29 research outputs found
Cancer Biomarker Discovery: The Entropic Hallmark
- Author
- A Alcaraz
- A Arabzadeh
- A Bagri
- A Balbin
- A Bantis
- A Ben-Naim
- A Bolander
- A Buhmeida
- A Burykin
- A Chetcuti
- A de Baey
- A Efeyan
- A Eroglu
- A Fabarius
- A Forget
- A Fujita
- A Geirsson
- A Geirsson
- A Geirsson
- A Guffanti
- A Hugel
- A Inoue
- A Isidoro
- A Jang
- A Kollara
- A Kuzmanov
- A Lundqvist
- A Maria McCrohan
- A Marreiros
- A Mendes
- A Mitra
- A Nassar
- A Petitjean
- A Petitjean
- A Pinzon-Charry
- A Richmond
- A Roesch
- A Santinelli
- A Schmidt
- A Shapiro
- A Sreekumar
- A Takeno
- A Urbanucci
- A Winter
- A Yemelyanov
- AA Babiker
- AA Babiker
- AA Tarhini
- AC Dudley
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- AK Meeker
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- AM Craig
- AM Lena
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- AP South
- AS Payne
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- AS Verkman
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- AV Skamrov
- AW Maniccia
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- B Wu
- B Wu
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- BF Goncalves
- BF Skinnider
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- BL Adamsen
- BL de Groot
- BR Johnson
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- BS Strauss
- C Adami
- C Bastide
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- C Haqq
- C Hayashi
- C Hornig
- C Ivorra
- C Kumar-Sinha
- C Langner
- C Magi-Galluzzi
- C Magi-Galluzzi
- C Muller-Tidow
- C Nessler-Menardi
- C Nunez
- C Pequeux
- C Rajesh
- C Xu
- C Yuli
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- CD Truong
- CG Pham
- CG Rogers
- CG Rogers
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- CP Gray
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- M Hatzfeld
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- WB Isaacs
- WD Dunsmuir
- WE Naugler
- William C. S. Cho
- WK Kaufmann
- WK Lee
- X Chen
- X Cheng
- X Dong
- X Dong
- X Huang
- X Li
- X Liu
- X Liu
- X Meng
- X Ouyang
- X Tang
- X Wu
- X Zhang
- XJ Yang
- XQ Wang
- Y Bu
- Y Cai
- Y Deng
- Y Ito
- Y Katagiri
- Y Kozuka
- Y Lai
- Y Liu
- Y Lu
- Y Lu
- Y Ohyama
- Y Shav-Tal
- Y Sugiyama
- Y Sun
- Y Wang
- Y Wang
- Y Wu
- Y Yamamoto
- Y Yang
- Y Zhou
- YB Lim
- YC Chao
- YJ Ko
- YL Liu
- YN Liu
- YT Sasaki
- YT Sasaki
- YU Katagiri
- Z Jiang
- Z Jiang
- Z Jiang
- Z Jiang
- Z Jiang
- Z Rudzki
- ZA Dotan
- ZR Yurkovetsky
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
Background: It is a commonly accepted belief that cancer cells modify their transcriptional state during the progression of the disease. We propose that the progression of cancer cells towards malignant phenotypes can be efficiently tracked using high-throughput technologies that follow the gradual changes observed in the gene expression profiles by employing Shannon's mathematical theory of communication. Methods based on Information Theory can then quantify the divergence of cancer cells' transcriptional profiles from those of normally appearing cells of the originating tissues. The relevance of the proposed methods can be evaluated using microarray datasets available in the public domain but the method is in principle applicable to other high-throughput methods. Methodology/Principal Findings: Using melanoma and prostate cancer datasets we illustrate how it is possible to employ Shannon Entropy and the Jensen-Shannon divergence to trace the transcriptional changes progression of the disease. We establish how the variations of these two measures correlate with established biomarkers of cancer progression. The Information Theory measures allow us to identify novel biomarkers for both progressive and relatively more sudden transcriptional changes leading to malignant phenotypes. At the same time, the methodology was able to validate a large number of genes and processes that seem to be implicated in the progression of melanoma and prostate cancer. Conclusions/Significance: We thus present a quantitative guiding rule, a new unifying hallmark of cancer: the cancer cell's transcriptome changes lead to measurable observed transitions of Normalized Shannon Entropy values (as measured by high-throughput technologies). At the same time, tumor cells increment their divergence from the normal tissue profile increasing their disorder via creation of states that we might not directly measure. This unifying hallmark allows, via the the Jensen-Shannon divergence, to identify the arrow of time of the processes from the gene expression profiles, and helps to map the phenotypical and molecular hallmarks of specific cancer subtypes. The deep mathematical basis of the approach allows us to suggest that this principle is, hopefully, of general applicability for other diseases
Pan-cancer analysis of whole genomes
- Author
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- The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium View Correspondence (jump link)
- Thiessen
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- Y. rj
- Y. rm
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- Y. uz
- Y. vr
- Y. wt
- Y. yc
- ya Al-Ahmadie
- Yachida
- Yamaguchi
- Yamaguchi T. N. k
- Yamamoto
- Yamaue
- Yang
- Yang
- Yang
- Yang
- Yang
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- Yoon
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- Yu
- Yu
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- Yugawa
- z ah
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- zd Gershenwald
- Zenklusen
- Zeps
- zf Ghossein
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang H. b
- Zhao
- Zheng
- Zhou
- Zhou
- Zhu
- Zhu
- zi zj
- zm Jayaseelan
- Zou
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- zt Kim
- zw Lewis
- Ó. A. th
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- Publication venue
- Publication date
- 11/12/2019
- Field of study
Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe
The gene and microRNA networks of stem cells and reprogramming
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- 'American Institute of Mathematical Sciences (AIMS)'
- Publication date
- 01/01/2018
- Field of study
Porous carbon spheres: Recent developments and applications
- Author
- Amorós-Pérez A Cano-Casanova L, Ouzzine M, et al.
- Anceschi A Magnacca G, Trotta F, et al.
- Baghel A Singh B, Prasad GK, et al.
- Bedin KC Martins AC, Cazetta AL, et al.
- Boopathi M Singh B, Vijayaraghavan R
- Böhringer B Guerra Gonzalez O, Eckle I, et al.
- Chang B Guan D, Tian Y, et al.
- Chang B Yang B, Guo Y, et al.
- Chen A Xia K, Zhang L, et al.
- Chen XY Chen C, Zhang ZJ, et al.
- Chen Z Ye S, Evans SD, et al.
- Choma J Osuchowski Ł, Dziura A, et al.
- Choma J Osuchowski Ł, Marszewski M, et al.
- Chowdhury ZZ Hamid SBA, Rahman MM, et al.
- Fan Y Liu PF, Yang ZJ, et al.
- Fernández JF Nierobisch P, Niemeyer B
- Fichtner S Hofmann J, Möller A, et al.
- Fu J Chen Z, Wang M, et al.
- Galeano C Meier JC, Soorholtz M, et al.
- Ge H Xu H, Lu T, et al.
- González-García P
- Hadidi L Mahmoud AYF, Purkait TK, et al.
- Hao ZQ Cao JP, Zhao XY, et al.
- Ho HC Goswami M, Chen J, et al.
- Hong M Chen J, Zhang M, et al.
- Hong YJ Kang YC
- Huang X Zhou LJ, Voiry D, et al.
- Huang YP Hsi HC, Liu SC
- Jahandar LM Atkinson JD, Hashisho Z, et al.
- Jahandar LM Atkinson JD, Hashisho Z, et al.
- Jia Z Li Z, Li S, et al.
- Khan MK Maclachlan MJ
- Kim C Kim K, Moon JH
- Kim MH Kim KB, Park SM, et al.
- Klefer H Munoz M, Modrow A, et al.
- Li R Wang L, Shahbazi A
- Li S Pasc A, Fierro V, et al.
- Lin F Wang Y, Lin Z
- Liu J Sun N, Sun C, et al.
- Liu J Wickramaratne NP, Qiao SZ, et al.
- Liu M Gan L, Xiong W, et al.
- Liu M Wang X, Zhu D, et al.
- Liu MX Deng XX, Zhu DZ, et al.
- Liu Z Ling L, Qiao W, et al.
- Lu W Liu M, Miao L, et al.
- Ma X Gan L, Liu M, et al.
- Manocha SM
- Mao H Chen X, Huang R, et al.
- Meng Y Wang S, Li C, et al.
- Menya E Olupot PW, Storz H, et al.
- Mestre AS Tyszko E, Andrade MA, et al.
- Mhamane D Kim MS, Park BH, et al.
- Moreno-Castilla C
- Munoz M Kolb V, Lamolda A, et al.
- Mutuma BK Matsoso B, Ranganathan K, et al.
- Nakagawa K Mukai SR, Tamura K, et al.
- Ng SWL Yilmaz G, Ong WL, et al.
- Oh WC Kim JG, Kim H, et al.
- Pan ZZ Dong L, Lv W, et al.
- Pappas GS Ferrari S, Huang X, et al.
- Pol VG Shrestha LK, Ariga K
- Qi J Li J, Li Y, et al.
- Ren W Zhang Z, Wang Y, et al.
- Roberts AD Li X, Zhang H
- Romero-Anaya AJ Lillo-Ródenas MA, Linares-Solano A
- Romero-Anaya AJ Lillo-Ródenas MA, Linares-Solano A
- Romero-Anaya AJ Ouzzine M, Lillo-Ródenas MA, et al.
- Ruan CQ Wang Z, Lindh J, et al.
- Schute K Louven Y, Detoni C, et al.
- Shao X Wang W, Xue R, et al.
- Shi Y Zhang X, Liu G
- Singh A Lal D
- Singh A Lal D
- Singh A Lal D
- Singh A Yadav RK, Srivastava A
- Song X Gunawan P, Jiang R, et al.
- Sun N Sun C, Liu H, et al.
- Sun N Sun C, Liu J, et al.
- Sun Y Li K, Zhao J, et al.
- Sun Y Zhao J, Wang J, et al.
- Sun Z Shen S, Ma L, et al.
- Tagliavini M Engel F, Weidler PG, et al.
- Tang J Wang J, Shrestha LK, et al.
- Tian H Liu J, O'Donnell K, et al.
- Veerakumar P Muthuselvam P, Pounraj T, et al.
- Wang M Zhang H, Wang Q, et al.
- Wang Q Liang X, Qiao W, et al.
- Wang Q Liang X, Zhang R, et al.
- Wang T Zhao P, Zhao Q, et al.
- Wang X Xin C, Shi C, et al.
- Wang Y Chang B, Guan D, et al.
- Wang ZQ Sun LX, Xu F, et al.
- Wei D Zhang Y, Fu J
- Wickramaratne NP Jaroniec M
- With PC Wilde N, Modrow A, et al.
- Wu Q Li W, Liu S
- Wu Q Li W, Tan J, et al.
- Yamaguchi J Tanaka T, Inagi R
- Yamamoto O Sawai J, Sasamoto T
- Yang JB Ling LC, Liu L, et al.
- Yang S Zhu Y, Cao C, et al.
- Yang W Feng Y, Xiao D, et al.
- Yang X Xia H, Liang Z, et al.
- Yenisoy-Karakaş S Aygün A, Güneş M, et al.
- Yu Q Guan D, Zhuang Z, et al.
- Zhang C Hatzell KB, Boota M, et al.
- Zhang C Lin S, Peng J, et al.
- Zhang C Song W, Sun G, et al.
- Zhang C Song W, Zhang X, et al.
- Zhang P Qiao ZA, Dai S
- Zhang P Zhu H, Dai S
- Zhang W Zhou Z
- Zhao Q Lin Y, Han N, et al.
- Zhou J Wang Y, Wang J, et al.
- Zhou L Xie G, Chen X
- Zhu D Wang Y, Gan L, et al.
- Publication venue
- 'American Institute of Mathematical Sciences (AIMS)'
- Publication date
- 01/01/2018
- Field of study
Target validation and drug discovery using genomic and protein–protein interaction technologies
- Author
- ABEDI M
- ALIZADEH AA
- APIC G
- ARONHEIM A
- Arthur J Blume
- ASIMIREMBWA CM
- BERGER SL
- BLUME AJ
- BOGARAD LD
- BUCHANAN SG
- BUCHANAN SG
- BYERS RJ
- CAO SX
- CAPRONIGRO G
- CHEN G
- CHIEN CT
- CLARKE PA
- CRAMERI R
- DAHANUKAR A
- DANNER S AND BELASCO J
- DENEGRI M
- DIATCHENKO L
- DREWS J
- DURFEE T
- FIELDS S
- FIELDS S
- GALLOP MA
- GAVIN A
- GERSTEIN M
- GILL G
- GOETZ AS
- GOLEMIS E
- GOPALKRISHNAN RV
- GYURISJ GOLEMIS E
- HEDGE P
- HELLER RA
- HO Y
- HUANG F
- HUBANK M
- INOUYE C
- International Human Genome SequencingConsortium
- ITO T
- ITO T
- JANE MOTZNY CK
- JIANG H
- JIANG H
- JIANG H KANG D-C
- KANG D-C JIANG H, WU Q, PESTKA S, FISHER
- KANG D-C LAFRANCE R, SU Z-Z, FISHER
- KATZ BA
- KEMMEREN P
- KRAEMER B
- LI JJ
- LI M
- LIANG P
- LIANG P
- LISITSYN NA
- MAGGIO ET
- MAROUN M
- MARTIN F
- MATZ MV
- MCBEATH G AND SCHREIBER SL
- MULLER PY
- Neil I Goldstein
- PARK YW
- PARMLEY SF
- Paul B Fisher
- PILLUTLA RC
- PILLUTLA RC HSIAO K-C
- RAIN J-C
- RAVERA MW
- Renuka C Pillutla
- RIECHMANN L
- RIGAUT G
- ROBERTS R
- SAGERSTROM CG
- SCHENA M
- SCHENA M
- SENGUPTA D
- SHEN R SU Z-Z
- STASSAR MJ
- SU Z-Z SHI Y, FISHER
- SU Z-Z SHI Y, FISHER
- SU Z-Z SHI Y, FRIEDMAN R et al.
- TONG AH
- UETZ P
- VELCULESCU VE
- VENTER JC
- VIDAL M
- VOJTEK AB
- VON MERING C
- VON MERING C
- WALHOUT A
- WAN JS
- WANG MM
- WANG ZF
- WANG ZF
- WRIGHT FA
- XU X
- YAFFE MB
- ZHANG B
- ZHANG JS
- ZHANG L
- ZHU H
- ZOZULYA S
- ZUCCONI A
- Publication venue
- 'Informa Healthcare'
- Publication date
- Field of study
Diversity in Genetic In Vivo
- Author
- Abida WM
- Aguilera C
- Ahmed KS
- Aho S
- Akman G
- Albers M
- Albert R
- Althoff EA
- Ando R
- Andreopoulos B
- Andresen M
- Aronheim A
- Atmakuri K
- Attri AK
- Bailer SM
- Bak G
- Baker K
- Baker K
- Bandyopadhyay S
- Barabási AL
- Bardiya N
- Bardwell AJ
- Barnard E
- Barnard E
- Barnea G
- Bartel PL
- Barz T
- Baskakov IV
- Battesti A
- Bauer P
- Becker F
- Beckmann S
- Bendixen C
- Benton R
- Berger BW
- Bernstein DS
- Bex C
- Bhat RA
- Bichet A
- Björklund O
- Blanchard D
- Bloch DB
- Blondel M
- Boder ET
- Bongards C
- Borloo J
- Boruc J
- Boruc J
- Bouffard P
- Boulton SJ
- Boysen JH
- Bracha-Drori K
- Brakemann T
- Braun P
- Braun P
- Breitkreutz A
- Brent R
- Brent R
- Broek D
- Brown KR
- Brymora A
- Bröder YC
- Bubulya A
- Cabello J
- Caberoy NB
- Cadima-Couto I
- Caligiuri M
- Campbell RN
- Cao Y
- Caro E
- Carter BT
- Castaño AR
- Castrillo G
- Chanda D
- Chandra H
- Charloteaux B
- Chen B
- Chen B
- Chen H
- Chen J
- Chen J
- Chen SC
- Chen YC
- Chew BS
- Chiang T
- Chidley C
- Chien CT
- Chockalingam K
- Choi JH
- Christ F
- Christensen RG
- Chu J
- Citovsky V
- Claessens A
- Clarke P
- Colland F
- Cormack RS
- Costanzo M
- Cox JS
- Crooks RO
- Cross GH
- Cusick ME
- Das S
- Datta S
- Davy A
- Day RN
- Day RN
- de Felipe KS
- de Folter S
- Deane CM
- Deeds EJ
- Defeu Soufo HJ
- Del Bene F
- Deng Q
- Deplancke B
- Deplancke B
- Deplazes A
- Dhayalan A
- Di Lallo G
- Dirnberger D
- Dirnberger D
- Dixit R
- Dixon AS
- Dmitrova M
- Dohmen RJ
- Dong S
- Dove SL
- Dove SL
- Dozhanskaya N
- Dreze M
- Du W
- Dube DH
- Dudak A
- Dues G
- Durai S
- Durfee T
- Dutta S
- Dyer MD
- Dünkler A
- Dünnwald M
- Ear PH
- Ecker K
- Edgerton MD
- Edwards AM
- Edwards SR
- Ehlert A
- Ehrhard KN
- Elbashir SM
- Elefsinioti A
- Elleuche S
- Endoh H
- Ewing RM
- Eyckerman S
- Eyckerman S
- Fan JY
- Faye C
- Feng SY
- Fiebitz A
- Filipovska A
- Finley RL
- Firestine SM
- Flajolet M
- Formstecher E
- Fossum E
- Fraser HB
- Frech C
- Friedel CC
- Fujikawa Y
- Fukuda N
- Fukuda N
- Fukuda N
- Fukuura M
- Galarneau A
- Gallagher SS
- Gandia J
- Garcia-Cuellar MP
- Gardiner L
- Gavin AC
- Gavin AC
- Gavin AC
- Gehl C
- Ghosh I
- Giniger E
- Gisler SM
- Goehler H
- Gohl C
- Goldberg DS
- Goll J
- Gomez TA
- Gonçalves SA
- Graf R
- Gray PN
- Greenfield NJ
- Grefen C
- Grefen C
- Grefen C
- Griesbeck O
- Grigoriev A
- Grigoriev A
- Grinberg AV
- Gu H
- Guda C
- Gunde T
- Guo B
- Guo D
- Guo D
- Guo M
- Gurezka R
- Gyuris J
- Hackbusch J
- Hagemann AI
- Hammani K
- Hammer MM
- Hao N
- Harrington L
- Hart GT
- Harvey SA
- Hashimoto J
- Hashimoto T
- Hassinen A
- Hazbun TR
- He B
- He F
- Henao-Mejia J
- Hengen PN
- Hennecke F
- Henthorn DC
- Herrmann F
- Hershko A
- Hershkovitz D
- Hiatt SM
- Hida N
- Hirst M
- Hishigaki H
- Ho Y
- Hollenberg SM
- Hook B
- Horswill AR
- Horswill AR
- Houser-Scott F
- Hruby A
- Hu JC
- Hu JC
- Hu X
- Hu X
- Huang A
- Huang H
- Huang H
- Huang J
- Huang TW
- Huang W
- Huang YC
- Hubsman M
- Hudry B
- Hussey SL
- Hwang CS
- Immink RG
- Irion U
- Ishimoto T
- Islam KM
- Isogai M
- Ito T
- Ivanic J
- Iwai K
- Jaaro H
- James P
- Jansen R
- Jansen R
- Jensen LJ
- Jeong H
- Jeong KJ
- Jiang R
- Jiang T
- Jiang W
- Jiang Y
- Jin F
- Jin F
- Johnsson N
- Joshi PB
- Joung JK
- Jung SO
- Kaboord B
- Kaihara A
- Kamiya T
- Kang PJ
- Kanno A
- Karna SLR
- Kato N
- Kato N
- Kato-Stankiewicz J
- Kaushansky A
- Kawahara T
- Keegan K
- Keegan L
- Kehat I
- Kelley BP
- Kemmeren P
- Keppler A
- Kerppola TK
- Keskin O
- Khadka S
- Kiemer L
- Kikis EA
- Kim JY
- Kim SB
- Kim SB
- Kimura T
- King AD
- King G
- Kishi T
- Klopffleisch K
- Knauer SK
- Kodama Y
- Kodama Y
- Kodama Y
- Koegl M
- Kojima T
- Kolmar H
- Kolmar H
- Korkegian A
- Korolik V
- Kotani K
- Kraakman L
- Kraichely DM
- Krogan NJ
- Kumar A
- Kumar S
- Kwaaitaal M
- König J
- LaCount DJ
- Lalonde S
- Langosch D
- Laser H
- Le Douarin B
- Le Guével R
- Leanna CA
- Lee LY
- Lee OH
- Lee SA
- Lee YR
- Legrain P
- Lehner B
- Lemercier G
- Letovsky S
- Levy ED
- Li C
- Li J
- Li JJ
- Li M
- Li W
- Lian HL
- Licitra EJ
- Lickfeld M
- Lidke DS
- Lievens S
- Lievens S
- Lievens S
- Lim J
- Lim YH
- Lima-Mendez G
- Lin H
- Lin HN
- Lin HY
- Lin M
- Lin X
- Liu B
- Liu H
- Liu JX
- Liu M
- Liu Y
- Long RM
- Lopato S
- Loving GS
- Lugari A
- Luker GD
- Luker KE
- Lundblad JR
- Luo J
- Ma J
- Ma J
- MacDonald ML
- MacDonald PN
- MacFarlane SA
- Magliery TJ
- Mahdavi MA
- Maier CJ
- Maier R
- Makhnevych T
- Manderson EN
- Marchadier E
- Maroun M
- Marsolier MC
- Massoud TF
- Matsui K
- Matthews LR
- McCraith S
- McDowall MD
- Meng X
- Meng X
- Mervine SM
- Michnick SW
- Michnick SW
- Mika S
- Miller CL
- Miller JP
- Miller RR
- Min J
- Miranda E
- Misawa N
- Miyashita S
- Moerdyk-Schauwecker M
- Mon H
- Morell M
- Morell M
- Morell M
- Mori K
- Moriyoshi K
- Morsy M
- Mrowka R
- Mueller SO
- Möckli N
- Müller J
- Müller MM
- Nakayama M
- Nateri AS
- Navlakha S
- Nguyen PQ
- Nishihara T
- Noirot-Gros MF
- Nooren IM
- Noyes MB
- Nyfeler B
- O'Hare H
- Obrdlik P
- Ohad N
- Ohad N
- Ortega AD
- Osborne MA
- Osborne MA
- Ou B
- Ozawa T
- Ozawa T
- Ozawa T
- Palomino A
- Pan J
- Park K
- Park SH
- Park SY
- Park YW
- Parrish
- Parrish JR
- Pastor-Satorras R
- Patil A
- Pattanaik S
- Paulmurugan R
- Paulmurugan R
- Paulmurugan R
- Paumi CM
- Pause A
- Pawson T
- Pearce MJ
- Peeters T
- Pelletier JN
- Pelletier JN
- Peralta-Yahya P
- Peterson FC
- Petrascheck M
- Phan J
- Pierce MM
- Piganeau N
- Pineda-Lucena A
- Piston DW
- Plaza S
- Polte TR
- Pratt MR
- Ptacek J
- Pu J
- Puliyappadamba VT
- Putz U
- Qian J
- Rahim G
- Rajagopala SV
- Rajagopala SV
- Raman K
- Ramani AK
- Raquet X
- Ravasi T
- Ray MR
- Rebois RV
- Reboul J
- Reeder MK
- Reguly T
- Reinders A
- Remy I
- Remy I
- Remy I
- Remy I
- Remy I
- Rodrigue A
- Rojo-Niersbach E
- Royant A
- Rual JF
- Ruokolainen S
- Russ WP
- Russell CL
- Sacco E
- Sadowski I
- Saka Y
- Sambourg L
- Sandrock K
- Sato S
- Schittenhelm RB
- Schneider D
- Schreiber SL
- Schuck P
- Schwarz T
- Schönhofer-Merl S
- Schüler A
- Scognamiglio PL
- Scott MS
- Selyunin AS
- SenGupta DJ
- SenGupta DJ
- Seok HY
- Serebriiskii IG
- Serebriiskii IG
- Serebriiskii IG
- Serebriiskii IG
- Serebriiskii IG
- Sharan R
- Sheerin DJ
- Shi Y
- Shi YY
- Shibasaki S
- Shih AM
- Shih HM
- Shimomura O
- Shin CJ
- Shioda T
- Shrivastav S
- Shui X
- Shyu YJ
- Shyu YJ
- Sieber P
- Siep M
- Sieweke MH
- Sieweke MH
- Simonis N
- Singh K
- Sivaneson M
- Skrabanek L
- Snider J
- Spektor TM
- Spotts JM
- Sprinzak E
- Srivastav RK
- Stagljar I
- Stanyon CA
- Starling AL
- Staudinger J
- Stefan E
- Stellberger T
- Stelzl U
- Stern S
- Stiel AC
- Stiel AC
- Strauch E-M
- Stumpf CR
- Subach FV
- Subramaniam R
- Sung MK
- Suzuki H
- Suzuki H
- Söderberg O
- Tafelmeyer P
- Takahashi Y
- Takemoto D
- Tao H
- Tavassoli A
- Tavassoli A
- Tavassoli P
- Teeri TH
- Thibodeaux GN
- Tirode F
- Tirosh I
- Titz B
- Titz B
- Tojo T
- Topper JN
- Triezenberg SJ
- Truong K
- Ueno A
- Uesugi M
- Uetz P
- Urech DM
- Ushioda R
- Vallet-Gely I
- Van Criekinge W
- Van del Belt K
- Van Leene J
- Varshavsky A
- Varshavsky A
- Vasilescu J
- Vazquez A
- Venkatesan K
- Vermeirssen V
- Vermeirssen V
- Vidal M
- Vidal M
- Vidalain PO
- Vignols F
- Vijay-Kumar S
- Villalobos V
- Vojtek AB
- Vollmeister E
- von Degenfeld G
- von Mering C
- Voss TC
- Waadt R
- Wafa LA
- Wagner A
- Walhout AJ
- Walhout AJ
- Walhout AJ
- Walter M
- Wang H
- Wang MM
- Wang S
- Wang TY
- Wang Y
- Wang Z-H
- Waraho D
- Wasserman T
- Weber M
- Weber-Boyvat M
- Webster NJ
- Weghuber J
- Wehr MC
- Wehrman T
- Wehrman TS
- Weinthal D
- Wiesner C
- Wiles AM
- Wilhelm JE
- Wilson T
- Wilson TE
- Wingler LM
- Wittke S
- Wolf F
- Wu G
- Wu-Baer F
- Wurm JP
- Wurster SE
- Wurster SE
- Xie Z
- Xu CW
- Yang J
- You X
- Young K
- Yu H
- Yu H
- Yu H
- Yu X
- Yun CW
- Zhang B
- Zhang J
- Zhang L
- Zhang S
- Zhang X
- Zhang Y
- Zhao X
- Zhao XM
- Zhong J
- Zhong Q
- Zhou J
- Zhou J
- Zhu H
- Zhu LJ
- Zilian E
- Zinzalla G
- Zolghadr K
- Zotenko E
- Zwart W
- Publication venue
- 'American Society for Microbiology'
- Publication date
- Field of study
Secretase Processing of Amyloid Precursor Protein (APP) and Neurodegeneration
- Author
- A Alberici
- A Alzheimer
- A Capell
- A Capell
- A Capell
- A Confaloni
- A Demuro
- A Fisher
- A Fisher
- A Fukumori
- A Herreman
- A Kinoshita
- A Kinoshita
- A Lleo
- A Olry
- A Olsson
- A Papassotiropoulos
- A Petit
- A Rostagno
- A Sant'Angelo
- A Schmechel
- A Yamasaki
- AC Nyborg
- AE Roher
- AJ Saunders
- AL Brunkan
- AL Mah
- AP Owens
- AR Cole
- AS Crystal
- AS Espeseth
- AY Hung
- AZ Saleh
- B De Strooper
- B Nawrot
- B Vincent
- B Xiong
- BD Bennett
- C Alves da Costa
- C Brou
- C Esh
- C Goutte
- C Goutte
- C Hattori
- C Kaether
- C Kaether
- C Lai
- C Lilliehook
- C McLendon
- C Prinzen
- C Rio
- C Yu
- CA Dickey
- CA Hansson
- CA Hansson
- CA Saura
- CA Saura
- CA von Arnim
- CA von Arnim
- CJ Phiel
- CL Moore
- CS Ho
- CV Prasad
- CY Ni
- D Andrau
- D Beher
- D Beher
- D Beher
- D Cai
- D Edbauer
- D Edbauer
- D Edbauer
- D Edbauer
- D Hartmann
- D Murakami
- DC Fewlass
- DC Lu
- DE Kang
- DF Seals
- DG Jo
- DG Jo
- DM Barten
- DM Skovronsky
- DM Skovronsky
- DM Skovronsky
- DM Walsh
- DY Kim
- DY Kim
- E Bergamini
- E Diaz-Rodriguez
- E Kojro
- E Kojro
- E Lopez-Perez
- E Lopez-Perez
- E McGowan
- E Rockenstein
- E Six
- EJ Coulson
- EL Meyer
- EM Hansson
- ES Walker
- ET Parkin
- ET Parkin
- F Acquati
- F Bihel
- F Bihel
- F Chen
- F Chiti
- F Fischer
- F Gruninger-Leitch
- FG Gervais
- G Abbenante
- G Evin
- G Levesque
- G Li
- G Ma
- G Pigino
- G Tian
- G Verdile
- G Weskamp
- G Yu
- G Yu
- G Zhao
- G Zhu
- GD King
- GG Glenner
- GG Glenner
- GG Westmeyer
- GM Rishton
- H Fukumoto
- H Fukumoto
- H Hasegawa
- H Jia
- H Kim
- H Klafki
- H Komano
- H Laudon
- H Loetscher
- H Qing
- H Runz
- H Steiner
- H Steiner
- H Tanahashi
- H Yu
- H Zetterberg
- HF Dovey
- HG Bernstein
- HJ Lee
- HK Wong
- HQ Wang
- HS Hong
- I Churcher
- I Hussain
- I Hussain
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Safety of Nonsteroidal Anti-inflammatory Drugs in Major Gastrointestinal Surgery: A Prospective, Multicenter Cohort Study
- Author
- Abbas Z
- Abburu S
- Abdelhadi M
- Abdikadir HR
- Abdulmajid A
- Abid A
- Abid H
- Abuhussein N
- Abul MH
- Acquaah F
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- Adeleja I
- Adjei H
- Afzal Z
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- Aidoo-Micah GE
- Aildasani L
- Aithie JM
- Akhtar S
- Al-Mousawi A
- Al-Obaedi O
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- Yousif A
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- Yuen R
- Zegeye MI
- Zhao J
- Ziff O
- Ziprin P
- Zuhair M
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
Background
Significant safety concerns remain surrounding the use of nonsteroidal anti-inflammatory drugs (NSAIDs) following gastrointestinal surgery, leading to wide variation in their use. This study aimed to determine the safety profile of NSAIDs after major gastrointestinal surgery.
Methods
Consecutive patients undergoing elective or emergency abdominal surgery with a minimum one-night stay during a 3-month study period were eligible for inclusion. The administration of any NSAID within 3 days following surgery was the main independent variable. The primary outcome measure was the 30-day postoperative major complication rate, as defined by the Clavien–Dindo classification (Clavien–Dindo III–V). Propensity matching with multivariable logistic regression was used to produce odds ratios (OR) and 95 % confidence intervals.
Results
From 9264 patients, 23.9 % (n = 2212) received postoperative NSAIDs. The overall major complication rate was 11.5 % (n = 1067). Following propensity matching and adjustment, use of NSAIDs were not significantly associated with any increase in major complications (OR 0.90, 0.60–1.34, p = 0.560).
Conclusions
Early use of postoperative NSAIDs was not associated with an increase in major complications following gastrointestinal surgery
Search for subsolar-mass black hole binaries in the second part of Advanced LIGO’s and Advanced Virgo’s third observing run
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- Wysocki DM
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- Zadrożny A
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- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 28/02/2023
- Field of study
Model-based Cross-correlation Search for Gravitational Waves from the Low-mass X-Ray Binary Scorpius X-1 in LIGO O3 Data
- Author
- Abbott R
- Abe H
- Acernese F
- Ackley K
- Adhicary S
- Adhikari N
- Adhikari RX
- Adkins VK
- Adya VB
- Affeldt C
- Agarwal D
- Agathos M
- Aguiar OD
- Aiello L
- Ain A
- Ajith P
- Akutsu T
- Albanesi S
- Alfaidi RA
- Allocca A
- Alléné C
- Altin PA
- Amato A
- Anand S
- Ananyeva A
- Anderson SB
- Anderson WG
- Ando M
- Andrade T
- Andres N
- Andrić T
- Andrés-Carcasona M
- Ansoldi S
- Antelis JM
- Antier S
- Apostolatos T
- Appavuravther EZ
- Appert S
- Apple SK
- Arai K
- Araya A
- Araya MC
- Areeda JS
- Aritomi N
- Arnaud N
- Arogeti M
- Aronson SM
- Arène M
- Asada H
- Ashton G
- Aso Y
- Assiduo M
- Aston SM
- Astone P
- Aubin F
- AultONeal K
- Babak S
- Badaracco F
- Badger C
- Bae S
- Bae Y
- Bagnasco S
- Bai Y
- Baier JG
- Baird J
- Bajpai R
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- Bakel NV
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- Barish BC
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- Barsuglia M
- Barta D
- Bartlett J
- Barton MA
- Bartos I
- Basak S
- Bassiri R
- Basti A
- Bawaj M
- Bayley JC
- Bazzan M
- Bedakihale VM
- Beirnaert F
- Bejger M
- Belahcene I
- Bell AS
- Benedetto V
- Beniwal D
- Benoit W
- Bentley JD
- BenYaala M
- Bera S
- Berbel M
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- Bernuzzi S
- Beroiz M
- Bersanetti D
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- Beuzekom MV
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- Blair CD
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- Danzmann K
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- Dasgupta A
- Datrier LEH
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- Dattilo V
- Dave I
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- Davies GSC
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- Durante O
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- Ewing BE
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- Ferguson DL
- Fernandez-Galiana A
- Ferrante I
- Ferreira TA
- Fidecaro F
- Figura P
- Fiore LD
- Fiori A
- Fiori I
- Fishbach M
- Fisher RP
- Fittipaldi R
- Fiumara V
- Flaminio R
- Floden E
- Fong HK
- Font JA
- Fornal B
- Forsyth PWF
- Franke A
- Frasca S
- Frasconi F
- Freed JP
- Frei Z
- Freise A
- Freitas O
- Frey R
- Fritschel P
- Frolov VV
- Fronzo CD
- Fronzé GG
- Fujii Y
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- Gabella WE
- Gadre BU
- Gair JR
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- Zhu Z-H
- Zimmerman AB
- Zucker ME
- Zweizig J
- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2022
- Field of study
We present the results of a model-based search for continuous gravitational waves from the low-mass X-ray binary Scorpius X-1 using LIGO detector data from the third observing run of Advanced LIGO and Advanced Virgo. This is a semicoherent search that uses details of the signal model to coherently combine data separated by less than a specified coherence time, which can be adjusted to balance sensitivity with computing cost. The search covered a range of gravitational-wave frequencies from 25 to 1600 Hz, as well as ranges in orbital speed, frequency, and phase determined from observational constraints. No significant detection candidates were found, and upper limits were set as a function of frequency. The most stringent limits, between 100 and 200 Hz, correspond to an amplitude h0 of about 10−25 when marginalized isotropically over the unknown inclination angle of the neutron star's rotation axis, or less than 4 × 10−26 assuming the optimal orientation. The sensitivity of this search is now probing amplitudes predicted by models of torque balance equilibrium. For the usual conservative model assuming accretion at the surface of the neutron star, our isotropically marginalized upper limits are close to the predicted amplitude from about 70 to 100 Hz; the limits assuming that the neutron star spin is aligned with the most likely orbital angular momentum are below the conservative torque balance predictions from 40 to 200 Hz. Assuming a broader range of accretion models, our direct limits on gravitational-wave amplitude delve into the relevant parameter space over a wide range of frequencies, to 500 Hz or more