New singularities in unexpected places

Spacetime singularities have been discovered which are physically much weaker than those predicted by the classical singularity theorems. Geodesics evolve through them and they only display infinities in the derivatives of their curvature invariants. So far, these singularities have appeared to require rather exotic and unphysical matter for their occurrence. Here, we show that a large class of singularities of this form can be found in a simple Friedmann cosmology containing only a scalar-field with a power-law self-interaction potential. Their existence challenges several preconceived ideas about the nature of spacetime singularities and has an impact upon the end of inflation in the early universe. This is the author accepted manuscript. The final version is available from World Scientific via http://dx.doi.org/10.1142/S021827181544012

Singular inflation

We prove that a homogeneous and isotropic universe containing a scalar field with a power-law potential, V(ϕ)=Aϕ^n, with 00 always develops a finite-time singularity at which the Hubble rate and its first derivative are finite, but its second derivative diverges. These are the first examples of cosmological models with realistic matter sources that possess weak singularities of “sudden” type. We also show that a large class of models with even weaker singularities exists for noninteger n>1. More precisely, if k<n<k+1 where k is a positive integer then the first divergence of the Hubble rate occurs with its (k+2)th derivative. At early times these models behave like standard large-field inflation models but they encounter a singular end state when inflation ends. We term this singular inflation.A.A.H.G. and J.D.B. are supported by the STFC.This is the author accepted manuscript. The final version is available from APS via http://dx.doi.org/10.1103/PhysRevD.91.08351

Pan-cancer analysis of whole genomes

Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe