2,157 research outputs found
An N=2 worldsheet approach to D-branes in bihermitian geometries: I. Chiral and twisted chiral fields
We investigate N=(2,2) supersymmetric nonlinear sigma-models in the presence
of a boundary. We restrict our attention to the case where the bulk geometry is
described by chiral and twisted chiral superfields corresponding to a
bihermitian bulk geometry with two commuting complex structures. The D-brane
configurations preserving an N=2 worldsheet supersymmetry are identified.
Duality transformations interchanging chiral for twisted chiral fields and vice
versa while preserving all supersymmetries are explicitly constructed. We
illustrate our results with various explicit examples such as the WZW-model on
the Hopf surface S3xS1. The duality transformations provide e.g new examples of
coisotropic A-branes on Kahler manifolds (which are not necessarily
hyper-Kahler). Finally, by dualizing a chiral and a twisted chiral field to a
semi-chiral multiplet, we initiate the study of D-branes in bihermitian
geometries where the cokernel of the commutator of the complex structures is
non-empty.Comment: LaTeX, 50 page
Development of a new detection algorithm to identify acute coronary syndrome using electrochemical biosensors for real-world long-term monitoring
Electrochemically based technologies are rapidly moving from the laboratory to bedside applications and wearable devices, like in the field of cardiovascular disease. Major efforts have focused on the biosensor component in contrast with those employed in creating more suitable detection algorithms for long-term real-world monitoring solutions. The calibration curve procedure presents major limitations in this context. The objective is to propose a new algorithm, compliant with current clinical guidelines, which can overcome these limitations and contribute to the development of trustworthy wearable or telemonitoring solutions for home-based care. A total of 123 samples of phosphate buffer solution were spiked with different concentrations of troponin, the gold standard method for the diagnosis of the acute coronary syndrome. These were classified as normal or abnormal according to established clinical cut-off values. Off-the-shelf screen-printed electrochemical sensors and cyclic voltammetry measurements (sweep between â1 and 1 V in a 5 mV step) was performed to characterize the changes on the surface of the biosensor and to measure the concentration of troponin in each sample. A logistic regression model was developed to accurately classify these samples as normal or abnormal. The model presents high predictive performance according to specificity (94%), sensitivity (92%), precision (92%), recall (92%), negative predictive value (94%) and F-score (92%). The area under the curve of the precision-recall curve is 97% and the positive and negative likelihood ratios are 16.38 and 0.082, respectively. Moreover, high discriminative power is observed from the discriminate odd ratio (201) and the Youden index (0.866) values. The promising performance of the proposed algorithm suggests its capability to overcome the limitations of the calibration curve procedure and therefore its suitability for the development of trustworthy home-based care solutions
Digital health care solution for proactive heart failure management with the Cordella Heart Failure System : results of the SIRONA firstâinâhuman study
Aims
Incorporation of remote monitoring of pulmonary artery pressure and vital signs has been demonstrated to reduce heart failure (HF) hospitalization and allâcause mortality in selected symptomatic HF patients. The aim of this study is to investigate the safety and accuracy of the new CordellaTM Pulmonary Artery Pressure Sensor (Endotronix, Inc., Chicago, IL, USA) and the usability of the comprehensive CordellaTM Heart Failure System (CHFS).
Methods and results
Multicentre, openâlabel, firstâinâhuman, feasibility study to evaluate the CHFS and the safety and accuracy of the Cordellaâą Pulmonary Artery Pressure Sensor in 15 patients with New York Heart Association class III HF. All patients were successfully implanted with the Cordella Pulmonary Artery Pressure Sensor, without sensor failure. No device systemârelated complications, defined as invasive treatment, device explant or death, occurred. The primary efficacy endpoint of a mean pulmonary artery pressure at 90âdays was met in all but one patients with a cohort difference of 2.7âmmHg (Cordella Sensor 22.5â±â11.8âmmHg, SwanâGanz catheter 25.2â±â8.5âmmHg). One patient did not go through the 90âday right heart catheterization for safety reasons. Patient adherence to daily measurement, transmission of vital signs and pulmonary artery pressure sensor readings were recorded 99% of the time.
Conclusion
The initial experience of the CHFS incorporating comprehensive vital signs and pulmonary artery pressure monitoring enables safe and accurate monitoring of HF status
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