An Evaluation of the Secondary Teacher Education Program at Utah State University by Selected Graduates

Introduction The present study attempted to identify the strengths and limitations of the Utah State University teacher preparation program, Recommendations of improvements and changes in the program were based on the evaluations of graduates of the teacher preparation program. Information was gathered to determine if any difference in graduate evaluations of the program would be found based on the graduate\u27s sex, age at graduation, community size teaching in, number of years of teaching experience, secondary major area of preparation, and the college graduated from. Method A questionnaire was developed to survey the evaluations of the graduates of the teacher preparation program who had graduated between June, 1968 and June, 1970 and who had one, two, or three years of teaching experience. A random sample of 305 graduates was drawn and from that sample 219 useable questionnaires were returned or 71.4 percent. Data from the questionnaire, Section II, The Undergraduate Teacher Preparation Program; Section III, The Student Teaching Experience; and Section IV, Adequacy of Instruction in the Preparation Program were analyzed using the analysis of variance test to identify statistically significant items. Response frequencies and percentages were further employed in the data analysis. Findings 1. Graduates evaluated the course of General Elementary Psychology (Psychology 53) and Educational Psychology (Psychology 106) as the least helpful in preparing them to teach. 2. Special methods courses in the graduate\u27s major preparation area and the student teaching experience were judged to be the most helpful in preparing graduates to teach. 3. Graduates evaluated that they received inadequate assistance from their cooperating teachers while student teaching in the areas of: (1) setting overall teaching goals and objectives, (2) relating theory to practice, and (3) assessing the learning needs of their students. 4. The evaluations of graduates indicated that they received inadequate assistance from their university supervisors while student teaching in the areas of: (1) observing students more objectively and subjectively, (2) selecting appropriate media and methods, (3) visiting you sufficiently to make a valid observation of your teaching, and (4) acted as a resource person in locating and utilizing teaching materials. 5. Graduates evaluated the instruction in the following teacher preparation content areas was not considered or inadequately considered in the program: (1) techniques for communicating with parents, (2) understanding how various school services affect the life of a student, (3) techniques for developing self-discipline among students, (4) applying research writings to teaching, (5) discipline (classroom management), (6) techniques for studying group processes, (7) social and cultural backgrounds of students, (8) understanding the teacher\u27s role in the school with regard to the extra-curricular activities. 6. Respondents indicated that the following teacher preparation content areas were adequately considered or highly emphasized in the teacher preparation program: (1) adolescent growth and development, (2) a desire to be innovative, (3) skills in developing teaching materials, (4) evaluating pupil progress, and (5) theories about how learning takes place. 7. Graduates indicated that there were three significant experience areas other than professional education classes which helped prepare them to teach: (1) church work with such related activities as sunday school teaching, youth groups, and missions; (2) experience with teachers while attending high school; and (3) experiences in college course work exclusive of education classes. 8. There was no significant difference in the evaluations of the teacher preparation program regardless of the sex of the graduate, of the age of the graduate at time of graduation, of the size of community teaching in, of the number of years of teaching experience, or of the college graduated from at Utah State University. 9. There was a significant difference at the .01 level in the evaluations of the teacher preparation program with regard to the major area of study of the graduates. Graduates in academic major preparation areas of social science; English, speech, drama; mathematics; science; and foreign language perceived the program more critically than did graduates in the non-academic major preparation areas of physical education, health; and industrial arts, home economics. 10. Graduates of the preparation program evaluated the program significantly different at the .05 level when compared to the middle value score of the instrument. Graduates evaluations were more critical of the program when compared with the middle value score

Heat flow measurements on a hydrothermally-active, slow-spreading ridge: The Escanaba Trough

Maximum heat flow measurements at three locations in the sediment-filled Escanaba Trough of the Gorda ridge exceed 1200 mW/m². At other ridge crests with thick sediment cover, heat flow values of this magnitude are accompanied by high temperature hydrothermal vent activity and massive sulfide deposition. A dredge haul from the southernmost high heat flow location recovered pyrrhotite, thereby confirming the presence of recent high temperature venting

Phorbol Esters and SDF-1 Induce Rapid Endocytosis and Down Modulation of the Chemokine Receptor CXCR4

The chemokine receptor CXCR4 is required, together with CD4, for entry by some isolates of HIV-1, particularly those that emerge late in infection. The use of CXCR4 by these viruses likely has profound effects on viral host range and correlates with the evolution of immunodeficiency. Stromal cell-derived factor-1 (SDF-1), the ligand for CXCR4, can inhibit infection by CXCR4-dependent viruses. To understand the mechanism of this inhibition, we used a monoclonal antibody that is specific for CXCR4 to analyze the effects of phorbol esters and SDF-1 on surface expression of CXCR4. On human T cell lines SupT1 and BC7, CXCR4 undergoes slow constitutive internalization (1.0% of the cell surface pool/min). Addition of phorbol esters increased this endocytosis rate >6-fold and reduced cell surface CXCR4 expression by 60 to 90% over 120 min. CXCR4 was internalized through coated pits and coated vesicles and subsequently localized in endosomal compartments from where it could recycle to the cell surface after removal of the phorbol ester. SDF-1 also induced the rapid down modulation (half time ∼5 min) of CXCR4. Using mink lung epithelial cells expressing CXCR4 and a COOH-terminal deletion mutant of CXCR4, we found that an intact cytoplasmic COOH-terminal domain was required for both PMA and ligand-induced CXCR4 endocytosis. However, experiments using inhibitors of protein kinase C indicated that SDF-1 and phorbol esters trigger down modulation through different cellular mechanisms

2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable ischemic heart disease

The recommendations listed in this document are, whenever possible, evidence based. An extensive evidence review was conducted as the document was compiled through December 2008. Repeated literature searches were performed by the guideline development staff and writing committee members as new issues were considered. New clinical trials published in peer-reviewed journals and articles through December 2011 were also reviewed and incorporated when relevant. Furthermore, because of the extended development time period for this guideline, peer review comments indicated that the sections focused on imaging technologies required additional updating, which occurred during 2011. Therefore, the evidence review for the imaging sections includes published literature through December 2011

Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial

Background Previous evidence indicates that adjuvant, short-course androgen deprivation therapy (ADT) improves metastasis-free survival when given with primary radiotherapy for intermediate-risk and high-risk localised prostate cancer. However, the value of ADT with postoperative radiotherapy after radical prostatectomy is unclear. Methods RADICALS-HD was an international randomised controlled trial to test the efficacy of ADT used in combination with postoperative radiotherapy for prostate cancer. Key eligibility criteria were indication for radiotherapy after radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to radiotherapy alone (no ADT) or radiotherapy with 6 months of ADT (short-course ADT), using monthly subcutaneous gonadotropin-releasing hormone analogue injections, daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as distant metastasis arising from prostate cancer or death from any cause. Standard survival analysis methods were used, accounting for randomisation stratification factors. The trial had 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 80% to 86% (hazard ratio [HR] 0·67). Analyses followed the intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov, NCT00541047. Findings Between Nov 22, 2007, and June 29, 2015, 1480 patients (median age 66 years [IQR 61–69]) were randomly assigned to receive no ADT (n=737) or short-course ADT (n=743) in addition to postoperative radiotherapy at 121 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 9·0 years (IQR 7·1–10·1), metastasis-free survival events were reported for 268 participants (142 in the no ADT group and 126 in the short-course ADT group; HR 0·886 [95% CI 0·688–1·140], p=0·35). 10-year metastasis-free survival was 79·2% (95% CI 75·4–82·5) in the no ADT group and 80·4% (76·6–83·6) in the short-course ADT group. Toxicity of grade 3 or higher was reported for 121 (17%) of 737 participants in the no ADT group and 100 (14%) of 743 in the short-course ADT group (p=0·15), with no treatment-related deaths. Interpretation Metastatic disease is uncommon following postoperative bed radiotherapy after radical prostatectomy. Adding 6 months of ADT to this radiotherapy did not improve metastasis-free survival compared with no ADT. These findings do not support the use of short-course ADT with postoperative radiotherapy in this patient population

Duration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial

Background Previous evidence supports androgen deprivation therapy (ADT) with primary radiotherapy as initial treatment for intermediate-risk and high-risk localised prostate cancer. However, the use and optimal duration of ADT with postoperative radiotherapy after radical prostatectomy remains uncertain. Methods RADICALS-HD was a randomised controlled trial of ADT duration within the RADICALS protocol. Here, we report on the comparison of short-course versus long-course ADT. Key eligibility criteria were indication for radiotherapy after previous radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to add 6 months of ADT (short-course ADT) or 24 months of ADT (long-course ADT) to radiotherapy, using subcutaneous gonadotrophin-releasing hormone analogue (monthly in the short-course ADT group and 3-monthly in the long-course ADT group), daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as metastasis arising from prostate cancer or death from any cause. The comparison had more than 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 75% to 81% (hazard ratio [HR] 0·72). Standard time-to-event analyses were used. Analyses followed intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov , NCT00541047 . Findings Between Jan 30, 2008, and July 7, 2015, 1523 patients (median age 65 years, IQR 60–69) were randomly assigned to receive short-course ADT (n=761) or long-course ADT (n=762) in addition to postoperative radiotherapy at 138 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 8·9 years (7·0–10·0), 313 metastasis-free survival events were reported overall (174 in the short-course ADT group and 139 in the long-course ADT group; HR 0·773 [95% CI 0·612–0·975]; p=0·029). 10-year metastasis-free survival was 71·9% (95% CI 67·6–75·7) in the short-course ADT group and 78·1% (74·2–81·5) in the long-course ADT group. Toxicity of grade 3 or higher was reported for 105 (14%) of 753 participants in the short-course ADT group and 142 (19%) of 757 participants in the long-course ADT group (p=0·025), with no treatment-related deaths. Interpretation Compared with adding 6 months of ADT, adding 24 months of ADT improved metastasis-free survival in people receiving postoperative radiotherapy. For individuals who can accept the additional duration of adverse effects, long-course ADT should be offered with postoperative radiotherapy. Funding Cancer Research UK, UK Research and Innovation (formerly Medical Research Council), and Canadian Cancer Society