watt
- Weinstock
- Weinstock
- Weinstock
- Weinstock
- Wells
- Wells
- Wells
- Wells
- Wells
- Wells
- Wells
- Wells
- West
- West
- Whitechurch
- Whitechurch
- Wilde
- Wilde
- Wilde
- Wilde
- Williams
- Williams
- Williams
- Williams
- Willis
- Willis
- Wilt
- Wilt
- Wolfreys
- Wolfreys
- Wollstonecraft
- Wollstonecraft
- Wood
- Wood
- Woolf
- Woolf
- Wordsworth
- Wordsworth
- Wordsworth
- Wordsworth
- Worth
- Worth
- Wright
- Wright
- Wright
- Wright
- Wurgaft
- Wurgaft
- Wustmann
- Wustmann
- Wynne
- Wynne
- Yang
- Yang
- Yorke
- Yorke
- Young
- Young
- Zuccato
- Zuccato
- Publication venue
- 'Cambridge University Press (CUP)'
- Publication date
- 01/01/2020
- Field of study
- …