66 research outputs found
Dynamic Evolution of Microscopic Wet Cracking Noises
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 06/09/2016
- Field of study
Characterizing the interaction between water and microscopic defects is one
of the long-standing challenges in understanding a broad range of cracking
processes. Different physical aspects of microscopic events, driven or
influenced by water, have been extensively discussed in atomistic calculations
but have not been accessible in microscale experiments. Through the analysis of
the emitted noises during the evolution of individual, dynamic microcracking
events, we show that the onset of a secondary instability known as hybrid
events occurs during the fast healing phase of microcracking, which leads to
(local) sudden increase of pore water pressure in the process zone, inducing a
secondary instability, which is followed by a fast-locking phase on the
microscopic faults (pulse-like rupture)
Pan-cancer analysis of whole genomes
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- Waddell
- Waddell
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- Wagener
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- Waring
- Warnatz
- Warrell
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- Weichenhan
- Weinberger
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- Weischenfeldt J. g
- Weisenberger
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- Wilkerson M. D. v
- Williams
- Wilmott
- Wilson G. W. k
- Wilson R. K. z
- Wintersinger
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- wv abg
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- Y. yc
- ya Al-Ahmadie
- Yachida
- Yamaguchi
- Yamaguchi T. N. k
- Yamamoto
- Yamaue
- Yang
- Yang
- Yang
- Yang
- Yang
- Yao
- Yaspo
- Yates
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- yb Ally
- yd Cherniack
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- Yellapantula
- yh Bathe
- yj Baylin
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- Yugawa
- z ah
- Z. ej
- Z. ep
- Z. fr
- Z. hv
- Z. hy
- Z. jq
- Z. kt
- Z. oe
- Zaikova
- Zapatka
- zd Gershenwald
- Zenklusen
- Zeps
- zf Ghossein
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang
- Zhang H. b
- Zhao
- Zheng
- Zhou
- Zhou
- Zhu
- Zhu
- zi zj
- zm Jayaseelan
- Zou
- Zou
- zt Kim
- zw Lewis
- Ó. A. th
- Ø. sk
- Publication venue
- Publication date
- 11/12/2019
- Field of study
Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
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- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
- Abel S
- Abeliovich H
- Abildgaard MH
- Abudu YP
- Acevedo-Arozena A
- Adamopoulos IE
- Adeli K
- Adolph TE
- Adornetto A
- Aflaki E
- Agam G
- Agarwal A
- Aggarwal BB
- Agnello M
- Agostinis P
- Agrewala JN
- Agrotis A
- Aguilar PV
- Ahmad ST
- Ahmed ZM
- Ahumada-Castro U
- Aits S
- Aizawa S
- Akkoc Y
- Akoumianaki T
- Akpinar HA
- Al-Abd AM
- Al-Akra L
- Al-Gharaibeh A
- Alaoui-Jamali MA
- Alberti S
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- Alessandri C
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- Zorzano A
- Zou W
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- Zwerschke W
- Álvarez ÉMC
- Ávalos Y
- Önal G
- Üstün S
- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Nitroglycerin: a homeopathic remedy.
- Author
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- Field of study
A recent deep earthquake doublet in light of long-term evolution of Nazca subduction
- Author
- A Chopelas
- A Hampel
- AM Dziewonski
- B Schmandt
- BLN Kennett
- D Engebretson
- DA Wiens
- DG Pearson
- E Sokos
- E Sokos
- EA Okal
- EA Okal
- F Gallovič
- G Ekström
- G Müller
- GP Hayes
- H Jung
- H Kanamori
- H Kawakatsu
- H Čížková
- H Čížková
- HW Green
- HW Green
- HW Green II
- J Quinteros
- J van Hunen
- J Zahradnik
- JD Collier
- JL Mosenfelder
- L Ye
- M Bouchon
- M Běhounková
- M Faccenda
- M Faccenda
- M Nishi
- M Palot
- M Sdrolias
- M Vallée
- P Wessel
- PF Ihmlé
- R Madariaga
- R Quintero
- R Tibi
- RD Müller
- S Omori
- S van der Lee
- SH Kirby
- SH Kirby
- SP Hicks
- T Garth
- T Katsura
- T Komabayashi
- V Vavryčuk
- WL Du Frane
- WL van Mierlo
- Y Fukao
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Slab morphology and deformation beneath Izu-Bonin
- Author
- AF Holt
- B Emmerson
- B Isacks
- BLN Kennett
- C Cai
- C Faccenna
- C Frohlich
- C Li
- CR Ranero
- D Zhao
- DF Argus
- ER Engdahl
- F Funiciello
- F Garel
- F Waldhauser
- G Jiang
- GV Burbach
- H Zhang
- H Zhang
- H Čížková
- HW Green II
- HW Green II
- HW Zhou
- J Dannberg
- JD Pesicek
- K Kuge
- L Stixrude
- L Ye
- LA Alpert
- LR Sykes
- M Faccenda
- M Gurnis
- M Obayashi
- M Obayashi
- M Ogawa
- MI Billen
- MJR Wortel
- MS Miller
- MS Miller
- MS Miller
- P Bird
- R Hilst van der
- R Hilst van der
- R Myhill
- R Myhill
- RD Hilst van der
- RD Müller
- RL Carlson
- RW Porritt
- S Cottaar
- S Omori
- S Padhy
- S Takemura
- T Furumura
- T Yang
- UH Faul
- X Pichon Le
- Y Fukao
- Y Fukao
- Y Takei
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Dry metastable olivine and slab deformation in a wet subducting slab
- Author
- A Beran
- A Mohiuddin
- A Schubnel
- AC Withers
- AD Rosa
- AH Peslier
- BR Hacker
- C Cai
- CM Sung
- CR Ranero
- G Jiang
- G Richard
- H Kagi
- H Kawakatsu
- H Keppler
- H Čı́žková
- HW Green II
- HW Green II
- J Ingrin
- J Quinteros
- J Zahradnik
- JA Tielke
- JP Brodholt
- JP Perrillat
- JR Smyth
- KD Litasov
- MW Schmidt
- N Bolfan-Casanova
- N Bolfan-Casanova
- N Hirano
- N Purevjav
- N Purevjav
- PE van Keken
- R Hae
- RE Pacalo
- S Demouchy
- S Demouchy
- S Kirby
- S Mei
- S Yoshioka
- SH Kirby
- SI Karato
- SI Karato
- SM Peacock
- T Hosoya
- T Iidaka
- T Komabayashi
- T Kubo
- T Kubo
- T Kudo
- T Yamasaki
- TP Ferrand
- WL Du Frane
- Y Fukao
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Sequential 123I-iododexetimide scans in temporal lobe epilepsy: comparison with neuroimaging scans (MR imaging and 18F-FDG PET imaging)
- Author
- AA Wilson
- Armin Mohamed
- Aysha Zaman
- BA Ardekani
- Chris Constable
- CT Dickson
- David Henderson
- EA Cavalheiro
- HE Laird II
- HM Hudson
- HW Muller-Gartner
- HW Muller-Gartner
- JO McNamara
- JW Cruickshank
- KL Boundy
- KL Boundy
- L Danober
- M Kassiou
- Michael J. Fulham
- Michael Kassiou
- MR Newton
- PK Hooper
- RA Bronen
- RA Morrisett
- RC Green
- RM Dasheiff
- S Eberl
- S Eberl
- Scott Beveridge
- SE Hamilton
- Sing Kai Lo
- SJ Kish
- SR Meikle
- Stefan Eberl
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Microscopic Evolution of Laboratory Volcanic Hybrid Earthquakes
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Deep origin and hot melting of an Archaean orogenic peridotite massif in Norway
- Author
- AE Ringwood
- C Herzberg
- D Ionov
- DA Carswell
- DA Carswell
- DG Pearson
- Dirk Spengler
- E Hellebrand
- E Takahashi
- EE Beyer
- Gareth R. Davies
- Herman L. M. van Roermund
- HK Brueckner
- HK Brueckner
- HLM Van Roermund
- HLM Van Roermund
- HLM Van Roermund
- HW Green II
- JH De Smet
- JR Van Orman
- K Ye
- KTM Johnson
- LF Dobrzhinetskaya
- LF Dobrzhinetskaya
- Luisa Ottolini
- Martyn R. Drury
- MJ Walter
- MP Terry
- MR Drury
- Paul R. D. Mason
- S Song
- SE Haggerty
- SR Burgess
- SS Schmidberger
- T Gasparik
- T Stachel
- WL Griffin
- Y Fei
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2006
- Field of study
The buoyancy and strength of sub-continental lithospheric mantle is thought to protect the oldest continental crust (cratons) from destruction by plate tectonic processes. The exact origin of the lithosphere below cratons is controversial, but seems clearly to be a residue remaining after the extraction of large amounts of mel
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