Networks : On the relation of bi- and multivariate measures

Date of Acceptance: 28/04/2015 Acknowledgement The article processing charge was funded by the German Research Foundation (DFG) and the Albert Ludwigs University Freiburg in the funding programme Open Access PublishingPeer reviewedPublisher PD

The concept of low status in group work

Thesis (M.S.)--Boston Universit

A numerically efficient implementation of the expectation maximization algorithm for state space models

Peer reviewedPostprin

Assessing the strength of directed influences among neural signals : An approach to noisy data

Acknowledgements This work was supported by the German Science Foundation (Ti315/4-2), the German Federal Ministry of Education and Research (BMBF grant 01GQ0420), and the Excellence Initiative of the German Federal and State Governments. B.S. is indebted to the Kosterlitz Centre for the financial support of this research project.Peer reviewedPreprin

The roles of STP and LTP in synaptic encoding

Long-term potentiation (LTP), a cellular model of learning and memory, is generally regarded as a unitary phenomenon that alters the strength of synaptic transmission by increasing the postsynaptic response to the release of a quantum of neurotransmitter. LTP, at CA3-CA1 synapses in the hippocampus, contains a stimulation-labile phase of short-term potentiation (STP, or transient LTP, t-LTP) that decays into stable LTP. By studying the responses of populations of neurons to brief bursts of high-frequency afferent stimulation before and after the induction of LTP, we found that synaptic responses during bursts are potentiated equally during LTP but not during STP. We show that STP modulates the frequency response of synaptic transmission whereas LTP preserves the fidelity. Thus, STP and LTP have different functional consequences for the transfer of synaptic information

Alternative N-Terminal Domains of PSD-95 and SAP97 Govern Activity-Dependent Regulation of Synaptic AMPA Receptor Function

SummaryPSD-95 and SAP97 are scaffolding proteins that have been implicated in regulating AMPA receptor incorporation and function at synapses. Gain- and loss-of-function approaches, however, have generated conflicting results. To minimize adaptations during development and potential dominant-negative effects of overexpression, we have combined silencing of endogenous PSD-95 in mature neurons with heterologous expression of specific SAP97 or PSD-95 isoforms. We find that both PSD-95 and SAP97 contain alternative N termini expressing either double cysteines that normally are palmitoylated (α-isoforms) or an L27 domain (β-isoforms). Whereas α-isoforms of PSD-95 and SAP97 influence AMPA receptor-mediated synaptic strength independent of activity, the effects of β-isoforms are regulated by activity in a CaMKII-dependent manner. Importantly, the synaptic effects of the β-isoforms are masked by the endogenous α-isoform of PSD-95. These results demonstrate that the different N termini of the predominant endogenous forms of PSD-95 (α-isoform) and SAP97 (β-isoform) govern their role in regulating synaptic function

Evaluating pharmacist based medication reconciliation: a literature review and case study

Medication errors are common through all phases of a hospitalization and represent a significant patient safety risk. Medication errors lead to Adverse Drug Events which are the most common type of error experienced in a hospital. Such events represent a significant public health issue and have gained national attention. Despite this attention, the current financial structure of the United States’ healthcare system inhibits providers from fully embracing efforts to reduce medication errors. Medication Reconciliation is the act of completing a medication history and correcting discrepancies between a patient’s previous medication regimen and the proposed medication order. Medication reconciliation characterizes a sustainable solution that can significantly reduce medication errors if performed correctly. Often, medication reconciliation is performed by a nursing admissions team or physicians, despite the research that proves pharmacists are suited best. When pharmacists perform medication reconciliation it denotes the most effective solution for reducing drug related errors. A case study of a large academic medical system’s Emergency Department examined the effectiveness of a nursing based medication reconciliation process. A pharmacist reviewed medication histories performed by a nursing admissions team to assess the prevalence and type of medication discrepancies. Interviews with key stakeholders conveyed the barriers in creating an effective medication reconciliation process