Pan-cancer analysis of whole genomes

Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe

A semi-quantitative methodology for risk assessment of university chemical laboratory

University chemical laboratory is a high-risk place for teaching and scientific research due to the presence of various physical and chemical hazards. In recent years, university chemical laboratory accidents occur frequently. This urges the need to enhance university chemical lab safety. A semi-quantitative methodology comprising Matter-Element Extension Theory (MEET) implemented with Combination Ordered Weighted Averaging (C-OWA) operator is proposed to assess the risk of a university chemical laboratory. First, an index-based risk assessment system of university chemical laboratory is built by identifying various risk factors from a system perspective. Then, C-OWA operator is used to calculate the weight of assessment indices, whereas MEET is employed to determine the correlation degree of assessment indices. Finally, the comprehensive risk of university chemical laboratories is assessed, and some safety measures are proposed to reduce the risk of university chemical laboratories. The applicability of the proposed methodology is tested using a practical case. It is observed that the methodology can be a useful tool for risk assessment and management of university chemical laboratories.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Safety and Security Scienc

柯大宜教學法之節奏唱名及手號應用於國中音樂教學之研究

音樂學系

寄養父母對親職教育之需求研究

[[abstract]]一、寄養父母最喜歡的實施方式是舉辦親子活動的方式；其次是大眾傳播的方式；再 其次才是經由各種討論或研習的團體輔導方式；而喜歡程度較低的是個別輔導方式。 二、寄養父母對親職教育實施方式的需求，因其性別、年齡、擔任寄養家庭年數、寄 養子女人數不同而有顯著差異。但不因其教育程度不同而有顯著差異。 依據本研究之結論，提出下列幾點建議，作為有關單位規劃與實施寄養父母親職教育 及未來進一步研究的參考。 壹、對寄養父母親職教育內容的建議 一、寄養父母親職教育的課程內容應力求多樣化，以滿足寄養父母廣泛的學習需求。 二、寄養父母親職教育的課程內容安排應採進階方式，以使寄養父母能根據自己的程 度與需求，選擇合適之課程。 三、「寄養父母問題檢核表」的應用，以促進寄養父母與社會工作員之間的溝通。 貳、對寄養父母親職教育實施方式的建議 一、應用各種親子活動，促進寄養兒童與寄養家庭間的互動與溝通，進而建立親密、 和諧的關係。 二、充份利用大眾傳播媒介，廣泛提供寄養父母親職親職教育資訊。 三、組織寄養父母學習式輔導團體，寄養父母可經由各種討論或研習，獲得情緒上的 支持、專業知識與親職技巧。 參、對未來研究之建議 一、以不同的方式，評估寄養父母對親職教育的需求 二、進一步進行寄養父母親職教育方案之效果研究 三、加強特定對象家長的親職教育研究

Trust to test translation practices: A case study of Shanghai, China

Trust is important in public health communication to culturally and linguistically diverse (CALD) communities during pandemics. This empirical research, using quantitative data from 107 foreign nationals at a university in Shanghai, probes into how trust varied in official translation services (OTS) and non-official translation services (NOTS) during COVID-19. Statistical analysis was carried out by IBM SPSS Statistics 26 and it was found that (1) NOTS which are more frequently used are more trusted compared with OTS; (2) NOTS are uncorrelated with demographics while OTS are correlated with demographics, among which education and trust in OTS suggest a linear positive relationship (Sig. = 0.003, β = 0.467), whereas age and trust in OTS suggest a linear negative relationship (Sig. = 0.027, β = −0.348); (3) there is a positive relationship between the frequency of using services and trust, i.e., higher frequency implies higher trust. The findings of this case study can have implications for policy makers and the representatives of CALD communities.Quantum Circuit Architectures and Technolog

Calculation of dam risk probability of cascade reservoirs considering risk transmission and superposition

Because of the risk transmission and superposition among dams in cascade reservoirs, the analysis and probability calculation of dam risk become more complex compared with a single reservoir. By analyzing the main risk sources and actionmechanisms, the disaster-causing factors, disaster-transmitting body and disaster-bearing body in the cascade reservoirs system were determined. By defining the influence coefficient (IC) to express the transmission and superposition degree of dam risk among cascade reservoirs, dam risk was divided into two parts: own risk (OR) and additional risk (AR). On this basis, the relevant concepts and equations for the calculation of the dam risk probability of cascade reservoirs were proposed. The numerical simulation was carried out to quantify the IC, and a Bayesian network analysis model was constructed to calculate the OR. Finally, taking five cascade reservoir dams in the Dadu River basin as examples, the value of their ORs, ARs and risk probabilities were calculated, and thereafter the weakest cascade, controlling cascade and general cascade in the system were divided. The proposed methodology realizes an effective connection with the dam risk calculation method of a single reservoir, which can provide a reference for the risk assessment and management of cascade reservoirs in the basin.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Safety and Security Scienc

Effect of CA bacteria on the carbonation process of γ-C2S

Carbonation has been proven to be a promising way to improve the mechanism properties and durability of steel slag products. CA bacteria can promote the hydration of CO2. In this study, one kind of alkali-resistant CA bacteria was chosen to investigate its effects on the carbonation process of γ-C2S. Results showed that bacteria could increase the compressive strength of carbonized γ-C2S by 19.0%. Main products of carbonized γ-C2S were vaterite, calcite and SiO2 gel. The addition of bacteria could only accelerate the deposition of calcium carbonate, while hardly changing the types and properties of the carbonation products. Additionally, accelerated carbonation makes it harder for the carbon dioxide to diffuse inward, leading to the decline of accelerating carbonation effect. However, CA bacteria could change the morphology of calcium carbonated during the carbonation process of β-C2S and further accelerate the hydration process of β-C2S. The pore structure can also be refined with the incorporation of bacteria

Accurate Scene Text Detection via Scale-Aware Data Augmentation and Shape Similarity Constraint

Scene text detection has attracted increasing concerns with the rapid development of deep neural networks in recent years. However, existing scene text detectors may overfit on the public datasets due to the limited training data, or generate inaccurate localization for arbitrary-shape scene texts. This paper presents an arbitrary-shape scene text detection method that can achieve better generalization ability and more accurate localization. We first propose a Scale-Aware Data Augmentation (SADA) technique to increase the diversity of training samples. SADA considers the scale variations and local visual variations of scene texts, which can effectively relieve the dilemma of limited training data. At the same time, SADA can enrich the training minibatch, which contributes to accelerating the training process. Furthermore, a Shape Similarity Constraint (SSC) technique is exploited to model the global shape structure of arbitrary-shape scene texts and backgrounds from the perspective of the loss function. SSC encourages the segmentation of text or non-text in the candidate boxes to be similar to the corresponding ground truth, which is helpful to localize more accurate boundaries for arbitrary-shape scene texts. Extensive experiments have demonstrated the effectiveness of the proposed techniques, and state-of-the-art performances are achieved over public arbitrary-shape scene text benchmarks (e.g., CTW1500, Total-Text, and ArT).Algorithmic

Effects of different joint wall lengths on in-plane compression properties of 3D braided jute/epoxy composite honeycombs

To comply with the trend in the development of engineering materials towards lightweight, high strength, eco-friendly, sustainable, and multi-functional, a three-dimensional braided integrated composite honeycomb is designed. The effects of geometrical parameters particularly joint wall lengths on the in-plane mechanical behavior of the honeycombs were investigated. The results show that the in-plane mechanical properties are related to the number of cell walls, and the angle between the cell wall and the loading direction. Increasing the number of cell rows to double and triple at similar areal density lead to an improvement of the maximum load up to 2.5, and 3.8 times, respectively. Similarly, the total absorbed strain energy increased up to 2.6 and 5.9 times, respectively. The displacement at the maximum load is increased by 1.6 and 2.7 times as a result of increasing the cell row number. The total absorbed strain energy increased to 1.7 and 1.3 times, respectively. The failure angle of the 3D braided composite honeycomb is about 4°–7°. This investigation presents the geometrical factors of a 3D braided composite honeycomb can be further designed and optimized, but it also provides a reference for the development and design of a new composite honeycomb.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Bio-based Structures & MaterialsStructural Integrity & Composite

Mitigating the autogenous shrinkage of alkali-activated slag by internal curing

Alkali activated slag (AAS) has shown promising potential to replace ordinary Portland cement as a binder material. Synthesized from industrial by-products, AAS can show high strength, thermal resistance and good durability. However, AAS has been reported to exhibit high autogenous shrinkage. Autogenous shrinkage is a critical issue for building materials since it can induce micro- or macro-cracking when the materials are under restrained conditions. Hence, this work aims at mitigating the autogenous shrinkage of AAS by means of internal curing. The influences of internal curing on microstructure formation and autogenous shrinkage are investigated. The results show that internal curing provided by superabsorbent polymers is a promising way to reduce the autogenous shrinkage of AAS