56 research outputs found
Children must be protected from the tobacco industry's marketing tactics.
- Author
- Abdallah Said
- Absalom Gareth
- Adams Nick
- Adeboyeku David
- Agate Rowan
- Agrawal Sanjay
- Ahmed Liju
- Allen Bev
- Anderson Paul
- Anwar Sadia
- Arabnia Gilda
- Ayres Jon
- Badman Ros
- Bafadhel Mona
- Baker Emma
- Banerjee Tushar
- Barker Jack
- Barnes Peter
- Barnett Emma
- Barnham Kate
- Barr Laura
- Barry Simon
- Bartoszewicz Charlotte
- Beasley Victoria
- Berry Matthew
- Bhowmik Angshu
- Bingham Lyn
- Bintcliffe Oliver
- Bloch Susannah
- Boland Alison
- Bolton Charlotte
- Booth Andrew
- Booton Richard
- Bothamley Graham
- Bott Julia
- Bourke Stephen
- Bradley Bethia
- Breen Ronan
- Brennan Amanda
- Bridges Diana
- Britton John
- Brown Joanna
- Brown Louise
- Brown Sarah
- Browne Emma
- Brunet Martin
- Burge Sherwood
- Burgin Karen
- Burke Hannah
- Bush Andrew
- Butcher Jane
- Buttery Robert
- Buxton Maria
- Calverley Peter
- Campbell Colin
- Campbell Ian
- Capstick Toby
- Carlin Chris
- Casswell Georgina
- Chaudhry Nauman
- Chavasse Richard
- Christensen Anne
- Christopher Anne
- Chua Felix
- Clarke Sarah
- Clive Amelia
- Colin Campbell
- Collett Anne
- Collins Andrea
- Collins Nicola
- Connell David
- Connellan Stephen
- Connelly Carol
- Connett Gary
- Connolly Bronwen
- Cookson John
- Cooper Angela
- Cooper David
- Costello Carol Ann
- Coutts Ian
- Cowie Calvin
- Cox Nicola
- Crawfurd Laura
- Creagh-Brown Ben
- Crooks Gillian
- Crooks Gillian
- Crooks Stephen
- Crossingham Iain
- Cullen Kathy
- Cummings Natalie
- Curry Denise
- Curtis Katrina
- Daniels Tracey
- Davey Claire
- Davidson Philip
- Davies Carol-Anne
- Davies Lisa
- Davies Peter
- Davies Sarah
- Davison John
- Davison Tony
- Dayer Mark
- Deegan Paul
- Denniston Sarah
- Deveson Pete
- Dewar Maria
- Diana Bridges
- Dobson Lee
- Docherty Marianne
- Dodd James
- Doe Simon
- Dow Claire
- Downs Janis
- Dowson Lee
- Durham Stephen
- Durrington Hannah
- Dutta P
- Dwarakanath Akshay
- Eaden James
- Edwards Adrian
- Edwards Catherine
- Edwards John
- Edwards Sheila
- Edwina Wooler
- Elizabeth Ringrose
- Elkin Sarah
- Elston Will
- Emerson Peter
- English Peter
- Esterbrook Georgina
- Everett Caroline
- Farmer Ray
- Feary Johanna
- Fern Karen
- Fleming Louise
- Fletcher Tim
- Ford David
- Ford Kate
- Forrest Ian
- Forster Georgia
- Fowler Robert William
- Fowler Stephen
- Fraser Una
- Freeman Debbie
- Fuld Jonathan
- Furness John
- Gaduzo Stephen
- Gardiner Karen
- Georgiadi Adamantia
- Ghosh Dipansu
- Gibson John
- Gill Alison
- Goldman Jon
- Goode Chris
- Graham Alison
- Graham Annika
- Graves Jennifer
- Gray Barry
- Gray Linda
- Greenhalgh Trish
- Greening Neil
- Griffiths Mark
- Griffiths Paul
- Griffiths Valerie
- Grove Alison
- Guadagno Alison
- Guyatt Fran
- Hailes Karen
- Haja Mydin Helmy
- Haney Sarah
- Hankinson Jenny
- Haqqee Raana
- Harle Amelie
- Harrison Brian
- Harrris Ann
- Hart Nicholas
- Harvey John
- Haslam Patricia L
- Heslop Karen
- Hewitt Lee
- Hickman Katherine
- Hicks Alex
- Higgins Bernard
- Hilton Kay
- Hoadley Jacky
- Hodgson Luke
- Hodson Matthew
- Holden Emma
- Holmes Steve
- Hopkinson Nicholas
- Hosker Harold
- Hough Alexandra
- Houghton Catherine
- Howell Tim
- Hughes John
- Hutchinson John
- Hynes Gareth
- Iftikhar Ahsan
- Iles Peter
- Ioakim Shona
- Janes Sam
- Jennings David
- Jha Akhilesh
- John Edwards
- Johnston Carol
- Jolley Caroline
- Jones Helen
- Kaul Sundeep
- Keaney Niall
- Keilty Sarah
- Kemp Samuel
- Ketchell Robert Ian
- Khan Katie
- Kim Randall
- Kowal Julia
- Kumar Sanjay
- Lacy-Colson Amruta
- Lane Amber
- Lane Ian
- Lebus Jenny
- Lenney Warren
- Lenney Warren
- Leonard Andrew
- Leonard Helen
- Lightbody Darren
- Lipman Marc
- Lithgow Anna
- Lloyd Jananee
- Lloyd Julie
- Lock Sara
- Lomas Dean David
- Long Alex
- Lord Victoria
- Lordan James
- Lowe Lesley
- Lyall Rebecca
- Lyons Elizabeth
- Lytton Stephen
- MacBean Vicky
- Macdonald Ian
- Mackenzie Nesta
- Mackinlay Carolyn
- Macmillan Alison Bennett
- Maddocks Matthew
- Majeed Azeem
- Malin Adam
- Mallia-Milanes Brendan
- Malone Sarah
- Man William
- Maqsood Usman
- Marsden Paul
- Marshall Robert
- Martin Katharine
- Martin Sarah
- Matthew Hodson
- Matusiewicz Simon
- Maxwell David
- McAuley Danny
- McCarvill Iona
- McHugh Martin
- McKee Martin
- McNicholl Diarmuid
- Meadows Chris
- Merritt Simon
- Milburn Heather
- Miller Joy
- Miller Lauren
- Mir Misbah
- Mitchell Sally
- Mitchelmore Philip
- Mohd Noh Mohd Shahrin
- Molloy Alanna
- Monaghan Valerie
- Montgomery Hugh
- Montgomery Mary
- Moore Caroline
- Moore-Gillon John
- Morgan David
- Morrison Douglas
- Moxham John
- Munday Maureen
- Mungall Sarah
- Murray Clare
- Mustfa Naveed
- Myerson James
- Narasimhan Divya
- Naveed Shams-un-nisa
- Nelson Christopher
- Newey Alison
- Nicholl David
- Nickol Annabel
- Nicoll Debby
- Nikolic Marko
- Nyman Cyril
- O'Callaghan Una
- O'Connor Sally
- O'Driscoll Ronan
- O'Hara Doreen
- O'Kane Cecilia
- Ohri Chandra
- Olive Sandra
- Olivier Sharon
- Olley Amy
- Ong Yee Ean
- Ormerod Lawrence
- Padmanaban Vijay
- Parker Samuel
- Parkes Marilyn
- Parmar Sonia
- Parry Diane
- Partridge Martyn
- Partridge Samuel
- Patel Anant
- Patel Irem
- Paterson Ian
- Paton James Y
- Pawulska Barbara
- Peedell Clive
- Pengo Martino
- Phitidis Elpida
- Pieri-Davies Sue
- Pillai Anilkumar
- Powell Helen
- Powrie Duncan
- Primhak Robert
- Prowse Keith
- Prowse Keith
- Purcell Helen
- Puthucheary Zudin
- Pye Kathy
- Quint Jennifer
- Radnan Paul
- Rafferty Gerrard
- Rajhan Ashwin
- Raju Raghu
- Ramsay Michelle
- Range Simon
- Redington Anthony
- Reilly Jacqui
- Restrick Louise
- Ridyard John
- Rigge Lucy
- Ringrose Elizabeth
- Robinson Grace
- Robinson Louise
- Rodman Anne
- Roots Debbie
- Roots Debbie
- Rosalind Backham
- Ross David
- Round Jonathan
- Ruiz Gary
- Russell Richard
- Ryan Helen
- Safavi Shahideh
- Saini Sarvesh
- Sapey Elizabeth
- Satia Imran
- Satkunam Karnan
- Scaffardi Anthony
- Scheele Kate
- Seaton Douglas
- Serlin Matthew
- Seymour John
- Shaheen Fizah
- Sharkey Emma
- Sharp Charles
- Sherrington Rebecca
- Shields Michael
- Shribman Jonathan
- Shrikrishna Dinesh
- Simon Ward
- Simonds Anita
- Simpson John
- Sloper Katherine
- Smith David
- Smith Peter
- Spencer Charlotte
- Spencer David
- Spiro Stephen
- Stableforth David
- Stanton Andrew
- Starren Elizabeth
- Steel Mark
- Steier Joerg
- Stern Myra
- Stewart Tara
- Stockley Robert
- Stocks Janet
- Stratford- Martin James
- Sturney Sharon
- Suh Eui-Sik
- Summers Geoffrey
- Sumner Helen
- Sutherland Tim
- Sylvester Karl
- Szram Joanna
- Tate Paul
- Taylor Amy
- Templeton-Wright Suzanne
- Thomas Ajit
- Thomas Angela
- Thomas Matt
- Thomson Fiona
- Thomson Neil
- Tilbrook Sean
- Timlett Amber
- Towns Rebecca
- Tracey Mathieson
- Treharne Jo
- Tunnicliffe Georgia
- Turner Sally
- Turner Steve
- Vaughan Sophie
- Voase Nia
- Walker Paul
- Walker Woolf
- Wallis Colin
- Walmsley Sandy
- Walters Nicola
- Ward Ann
- Ward Simon
- Warner John
- Warwick Geoffrey
- Watson John
- Wedzicha Wisia
- Wheatley Iain
- White John
- Whitfield Ruth
- Wicker Jacquelyne
- Wieboldt Jason
- Williams Ruth
- Williamson Kathryn
- Wilson Patrick
- Wilson Robert
- Winter Barbara
- Winter Robert
- Winter-Burke Alice
- Wood Fraser
- Wood Marion
- Woodcock Ashley
- Woodhead Mark
- Wooler Edwina
- Woolhouse Ian
- Wright Joanne
- Yasso Razouqi
- Zoumot Zaid
- Zurek Andrew
- Publication venue
- 'BMJ'
- Publication date
- 01/01/2013
- Field of study
Recommended from our members
Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.
- Author
- Abbass Hakam
- Adhikari Neill
- Affleck Julia
- Agno Sathianathan Ronan
- Ahmad Norfaizan
- Ahmed Iram
- Ainscough Kate
- Al Qasim Eman
- Al Swaidan Lolowa
- Al-Bassam Wisam
- Al-Beidh Farah
- Al-Beidh Farah
- Albert Martin
- Alegria Ana
- Alexander Brian
- Alexander Peter
- Allan Angela
- Allan Elizabeth
- Allen Louise
- Allibone Suzanne
- Amaro dos Santos Catorze Teodoro
- Anderson Tom
- Andric Zdravko
- Angus Derek
- Angus Derek C
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Annane Djillali
- Anstey Matthew
- Antcliffe David
- Aparicio Christelle
- Appelt Peter
- Arabi Yaseen
- Arabi Yaseen
- Arbane Gill
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arishi Hatim
- Arnold Donald
- Asghar Adeeba
- Ashelford Angela
- Attwood Ben
- Austin Karen
- Aysel Florescu Simin
- Azaiz Amine
- Babel Jakša
- Babio-Galan Maite
- Badie Julio
- Bagshaw Sean
- Baillie Kenneth
- Baker Evelyn
- Bakthavatsalam Dhanalakshmi
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbazza Leanne
- Barber Russell
- Barge Deborah
- Barnes Nicky
- Baršić Bruno
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bates Michelle
- Bauchmuller Kris
- Bean Sarah
- Beane Abigail
- Beane Abigail
- Beasley Richard
- Begin Phillipe
- Bellemare David
- Benettaib Fatna
- Benzekri Dalila
- Berdaguer Fernando Daniel
- Bergin Colin
- Berry Lindsay
- Berry Lindsay
- Berry Scott
- Berry Scott
- Bhimani Zahra
- Bhimani Zahra
- Bihari Shailesh
- Bihari Shilesh
- Binnie Alexandra
- Bion Julian
- Biradar Vishwanath
- Birch Janine
- Birch Jenny
- Birchall Katie
- Birkinshaw Isobel
- Black Ethel
- Bloos Frank
- Board Jasmin
- Bone Allsion
- Bonner Stephen
- Bonten Marc
- Bonten Marc
- Borgatta Barbara
- Borrill Zoe
- Bosch Ziekenhuis Jeroen
- Boschert Catherine
- Bossard Isabelle
- Boumahni Dounia
- Bourgoin Charlotte
- Bourne Michelle
- Bourne Richard
- Bouwman Wietske
- Bowler Helen
- Boyd Craig
- Bracke Stephanie
- Bradbury Charlotte
- Bradbury Charlotte
- Bradley-Potts Joanne
- Brailsford Jane
- Brain Matthew
- Brant Emily
- Breen Patrick
- Brett Stephen
- Brewer Chris
- Brickell Kathy
- Brightling Chris
- Brillinger Nicole
- Brimfield Lutece
- Brinkerhoff Gail
- Brochard Laurent
- Brohi Farooq
- Browne Troy
- Brunkhorst Frank
- Brunkhorst Frank
- Budd Joanna
- Buehner Ulrike
- Buhr Heidi
- Bullman Laetitia
- Burns Karen
- Burt Karen
- Buscher Hergen
- Butler Amelia
- Butler M
- Buxton Meredith
- Buxton Meredith
- Buzgau Adrian
- Byrne Deborah
- Byrne Kathleen
- Bélteczki János
- Cabreros Leilani
- Calfee Carolyn
- Callender Owen
- Campbell Andy
- Campbell Hilary
- Campbell Lewis
- Camsooksai Julie
- Caplin Cecile
- Carbonneau Elaine
- Carmona Flores Rosario
- Carr-Knott Lisa
- Carrier François Martin
- Carrier Marc
- Cartner Brittney
- Casey Ruth
- Casey Siobhan
- Castro Ferreira Ricardo Manuel
- Cate Heidi
- Cathcart Susanne
- Cavayas Alexandros
- Cawley Kathryn
- Cazzola Federica
- Centofanti John
- Chablani Manish
- Chamara Warnapura Loku
- Chan Carmen
- Chan Charles
- Chan Peter
- Charlewood Richard
- Charron Cyril
- Chartier Delphine
- Chasse Michael
- Chassé Michaël
- Chen Yan
- Cheng Allen
- Cheng Allen C
- Cherian Shiney
- Cheung Winston
- Chhablani Manish
- Chudeau Nicolas
- Cirstea Emanuel
- Clarey Emma
- Claridge Helen
- Clark Michele
- Clark Sarah
- Claxton Andrew
- Clermont Giles
- Cloutier Ève
- Coburn Susan
- Codreanu Daniel
- Coghlan Phoebe
- Cole Jade
- Coles Holly
- Coles Jennifer
- Colin Gwenhael
- Collier Dawn
- Collins Daniel
- Collins Emma
- Collins Joanne
- Connor Jason
- Cooke Jill
- Cooper Jamie
- Cooper Melanie
- Cornell Sarah
- Cort Jon
- Courtin Laura
- Cowdrey Keri-Anne
- Cowley Nicholas
- Cowton Amanda
- Coyne Mark
- Craner Michelle
- Craven Thomas
- Creagh-Brown Ben
- Crisp Nikki
- Croft Maria
- Cusack Rebecca
- Cutler Sean
- Cviljevic Sabina
- Cárcel Fernández Sheila
- Daly James
- Daly Zoe
- Daneman Nick
- Dark Paul
- Darreau Cédric
- Dasgin Joanne
- Davey Miriam
- Davidson Neil
- Davies Gwyneth
- Davies Louisa
- Davies Michelle
- Dawda Ashlish
- Day Christopher
- De Beaux Fiona
- De Bus Liesbet
- de Courcy-Golder Kim
- de Jager P
- de Jong Menno
- De Jong Menno
- de Jonge E
- de la Fuente Martos Carmen
- de Lima Pereira Tiago Nuno Alfaro
- de Man Angelique
- De Waele Jan
- Dearden Joy
- Dechert William
- Deelchand Vashish
- Dela Rosa Arnold
- Dell Amanda
- Demetriou Carrie
- Depante Maria Theresa
- Depuydt Pieter
- Dequin PierreFrançois
- Derde Lennie
- Derde Lennie
- Detry Michelle
- Detry Michelle
- Deye Nicolas
- Digby Stephen
- Distler Michael
- Doble Patricia
- Donnelly Adrian
- Donnison Phil
- Doran Peter
- Dragija Lidija
- Driscoll Alana
- Drummond Andrew
- Duan Erick
- Duffy Eamon
- Duke Graeme
- Duncan Tracey
- Duplaix Mathilde
- Dushianthan Ahilanandan
- Dyas Sarah
- D’Aragon Frédérick
- D’Souza Ramsy
- Effelaar Evelien
- Elhassan Munzir
- Elin Hall Rebecca
- Ellis Christine
- Elmahi Einas
- Elsefi Tarek
- English Shane
- Estcourt Lise
- Estcourt Lise
- Estensen Kristen
- Everitt Robert
- Evers Mirjam
- Farahi Neda
- Fartoukh Muriel
- Faulkner Beverley
- Faulkner Maria
- Fazekas Ágnes
- Felton Tim
- Ferguson Niall
- Ferguson Susan
- Fergusson Dean
- Fernández de Pinedo Artaraz Ziortza
- Ferrier Janet
- Fierens Jan
- Finn André
- Finn Stephanie
- Fischer Roy
- Fitzgerald Mark
- Fitzgerald Mark
- Fletcher Simon
- Flint Neil
- Forbes Andrew
- Forbes Loretta
- Forton Daniel
- Fortune Louise
- Fottrell-Gould Deirdre
- Fowler Rob
- Fowler Robert
- Fox Claire
- Francia Federica
- Francoeur Charles
- Frey Anna
- Friedrich Hinrichs Carl
- Frohlich Stephen
- Fysh Ed
- Gallagher Linda Jude
- Ganguly Saibal
- Ganpat Radhika
- Garcia Rebecca
- Gardiner-Hill Caroline
- Garrard Hywel
- Garrard William
- Gates Simon
- Gattas David
- Gellamucho Minerva
- Gendall Emma
- Genetu Roman Mary
- Geng Wenli
- Geri Guillaume
- Ghamraoui Ali
- Ghosh Alison
- Gibson Charly
- Girard Timothy
- Girijadevi Dinu
- Gledhill Lisa
- Godement Mathieu
- Golden David
- Goligher Ewan
- Gomm Linda
- Goodson Jennifer
- Goodwin Jayne
- Goossens Herman
- Goossens Herman
- Gopal Shameer
- Gopinath Amitha
- Gordon Anthony
- Gordon Anthony C
- Gordon Elizabeth
- Gosbell Iain
- Gould Richard
- Grecu Irina
- Green Cameron
- Green Cameron
- Gregory Jane
- Gresha Rebecca
- Grimmer Lisa
- Grimwade Kate
- Guilder E
- Guitton Christophe
- Hacking Danielle
- Hadebe Bernard
- Hagel Stefan
- Haidar Ghady
- Hall Andrew
- Hall Kathryn
- Hamilton David Oliver
- Hamilton-Davies Colin
- Hamlyn Vincent
- Hammond Naomi
- Haniffa Rashan
- Haniffa Rashan
- Hanson Jane
- Harford Rachel
- Harland Cain
- Harrington Kate
- Harris Nichola
- Harrison Susie
- Hart Ciaran
- Harvala-Simmonds Heli
- Harvey Daniel
- Harward Meg
- Hawcutt Daniel
- Hawkins Nancy
- Hay Sophie Kennedy
- Hayes Kati
- Hayes Leanne
- Hays Carole
- Health Monash
- Heinonen Jonna
- Heming Nicholas
- Henderson Seton
- Henderson Steven
- Henning Jeremy
- Henry Joanne
- Heritier Stephane
- Hickey Naomi
- Higgins Alisa M
- Higgins Lisa
- Hill Helen
- Hills Thomas
- Hills Tom
- Hird Clare
- Hodgson Carol
- Hoff Uwe
- Hoiting Oscar
- Holland Nicky
- Hollos Laszlo
- Homes Jennifer
- Hope David
- Hopkins Phil
- Hormis Anil
- Horton Michelle
- Horton Sarah
- Horvat Christopher
- Horvat Christopher
- Howcroft Clare
- Howle Ryan
- Huang David
- Huckle Abby
- Hughes Emma
- Hugill Keith
- Hullegie Sebastiaan
- Hullegie Sebastiaan J
- Hulley Amanda
- Hulme Jonathan
- Hunt Beverley
- Hunter Stephanie
- Hutter Joanne
- Hutton Paula
- Innes Richard
- Ireland Jane
- Isgro Graziella
- Ivatt Helen
- Jackson Matthew
- Jackson Shane
- Jackson Susan
- Jacques Nicola
- Jacquier Sophie
- Jagannathan Vijay
- Janin Pierre
- Jarczak Dominik
- Jeblaoui Asma
- Jeffrey Helen
- Jenkins Sarah
- Jha Rajeev
- Jhanji Shaman
- Johns Maggie
- Johnson David
- Johnson Rebekah
- Johnston Paul
- Jones Andrea
- Jones Jo
- Joseph Sibet
- José Nuno
- Juhaz Vera
- Kalchthaler Kyle
- Kalogirou Michael
- Kamel Toufik
- Karachi Tim
- Karlikowski Michal
- Karlsson Sari
- Kasipandian Vidya
- Kayani Abdul
- Kazemi Alex
- Keen Alexandra
- Keenan Samantha
- Keet Owen
- Kell Kay
- Kelly Martin
- Kelsall Olivia
- Kernan Maeve
- Kersiake Ian
- Khalid Imrana
- Khare Divya
- Kiiski Heikki
- Kimpton Sarah
- King Andrew
- Kinney Fiona
- Kirkby Amy
- Klinikum Neukölln Vivantes
- Kluge Stefan
- Knott Cameron
- Kol Mark
- Kolanos Steffi
- Koppen Cassandra
- Kosa Alma Gabriela
- Kotarski Viktor
- Kovács Sándor
- Kreß Gabriele
- Krishnamurthy Vinodh
- Kruger Peter
- Kruger Peter
- Kuitunen Anne
- Kumar Anand
- Kumar Nikhil
- Kunz Kevin
- Kurenda Catherine
- Kutleša Marko
- Kušan Ira
- KyereDiabour Thyra
- Kyeremeh Lynsey
- Labbe Vincent
- Laffan Mike
- Laffey John
- Laha Shondipon
- Lai Vivian
- Lamb Thomas
- Lamonagne Francois
- Lamontagne Francois
- Lamontagne Francois
- Lamontagne François
- Landais Mickaël
- Lane Janis-Best
- Lankester Liana
- Laver Russell
- Lawler Patrick
- Lawler Patrick R
- Lawless Patrick
- Lazaro Juan Martin
- Leaver Susannah
- Leblond Julie
- Lee Kelvin
- Lee Stephanie
- Leparco Cécile
- Lesona Eden
- Leszkoven János
- Lewis Roger
- Lewis Roger J
- Lewis Sarah
- León López Rafael
- Limb James
- Linstrum Kelsey
- Linstrum Kelsey
- Litton Ed
- Litton Edward
- Litton Edward
- Lomme Kaatje
- London Emily
- Lorenzi Elizabeth
- Lorenzi Elizabeth
- Lother Sylvain
- Lowe Benjamin
- Lowrey Julie
- Luis David
- Luk Tracy
- L’Hotellier Sylvie
- Mackay Callum
- Mackay Euan
- MacLennan Sheila
- Maguire Teena
- Magyar István
- Maiden Matthew
- Makowski Arystarch
- Malakoutis Salim
- Malfroy Sylvain
- Malissin Isabelle
- Maloney Carolyn
- Manax Victoria
- Mandadapu Vineela
- Mangindaan Yara
- Maquigneau Natacham
- Marabi Yaseen
- Mariappa Vasanth
- Marin-Corral Judith
- Markgraf Rene
- Marroquin Oscar
- Marshall John
- Marshall John
- Marshall Nicola
- Mart Emma
- Marten Nicole
- Martin Jane
- Martin Timothy
- Martynoga Robert
- Maselli Astrid
- Masse Marie-Helene
- Mateo López Maria Isabel
- Matsa Ramprasad
- Mattocks Lehentha
- Maxime Virginie
- Mc Goldrick Clare
- Mc Master Moyra
- McArthur Colin
- McArthur Colin
- McAuley Daniel
- McAuley Daniel
- McAuley Danny
- McCallum Peter
- McClintock Declan
- McConnochie Rachael
- McCracken Phobe
- McCue Claire
- McCullagh Iain
- McCullough James
- McDyer John
- McGhee Christopher
- McGlothin Anna
- McGlothlin Anna
- McGloughlin Steve
- McGlynn Deborah
- McGuigan Peter
- McGuinness Shay
- McGuinness Shay
- McIntyre Lauralyn
- McLachlan Danielle
- McMillan Alexandra
- McNamara Robert
- McNicholas Bairbre
- McQuilten Zoe
- McVerry Bryan
- McVerry Bryan
- McWilliam Stephen
- Megarbane Bruno
- Mehrtens Jan
- Menon David
- Menzies Daniel
- Mercier Emmanuelle
- Mercier Romain
- Meredith Megan
- Metherell Stella
- Mevavala Bhaumik
- Mew Louise
- Meyer Jason
- Mezher Chaouki
- Mfuko Celina
- Mguni Nhlanhla
- Middeldopr Saskia
- Miezitis Sydney
- Millen Tina
- Miller Eliza
- Mills Gary
- Miln Rebecca
- Mineall Sarah
- Mirković Gordan
- Misak Cheryl
- Misztal Beata
- Mitchard Sarah
- Moine Pierre
- Monchi Mehran
- Moneer Hagazy Mohamned
- Montague Laura
- Montgomery Stephanie
- Montgomery Stephanie
- Moore Lorraine
- Morel Guillaume
- Moreno Cuesta Jeronimo
- Morgan Matt
- Morpeth Susan
- Morris Sheila
- Morrison Lynette
- Mouncey Paul
- Mouncey Paul
- Moviat M
- Mullan Dee
- Muller Grégoire
- Munt Sheila
- Murphy Sheenagh
- Murray Lauren
- Murthy Srinivas
- Murthy Srinivas
- Music Edvin
- Muñoz-Bermúdez Rosana
- Mwaura Esther
- Myers Erina
- Naiker Kevin
- Nair Priya
- Nay Mai-Anh
- Neal Matthew
- Nee Jens
- Netea Mihai
- Netherton Kimberley
- Neto Ary
- Neves Pessoa Lucilia Maria
- Newby Lynette
- Newman Tabitha
- Nichol Alistair
- Nichol Alistair
- Nicholier Tiphaine Barbarin
- Nichols Lesley
- Nicholson Andrew
- Nicholson Sarah
- Nierhaus Axel
- Nikitas Nikitas
- Noble Harriet
- North Julie
- Nortje Jurgens
- Oakley Susan
- Oborska Aneta
- Oczkowski Simon
- Olatunji Shaanti
- Orath Prabakaran Rajalakshmi
- Orford Neil
- Oritz-Ruiz de Gordoa Laura
- Orr Katrina
- Oza Deepali
- O’Brien Julie
- O’Dywer Michael
- O’Kane Cecilia
- O’Kane Sinéad
- O’Malley Laura
- O’Neill Aisling
- Page Valerie
- Paling A
- Panwar Rakshit
- Paramasivam Elankumaran
- Parekh Dhruv
- Parke Rachael
- Parke Rachael
- Parker Jane
- Parker Lorraine
- Parrilla Gómez Francisco
- Parsons Penny
- Pasi John
- Pasieka Bastian
- Patanwala Asad
- Patch Sarah
- Patel Amit
- Patel Kamal
- Pateman Kelsey
- Paterson David
- Patterson Lisa
- Peake Sandra
- Pearson Karen
- Pegler Suzannah
- Pellicano Annamaria
- Pereira Sousa Bastos Joana Margarida
- Pereira Rita
- Peters Anna Linda
- Peters Marco
- Peters Svenja
- Petros Sirak
- Pettilä Leena
- Phalod Gunjan
- Philbin Jennifer
- Phillips Barbara
- Phull Mandeep-Kaur
- Pillai Suresh
- Pinder Meredith
- Pinnell Jez
- Pitts Sally
- Pletz Mathias
- Pletz Mathias
- Plumb Benjamin
- Pogreban Tatiana
- Pogson David
- Polderman F
- Polgarova Petra
- Pomeroy Fiona
- Porteous Rebecca
- Porter David
- Potter Alison
- Pourcine Franck
- Powell Elizabeth
- Powell Matthew
- Presneill Jeffrey
- Pridee Nicole
- Prinssen Anton
- Prout Rachel
- Pugh Richard
- Pulletz Mark
- Purandare Laura
- Purohit Dharam
- Purvis Sarah
- Puthucheary Zudin
- Puxty Kathryn
- Quayle Rachael
- Quinn Kevin
- Qureshi Hafiz
- Rad Laura
- Rademaker Emma
- Rae Nicola
- Raithatha Ajay
- Ramali Mohamed
- Ramanan Mahesh
- Ramos Lidia
- Randell Georgina
- Rauniyar Rashmi
- Raymakers Kik
- Reddy Amie
- Reddy Harsha
- Rees Tabitha
- Reeve Brenda
- Regli Adrian
- Reill Lorenz
- Rengers Els
- Reschreiter Henrik
- Reynolds Claire
- Reynolds John
- Rhodes Jonathan
- Richards-Belle Alvin
- Ricketts Daniel
- Rietveld Ilse
- Ristimäki Sanna
- Ritzema Carter Jay
- Robert Alain
- Roberts David
- Robertson Yvonne
- Robinson Matt
- Robinson Philip
- Rochwerg Bram
- Rodden Natalie
- Rodriguez Fernandez Jorge
- Roedl Kevin
- Rohde Gernot
- Rojo Roceld
- Rook Clare
- Rooney Kevin
- Rosaroso Lace Paulyn
- Rose Steve
- Rostron Anthony
- Rowan Kathryn
- Rowan Kathryn
- Rowan Kathy
- Rowland Matthew
- Roy Alistair
- Roynon-Reed Anna
- Rozendaal Wim
- Russell Robert
- Ryalls Kim
- Ryan Lucy
- Sagnier Anne
- Salazar Degracia Anna
- Salerno Tania
- Salet A
- Salisbury Sarah
- Sall Jas
- Salmon Charlotte
- Sandhu Gyan
- Sanil Ashish
- Sanil Ashish
- Santamaria John
- Santos Filipa
- Santos Marlene
- Santos Marlene
- Saull Michelle
- Saunders Christina
- Saunders Christina
- Schischka Livia
- Schneider Francis
- Schotsman Joost
- Schuster-Bruce Martin
- Schutgens Roger
- Schweikert Sacha
- Schütze Bianka
- Scully Michael
- Sellers Katharine
- Selvamoni Selvin
- Senya Ho Jan
- Seppelt Ian
- Serri Karim
- Sever Helena
- Seymour Christopher
- Seymour Christopher
- Shah Asim
- Shakih Arif
- Shankar-Hari Manu
- Shaw David
- Shaw Joanne
- Shearer Audrey
- Sheffield Jonathan
- Shehabi Yahya
- Shovelton Charmaine
- Shrestha Tapaswi
- Shyamsundar Murali
- Siami Shidasp
- Silversides Jon
- Sim Malcolm
- Simmonds Catherine
- Simons Koen
- Simpson Joanne
- Simpson Scott
- Singh Vanessa
- Singleton Jo
- Sinha Pratik
- Slevin Kathryn
- Small Charlotte
- Smallwood Andrew
- Smee Joanna
- Smith Joanne
- Smith John
- Smith Judith
- Smith Julie
- Smith Kirsy
- Smith Margaret
- Smith Roger
- Smith Simon
- Smith Tim
- Smuts Sara
- Smyth Michelle
- Soar Natalie
- Somerville Alastair
- Song Rima
- Sousa Arias Sonia
- Southern David
- Southin Sara
- Spencer Thomas
- Spittle Nick
- Spivey Michael
- Stanciu Delia
- Stanworth Simon
- Sterba Martin
- Stevenson Hannah
- Stewart Richard
- Strzelecka Anna
- Sundara Raman Ajay
- Sundaran Dhinesh
- Sutherland Helen
- Sutterlin Laetitia
- Sutu Mihaela
- Sweet Katie
- Szakmany Tamas
- Szigligeti Gábor
- Szőke Viktória
- Tallott Mandy
- Tatham Kate Colette
- Templeton Maie
- Thomas Amy
- Thomas Helen
- Thomas Matt
- Thomas Matthew
- Thompson Taylor
- Thomson Nicola
- Thrush Jessica
- Tilney Emma
- Tinmouth Alan
- Tong Steve
- Tooley Joe
- Touma Omar
- Trapani Tony
- Trask Kara
- Triulzi Darrell
- Trodd Dawn
- Tsang Jennifer
- Tully Redmond
- Turgeon Alexis
- Turki Salah
- Turner Anne
- Turner Anne
- Turner-Bone Ian
- Turns Margaret
- Uddin Ruzena
- Udy Andrew
- Uyeki Tim
- Vaara Suvi
- Vahtera Annukka
- Vamplew Luke
- van Bentum Puijk Wilma
- van Bentum-Puijk Wilma
- van Bentum-Puijk Wilma
- van Beurden Marloes
- van de Veerdonk Frank
- van de Veerdonk Frank
- Van Der Heyden Kym
- van der Poll Tom
- van’t Hoff Willian
- Vates Jennifer
- Vautier Sarah
- Vazquez-Grande Gloria
- Venkatesh Bala
- Venkatesh Balasubramanian
- Venz Ellen
- Verlander Mark
- Verrier Nathalie
- Victor Saji
- Vieillard-Baron Antoine
- Voicu Sebastian
- Vowell Emma
- Vujaklija Brajković Ana
- Vuylsteke Alain
- Wagh Atul
- Walden Andrew
- Walker Rachel
- Walsh Joanne
- Walsh Tim
- Walsham James
- Ward Kathryn
- Warnock Majella
- Waterson Sharon
- Watkins Claire
- Watpool Irene
- Watters Malcolm
- Waugh Victoria
- Webb Steve
- Webb Steven A
- Wedd Steve
- Weismann Dirk
- Weissman Alexandra
- Wells Colin
- Welters Ingeborg
- Wetherill Bill
- Whelan Ruth
- Whileman Amanda
- Whitbread Jennifer
- White Hayden
- White Ian
- White Katie
- Whitehead Christina
- Wibrow Bradley
- Wigbers J
- Wilby Elizabeth
- Wild Laura
- Wild Laura
- Wilding Laura
- Wiley Daisy
- Wilhelmsen Elva
- Wilkinson Dean
- Willams Felicity
- Williams Alexandra
- Williams Erin
- Williams Hannah
- Williams Karen
- Williams Patricia
- Williams Patricia
- Williams Penny
- Williams Tony
- Williams Virginie
- Williamson Dawn
- Williamson James
- Wilson Karen
- Wilson Maggie
- Wiseman Sophie
- Wong Helen
- Wood Erica
- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Writing Committee for the REMAP-CAP Investigators
- Xavier Kugan
- Xia Le Tai Charlotte
- Yarad Elizabeth
- Yates David
- Young Chelsea
- Young Ian
- Young Meredith
- Young Paul
- Yusuff Hakeem
- Zaharia Miahela Florentina
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zammit Claire
- Zapalac Marija
- Zarychanski Ryan
- Zarychanski Ryan
- Zhao Xiao Bei
- Zinzoni Vanessa
- Zitter Letizia
- Đimoti Renata
- Publication venue
- JAMA: Journal of the American Medical Association
- Publication date
- 06/10/2020
- Field of study
Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, and Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020. Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (n = 143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (n = 152), or no hydrocortisone (n = 108). Main Outcomes and Measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%). Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (n = 137), shock-dependent (n = 146), and no (n = 101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively. Conclusions and Relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions. Trial Registration: ClinicalTrials.gov Identifier: NCT02735707
Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution.
- Author
- Abbosh Christopher
- Abbosh Christopher
- Abbosh Christopher
- Adams Haydn
- Adams Haydn
- Aerts Hugo J. W. L.
- Aerts Hugo JWL
- Ahmad Tanya
- Ahmad Tanya
- Ahmed Asia
- Ahmed Asia
- Aissa Assma Ben
- Akarca Ayse U
- Akarca Ayse U
- Al Bakir Maise
- Al Bakir Maise
- Alzetani Aiman
- Amadi Anita
- Ambrose Lyn
- Anand Girija
- Anand Girija
- Aranda Marie
- Asante-Siaw Julius
- Ashish Chandra
- Attanoos Richard
- Attanoos Richard
- Attard Gert
- Azcarate Leire
- Baijal Shobhit
- Bakar Yusura
- Bakir Maise Al
- Bancroft Hollie
- Bancroft Hollie
- Beck Stephan
- Begum Sharmin
- Bell Harriet
- Bell Harriet
- Bellamy Mary
- Bennett Jonathan
- Bhayani Harshil
- Bi Wenya Linda
- Biankin Andrew
- Biggs Jennifer
- Birkbak Nicolai J
- Birkbak Nicolai J.
- Bishop Paul
- Blackhall Fiona
- Blackhall Fiona
- Blackhall Fiona
- Booton Richard
- Borg Elaine
- Borg Elaine
- Borg Elaine
- Bosshard-Carter Leticia
- Bova Steve
- Bowman Alex
- Brady Ged
- Brandner Sebastian
- Brenton James
- Bridgewater John
- Buchan Keith
- Buderi Silviu
- Bury Jonathan
- Caldas Carlos
- Califano Raffaele
- Campbell Peter
- Carnell Dawn
- Carter Louise
- Chambers Antony
- Chambers Tim
- Chambers Tim
- Chaturved Anshuman
- Chavan Hema
- Chee Serena
- Chemi Francesca
- Chetty Mahendran
- Chetty Mahendran
- Choudhary Junaid
- Chowdhury Simon
- Cluroe Alison
- Cockcroft Peter
- Collard Martin
- Colloby Peter
- Conibear John
- Constantin Tudor
- Constatin Tudor
- Costa Marta
- Crosbie Phil
- Crosbie Phil
- Czyzewska-Khan Justyna
- Czyzewska-Khan Justyna
- Danson Sarah
- Davies Helen
- Davies Helen
- De Sousa Paulo
- Denner Tamara
- Dentro Stefan
- Dessimoz Christophe
- Devaraj Anand
- Dhomen Nathalie
- Dive Caroline
- Dive Caroline
- Dive Caroline
- Djearaman Madava
- Doran Helen
- Edwards Alison
- Edwards John
- Eeles Ros
- Elena Cufari Maria
- Elgar Greg
- Elgar Greg
- Endozo Raymondo
- Enver Tariq
- Escudero Mickael
- Evison Matthew
- Ezhil Veni
- Ezhil Veni
- Falzon Mary
- Falzon Mary
- Falzon Mary
- Farrelly Laura
- Feeney Sarah
- Fennell Dean
- Fennell Dean
- Fennell Dean A.
- Fennessy Fiona M.
- Finch Jonathan
- Fisher Patricia
- Fitzgerald Rebecca
- Flanagan Adreinne
- Fontaine Eustace
- Forster Martin
- Forster Martin D.
- Foster Chris
- Fraioli Francesco
- Fraser Sioban
- Furness Andrew
- Ganguly Apratim
- George Jeremy
- Georgiou Andy
- Gilbertson Richard
- Gishen Faye
- Goh Gerald
- Goldman Jacki
- Gomersall Lesley
- Gomersall Lesley
- Gorman Pat
- Gosney John
- Gower Nicole
- Graca Sofia
- Green Sophie
- GrÖnroos Eva
- GrÖnroos Eva
- Gulati Sakshi
- Hackshaw Allan
- Hackshaw Allan
- Hackshaw Allan
- Hafez Dina
- Hamilton Morag
- Harrison David
- Harrison Phil
- Hartley John A
- Hartley John A
- Hayward Martin
- Hayward Martin
- Hector Gemma
- Herrero Javier
- Herrero Javier
- Hiley Crispin
- Hiley Crispin
- Hill Jennifer
- Hochauser Daniel
- Horey Tracey
- Horswell Stuart
- Hynds Robert E
- Idries Faiza
- Iles Natasha
- Iles Natasha
- Irvin-sellers Melanie
- Irvin-sellers Melanie
- Ismail Babikir
- Ismail Babikir
- Jamal-Hanjani Mariam
- Jamal-Hanjani Mariam
- Jamal-Hanjani Mariam
- Janes Sam M
- Janes Sam M
- Jimenez-Linan Merche
- Johnson Benjamin
- Johnson Diana
- Johnson Diana
- Jordan Simon
- Joseph Leena
- Joseph Leena
- Joshi Kroopa
- Kadiri Salma
- Kadiri Salma
- Kareht Stephanie
- Keerio Allah Dino
- Kerr Amy
- Kerr Amy
- Kerr Keith
- Kerr Keith
- Khan Sajid
- Khan Sajid
- Kirkizlar Eser
- Kitsanta Yota
- Kolvekar Shyam
- Kolvekar Shyam
- Kornaszewska Malgorzata
- Kornaszewska Malgorzata
- Krebs Matt
- Krysiak Piotr
- Kwayie Angela
- Langman Gerald
- Langman Gerald
- Langman Gerald
- Larkin James
- Lau Kelvin
- Lawrence David
- Lawrence David
- Laycock Joanne
- Laycock Joanne
- Le Quesne John
- Le Quesne John
- Lederman Jonathan
- Lee Siow Ming
- Lee Siow Ming
- leek Angela
- Lester Jason
- Lester Jason
- Light Teresa
- Lim Eric
- Lin C. Jimmy
- Lock Sara
- Lock Sara
- Loda Massimo
- Lok Chi-wah
- Lowe Helen L
- Lowe Helen L
- Lynch Joanna
- Lynch Mark
- MacKenzie Mairead
- Marafioti Teresa
- Marafioti Teresa
- Marafioti Teresa
- Marais Richard
- Marie Quinn Anne
- Marshall Hilary
- Martinson Luke
- Martinson Luke
- Martinson Luke
- Mashinga Hillaria
- Matthews Nik
- Matthews Nik
- Matthews Sue
- Maughan Tim
- McDermott Ultan
- McGranahan Nicholas
- McGranahan Nicholas
- McKenzie Mairead
- McNeish Iain
- Mendes Ruheena
- Mensah Natalie
- Middleton Gary
- Middleton Gary
- Middleton Gary
- Miller Joy
- Mitchison Miriam
- Mitter Richard
- Monteiro William
- Moore David
- Moore David
- Moore David A
- Moore Katrina
- Morgan Fiona
- Moss Stuart
- Murugaesu Nirupa
- Naidu Babu
- Naidu Babu
- Naidu Babu
- Naik Ashwini
- Naik Ashwini
- Nakas Apostolos
- Nakas Apostolos
- Navani Neal
- Nelson Louise
- Ngai Yenting
- Ngai Yenting
- Nicholson Andrew G
- Nicolson Marianne
- Nicolson Marianne
- Nonaka Daisuke
- Novasio Juliette
- Novelli Marco
- Novelli Marco
- Nye Emma
- Oien Karin
- Olisemeke Bernard
- Ottensmeier Christian
- Ottensmeier Christian
- Oukrif Dahmane
- Oukrif Dahmane
- Palmer Shirley
- Panagiotopoulos Nikolaos
- Panagiotopoulos Nikolaos
- Papadatos-Pastos Dionysis
- Parker Peter
- Phillimore Ben
- Pierce Jackie
- Postmus Pieter
- Prakash Vineet
- Prakash Vineet
- Primrose Lindsay
- Proctor Ian
- Proli Chiara
- Provenzano Elena
- Quesne John Le
- Quezada Sergio
- Quezada Sergio
- Quezada Sergio A
- Quinn Anne Marie
- Quinn Anne Marie
- Rabinowitz Matthew
- Rabinowitz Matthew
- Rammohan Kendadai
- Rathinam Sridhar
- Rathinam Sridhar
- Raubenheimer Hilgardt
- Remmen Hardy
- Remmen Hardy
- Rice Alexandra
- Riley Joan
- Riley Joan
- Riley Joan
- Rogan Jane
- Ronquillo John Carlo
- Rosenthal Rachel
- Rosenthal Rachel
- Rothwell Dominic G
- Rowan Andrew
- Rowan Andrew
- Russell Peter
- Russell Peter
- Salari Raheleh
- Salari Raheleh
- Schmid Peter
- Schwarz Roland F
- Shackcloth Michael
- Shafi Seema
- Shafi Seema
- Shah Rajesh
- Shah Rajesh
- Sharp Abby
- Shaw Emily
- Shaw Jacqui
- Shaw Jacqui A
- Shaw Jacqui A
- Sheaff Michael
- Shiu Kai-Keen
- Simeon Celia
- Sinclair Ron
- Smith Amy
- Smith Elaine
- Smith Sean
- Sottoriva Andrea
- Spicer James
- Sponer Nicole
- Sponer Nicole
- Stares Mark
- Sterling Caroline
- Stewart Aengus
- Stewart Aengus
- Stewart Grant
- Stone Paddy
- Stone Richard Kevin
- Summers Yvonne
- Summers Yvonne
- Summers Yvonne
- Suvarna Kim
- Swanton Charles
- Swanton Charles
- Swanton Charles
- Szallasi Zoltan
- Tanchel Bruce
- Tavare Simon
- Tavares Barbosa Monica
- Taylor Joanne
- Taylor Magali
- Taylor Paul
- Thakrar Ricky
- Thakrar Ricky
- Thomas Anne
- Tomlinson Ian
- Tookman Adrian
- Trevisan Giorgia
- Trotter Simon
- Trotter Simon
- Tugwood Jonathan
- Turajlic Samra
- Turajlic Samra
- Turajlic Samra
- Van Loo Peter
- Van Loo Peter
- Van Loo Peter
- Veeriah Selvaraju
- Veeriah Selvaraju
- Verjee Azmina
- Waddington Rachael
- Walczak Henning
- Walter Harriet
- Ward Sophia
- Ward Sophia
- Watkins Thomas B K
- Watkins Thomas B K
- Watts Colin
- Webb Joanne
- Webb Joanne
- Wilcox Maggie
- Wilcox Maggie
- Wilson Gareth
- Wilson Gareth A.
- Wilson Rodelaine
- Wong Yien Ning Sophia
- Xu Hang
- Zambrana Francisco
- Zimmermann Bernhard
- Zimmermann Bernhard G.
- Publication venue
- Nature
- Publication date
- 01/01/2017
- Field of study
The early detection of relapse following primary surgery for non-small-cell lung cancer and the characterization of emerging subclones, which seed metastatic sites, might offer new therapeutic approaches for limiting tumour recurrence. The ability to track the evolutionary dynamics of early-stage lung cancer non-invasively in circulating tumour DNA (ctDNA) has not yet been demonstrated. Here we use a tumour-specific phylogenetic approach to profile the ctDNA of the first 100 TRACERx (Tracking Non-Small-Cell Lung Cancer Evolution Through Therapy (Rx)) study participants, including one patient who was also recruited to the PEACE (Posthumous Evaluation of Advanced Cancer Environment) post-mortem study. We identify independent predictors of ctDNA release and analyse the tumour-volume detection limit. Through blinded profiling of postoperative plasma, we observe evidence of adjuvant chemotherapy resistance and identify patients who are very likely to experience recurrence of their lung cancer. Finally, we show that phylogenetic ctDNA profiling tracks the subclonal nature of lung cancer relapse and metastasis, providing a new approach for ctDNA-driven therapeutic studies
Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans
- Author
- Abbasi Z
- Abdul-Hamid M Akhlil
- Abel Paul D
- Abrams Paul H
- Adab Fawzi A
- Adamson Andrew
- Adeyoju A
- Adolfson Jan
- Afzal Naveed
- Ahiaku Ernest K N
- Ahmed Munir
- Al Sudani Mohammed L
- Al-Samarraie Amir S M
- Al-Samerraie [Unknown]
- Al-Singary Waleed
- Al-Sudani [Unknown]
- Alcock Christopher
- Alexander Kimberly
- Ali Zulfiqar
- Almond David J
- Alonzi Roberto
- Aly Markus
- Amin Al Olama Ali
- Anderson John
- Andrews Henry
- Andrews Steven
- Anjum Iqbal
- Anson Ken
- Anyamene Nicola A
- Apakama Ike
- Aparcia F
- Archbold J A A
- Arndt Volker
- Ash D
- Ashford Richard F U
- Auvinen Anssi
- Azzabi A
- Badenoch David
- Bahl Amit
- Bailey Karen
- Bailey M J
- Ball Andrew J
- Banerjee G
- Barber Jim
- Barber N
- Baria [Unknown]
- Barnes Douglas G
- Barros-Silva Joao
- Barwell Julian
- Bashir J
- Basu Pradip
- Bates Christopher A
- Batra Jyotsna
- Bax N A
- Baxter-Smith D
- Bdesha Amar
- Beacock Christopher J M
- Beaney Ronald P
- Beard Ralph
- Beatty John D
- Beck Rupert
- Beese Gail
- Beesley Sharon
- Bell C Richard W
- Bellringer James
- Benlloch Garcia Sara
- Benson Richard
- Beresford [Unknown]
- Bevis Christopher R A
- Bhana Rajanee
- Bhanot S
- Bhatnagar A
- Bhatt R I
- Birch Brian
- Birtle Alison
- Bishop M
- Biyani C Shekhar
- Blacklock A R E
- Blades Rosemary
- Bliss Peter
- Bloomfield David J
- Boddy S
- Bollina Prasad
- Bonnington Sue
- Booth C M
- Bose Pradeep
- Bott Michael C
- Bottomley David
- Boucher Nigel R
- Bowen J
- Bower Mark
- Bowsher W G
- Boyd P J R
- Bradshaw Lynne
- Bramble F James
- Brenner Hermann
- Brewster Simon F
- Briggs Tim
- Brock Cathryn
- Brock Sue
- Bromage Stephen
- Broms Michael
- Brough Richard
- Brown Andrew A
- Brown Paul
- Brown Paul M
- Brown Richard
- Brown Stephen
- Browning Tony J
- Bryan N
- Burgess Neil A
- Burns-Cox Nicholas
- Butterbach Katja
- Butterworth Paul C
- Cahill D
- Callaghan P S
- Calleary John
- Calleja M
- Calman Frances
- Camilleri Philip
- Campbell Alister
- Cannon Andrea
- Cannon-Albright Lisa
- Carnell Dawn M
- Carr T W
- Carter Adam C
- Carter Charles J M
- Carter Simon
- Castle Bruce M
- Catto James
- Cavalli-Bjoerkman Carin
- Chadwick David
- Chahal Rohit
- Chakraborti P
- Chappell [Unknown]
- Charig C
- Chetiyawardana Anula D
- Chilton Christopher
- Chinegwundoh F I
- Chong Irene
- Choudhury Ananya
- Chow Wai-Man
- Christmas Timothy J
- Christova Svetlana
- Churn Mark J
- Cieza-Borrella Clara
- Clarke Noel W
- Clavijo-Eisele Jorge
- Clements Judith A
- Coe M
- Coetzee Gerhard A
- Cohen N P
- Coker C
- Cole David J
- Cole O
- Cole Trevor
- Collins Angus
- Collins Gerald
- Collinson Matthew
- Conn I
- Connell C
- Conti David V
- Cook Audrey
- Cook Margaret
- Cooke Peter
- Cooksey Graeme
- Coombs L
- Cooper Debbie
- Copland Robert F
- Cornaby Andrew J
- Cornford P A
- Corolis [Unknown]
- Corr John
- Costello C B
- Coull Mrs N
- Cowan Richard
- Cox Angela
- Cox Robert
- Coyle C
- Crew Jeremy
- Crisp John C
- Cross W
- Cruger Dorthe
- Crundwell Malcolm
- Cummings [Unknown]
- Cybulski Cezary
- Dadaev Tokhir
- Dahar Nazeer
- Daniel Francis N
- Darrad J
- Daruwala Pallon
- Das Gautam
- Datta Shibendra
- Davidson S
- Davies Joseph
- Davis Michael
- Davison Owen W
- Dawkins Guy
- Dawson Chris
- De Bolla Alan R
- Dearnaley David
- Desai Ken M
- Deutsch George P
- Dick John
- Dickinson Andrew J
- Dickson Jeanette
- Dikov Tihomir
- Dinneen Michael
- Dixit Sanjay
- Dobbs H Jane
- Doble A
- Doble Andrew
- Dodds David
- Doherty Alan
- Donaldson P
- Donovan Jenny L
- Dooldeniya M
- Douglas S Fiona
- Down Liz
- Drake [Unknown]
- Duchesne Gill M
- Duffy Peter
- Dunn Michael
- Dunsmuir W D
- Durkan Garrett
- Durrani Sajid K
- Easton Douglas
- Eaton Alan C
- Eccles Diane
- Eckert Allison
- Eddy B
- Eden C D
- Edwards J
- Eeles Rosalind A
- El-Modir A
- Elkabir Jeremy
- Elliott Emma
- Elliott P Tony
- Ellis B W
- Ellis R
- Elves Andrew W S
- Elwell Christine
- Emberton Mark
- Emmerson Louise
- England Roland C D
- Errington R D
- Evans D Gareth
- Falconer Alison
- Fawcett Derek
- Featherston C
- Featherstone Carolyn J
- Feggetter Jeremy
- Ferguson C
- Fermont D
- Ferro Michael
- Fisher Cyril
- Fitzgerald Liesel
- Fitzgerlad Liesel M
- Fletcher Matthew
- Folkes A
- Ford Trevor F
- Foster Paul W
- Franks Kevin N
- Freedman Mathew
- Frim Olivera
- Gale Joanna
- Gallegos Christopher
- Gelister James S
- George Anne
- Ghana [Unknown]
- Gibbs Stephanie
- Gilbert Hugh
- Giles Graham G
- Gillatt David
- Glaholm John
- Glass Jonathan M
- Glenister James
- Goode Thomas D
- Gordon E M
- Govindasami Koveela
- Gower Richard L
- Graham John
- Green Damian
- Greenland Jonathan
- Grieve Robert
- Griffiths Thomas R L
- Gronberg Henrik
- Gujral Sandy
- Gupta Nishi
- Gurun Riza Murat
- Gustafsson Sven
- Guy Michelle
- Guy Peter J
- Haiman Christopher A
- Haldar Neil
- Halder N
- Haley James
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- Harland Stephen J
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- Harris D
- Harris Sarah
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- Hawkyard Simon
- Hazel Steve
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- Heathcote Peter
- Hehir Michael
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- Henderson Brian E
- Hendry David
- Henley Mike
- Henrique Rui
- Henry Ann
- Herbert Pippa
- Herkommer Kathleen
- Hetherington John
- Hickish Tamas
- Hicks James A
- Hilman Serena
- Hindley Richard
- Hindmarsh John R
- Hines John
- Hingorani M
- Ho Edwin T S
- Hodgson Shirley
- Hoffman U
- Holden David
- Holding Peter
- Hollingdale A
- Hollins Graham W
- Holmes Simon A V
- Holt Sarah
- Hopper John L
- Horan Gail
- Horwich Alan
- Hoskin Peter
- Howell Graham P
- Howson Joanne
- Hrouda D
- Huddart Robert
- Hudson Liz
- Hughes Michael
- Hughes Owen
- Hughes Rob
- Humber Caroline
- Iacovou John W
- Ibrahim A
- Inglis John A
- Irving Stuart
- Irwin C
- Iversen Peter
- Izatt Louise
- Izegbu Victor
- Jameel Basharat
- James Michael J
- James N
- James R Lester
- Javle Pradip
- Jenkins P
- Jhavar Sameer
- Johansson Jan-Erik
- Jones Chris R
- Jones David A
- Jones Gareth
- Jones Mandy
- Joseph J
- Joss Shelagh
- Jugurnauth-Little Sara
- Kachakova Darina
- Kaisary Amir
- Kaliski Alexandre L
- Kaneva Radka
- Kapur G
- Karim O
- Karlsson Ami
- Karp Stephen J
- Kedda Mary-Anne
- Keeley F X
- Kelkar Anand R
- Kelleher J P
- Kelly John
- Kenwrick Sue
- Kerr Kris
- Key Tim J
- Khan F
- Khaw Kay-Tee
- Khoo Vincent
- Kibel Adam S
- Kierzek Andrzej
- Kimber Rachel M
- Kinder R
- Kirby Roger S
- Kirk David
- Kirkbride Peter
- Kirollos Magdi M
- Klarskov Peter
- Kluzniak Wojciech
- Kockelbergh Roger
- Koenig Philip C W C
- Kooiman Gordon G
- Koreich O
- Kote-Jarai Zsofia
- Koupparis Anthony
- Kourah Mohamed
- Kraus Sigurd
- Kujala Paula
- Kujawa Magda L
- Kulkarni Ravi
- Kumar M
- Kumar Rajeev
- Kunkler Ian H
- Kynaston H
- Kynaston Howard
- Lachlan Katherine L
- Laing Robert
- Lalloo Fiona
- Lancashire M
- Lane Athene
- Langley Stephen E M
- Laniado Marc
- Larner T R
- Lau Maurice W
- Lawrence W T
- Lawson Anne
- Le Roux Pieter J
- Leader Mary
- Lee A
- Lee J O
- Lee L
- Lemburger R John
- Lennon Teresa
- Leone Priscilla
- Leongamornlert Daniel
- Lester Jason
- Leung Hing
- Lewis D Christopher
- Lewis J
- Li Qiuyan
- Lim Hui-Yi
- Lin Hui-Yi
- Liston Thomas
- Livni Naomi
- Livsey Jacqueline
- Lloyd S
- Locke Imogen
- Lodge Richard
- Logue John
- Longmuir Mark
- Lophatananon Artitaya
- Lophatonanon Artitaya
- Lubinski Jan
- Lucas Malcolm G
- Luedeke Manuel
- Luscombe C J
- Lydon Anna
- Lynch Michael
- Lynn Naing N K
- Lyons Norma
- MacDermott James P A
- Macdonagh Ruaraidh P
- Macdonald [Unknown]
- Madaan Sanjeev
- Madhava Kudingila R
- Maeaettaenen Liisa
- Maguire Joseph
- Maher E R
- Mahmood Rana
- Maia Sofia
- Maier Christiane
- Mair Graeme H M
- Malone Greg
- Malone Peter R
- Mangar Stephen A
- Mantle Mark
- Mark I
- Marsden Gemma
- Mason M D
- Mason Malcolm
- Mason Robert
- Matanhelia [Unknown]
- Matenhelia Shyam
- Matthews Philip N
- McAleese J
- McBride Donna
- Mcdonnell Shannon K
- McDonnell Shannon K
- McFarlane Jonathan
- McGrath [Unknown]
- McIlhenny Craig
- McInerney Paul
- McIntosh Gregor
- McKinna F
- McLaren Duncan
- McLarty Esther
- McMenemin Rhona
- McNeill Alan
- McNicholas T A
- Meddings Robert N
- Mee A David
- Melcher Lucinda
- Memon [Unknown]
- Menzes Pravin
- Michael Agnieszka
- Miller Marek
- Mills Robert
- Mitchell S
- Mitev Vanio
- Mithal Natasha
- Mitkova Atanaska
- Mitra Anita
- Mobb Gillian E
- Moffat Leslie E F
- Mokete [Unknown]
- Money-Kyrle Julian
- Montgomery Bruce
- Moody Hilary
- Moody Martin P
- Morgan Angela
- Morley Roland
- Morris Sean B
- Morrison Patrick
- Mort Diana
- Mostafid Amir H
- Motiwala Hanif
- Mufti Gulzar
- Muir Gordon
- Muir Kenneth
- Mumtaz Faiz
- Murphy Michael
- Murray Alexandra
- Murray Keith W
- Murrell Shirley
- Murtola Teemu
- Muthukumar D
- Naerger Harry
- Namasivayam Siva
- Nargund Vinod
- Nawrocki [Unknown]
- Neal David E
- Neilson Donald
- Nethersell A
- Newby Jacqueline C
- Newman Hugh
- Newton R
- Nielsen Sune F
- Nordestgaard Børge G
- O'Boyle P J
- O'Brien J
- O'Brien Tim S
- O'Donnell H
- O'Donoghue E
- O'Donoghue Neil
- O'Reilly P
- O'Rourke J S
- O'Sullivan Joe
- O'Sullivan Patricia
- Oakley Neil
- Ogden Chris
- Ohja Hemant
- Oliver Tim
- Omara Tracy
- Ong Eng K
- Osborn David
- Ostler Peter
- Owen J
- Palfrey Edward
- Panades Miguel
- Panakis Niki
- Pancharatnam M
- Pandha Hardev
- Pantelides Michalakis L
- Panwar U
- Parikh Omi
- Park Hyun
- Park Jong Y
- Parker Chris
- Parker Christopher H
- Parys Bohdan T
- Pascoe Sarah
- Pashayan Nora
- Patel Anup
- Paterson Joan
- Pathack S
- Pati Jhumur
- Patterson Helen
- Pattu [Unknown]
- Paul A
- Paul Alan
- Paulo Paula
- Payne Heather
- Peake David
- Pedersen John
- Pedley I
- Pengelly A
- Peracha Amjad M
- Perry Matthew
- Persad Raj
- Peters John
- Pharoah Paul
- Philp N H
- Philp T
- Pickering Lisa M
- Pigott Katharine
- Pinto Pedro
- Plail R
- Plowman P Nicholas
- Pocock Richard D
- Pope A J
- Popert Rick
- Popov Elenko
- Porter Tim
- Potter John M
- Pow-Sang Julio
- Powell Christopher
- Powell Philip
- Powles Thomas B
- Prasad Krishna
- Prasad Seshadri Sri
- Prejbisz J W
- Prescott Stephen
- Protheroe Andrew
- Qureshi Khaver N
- Raby Nigel
- Radlein Selina
- Ragavan Narasimhan
- Raju Palaniappa G S
- Ramachandra Prakash B
- Raman R
- Rane Abhay
- Rankin Julia
- Rao Y
- Ratan Hari L
- Ravi Ramachandran
- Ravishankar K
- Read [Unknown]
- Reddy Paul J
- Rimington Peter R
- Rinckleb Antje
- Rincon Maria
- Riska Shaun
- Ritchie Peter A
- Roberts J Trevor
- Robertson Andrew
- Robinson Angus
- Robinson Anne C
- Robinson Lee Q
- Rochester Mark A
- Roder Andreas
- Rogers P B
- Rosario Derek
- Rosenbaum Tomas P
- Rothwell Neil
- Rowbotham Carl
- Rowe [Unknown]
- Rowley Kathryn
- Ruddy Deborah
- Rundle John
- Russell John M
- Ryan P G
- Sabharwal A
- Saggar Anand K
- Samanci Ali
- Sangar Vijay K
- Santos Joana
- Saunders Edward J
- Saunders Pamela
- Sawyer Emma J
- Saxby M F
- Schaid Daniel J
- Schleutker Johanna
- Schumacher Fredrick
- Schwaibold Hartwig
- Scoble John E
- Scrase Christopher
- Selim [Unknown]
- Sellers Thomas
- Sells Henry
- Sethia Krishna K
- Severi Gianluca
- Shackley David C
- Shaffer [Unknown]
- Shah Nihil
- Shakespeare D
- Shanley Sue
- Sharma Neerah K
- Sheehan Denise J
- Sherwin Elizabeth
- Shum Poh Lin
- Side Lucy
- Sidek Norma
- Signorello Lisa B
- Sikora Karol
- Simcock R
- Sinclair Andrew M
- Singh Pravin
- Siva M
- Slavov Chavdar
- Smith James
- Smith Michael F
- Sokal Michael
- Sole Graham M
- Southey Melissa C
- Speakman Mark J
- Spiers Alexander
- Spurdle Amanda
- Sreenivasan Thiagarajan
- Srihari Narayanan N
- Srinivasan [Unknown]
- Sriram Rajagopalan
- Staffurth John N
- Stanford Janet L
- Stattin Paer
- Stegmaier Christa
- Stephens Sarah
- Stewart D
- Stockdale Andrew
- Stott Mark A
- Stower M J
- Strachan John R
- Stuart Nicholas S A
- Sugden Elaine
- Summerton Duncan
- Sundar Santhanam
- Sundaram S K
- Suresh Gokarakonda
- Susnerwala Shabbir
- Swami Kuchibhotla S
- Symons Stephanie J
- Syndikus Isabel
- Taari Kimmo
- Tahir Saad
- Tammela Teuvo L
- Tammela Teuvo L J
- Tanquay J
- Taylor J W
- Taylor John W
- Teixeira Manuel R
- Terry T
- Thibodeau Stephen N
- Thomas Robert J
- Thomas Stephen A
- Thompson Alan
- Thompson Pauline
- Thomson Alastair H
- Thurston A
- Tidball Sarah
- Tillmans Lori
- Tilsley Owen
- Tindall Stuart F
- Tipples K
- Tong [Unknown]
- Toussi Hamid
- Toy Elizabeth W
- Travis Ruth C
- Trembath Richard C
- Tulloch David N
- Turner Kevin J
- Turner Megan
- Tweedle James
- Tymrakiewicz Malgorzata
- Tyrell C J
- Umez-Eronini N
- Urwin Graeme H
- Vale Justin A
- Van As [Unknown]
- Van As Nicholas
- Vasanthan Subramaniam
- Vesey Sean
- Vilarino-Varela Maria
- Violet John
- Virdi Jaspal
- Viñuela Ana
- Vlahova Aleksandrina
- Vogel Walther
- Wade Robert
- Wahlfors Tiina
- Waite Katherine
- Walker E M
- Walker Roger
- Wallace David M A
- Wallinder Hans
- Wang Liang
- Watkin Nicholas A
- Watson M E
- Waxman J H
- Waymont Brian
- Weaver Andrew
- Webb Ralph J
- Wedderburn Andrew
- Weischer Maren
- Wells Paula
- Wemyss-Holden G D
- Weston P M T
- Wheatley Duncan
- Whelan P
- Whillis D
- Whitmore Ian
- Wiklund Fredrik
- Wilde Adam D
- Wiles Vicki
- Wilkins Marie
- Wilkinson Rosemary
- Williams John H
- Williams Simon
- Willis Michael
- Wills Michael I
- Wilson J R
- Wilson Richard
- Winkler Mathias H
- Wise Marcus
- Wokozorczyk Dominika
- Wokołorczyk Dominika
- Wood Glenn
- Woodhams Simon
- Woodhouse C
- Woodward Cathryn
- Woolf [Unknown]
- Woolfenden K A
- Worlding Jane
- Wright Mark
- Wu Huihai
- WYLIE [Unknown]
- Wylie James P
- Wynne Chris
- Yeadon Trina
- Zachariah Babu
- Zang Angelika
- Zarkar A
- Zheng Wei
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2015
- Field of study
Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have
fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in
25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16
regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of
correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP,
while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in
Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium
(LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region.
Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant
enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the
refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa,
an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of
PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent
signals within the same regio
Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial
- Author
- Abbas Jalal
- Abraham Sybil
- Ackert Jessica
- Adams Patricia
- Aggarwala Gaurav
- Aher Nutan
- Ahlqvist Jørn
- Ahn Chul Woo
- Akers Teresa
- Akhras Ronald
- Akhter Faiq
- Aksentyev Sergey
- Al Kawas Firas
- Alexander Karen
- Althouse Denise
- Altobelli Desma
- Alvarisqueta Andres
- Ambrosy Andrew
- Andersen James
- Andersen Ulla
- Anderson Michelle
- Anglade Moise
- Arbañil Hugo
- Arciszewska Malgorzata
- Argoud Georges
- Ariani Mehrdad
- Ashdji Reswan
- Avogaro Angelo
- Avramidis Iakovos
- Axthelm Christoph
- Aye Myint
- Babi Charleen
- Bachus Erasmus
- Baik Sei-Hyun
- Bailey Matt
- Bakhtari Ladan
- Baksi Arun
- Balasubramani Mathangi
- Baldovino Jorge
- Banach Marek
- Banerjee Subhash
- Bartlett Andrew
- Bartone Susan
- Baum Howard
- Bays Harold
- Bazhan Larysa
- Beasley Richard
- Beaudry Yves
- Beaulieu Gail
- Beboso Ronnie
- Bedard Jacques
- Beijerbacht Hugo Peter
- Belfort de Aguiar Renata
- Benjamin Sabrina
- Berger Dirk
- Berlingieri Joseph
- Berndtsson Blom Katarina
- Besada Diego
- Bethel M Angelyn
- Bhagwat Ravi
- Bhargava Anuj
- Bhosale Archana
- Bieler Tasso
- Bijata-Bronisz Renata
- Birkeland Kare
- Birkenfeld Andreas
- Blagden Mark
- Bloomfield Gerald
- Bode Bruce
- Boemi Massimo
- Bonadonna Riccardo
- Bondar Irina
- Bott Jochen
- Bousboulas Stavros
- Boye Alain
- Bratcher Christina
- Breneman Jody
- Briskin Toby
- Bristianou Magdalini
- Brockmyre Andrew
- Broughton Raymond
- Brown Judith
- Brown Kim
- Brychta Tomas
- Brønnum-Schou Jens
- Budhraja Madhusudan
- Bull Georgina
- Bundy Charles
- Burgess Lesley
- Busch Klaus
- Caca Karel
- Cadinot Didier
- Calderon Jorge
- Calella Pedro
- Califf Robert M
- Calvo Gómez Carlos
- Camacho Luis
- Cannon Kevin
- Cano Rodríguez Isidoro
- Cantero Maria Cecilia
- Carr Jewell
- Casson Ed
- Castaño Patricia
- Castro Conde Almudena
- Cathcart Harold
- Cavale Arvind
- Cech Vladimir
- Cequier Fillat Angel
- Cervantes-Escárcega Jose-Luis
- Cha Bong-Soo
- Chau Tuan
- Chaykin Louis
- Chehayeb Raja
- Chen David
- Chen Jung-Fu
- Chertkoff Alejandro
- Cheung Deanna
- Cheung Stephen
- Chevts Julia
- Chiang Chern-En
- Childress Richard
- Christian Tamra
- Chung Choon-Hee
- Coetzee Kathleen
- Cohen Allan
- Coker Rebecca
- Cole Joanna
- Collier Jeannie
- Condit Jonathan
- Consoli Agostino
- Conway James
- Cooksey Erin
- Cookson Tobias
- Cooper John
- Cooper Lauren
- Copland Allan
- Cornel Jan
- Cornett George Mitchell
- Crenier Laurent
- Cuadrado Jesus
- Cuatrecasas Cambra Guillem
- Cusson Jean
- D'Agostino Ralph B
- D'Agostino Ralph B.
- Daga Shruti
- Damyanova Velichka
- Dauber Ira
- Davila William
- Dawood Saleem
- De Armas Luis
- De Cosmo Salvatore
- De Loredo Luis
- De Teresa Parreño Luis
- de Álvaro Moreno Fernando
- Dean Julius
- Debroye Corinne
- Del Prato Stefano
- Del Prato Stefano
- Delgado Lista Javier
- Della Siega Anthony
- DeMets David
- Demidova Irina
- Derezinski Tadeusz
- Deshpande Sameer
- Detweiler Robert
- Devore Adam
- Di Bartolo Paolo
- Di Giovanna Michael
- Diaz Ernesto
- Dimitriadis Georgios
- Dimitrov Stefan
- Distiller Larry
- Dombrowski Keith
- Dominguez Andrea
- Domínguez Escribano José Ramón
- Donaldson Jill
- Donaubauer Torsten
- Dor Isaac
- Dotta Francesco
- Dreval Alexander
- Drummond Waymon
- Dumas Richard
- Dumbre Snehal
- Dungan Kathleen
- Durán García Santiago
- Duyck Francis
- Dvorakova Eva
- Dzongowski Peter
- Eagerton Donald
- Eapen Zubin
- Earl John
- Eaton Charles
- Ebo Geraldine
- Edelsberger Tomas
- Eliasson Bjorn
- Eliasson Ken
- Elisaf Moses
- Ellison Howard
- Elvira González Javier
- Emslie-Smith Alistair
- Endsley Patricia
- Enns Robert
- Erlinger Rudolf
- Ershova Olga
- Español Maria Vanesa
- Espinoza Augusto Dextre
- Farris Neil
- Ferguson Murdo
- Fernandez-Salazar Eva
- Fernández Rodríguez José María
- Fiel Thomas
- Finkelstein Hernan
- Firek Anthony
- First Brian
- Fleming John
- Flota-Cervera Luis Fernando
- Forgosh Les
- Frechtel Gustavo
- French William
- Fretes Jose
- Friedman Daniel
- Frontoni Simona
- Funke Klaus
- Fushtey Ivan
- Gadzinski Waldemar
- Gajek Jacek
- Galatius Søren
- Galetta Marianna
- Galstyan Gagik
- Gambineri Alessandra
- Gandy Winston
- Garcia Ronald
- Garganeeva Alla
- Garrido Santos Natalia
- Garrido Elizabeth
- Garvey Louisa
- Gaudet Daniel
- Gazzaruso Carmine
- Gentry Tracy
- Giaccari Andrea
- Gill Santosh
- Giorgino Francesco
- Goday Arno Alberto
- Godse Rupali
- Gomez Huelgas Ricardo
- Gonzales Rolando Vargas
- Gonzalez Joaquin
- González Juanatey José Ramón
- González-González José Gerardo
- Goodman Shaun
- Gordon Murray
- Gouet Didier
- Grachova Mariya
- Granger Christopher B
- Granger Christopher B.
- Green Fiona
- Green Jennifer B
- Green Jennifer B
- Greene Deb
- Greene Stephen
- Grondin Francois
- Grosskopf Josef
- Groutars Reginald G.E.J.
- Guerci Bruno
- Guice Michael
- Guimaraes Patricia
- Gulseth Hanne
- Gummadi Siva
- Gunstone Anthony
- Gupta Anil
- Gupta Milan
- Gupta Nikita
- Guttormsen Gaute
- Ha JuYoung
- Hackenyos Jonathan
- Haddock Trevorlyn
- Hagenow Andreas
- Hairston Kristen
- Hajdú Csaba
- Halciakova Katarina
- Halperin Frank
- Haluzik Martin
- Hamann Monika
- Hanson Lenita
- Haque Ghazala
- Harcsa Eleonóra
- Harris Tara
- Harrison Lindsay
- Harrison Rob
- Hartard Manfred
- Hartman Israel
- Heitner John
- Hejeebu Srini
- Henry Patrick
- Hereghty Belinda
- Hermany Paul
- Hernandez Mijares Antonio
- Hernandez Adrian F
- Hernandez Adrian F.
- Hernandez-Cassis Carlos
- Heymer Peter
- Hidalgo Horacio
- Higgins Alexander
- Hoek Boudewijn A
- Holman Rury
- Hoogslag Pieter A.M.
- Houle Pierre-Alain
- Hove Jens
- Howell Christina
- Hramiak Irene
- Huppertz Wolfgang
- Hutayanon Pisit
- Ibrahim Hassan
- Illies Gabriele
- Issa Basil
- Izmozherova Nadezhda
- Jackson-Voyzey Ewart
- Jacob Stephan
- Jacobs Shahram
- James Kourtnei
- James Rachel
- Jang Hak Chul
- Janmohamed Salim
- Janmohamed Salim
- Jarosz Marie
- Jenkins Wendy
- Jensen Jan Skov
- Jerjes-Díaz Carlos Sánchez
- Jiménez Díaz Víctor Alfonso
- Jintapakorn Woravut
- Jodar Gimeno Esteban
- Johnson Andrew
- Johnson David
- Johnson Megan
- Jones Michael
- Jones Nigel P
- Jones Nigel P
- Jordan Dedrick
- Joshi Parag
- Jung Thomas
- Kadgaonkar Neha
- Kahrmann Gerd
- Karetnikova Victoria
- Karka Mounika
- Karmalkar Anisha
- Kast Petra
- Kaster Steven
- Katerenchuk Vitaliy
- Kellerer Monika
- Kellum Daniel
- Kelly Aoife
- Kempe Hans-Peter
- Kessler Laurence
- Khandelwal Chaitali
- Kharakhulakh Marina
- Khariouzov Andrei
- Khokhlov Aleksandr
- Kim Chong-Jin
- Kim Christopher
- Kim Ellen
- Kim Hye Soon
- Kim In Joo
- Kirby William
- Klausmann Gerhard
- Klein Christiane
- Kleinecke-Pohl Uwe
- Kleinertz Klaus
- Klodawska Katarzyna
- Knouse Albert
- Kobalava Zhanna
- Kober Lars
- Koch Thorsten
- Kocsis Gyozo
- Kolls Brad
- Kong David
- Konyves Laszlo
- Kooy Adriaan
- Korpachev Vadym
- Kosch Christine
- Koshelskaya Olga
- Kosiborod Mikhail
- Koskinen Pekka
- Kosmacheva Elena
- Kostin Vladimir
- Kotsa Kalliopi
- Kouz Simon
- Kovacheva Snezhina
- Kovacs Christopher
- Koziolova Natalia
- Kragten Johannes A.
- Kravchun Nonna
- Kristiansen Ole Peter
- Krizova Jarmila
- Krzyzagorska Ewa
- Kulback Steven
- Kulkarni Mangesh
- Kumar Mariananda
- Kumar Rakesh
- Kumar Somesh
- Kumari Aditi
- Kuruvanka Tulsidas
- Kuzin Anatoly
- Labroo Ajay
- Lalau Jean-Daniel
- Landry Daniel
- Larin Oleksandr
- Larnefeldt Hans
- Lasswell William
- Lastuvka Jiri
- Lauder Steven
- Lauro Davide
- Lee Eun Young
- Lee Hyoung Woo
- Lee Kwan-Woo
- Lee Moon Kyu
- Leiter Lawrence A
- Leiter Lawrence A.
- Lentz John
- Lenzmeier Thomas
- Lesnov Victor
- Lewis David
- Li Wenyan
- Li Zhaoping
- Lieverse Aloysius G.
- Lif-Tiberg Cornelia
- Lillestol Michael
- Linderfalk Carina
- Lindsay Alistair
- Little Raymond
- Litvak Marcos
- Llamas Edmundo-Alfredo Bayram
- Lokhngina Yuliya
- Lombard Landman
- Longley Troy
- Lonn Eva
- Lopes Renato
- Lopez-Sendon Jose
- Lorimer Jamie
- Lorra Babette
- Lorraine Richard
- Loureyro Juan
- Lozanov Lachezar
- Lucas Morante Tomás
- Luedemann Joerg
- Luna Alejandro
- Lund Gustav
- Lund Per
- Lundman Pia
- Luttermann Matthias
- Lysenko Tatyana
- Maclean Malcolm
- Madej Andrzej
- Maffei Laura
- Makotoko Ellen
- Maldonado Natacha
- Mandal Trisha
- Mandawat Aditya
- Mankovsky Boris
- Manrique Helard
- Marazuela Monica
- Margaritov Viktor
- Markov Valentin
- Marquess Marsha
- Martell Claros Nieves
- Mathews Robin
- Mathieu Chantal
- Mauricio Puente Didac
- Maxeiner Stephan
- Mayorov Alexander
- McGuire Darren
- McKeown-Biagas Cecilia
- McKnight John
- McLaughlin Patricia
- McMurray John J.V.
- McMurray John J.V.
- McNeill Robert
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- Thorpe Karl M
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- Van Gaal Luc
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- Vemulapalli Sreekanth
- Venugopal Chandra
- Verbovaya Nelli
- Vercammen Chris
- Verra Fernando
- Vidrio-Velázquez Maricela
- Viergever Eric P.
- Villagordoa-Mesa Juan
- Vishneva Elena
- Vizel Saul
- Vlasenko Maryna
- Vo Anthony
- Voinot Christel
- Vorobyev Sergey
- Vorokhobina Natalya
- Vouillarmet Julien
- Vrkoc Jan
- Wang Chih-Yuan
- Wang Ji-Hung
- Watson Anthony
- Watson David
- Welch Michelle
- Welker James
- White Alexander
- Wilhelm Karl
- Willis John
- Wilson Matt
- Wilson Tim
- Witek Robert
- Wium Cecilie
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- Woo Vincent
- Wraight Ella
- Wynne Alan
- Xing Weibing
- Yamwong Sukit
- Yazdani Shahram
- Ye June
- Yoo Soon Jib
- Yordanov Victor
- Yu Jaemyung
- Zabalua Silvina
- Zaidman Cesar
- Zang Eddie
- Zanozina Olga
- Zeller-Stefan Helga
- Zhdanova Elena
- Zlova Tetiana
- Zubiate Carlos
- Zykova Tatyana
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Background:
Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine the safety and efficacy of albiglutide in preventing cardiovascular death, myocardial infarction, or stroke.
Methods:
We did a double-blind, randomised, placebo-controlled trial in 610 sites across 28 countries. We randomly assigned patients aged 40 years and older with type 2 diabetes and cardiovascular disease (at a 1:1 ratio) to groups that either received a subcutaneous injection of albiglutide (30–50 mg, based on glycaemic response and tolerability) or of a matched volume of placebo once a week, in addition to their standard care. Investigators used an interactive voice or web response system to obtain treatment assignment, and patients and all study investigators were masked to their treatment allocation. We hypothesised that albiglutide would be non-inferior to placebo for the primary outcome of the first occurrence of cardiovascular death, myocardial infarction, or stroke, which was assessed in the intention-to-treat population. If non-inferiority was confirmed by an upper limit of the 95% CI for a hazard ratio of less than 1·30, closed testing for superiority was prespecified. This study is registered with ClinicalTrials.gov, number NCT02465515.
Findings:
Patients were screened between July 1, 2015, and Nov 24, 2016. 10 793 patients were screened and 9463 participants were enrolled and randomly assigned to groups: 4731 patients were assigned to receive albiglutide and 4732 patients to receive placebo. On Nov 8, 2017, it was determined that 611 primary endpoints and a median follow-up of at least 1·5 years had accrued, and participants returned for a final visit and discontinuation from study treatment; the last patient visit was on March 12, 2018. These 9463 patients, the intention-to-treat population, were evaluated for a median duration of 1·6 years and were assessed for the primary outcome. The primary composite outcome occurred in 338 (7%) of 4731 patients at an incidence rate of 4·6 events per 100 person-years in the albiglutide group and in 428 (9%) of 4732 patients at an incidence rate of 5·9 events per 100 person-years in the placebo group (hazard ratio 0·78, 95% CI 0·68–0·90), which indicated that albiglutide was superior to placebo (p<0·0001 for non-inferiority; p=0·0006 for superiority). The incidence of acute pancreatitis (ten patients in the albiglutide group and seven patients in the placebo group), pancreatic cancer (six patients in the albiglutide group and five patients in the placebo group), medullary thyroid carcinoma (zero patients in both groups), and other serious adverse events did not differ between the two groups. There were three (<1%) deaths in the placebo group that were assessed by investigators, who were masked to study drug assignment, to be treatment-related and two (<1%) deaths in the albiglutide group.
Interpretation:
In patients with type 2 diabetes and cardiovascular disease, albiglutide was superior to placebo with respect to major adverse cardiovascular events. Evidence-based glucagon-like peptide 1 receptor agonists should therefore be considered as part of a comprehensive strategy to reduce the risk of cardiovascular events in patients with type 2 diabetes.
Funding:
GlaxoSmithKline
Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector
- Author
- Aaboud Morad
- Aad Georges
- Abbott Brad
- Abdinov Ovsat
- Abeloos Baptiste
- Abidi Syed
- AbouZeid Ossama
- Abraham Nicola
- Abramowicz Halina
- Abreu Henso
- Abreu Ricardo
- Abulaiti Yiming
- Acharya Bobby
- Adachi Shunsuke
- Adamczyk Leszek
- Adelman Jahred
- Adersberger Michael
- Adye Tim
- Affolder Tony
- Afik Yoav
- Agatonovic-Jovin Tatjana
- Agheorghiesei Catalin
- Aguilar-Saavedra Juan
- Ahlen Steven
- Ahmadov Faig
- Aielli Giulio
- Akatsuka Shunichi
- Akerstedt Henrik
- Akilli Ece
- Akimov Andrei
- Alberghi Gian
- Albert Justin
- Albicocco Pietro
- Alconada Verzini Maria
- Alderweireldt Sara
- Aleksa Martin
- Aleksandrov Igor
- Alexa Calin
- Alexander Gideon
- Alexopoulos Theodoros
- Alhroob Muhammad
- Ali Babar
- Aliev Malik
- Alimonti Gianluca
- Alison John
- Alkire Steven
- Allbrooke Benedict
- Allen Benjamin
- Allport Phillip
- Aloisio Alberto
- Alonso Alejandro
- Alonso Francisco
- Alpigiani Cristiano
- Alshehri Azzah
- Alstaty Mahmoud
- Alvarez Gonzalez Barbara
- Alviggi Mariagrazia
- Amadio Brian
- Amaral Coutinho Yara
- Amelung Christoph
- Amidei Dante
- Amor Dos Santos Susana
- Amoroso Simone
- Anastopoulos Christos
- Ancu Lucian
- Andari Nansi
- Andeen Timothy
- Anders Christoph
- Anders John
- Anderson Kelby
- Andreazza Attilio
- Andrei George
- Angelidakis Stylianos
- Angelozzi Ivan
- Angerami Aaron
- Anisenkov Alexey
- Anjos Nuno
- Annovi Alberto
- Antel Claire
- Antonelli Mario
- Antonov Alexey
- Antrim Daniel
- Anulli Fabio
- Aoki Masato
- Aperio Bella Ludovica
- Arabidze Giorgi
- Arai Yasuo
- Araque Juan
- Araujo Ferraz Victor
- Arce Ayana
- Ardell Rose
- Arduh Francisco
- Arguin Jean-Francois
- Argyropoulos Spyridon
- Arik Metin
- Armbruster Aaron
- Armitage Lewis
- Arnaez Olivier
- Arnold Hannah
- Arratia Miguel
- Arslan Ozan
- Artamonov Andrei
- Artoni Giacomo
- Artz Sebastian
- Asai Shoji
- Asbah Nedaa
- Ashkenazi Adi
- Asquith Lily
- Assamagan Ketevi
- Astalos Robert
- Atkinson Markus
- Atlay Naim
- Augsten Kamil
- Avolio Giuseppe
- Axen Bradley
- Ayoub Mohamad
- Azuelos Georges
- Baas Alessandra
- Baca Matthew
- Bachacou Henri
- Bachas Konstantinos
- Backes Moritz
- Bagnaia Paolo
- Bahmani Marzieh
- Bahrasemani Sina
- Baines John
- Bajic Milena
- Baker Oliver
- Bakker Pepijn
- Baldin Evgenii
- Balek Petr
- Balli Fabrice
- Balunas William
- Banas Elzbieta
- Bandyopadhyay Anjishnu
- Banerjee Swagato
- Bannoura Arwa
- Barak Liron
- Barberio Elisabetta
- Barberis Dario
- Barbero Marlon
- Barillari Teresa
- Barisits Martin-Stefan
- Barkeloo Jason
- Barklow Timothy
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- Barnett Bruce
- Barnett Michael
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- Baroncelli Antonio
- Barone Gaetano
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- Barranco Navarro Laura
- Barreiro Guimarães da Costa João
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- Bartoldus Rainer
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- Borissov Guennadi
- Bortfeldt Jonathan
- Bortoletto Daniela
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- Boscherini Davide
- Bosman Martine
- Bossio Sola Jonathan
- Boudreau Joseph
- Bouhova-Thacker Evelina
- Boumediene Djamel
- Bourdarios Claire
- Boutle Sarah
- Boveia Antonio
- Boyd James
- Boyko Igor
- Bozson Adam
- Bracinik Juraj
- Brandt Andrew
- Brandt Gerhard
- Brandt Oleg
- Braren Frued
- Bratzler Uwe
- Brau Benjamin
- Brau James
- Breaden Madden William
- Brendlinger Kurt
- Brennan Amelia
- Brenner Lydia
- Brenner Richard
- Bressler Shikma
- Briglin Daniel
- Bristow Timothy
- Britton Dave
- Britzger Daniel
- Brochu Frederic
- Brock Ian
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- Brooks William
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- Bruno Salvatore
- Brunt Benjamin
- Bruschi Marco
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- Bryngemark Lene
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- Buat Quentin
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- Buckley Andrew
- Budagov Ioulian
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- Bullock Daniel
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- Buzatu Adrian
- Buzykaev Aleksey
- Büscher Daniel
- Büscher Volker
- C-Q Changqiao
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- Caforio Davide
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- Calderini Giovanni
- Calfayan Philippe
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- Calvet David
- Calvet Samuel
- Calvet Thomas
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- Camincher Clement
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- Campoverde Angel
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- Cantero Josu
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- Carbone Ryne
- Cardarelli Roberto
- Cardillo Fabio
- Carli Ina
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- Carlino Gianpaolo
- Carlson Benjamin
- Carminati Leonardo
- Carney Rebecca
- Caron Sascha
- Carquin Edson
- Carrillo-Montoya German
- Carrá Sonia
- Casadei Diego
- Casado Maria
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- Casper David
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- Castillo Gimenez Victoria
- Castro Nuno
- Catinaccio Andrea
- Catmore James
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- Caudron Julien
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- Cavallaro Emanuele
- Cavalli Donatella
- Cavalli-Sforza Matteo
- Cavasinni Vincenzo
- Celebi Emre
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- Cerda Alberich Leonor
- Cerri Alessandro
- Cerrito Lucio
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- Cervelli Alberto
- Cetin Serkant
- Chafaq Aziz
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- Chan Wing
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- Charlton Dave
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- Cheu Elliott
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- Chiarelli Giorgio
- Chiodini Gabriele
- Chisholm Andrew
- Chitan Adrian
- Chiu Yu
- Chizhov Mihail
- Choi Kyungeon
- Chomont Arthur
- Chouridou Sofia
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- Christodoulou Valentinos
- Chu Ming
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- Cueto Ana
- Cuhadar Donszelmann Tulay
- Cukierman Aviv
- Cummings Jane
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- Cúth Jakub
- D'amen Gabriele
- D'Auria Saverio
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- D'Onofrio Monica
- Da Cunha Sargedas De Sousa Mario
- Da Via Cinzia
- Dabrowski Wladyslaw
- Dado Tomas
- Dai Tiesheng
- Dale Orjan
- Dallaire Frederick
- Dallapiccola Carlo
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- Daneri Maria
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- Davison Peter
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- de Asmundis Riccardo
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- De Maria Antonio
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- De Vasconcelos Corga Kevin
- De Vivie De Regie Jean-Baptiste
- De Kaushik
- Debbe Ramiro
- Debenedetti Chiara
- Dedovich Dmitri
- Dehghanian Nooshin
- Deigaard Ingrid
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- DeMarco David
- Demers Sarah
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- Demilly Aurelien
- Denisov Sergey
- Denysiuk Denys
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- Derkaoui Jamal
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- Yamamoto Akira
- Yamamoto Shimpei
- Yamanaka Takashi
- Yamane Fumiya
- Yamatani Masahiro
- Yamazaki Tomohiro
- Yamazaki Yuji
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- Yao Weiming
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- Zaitsev Alexander
- Zakharchuk Nataliia
- Zalieckas Justas
- Zaman Aungshuman
- Zambito Stefano
- Zanzi Daniele
- Zeitnitz Christian
- Zemaityte Gabija
- Zemla Andrzej
- Zeng Jian
- Zeng Qi
- Zenin Oleg
- Zerwas Dirk
- Zhang Dengfeng
- Zhang Dongliang
- Zhang Fangzhou
- Zhang Guangyi
- Zhang Huijun
- Zhang Jinlong
- Zhang Lei
- Zhang Liqing
- Zhang Matt
- Zhang Peng
- Zhang Rui
- Zhang Ruiqi
- Zhang Xueyao
- Zhang Yu
- Zhang Zhiqing
- Zhao Xiandong
- Zhao Yongke
- Zhao Zhengguo
- Zhemchugov Alexey
- Zhou Bing
- Zhou Chen
- Zhou Li
- Zhou Maosen
- Zhou Mingliang
- Zhou Ning
- Zhou You
- Zhu Cheng
- Zhu Hongbo
- Zhu Junjie
- Zhu Yingchun
- Zhuang Xuai
- Zhukov Konstantin
- Zibell Andre
- Zieminska Daria
- Zimine Nikolai
- Zimmermann Christoph
- Zimmermann Stephanie
- Zinonos Zinonas
- Zinser Markus
- Ziolkowski Michael
- Zobernig Georg
- Zoccoli Antonio
- Zou Rui
- zur Nedden Martin
- Zwalinski Lukasz
- Åkesson Torsten
- Šfiligoj Tina
- Ženiš Tibor
- Živković Lidija
- Άlvarez Piqueras Damián
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements
New genetic loci link adipose and insulin biology to body fat distribution.
- Author
- Aalto Ville
- Aasarød Knut
- Abecasis Goncalo R
- Abecasis Gonçalo
- Absher Devin
- Adair Linda S
- Adam Martin
- Adeyemo Adebowale
- Ahlqvist Emma
- Ahmadi Kourosh R
- Ahola Aila
- Ainali Chrysanthi
- Akylbekova Ermeg
- Ala-Korpela Mika
- Alavere Helen
- Albagha Omar M E
- Albrecht Eva
- Alen Markku
- Alexander Myriam
- Alhenc-Gelas François
- Alizadeh Behrooz Z
- Allison Matthew A
- Alonso Nerea
- Altshuler David
- Ambite Jose Luis
- Amin Najaf
- Amouyel Philippe
- An Ping
- Anderson Carl A
- Anderson Denise
- Anderson Garnet
- Andrews Jeanette S
- Antonella Mulas
- Antti Jula
- Aragaki Aaron K
- Arking Dan E
- Arnold Alice
- Arnold Alice M
- Arora Pankaj
- Arscott Gillian M
- Artigas Maria Soler
- Arveiler Dominique
- Asiki Gershim
- Aspelund Thor
- Assimes Themistocles L
- Atalay Mustafa
- Atkinson Elizabeth J
- Aulchenko Yurii
- Avery Christy
- Bain Stephen C
- Bakker Stephan J L
- Balcells Susana
- Balkau Beverley
- Ballantyne Christie M
- Balmforth Anthony J
- Bandinelli Stefania
- Barbalic Maja
- Barrett Amy
- Barroso Ines
- Barroso Inês
- Basart Hanneke
- Basart Hanneke V
- Bataille Veronique
- Baumert Jens
- Beckmann Jacques S
- Beekman Marian
- Been Latonya F
- Beilby John
- Beilby John P
- Bell Jordana T
- Bellis Claire
- Bennett Amanda J
- Bennett Franklyn
- Berenson Gerald S
- Bergman Richard N
- Bergmann Sven
- Berndt Sonja I
- Berne Christian
- Bidulescu Aurelian
- Bielak Lawrence F
- Bierut Laura J
- Biffar Reiner
- Bis Joshua C
- Blackburn Hannah
- Blangero John
- Blankenberg Stefan S
- Blüher Matthias
- Boban Mladen
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle Eric
- Boezen H Marike
- Bolton Jennifer L
- Bolton Judith A Hoffman
- Bonnet Fabrice
- Bonnycastle Lori L
- Boomsma Dorret I
- Borecki Ingrid
- Boright Andrew P
- Borja Judith B
- Bornstein Stefan R
- Boston Jonathan
- Bots Michiel L
- Bouatia-Naji Nabila
- Bouchard Claude
- Bovet Pascal
- Boyd Heather A
- Bragg-Gresham Jennifer L
- Brambilla Paolo
- Brand Eva
- Brand Stefan-Martin
- Brandi Maria Luisa
- Braund Peter S
- Brennan Eoin P
- Brismar Kerstin
- Brody Jennifer
- Broekmans Frank J
- Broer Linda
- Brown Matthew A
- Brown Morris J
- Brown-Gentry Kristin
- Bruinenberg Marcel
- Buchkovich Martin L
- Buckley Brendan M
- Buil Alfonso
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- Burgdorf Christof
- Buring Julie E
- Burnett Mary S
- Burnier Michel
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- Bush William S
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- Cauchi Stéphane
- Cauley Jane A
- Caulfield Mark
- Cavalieri Margherita
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- Center Jacqueline R
- Cesana Giancarlo
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- Chang Hsing-Yi
- Chang Yen-Pei C
- Chanock Stephen J
- Charchar Fadi J
- Chasman Dan
- Chaturvedi Nish
- Chen Constance
- Chen Han
- Chen Ida
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- Chen Ming-Huei
- Chen Wei
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- Cho Yoon Shin
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- d'Adamo Pio
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- Dailiana Zoe
- Danesh John
- Danoy Patrick
- Dastani Zari
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- Daw E Warwick
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- Day Ian N M
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- Dreisbach Albert W
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- Elks Cathy E
- Ellinghaus David
- Elliott Paul
- Elosua Roberto
- Emilsson Valur
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- Erdmann Jeanette
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- Eriksson Joel
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- Forrester Terrence
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- Fuchsberger Christian
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- Garcia Melissa
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- Garnaas Maija
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- Geller Frank
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- Heliövaara Markku
- Helmer Catherine
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- Herrera Lizbeth
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- Järvelin Marjo-Riitta
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- Witteman Jacqueline C M
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- Wong Tien Y
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- Wood Andy
- Workalemahu Tsegaselassie
- Wright Alan F
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- Wu Joseph M W
- Wu Ying
- Würtz Peter
- Xiao Su-Mei
- Yajnik Chittaranjan S
- Yang Jian
- Yang Qiong
- Yang Tsun-Po
- Yao Jie
- Yengo Loïc
- Yerges-Armstrong Laura M
- Young Alicia
- Young Elizabeth H
- Young J H
- Young Lauren
- Yuan Xin
- Zaboli Ghazal
- Zalloua Pierre A
- Zarrabeitia María T
- Zelenika Diana
- Zemunik Tatijana
- Zerbini Gianpaolo
- Zgaga Lina
- Zhai Guangju
- Zhang Feng
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng Hou-Feng
- Zheng Wei
- Zhou Yanhua
- Zhu Haidong
- Zhu Kun
- Zhu Xiaofeng
- Zhuang Wei V
- Zhuang Wei Vivian
- Ziegler Andreas
- Zillikens M Carola
- Zimmermann Martina E
- Zitting Paavo
- Zondervan Krina T
- Zukowska-Szczechowska Ewa
- Zygmunt Marek
- Ärnlöv Johan
- Österholm Anne-May
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
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- Avis Terry
- Ayele Mulu
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- Bates Karen
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- Batzer Mark
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- Bayul Tashi
- Beall Keith
- Beard Lisa
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- Bituin Aleksandr
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- Chen Jianlong
- Chen Jie
- Chen Jin
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- Chen Lihong
- Chen Lixia
- Chen Ray
- Chen Shu
- Chen Tong
- Chen Xiaoyun
- Chen Xinyi
- Chen Yanjiong
- Chen Yiyu
- Chen Zhu
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- Cheng Zhihua
- Chertkov Olga
- Cheshatsang Yama
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- Cleveland David
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- Coates Julia
- Cobley Victoria
- Cockrell Raynard
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- Cohn Judith D.
- Colayco Rick
- Cole Lotte
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- Collings Simon
- Collins Francis S.
- Collins John
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- Collymore Al
- Colman Louise
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- Comstock Robin
- Cong Bin
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- Connolly Anthony
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- Conrad Ansgar
- Conroy Donald
- Considine Tony
- Constance Doug
- Cook April
- Cook Leanna
- Cooke Patrick
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- Cooper Rachel
- Cooper Robert
- Copeland Alex
- Coppola Maria
- Copsey Teresa
- Corby Nicole
- Cordes Matt
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- Cummings Auli
- Cummings Kirsti
- Cummings Paul
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- Curwen Valery
- Cutts Jeffrey
- Czubayko Martin
- D\u27Souza Lisa Marie
- Da Silva Corinne
- Dai Li
- Dalin Eillen
- Dang Michelle
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- Daniels Rachael
- Dathorne Stephanie R.
- Daum Christopher
- David Robert
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- Davies Jonathon
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- Dawson Elisabeth
- De Anda Claudia
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- Dear Simon
- Dearden Frances
- DeArellano Kurt
- Deaven Larry I.
- Deaven Larry L.
- Deere Kerry
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- Doggett Norman
- Doggett Norman A.
- Dong Hui
- Dong Kimberly
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- Donlin Jeremy E.
- Dooley Kathy
- Dooling David
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- Doucette-Stamm Lynn
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- Dunn Anne
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- Durbin Richard
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- Wu Chungen
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- Wyatt Julia
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- Wylie Kris
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- Xi Yan
- Xi Yingying
- Xie Fei
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- Xue Rui
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- Yakub Syed
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- Zembeck Lisa
- Zeng Yixin
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- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Large expert-curated database for benchmarking document similarity detection in biomedical literature search
- Author
- Aanei Carmen M.
- Abid Muhammad B.
- Abramowitz Matthew K.
- Abu-Zaid Ahmed
- Adamo Vincenzo
- Adeyemo Adebolajo A.
- Afnan Masoud
- Agarabi Cyrus
- Aggelidou Maria
- Ahmad Haroon
- Ahmad Rafi
- Aizat Wan M.
- Ajani Penelope A.
- Akinwumi Sayo A.
- Al-Farha Abd A.
- Al-Lawama Manar
- Al-Owaifeer Adi M.
- Al-Riyami Arwa Z.
- Alanio Alexandre
- Alaux Cedric
- Albery Gregory F.
- Albiol Joan
- Albrecht Dirk R.
- Albuquerque Lucia G.
- Alhowimel Ahmed
- Ali Junaid
- Alimba C.G.
- Allardyce Judith
- Almeida Gabriel M.F.
- Alonso-Caneiro David
- Alper Ozgul M.
- Alshehri Mansour
- Alsuhaibani Mohammed
- Alzghari Saeed K.
- Amer Said E.D.R.
- Amir Shimon
- Amiya Eisuke
- Ammerman Brooke A.
- Amorim Rogerio M.
- An Qianli
- Anazodo Udunna C.
- Andersen Stig U.
- Andersen Vibeke
- Angus Kathryn
- Anikin Andrey
- Aplin John D.
- Argyropoulos Christos
- Armitage Charles
- Asaduzzaman Muhammad
- Asady Hadi
- Ascher David B.
- Ashry Mohamed
- Asmann Yan W.
- Assaeed Abdulaziz M.
- Atack John M.
- Atanasov Atanas G.
- Atchison David A.
- Atkins Gerald J.
- Atlas Lauren
- Ato Dai
- Avery Simon V.
- Avillach Paul
- Azubuike Samuel O.
- Baade Peter D.
- Bach-Mortensen Anders
- Backman Lars
- Badie Christophe
- Bae Taeok
- Bagloee Saeed Asadi
- Bai Xiaoyong
- Baier Dirk
- Bail Kasia
- Baines Rebecca L.
- Baker Chris I.
- Bakkach Joaira
- Baldi Alfonso
- Ball Elizabeth
- Ballantyne Maghan
- Baltiansky Lior
- Ban Bo
- Bannon Ross
- Bansal Abhisheka
- Bar Ido
- Bardot Olivier
- Barnett Adrian G.
- Barraud Pierre
- Bartas Martin
- Basharat Zarrin
- Basner Mathias
- Bathelt Joe
- Batra Jyotsna
- Baumert Philipp
- Bazanova O.M.
- Beale Andrew
- Beck Charles R.
- Beck Jill
- Becker Daniel
- Beddoe Travis
- Belachew Kiflemariam Y.
- Bell Melanie L.
- Ben-Nafa Walid
- Benezeth Yannick
- Bengtsson-Palme Johan
- Benkeser David
- Berbesque Colette
- Berezikov Eugene
- Bergsland Niels
- Berners-Price Sue
- Bernhardt Peter
- Bernier Meghan L.
- Berrevoet Frederik
- Berry Edward
- Berthold Maximilian
- Bessa Theolis B.
- Beyene Tariku J.
- Bhardwaj Vivek
- Biedermann Peter H.W.
- Bijleveld Erik
- Billington Craig
- Binder Karin
- Birch John
- Bittner Florian
- Bitzer Michael
- Black Emma
- Blakely Randy D.
- Blanchard Adam M.
- Blancher Antoine
- Blanck Oliver
- Bland Nicholas S.
- Blankstein Ron
- Blaskovich Mark A.T.
- Bleackley Mark
- Blombach Fabian
- Blum Robert
- Boah Michael
- Boakye Dominic W.
- Bodagh Neil
- Boehme Karen A.
- Boelaert Marleen
- Bogdanos Dimitrios
- Bonatsos Vasileios
- Bonvin A.M.J.J.
- Boon Michele H.
- Borges Paulo
- Bosch Carles
- Bosch Oliver
- Bouboulis George
- Boudreau Shellie A.
- Bourgoin Thierry
- Bourke Emer
- Bouvard Daniel
- Boykin Laura M.
- Br\ufchl Albert
- Bradley Graeme
- Bradshaw William
- Bramoweth Adam D.
- Brand Thomas
- Braubach Oliver
- Braun Daniel
- Braun R. J.
- Brenneisen Peter
- Bridges Kristina M.
- Bromfield Elizabeth
- Brooks Anastasia
- Brown James A.L.
- Brown Joshua
- Brown Peter
- Browngardt Christopher
- Brownlie Jeremy
- Brox-Ponce Josue
- Brunetti Arturo
- Bukowy-Bieryllo Zuzanna
- Bul Kim C.M.
- Bull James A.
- Bullen Benjamin
- Burt Austin
- Burton Kathryn J.
- Bush Stephen J.
- Butkowski Eugene G.
- Butler Lisa M.
- Byrareddy Siddappa N.
- Byrne Hugh J.
- Cabantous Stephanie
- Cai Yufeng
- Calabr\uf2 Giovanna E.
- Calatayud Sara
- Callahan Tiffany J.
- Campana Luca G.
- Campbell Matthew
- Candal Eva
- Canham Colin D.
- Cao Bing
- Cao Zanxia
- Cao Zehong
- Cardoso Pedro
- Carlson Kimberly
- Carninci Piero
- Carroll Grace
- Carter Dee
- Carvajal Richard
- Cascella Marco
- Casillas S\uf2nia
- Castelvetro Valter
- Caswell Patrick T.
- Catry Thibault
- Cavalli Giacomo
- Cernava Tomislav
- Cerovsky Vaclav
- Ch\ue1vez-Fumagalli Miguel A.
- Chacko George
- Chagoyen Monica
- Chakraborty Sayan
- Chalmers Kelsey
- Chan Sherwin S.
- Chandrasekaran Arun R.
- Chang Shun C.
- Chang Wei
- Chao Fengqing
- Chao Jie
- Charrier Elisabeth E.
- Chatterjee Pranab
- Chatzitheochari Stella
- Che Zhengping
- Chen Andrew T.Y.
- Chen Branson
- Chen Chang-Er
- Chen Chang-Shi
- Chen Dong F.
- Chen Haimin
- Chen Hao
- Chen He
- Chen Huaming
- Chen Hui
- Chen Jui-Tung
- Chen Liming
- Chen Xiaoyin
- Chen Xin
- Chen Yi-Chun
- Chen Yinglong
- Chen Youning
- Chen Yu-Chih
- Chen Zhao
- Cheng Changxiu
- Cheng Jianlin
- Cheng Shuiqin
- Chenguang [NO FIRST NAME IN SCOPUS]
- Cheung Johnny T.K.
- Chhatriwalla Adnan K.
- Chikowe Ibrahim
- Chinapaw Mai
- Chinopoulos Christos
- Cho William C.S.
- Choi Jane R.
- Choi Youngrok
- Chong Lillian
- Chowdhury Debashish
- Chowdhury Mohiuddin A.K.
- Christensen Martin R.
- Christoffersen Tore
- Chuang Trees-Juen
- Chung Hee-Jung
- Chwalibog Andre
- Ciresi A.
- Cobine Paul A.
- Cockcroft Shamshad
- Coelho Luis P.
- Colella Vito
- Collevatti Rosane G.
- Comel Jo\ue3o C.
- Conesa Ana
- Conway Aaron
- Cook Penny A.
- Cooke Robert S.C.
- Cooper David N.
- Cooper Jeffrey
- Coqueret Olivier
- Corea Enoka M.
- Cornejo Diego A.V.
- Cosacak Mehmet I.
- Cosse Cyril
- Costa Antonio
- Costa Bruno M.
- Costa Elisio
- Costa Vincent D.
- Cottini Marzia
- Coupland Carol
- Covington Natalie V.
- Crawford Stephanie Y.
- Cruz Aparecido D.
- Cu\uedv P\ue1raic O.
- Cuenda Ana
- Cui Huijuan
- Cui Qiang
- Cui Yanru
- Culver David C.
- Cunningham Catriona
- Cuypers Maarten
- Cyr Normand
- D\u27Angiulli Amedeo
- Dahms Tanya E.S.
- Dai Zhanwu
- Daigle France
- Dalgleish Raymond
- Dalrymple Brian P.
- Danchin Antoine
- Danielsen H\ue5vard E.
- Dao Myriam
- Darras S\ue9bastien
- Dauga Delphine
- Daulatabad Swapna V.
- Davidson Sean M.
- Day David A.
- de Keersmaecker Kim
- de Leeuw Frank-Erik
- de Maio Nicola
- Dean Lorraine T.
- Debrabant Birgit
- Degirmenci Volkan
- Del Tredici Andria L.
- Delahay Robin M.
- Delarocque Julien
- Demaison Luc
- Deng Zaian
- Denzel Martin S.
- Deschodt Mieke
- Devkota Hari P.
- Devkota Kiran
- Devos Lucie
- Devriendt Koenraad
- Dhar Aurup R.
- Dhariwal Raman
- Dhaval [NO FIRST NAME IN SCOPUS]
- Diao Jiajie
- Ding Jiandong
- Ding Ke-Feng
- Dings Ruud P.M.
- Diodato Daria
- Diouf Barthelemy
- Dixon Ray
- Dlamini S.V.
- Doan Lisa V.
- Dogan Yunus
- Domingues Helena S.
- Dong Kexian
- Dong X.C.
- Dong Zheng
- Donner Claudio F.
- Dono Marcos
- Doxey Andrew C.
- Dressick Walter
- Drevon Christian A.
- Dreyer Niklas
- Duan Huiling
- Ducho Christian
- Ducommun Bernard
- Dudley Kevin J.
- Duffey Maelle
- Dufies Maeva
- Duijf Pascal H.G.
- Dumaz Nicolas
- Dutt Avik
- Dwarakanath Bilikere S.
- Ebell Mark H.
- Echeverr\ueda Natalia
- Ecke Thorsten
- Eckweiler Denitsa
- Eerola Tuomas
- Effiong Andem
- Egea Luis G.
- Ehret Felix
- Eisenhardt Steffen
- Eixarch Elisenda
- Ekstrand Chelsea
- El-Adawy Hosny
- El-Esawi Mohamed A.
- El-Said Mohammed
- Elewa Yaser H.A.
- Elkum Naser
- Emmrich Julius V.
- Engel Michael S.
- Engel Nadja
- Epp Trevor
- Erickson Timothy B.
- Esfahlani Shabnam S.
- Eskelinen Eeva-Liisa
- Eskew Evan A.
- Esnakula Ashwini K.
- Eustace Alex J.
- Evangelou Evangelos
- Fairhead Michael
- Falk Sebastian
- Fallah Mazyar
- Falter-Wagner Christine M.
- Fan Dongsheng
- Fan Xiao
- Farber Debora B.
- Fardet Tanguy
- Farhoudi Ramin
- Faruk Mohammed
- Faville Marty J.
- Faye Martin
- Feghali Karine A.
- Feifei Shi
- Fejzo Marlena S.
- Feleke Berhanu E.
- Ferguson Trevor S.
- Fernandez-Fernandez Beatriz
- Fernandez-Triana Jose
- Festa Fernanda
- Feteira Antonio
- Feurer Thomas
- Feyerabend Frank
- Fierz Walter
- Filipp Fabian
- Flegel Willy A.
- Fleres Francesco
- Flood-Page Patrick
- Florio Tullio
- Foley Kieran G.
- Forano Evelyne
- Forsayeth John
- Foster Emma J.
- Foster Stephen
- Founou Luria L.
- Fox Simon A.
- Franks Steven J.
- Freitas Angela
- Frentiu Francesca D.
- Friebe Michael
- Frilander Mikko J.
- Fu Fan
- Fu Xinmiao
- Fujita Satoshi
- Furer Tzvi
- Furuta Saori
- Fuss Johannes
- Gabrielsen Mads
- Gadelkareem Rabea A.
- Gajda Maksymilian
- Galea Ian
- Galimov Evgeny
- Galluzzi Luca
- Gani Federica
- Ganpule Arvind P.
- Gao Jianzhao
- Gao Tian
- Gao Yibo
- Garc\ueda-Alix Antonio
- Garcia-Rivera Enid J.
- Garip Gulcan
- Gatchell Michael
- Gaullier Guillaume
- Gazdar Adi
- Gebremedhin [NO FIRST NAME IN SCOPUS]
- Gedye Kristene
- Gelfer Yael
- Gemmill Alison
- George Ronald B.
- Ghelardi Emilia
- Ghosh Sayantan
- Gianchecchi Elena
- Giganti Francesco
- Gill Martin R.
- Gilliham Matthew
- Giordano Maurizio
- Giunta Cecilia
- Gladue Douglas P.
- Gleason Joshua M.
- Gleeson Paul A.
- Gloyn Liz
- Gnasso Agostino
- Goarant Cyrille
- Gobet Ang\ue9lique
- Goggs Robert
- Gong Haipeng
- Gonz\ue1lezlez-Prendes Rayner
- Goodin Amie
- Goodyear Carl S.
- Gora Diop
- Gough Michael J.
- Gouil Quentin
- Govender Pragashnie
- Govinden Usha
- Goyal Ravinder
- Gr\ue9bert Th\ue9ophile
- Gr\ufcneberg Patrick
- Grabowski Piotr
- Graham Emily B.
- Graham Kathryn E.
- Grande-P\ue9rez Ana
- Graves Patricia M.
- Greene Garrett
- Greenwald Noah F.
- Greidanus Harm
- Greiff Victor
- Grey James
- Grice Darren
- Gridneva Zoya
- Grimm Dominik G.
- Groen Ewout J.N.
- Grothe Michel J.
- Gruber Jens
- Grunau Christoph
- Grundle D.S.
- Grybos Malgorzata
- Guerra-Mora Jos\ue9 R.
- Guerrero Fabricio
- Guignard L\ue9o
- Guisado J.L.
- Gumede Nicksy
- Gumulya Yosephine
- Guo Chengying
- Guo Xinyi
- Guo Yabin
- Gupta Himanshu
- Gurevich Vsevolod V.
- Gurney-Champion Oliver J.
- Gusev Oleg
- Guti\ue9rrez-Sacrist\ue1n Alba
- H\ufcttner Felix J.
- Habes Mohamad
- Hacker Elke
- Hackshaw Allan
- Haenssgen Marco J.
- Hage Steffen R.
- Hagen Guy
- Hahn Steven
- Hall Adam
- Hall Richard
- Haller Dagmar M.
- Hammerschmidt Sven
- Han Hyemin
- Han Jianwei
- Han Qian
- Han Renzhi
- Handfield Martin
- Hanson Jack
- Haore Gbaguidi
- Hapuarachchi Hapuarachchige C.
- Harder Timm
- Hardingham Jennifer E.
- Harper Paul
- Harrison Pille
- Hartmann Marcus D.
- Harvey David J.
- Hasler David
- Haston Scott
- He Shuonan
- Heck Michelle
- Heers Marcel
- Heffler Enrico
- Heijne Marloes
- Heinemann Stephanie
- Heinrich Michael
- Helanter\ue4 Heikki
- Herbelet Sandrine
- Hew Khe F.
- Higginbottom Daniel B.
- Higuchi Yohei
- Hilaire Cynthia St.
- Hilton Rachel
- Hiroi Noboru
- Hobbs Emma
- Hodzic Enisa
- Hoenner Xavier
- Hogg William E.
- Hogrebe Alexander
- Hojsgaard Diego
- Holgate Joan Y.
- Hone Andrew
- Hongoh Yuichi
- Honjo Ken
- Horbar Jeffrey
- Hori Hikaru
- Hu Guoku
- Hu Pingzhao
- Huang Ancheng
- Huang Guangqun
- Huang Zhengping
- Huber Heinz P.
- Huber Michael
- Hueso Luis E.
- Huirne Judith
- Hulse-Kemp Amanda M.
- Hunter Kylie E.
- Hurt Lisa
- Idborg Helena
- Ide Kazuki
- Ijzerman Adriaan P.
- Ikeo Kazuho
- Ikonomopoulou Maria P.
- Ingley Evan
- Iskander-Rizk Sophinese
- Iyer Lavanya M.
- J\ue9gousse Clara
- Jahan Yasmin
- Jakeman Philip M.
- James Ameh S.
- Janga Sarath C.
- Janzen Thijs
- Jayaraman Jayakumar
- Jean-Quartier Claire
- Jeltsch Albert
- Jensen Arne
- Jeon Sang-Min
- Jesus Carlos
- Jeurissen Patrick
- Jia Hong
- Jia Husen
- Jia Shuqin
- Jia Yangyang
- Jian Gao
- Jiang Fan
- Jiang Jianping
- Jiang Xingyu
- Jibb Lindsay A.
- Jin Yi
- Jo Daehyun
- Joel Emmanuel
- Joffroy Bastian
- Johnson Andrew M.
- Johnson Daniel M.
- Johnston Marie
- Jongen Stefan
- Jonscher Karen R.
- Jorens Philippe G.
- Jorgensen Jens O.L.
- Josse Claire
- Joubert Johan W.
- Jung Sin-Ho
- Junior Antonio M.
- Jurman Giuseppe
- Jutzeler Catherine
- Kabra Dhiraj
- Kahan Thomas
- Kaiser Stefan
- Kalatzis Panagiotis
- Kamagata Koji
- Kamboj Sunjeev K.
- Kambondo George
- Kamiya Haruyuki
- Kane Nolan C.
- Kang Yong-Kook
- Kanj Souha S.
- Karamanos Yannis
- Karim Masud
- Karmakar Chandan
- Karnati Priyanka
- Karp Natasha A.
- Karsay Kathrin
- Kasian Olga
- Kauppila Joonas H.
- Kaur Harsheen
- Kaya Cihan
- Kaye Linda K.
- Ke An
- Keitel Anne
- Kelly Daniel
- Kelly Ryan
- Kelly Sarah
- Kelly Shona
- Kempe Andreas
- Kenna Ralph
- Kennedy Jonathan
- Keown Jeremy R.
- Kersten Birgit
- Khalaf Roy A.
- Khalid Javaria M.
- Khan Murad M.
- Khatlani T.
- Kheir Fayez
- Khider Tarig
- Khoo Chin M.
- Khwaja Nyil
- Kichatova V.S.
- Kickert Rob
- Kidibule Peter E.
- Kieselmann Jennifer P.
- Kievit Rogier A.
- Kijanka Gregor S.
- Kim Hyeon J.
- Kim Yong-Min
- King Sarah R.B.
- Kinyanjui Timothy
- Kiraǧ N\ufckhet
- Kish J.K.
- Kitazawa Takeshi
- Kiyani Musa
- Klein Reinhild
- Klempnauer Karl-Heinz
- Kleppe Andreas
- Klump Hannes
- Kluz Tomasz
- Knox Paul
- Kobayashi Tatsuya
- Kobold Sebastian
- Koch Karl-Wilhelm
- Kohanbash Gary
- Kohls Gregor
- Kohonen-Corish Maija R.J.
- Koleva-Kolarova Rositsa G.
- Kong Xiangpeng
- Konkle-Parker Deborah
- Korpela Kalevi M.
- Kosanic Sasha
- Kostrikis Leondios G.
- Koutoukidis Dimitrios A.
- Kovesi Tom
- Kraiczy Peter
- Kramer Paul
- Kraschnewski Jennifer L.
- Kratz Harald
- Krause G\ufcnter
- Krebsbach Paul H.
- Kristensen S\uf8ren R.
- Kristiansson Erik
- Kueberuwa Gray
- Kugler Jan-Michael
- Kulkarni Ameya
- Kumar Addanki P.
- Kumar Dilip
- Kumar Gyanendra
- Kumar Narendra
- Kumar Nitin
- Kumari Prerna
- Kunimatsu Akira
- Kurdak Hatice
- Kurgan Lukasz
- Kurniawan Nicholas A.
- Kwon Young D.
- Labutin Dmitry
- Lachat Carl
- Lacy-Colson Jon
- Lagisz Malgorzata
- Lai Hei M.
- Laky Brenda
- Lalaouna David
- Lamberts Aniek
- Lammerding Jan
- Lange Matthias
- Lanza Giuseppe
- Larrosa Mar
- Laslett Andrew L.
- Latif Asam
- Lau Colleen L.
- Lauschke Volker M.
- Laverman Gozewijn D.
- Lazo-Langner Alejandro
- Le Thuc D.
- Leclair Elizabeth E.
- Leclercq Guy
- Lee Kyung-Woo
- Lee Ming-Yih
- Lee Moon-Soo
- Lee Senhong
- Leem Jung W.
- Leightley Daniel
- Leite Andreia
- Lercher Lukas
- Lewis James S.
- Li Bingling
- Li Genyuan
- Li Jian
- Li Jiansheng
- Li Jiuyong
- Li Maoteng
- Li Qingchun
- Li Tangliang
- Li Ying
- Li Yongzhe
- Li You
- Li Zhixiu
- Liang Dai
- Liang Huakang
- Liang Shide
- Liao Wei-Ting
- Liao Zheng-Yin
- Lidbury Brett A.
- Lieb Klaus
- Liehr Thomas
- Liew Alan W.C.
- Lim Chinten J.
- Lim Renly
- Lim Yau Y.
- Lima Luiz R.A.
- Lin Jessica
- Lin Li
- Lin Michael Z.
- Lindsey Merry L.
- Line Paul-Dag
- Ling Tong
- Linn Sabrina N.
- Litfin Thomas
- Liu Dengcai
- Liu Enwu
- Liu Fang
- Liu Fengbin
- Liu Haiyan
- Liu Hongde
- Liu Siqi
- Liu Xiaodong
- Liu Yu-Peng
- Liu Yuchen
- Liu Zhonghua
- Liusuo Wang
- Lizer J.
- Lloyd Vett K.
- Lo Te-Wen
- Lobreglio Giambattista
- Locci Emanuela
- Loft Nikolai D.
- Loidl Josef
- Lopez-Escamez Jose A.
- Lopez-Ruiz Francisco J.
- Lorenzen Johan
- Lorkowski Stefan
- Lovell Nigel H.
- Lowies Cher
- Lu Cheng
- Lu Hua
- Lu Jin-Jian
- Lu Qiang
- Lu Wei
- Lu Yao
- Lu Zhiyong
- Luengo Gustavo S.
- Lum Fok M.
- Lund Bjarte A.
- Lundh Lars-Gunnar
- Luo Hang
- Lussier Alexandre A.
- Luu Andreas M.
- Lygirou Vasiliki
- Lynch Iseult
- Lysy Philippe A.
- Lyu Ran
- Ma Chuang
- Ma Lan
- Ma Liping
- Ma Lisong
- Ma Ruiyan
- Ma Wujun
- Mabb Angela
- Machhi Jatin
- Mack Heather G.
- Mackey David A.
- Macleod Angus
- Macwan Isaac
- Madala Hanumantha R.
- Madani Nima
- Mahato Ajay K.
- Mahavadi Poornima
- Mahdavi S.R.
- Maher Pamela
- Maher Toby
- Mai Zhi-Ming
- Maibach Edward W.
- Maity Sankar N.
- Majeed Haroon
- Major Rupert W.
- Makowiecki Kalina
- Malgrange Brigitte
- Mali Samira
- Mallinson Daniel J.
- Mallis Panagiotis
- Mamoulakis Charalampos
- Mangoni Arduino A.
- Manke Thomas
- Manstead Antony S.R.
- Mantalaris Athanasios
- Mao Wenzhi
- Marchbank Kevin J.
- Margelyte Ruta
- Maria Caracausi
- Marinello Francesco
- Markonis Y.
- Marsal Jan
- Marschalek Rolf
- Marschall H. U.
- Marsili Luca
- Mart\uedn Carmen S.
- Martin Adam
- Martin Francis L.
- Martinez-Raga Jose
- Martinez-Salas Encarnacion
- Martinez-Sobrido Luis
- Martis Elvis
- Marvin-Dowle Katie
- Marzocchi Ugo
- Mason Leanda D.
- Mather Diane E.
- Mathieu Daniel
- Matsui Yoichi
- Mavoa Suzanne
- Maza Elie
- McCrum Christopher
- McCutcheon James E.
- McGarrigle Christine A.
- McKay Gareth J.
- McMillan Brian
- McMillan Nigel
- McWilliams Lorna
- Meads Catherine
- Medina Loreta
- Megersa Moa
- Mendes Caetano S.M.
- Menichetti Julia
- Mercieca-Bebber Rebecca
- Meresh Edwin
- Merideth Ben
- Merino-Plaza Maria J.
- Merlaen Britt
- Merrick B. Alex
- Meseko Clement
- Messina Rossella
- Metzger Dennis W.
- Meule Adrian
- Meunier Frederic A.
- Michaelis Martin
- Micheau Olivier
- Middelveen Marianne
- Miele Adriana E.
- Mier Pablo
- Mihara Hisaaki
- Miller Jack J.
- Min Rogier
- Minde David-Paul M.
- Minges Alexander
- Mintz Eric M.
- Miotla Pawel
- Mishra Anand K.
- Mishra Eleanor
- Mishra Virendra R.
- Mitchell Kate M.
- Mizukami Takuo
- Moal Iain
- Moalic Yann
- Mohapatra D.P.
- Mohebbi Alireza
- Molari Massimiliano
- Molleman Lucas
- Mondal Saiful R.
- Montagutelli Xavier
- Monteiro Antonia
- Montes Matthieu
- Moore Matthew D.
- Moores Carly
- Moran John V.
- Morcillo Esteban
- Morozov Sergey Y.
- Morrice Nicola
- Mort Matthew
- Moskalensky Alexander E.
- Moss W.N.
- Mota Jorge
- Moultos Othonas A.
- Moyer Robert
- Mozaheb Zahra
- Muhammad Junaid
- Mukherjee Maheswari
- Murai Noriyuki
- Murphy Denis J.
- Murphy Susan K.
- Murray Shauna A.
- Musinguzi Conrad
- Muth Thilo
- Muyaya Ley
- Naganawa Shinji
- Nagler Katja
- Nakayama Kazuhiko
- Nammi Srinivas
- Nandakumar Kutty S.
- Nandhakumar Amar
- Nanou Afroditi
- Naqash Amreen
- Narayan Edward
- Nasios Grigorios
- Natoli Roman M.
- Navaratnarajah [NO FIRST NAME IN SCOPUS]
- Navarin Nicol\uf2
- Negera Edessa
- Neumann Philipp-Alexander
- Ng Grace
- Ng Sheryl H.X.
- Nguyen Frederique
- Nguyen Joe T.
- Nguyen Thi T.H.
- Ni Duan
- Nicol Christine
- Nicoletti Rosario
- Nida [NO FIRST NAME IN SCOPUS]
- Nie Jiyun
- Nie Yingjiu
- Niehof Monika
- Niemeyer Frank
- Nilsen Erlend B.
- Nilsson Henrik
- Nixon Brett
- Nobile Clarissa J.
- Nolan Fiona
- Nolet Philippe
- Nord\ue9n Rickard
- Nordberg Ana
- Norris Adam D.
- Notcovich Shirli
- Nowicki Jessica P.
- Nwaiwu Ogueri
- O\u27Mahony Margaret
- O\u27Toole Ronan
- Obeidat Monther
- Ogami Koichi
- Oh Deog-Hwan
- Ohgami Robert S.
- Ohlsson Sophie
- Ohst Barnabas
- Ohtomo Toshihiko
- Olatunbosun Oluremi
- Oldenmenger Wendy H.
- Ollivier Quinn R.
- Olofsson Per
- Olova Nelly
- Olszewski Pawel
- Olumayede Emmanuel
- Onzima Robert
- Orme Mark W.
- Ortiz Alberto
- Osses Dani\uebl F.
- Oster Henrik
- Ostrikov Kostya
- Otto Siegmar
- Ou Jianhong
- Outeiro Tiago F.
- Ouyang Songying
- Owais Mohammed
- Pace-Asciak Pia
- Paganoni Sabrina
- Page Andrew
- Pallebage-Gamarallage Menuka
- Palm Christoph
- Palma Jose-Alberto
- Pan Chih-Long
- Pan Zihang
- Panthee Suresh
- Panwar Ajay
- Paradies Yin
- Parchi Piero
- Park Caroline
- Park Charny
- Park Dong I.
- Park Seyoung
- Parsons Jerod R.
- Parsons Michael H.
- Parsons Nick
- Pascal Pigny
- Paterson Russell
- Patil Chandrashekhar D.
- Patterson Chris
- Paul Elisabeth
- Pearce Simon P.
- Pearson James A.
- Peckham Michelle
- Pedemonte Nicoletta
- Pedro Sansoa A.
- Peifer Mark
- Pelkonen Tuula
- Pelleri Maria C.
- Pellizzon Michael A.
- Penagos-Tabaree Felipe
- Peng Xiangda
- Peng Yousong
- Perco Paul
- Pereira Joana L.
- Peres Marco A.
- Perry Samuel R.
- Peter Jessica
- Peterson Brent M.
- Petrelli M.
- Pezzuolo Andrea
- Pheko Mpho
- Pianosi Paolo T.
- Pichugin Alexander
- Pinto Carlos J.C.
- Pinto Ines M.
- Pinto Karina A.
- Pinzi Valentina
- Piotrowski Marcin
- Piovesan Allison
- Plantinga Arnoud
- Plevris John N.
- Pluess Michael
- Podolsky Illya M.
- Pollesello Piero
- Polz Martin
- Ponti Giovanna
- Popoola Segun I.
- Porcelli Piero
- Portilla Maribel
- Portillo M.C.
- Pourret Olivier
- Pozdnyakov Ilya
- Prajapati Anilkumar S.
- Pranata Raymond
- Prescott Julie
- Pridans Clare
- Prieto Daniel
- Prince Martin
- Pritchard Antonia L.
- Psaroulaki Anna
- Pujala Ravi K.
- Pulia Michael
- Pulido-Arjona Leonardo
- Pullan Wayne
- Pusch Stefan
- Qi Dongchen
- Qi Peng-Fei
- Qi Xingshun
- Qian Siyu
- Qin Lei
- Quinn Gwendolyn P.
- Quinn Terence J.
- Rafe Ali
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- Raghava Gajendra P.S.
- Rahimi Farid
- Rahman Proton
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- Raman Ayush
- Ramula Satu
- Ranft Andreas
- Raote Ishier
- Rappsilber Juri
- Rassaf Tienush
- Raucher-Ch\ue9n\ue9 [NO FIRST NAME IN SCOPUS]
- Rawski Rafal
- Ray Asit
- Raza Ali
- Razak Lubna A.
- Rebl Henrike
- Reddan Tristan
- Refai Osama
- Refardt Julie
- Regan Tim
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- Reiling Jan H.
- Remacle Claire
- Reschke Cristina R.
- Rezaei Mohsen
- Rhodes Johanna
- Ricciardi Walter
- Richa Tambi
- Richardson Mark F.
- Riddick Eric W.
- Riess Olaf
- Ritter Uwe
- Riva Giuseppe
- Roach Neil W.
- Roberts David D.
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- Robinson K.R.
- Robles Guillermo
- Rodrigues Tiago
- Rodriguez Cesar
- Roislien Jo
- Roobol Monique J.
- Ross Kehinde
- Ross Stephanie A.
- Rossoni Luca
- Rotge Jean-Yves
- Rouet Romain
- Rovas Alexandros
- Rowe Alexandra
- Rowe Anna D.
- Rudolf Kevin
- Ruepp Andreas
- Rusch Peter
- Rust Petra
- S\uf6relius Karl
- Saad Sonia
- Sabnis Sandeep C.
- Sack George H.
- Sacks Frank M.
- Sadoine Margaux L.
- Safaei Soroush
- Saggar Manish
- Saito Yu
- Salama Mohamed F.
- Saleh Sherif
- Sallmon Hannes
- Sampson Christopher
- Santos Manuela
- Saudemont Aurore
- Sava Gianni
- Schmidt Axel
- Schmutz Axel
- Schneeberger Pierre H.H.
- Schrading Simone
- Schramm Alexander
- Schreiber Martin
- Schuele Birgitt
- Schuler Sidney
- Schulte Leon N.
- Schuon Robert A.
- Schurr Roey
- Schwotzer Daniela
- Schymkowitz Joost
- Sczyrba Alexander
- Searles Stephen
- Sebastian Agata
- Seib Kate L.
- Selinski Jennifer
- Seltmann Stefanie
- Senghore Thomas
- Seow Esmond
- Sepanski Robert
- Sergeant Kjell
- Sha Feng
- Shabalin Ivan G.
- Shahid Shaouli
- Shalchyan Vahid
- Shalev Nir
- Shang Jin-Long
- Sharma Neeraj
- Sharma Saurab
- Sheehan Barry
- Shen Jun
- Shi Chunhu
- Shi Han-Ping
- Shimada Tomohiro
- Shin Jeon-Soo
- Shirvalkar Prasad
- Shiryayev Oleg
- Shohayeb Belal
- Shortt Colette
- Siebers Robert
- Sillanp\ue4\ue4 Elina
- Silveyra Patricia
- Singer Josef
- Singh Jugpreet
- Singh Mandeep
- Singh Manisha
- Skinner Debra
- Small Ian
- Smeets Paul A.M.
- Smith Simon S.
- Smith Taylor
- Smout Michael J.
- So Po-Wah
- Soares Ant\uf3nio
- Solano Francisco
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- Sonenshine Daniel E.
- Song Chunjiao
- Song Haijun
- Song Jiangning
- Song Lijuan
- Soraggi Samuele
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- Steckhan Nico
- Stein Nils
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- Stevanovic Dejan
- Stewart Christopher J.
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- Stine Keith
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- Strehlow Jan
- Strobl Frederic
- Strzalka Wojciech
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- Sukocheva Olga
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- Sumant Anirudha V.
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- Sun Gang
- Sun Jim
- Sun Xianbao
- Sundar Raghav
- Supriyanto Irwan
- Surve Chinmay R.
- Suzuki Tomo
- Swali Ritu
- Sydes Matthew
- Syme Caitlin
- Szabo Attila
- Szymanski Wiktor
- Tacon Paul
- Taherzadeh Ghazaleh
- Tahir Nur D.M.
- Tai Chan N.P.
- Takeuchi Hisashi
- Tamaian Radu
- Tan Aik-Choon
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- Tan Ene-Choo
- Tan Kok H.
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- Tanaka Kozo
- Tang Fei
- Tang Haixu
- Tang Jun
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- Tanino Y.
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- Tao Wanyin
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- Tayebi Mourad
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- Tempel Wolfram
- Tennakoon Sumudu
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- Terrier Olivier
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- Theron G.
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- Thomas Lisa-Marie
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- Toelzer Christine
- Tofani Marco
- Tolle Fabrice
- Tomov Nikola
- Tong Xin
- Torga Gonzalo
- Toth Ervin
- Tovar Miguel
- Tr\uf6der Simon E.
- Tran Linh
- Tressoldi Patrizio
- Tripathi Sushil
- Tsapas Apostolos
- Tsirigotis Konstantinos
- Tuladhar Anil M.
- Turak Ayse
- Tuttle Lisa M.
- Tuttle Neil
- Tzotzos George
- Uchendu Florence
- Udo Edet E.
- Uhle Florian
- Ukubuiwe Azubuike C.
- Ung Carolina O.L.
- Utsumi Toshiaki
- Uversky Vladimir N.
- Vaidyanathan Subramanian
- Vaillant Michel
- Valenti Anna
- Valgepea Kaspar
- Valsesia Armand
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- Vandenbroucke Roosmarijn E.
- Vanneste Sven
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- Verlot Pierre
- Vesk Peter A.
- Veys Ralf
- Vickers Paul
- Vickstrom Casey
- Victor Victor M.
- Vidal Arnau
- Villemur Richard
- Villet Martin H.
- Vindin Howard
- Vitriol Veronica
- Viveiros Miguel
- Vohl Marie-Claude
- Voolstra Christian R.
- Vorholt Julia A.
- Voskarides Konstantinos
- Voutchkova Denitza D.
- Vuillemin Anne
- Wakelin Steven
- Waldron Levi
- Walker Mirella
- Walsh Laurence J.
- Wang Amanda Y.
- Wang Fang
- Wang Fuan
- Wang Horng-Dar
- Wang Jinhui
- Wang Jiucun
- Wang Jun
- Wang Qing
- Wang Teng
- Wang Xiaomin
- Wang Yun
- Wang Zhenxing
- Watanabe Yoichi
- Watari Ricky
- Waugh Jason
- Webb S.A.
- Webster Rebecca
- Webster Ruth
- Wei Junnian
- Wei Pan
- Weigert Andreas
- Weinstock Christof
- Welter Danielle
- Wen Jet-Chau
- Werner Gijsbert D.A.
- Werten Sebastiaan
- Westermair Anna L.
- Wham Carol
- White Ethan P.
- Wibowo David
- Widera Darius
- Wiener Jan
- Wilharm Gottfried
- Wilkinson Simon
- Williams Brendan A.
- Williams Richard
- Willmann Raffaella
- Wilson Alex
- Wilson Coralie
- Wingenbach Tanja S.H.
- Winslade Matthew
- Wirth Brunhilde
- Wojan Timothy R.
- Woldesemayat Adugna A.
- Wolff Mathieu
- Wong Alvin
- Wong Bryan M.
- Workman Alan D.
- Wu Dalei
- Wu Tzu-Wei
- Wu Yi-Rui
- Wuerbel Hanno
- Wyart [NO FIRST NAME IN SCOPUS]
- Xavier Rose M.
- Xia Wenfeng
- Xiang Tingxiu
- Xiao Han
- Xiao Shumin
- Xiao Xiangshu
- Xie Li-Xin
- Xiong Peng
- Xu Beisi
- Xu Dong
- Xu Haotian
- Xu J.W.
- Xu Jialin
- Xu Jianping
- Xu Juan
- Xu Jun
- Xu Shicai
- Xu Shilin
- Xu Taosheng
- Xu Ziyue
- Xue Bin
- Xue Yu
- Yadollahpour Ali
- Yalcin Suayib
- Yamato Masayuki
- Yan Hong
- Yang Chongjun
- Yang Dongdong
- Yang En-Cheng
- Yang Hui
- Yang Long
- Yang Mingjun
- Yang Shiqi
- Yang Sunny Y.
- Yang Wei
- Yang Yongliang
- Yankilevich Patricio
- Yao Ruifeng
- Yao Wen
- Yassine Abdul-Amir
- Ye Yuzhen
- Ye Zhi-Qiang
- Yeung Andy W.K.
- Yin Cong-Cong
- Yin Qinan
- Yli-Kauhaluoma Jari
- Yoneyama Hiroshi
- Yoon Jihoon G.
- You Yuyi
- Yousefzadeh Abbas
- Yu Chenglong
- Yu Ying
- Yu Yongbo
- Yuan Christina M.
- Yuan Guo-Cheng
- Yuh Chiou-Hwa
- Zabetakis Ioannis
- Zaccolo Manuela
- Zaitsu Masayoshi
- Zare Asma
- Zaritsky Arno
- Zaucha Jan
- Zeineb Zian
- Zeng Chen
- Zeng Erliang
- Zeng Zhen
- Zevnik Branko
- Zhan Jian
- Zhan Xiao-Yong
- Zhang Chengrong
- Zhang Chi
- Zhang Chongxing
- Zhang Gong
- Zhang Haowen
- Zhang Jilei
- Zhang Junpeng
- Zhang Kai
- Zhang Li
- Zhang Linxing
- Zhang Rongqiang
- Zhang Tongchuan
- Zhang Tuo
- Zhang Wei
- Zhang Weijia
- Zhang Xianglilan
- Zhang Xiaolei
- Zhang Yao
- Zhang Yi
- Zhang Yingkai
- Zhang Yusen
- Zhang Zhe
- Zhang Zhiyong
- Zhang Zhong-Yin
- Zhang Zhongheng
- Zhao Guoyan
- Zhao Haochen
- Zhao Jing
- Zhao Xin
- Zhao Yuan
- Zheng Shan
- Zhou Bailing
- Zhou Jianyu
- Zhou Kai
- Zhou Min
- Zhou Xiaofan
- Zhou Xiaoyan
- Zhou Yaoqi
- Zhu Dongjie
- Zhu Shu
- Zhu Zhenxing
- Ziegler Andreas
- Zinke Katharina
- Zuberbier Torsten
- Zuckerman Hannah
- Publication venue
- Publication date
- 01/01/2019
- Field of study
Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
- Author
- Abecasis Goncalo
- Abecasis Gonçalo R.
- Aben Katja K.
- Absher Devin
- Aherrahrou Zouhair
- Ahlqvist Emma
- Ahmadi Kourosh
- Ahmed Nabeel
- Alavere Helene
- Alibrandi Maria T S
- Allayee Hooman
- Almgren Peter
- Altshuler David
- Amin Najaf
- Anand Sonia S.
- Andersen Karl
- Anderson Jeffrey L.
- Ardissino Diego
- Ardlie Kristin
- Armitage Jane
- Arnold Alice M.
- Aspelund Thor
- Assimes Themistocles L.
- Assmann Gerd
- Atwood Larry D.
- Aulchenko Yurii S.
- Azhar Muhammad
- Balkau Beverley
- Ball Stephen G.
- Balmforth Anthony J.
- Barbalic Maja
- Barker Adam
- Barker David J P
- Barlassina Christina
- Barlera Simona
- Barnes Daniel
- Barnes Timothy A.
- Barrett Amy
- Barroso H
- Barroso Inês
- Bataille Veronique
- Becker Diane M.
- Becker Lewis C.
- Beckmann Jacques S.
- Beilby John P.
- Ben-Shlomo Yoav
- Benediktsson Rafn
- Bennett Amanda J.
- Berger Klaus
- Bergman Richard N.
- Bergmann Sven
- Bernd Sonja I.
- Berndt Sonja I
- Biebermann Heike
- Bis Joshua C.
- Blagieva Roza
- Blakemore Alexandra I F
- Blankenberg Stefan
- Boehm Bernhard O.
- Boehnke Michael
- Boehnke Mike
- Boeing Heiner
- Boekholdt S. Matthijs
- Boerwinkle Eric
- Boes Tanja
- Bonnycastle Lori L.
- Boomsma Dorret I.
- Borecki Ingrid B.
- Bornstein Stefan R.
- Boström Kristina Bengtsson
- Bouatia-Naji Nabila
- Bowman Louise
- Bragi Walters G.
- Braund Peter S.
- Bravenboer Bert
- Brown Morris J.
- Buchanan Thomas A.
- Bumpstead Suzannah
- Burnett Mary Susan
- Burtt Noisël P.
- Busonero Fabio
- Buysschaert Ian
- Cambien Francois
- Campbell Harry
- Cappuccio Francesco P.
- Cardiogenics [Unknown]
- Carlquist John F.
- Cauchi Stephane
- Caulfield Mark
- Cavalcanti-Proença Christine
- Chambers John C.
- Chanock Stephen J.
- Charpentier Guillaume
- Chasman Daniel I.
- Chatterjee Nilanjan
- Chen Chih Mei
- Chen Han
- Chen Li
- Chines Peter S.
- Cichon Sven
- Clarke Robert
- Codd Veryan
- Coin Lachlan
- Collins Francis S.
- Collins Rory
- Connell John
- Cooper Cyrus C.
- Cooper Matthew N.
- Cornelis Marilyn
- Couper David J.
- Crawford Gabe
- Cupples L. Adrienne
- Daly Mark J.
- Danesh John
- Davies Robert W.
- Day Ian N M
- de Faire Ulf
- Dedoussis George
- Dehghan Abbas
- Deloukas Panos
- Demissie Serkalem
- den Heijer Martin
- Dennison Elaine M.
- Dermitzakis Emmanouil T.
- Devaney Joseph M.
- di Meglio Paola
- Diemert Patrick
- Dimas Antigone S.
- Dina Christian
- Dixon Anna L.
- Do Ron
- Doering Angela
- Doney Alex S F
- Donnelly Peter
- Dorret I Boomsma
- Duan Jubao
- Dupuis Josée
- Durbin Richard
- Ebrahim Shah
- Eifert Sandra
- Eiriksdottir Gudny
- El Mokhtari Nour Eddine
- Elliott Amanda L.
- Elliott Katherine S.
- Elliott Paul
- Ellis Stephen G.
- Elosua Roberto
- Engert James C.
- Epstein Stephen E.
- Erdmann Jeanette
- Erdos Michael R.
- Eric E Schadt
- Eriksson Johan G.
- Eriksson Per
- Esko Tõnu
- Estrad Karol
- Estrada Karol
- Eury Elodie
- Facheris Maurizio F.
- Farooqi I. Sadaf
- Farrall Martin
- Feitosa Mary F.
- Felix Stephan B.
- Ferrannini Ele
- Ferreir Teresa
- Ferreira Teresa
- Fischer Marcus
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- Fisher Eva
- Florez Jose C.
- Folkersen Lasse
- Folsom Aaron R.
- Forsen Tom J.
- Fox Caroline S.
- Franklin Christopher S.
- Franzosi Maria Grazia
- Frayling Timothy M.
- Freimer Nelson B.
- Freyer Jennifer
- Friedrich Nele
- Froguel Philippe
- Frossard Philippe
- Fu Mao
- Gaget Stefan
- Ganser Martha
- Gardezi Ali
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- Geus Eco J C
- Gieger Christian
- Gigante Bruna
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- Glass Daniel
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- Goddard Michael E.
- Goel Anuj
- Goodall Alison H.
- Goyette Philippe
- Grallert Harald
- Grarup Niels
- Green Fiona
- Green Todd
- Greenawalt Danielle M.
- Gretarsdottir Solveig
- Griffin Simon
- Groop Leif
- Groop Leif C.
- Groves Christopher J.
- Grundberg Elin
- Gräßler Jürgen
- Grönberg Henrik
- Gu Harvest
- Gudnason Vilmundur
- Guiducci Candace
- Gulcher Jeffrey R.
- Gustafsso Stefan
- Gustafsson Stefan
- Gyllensten Ulf
- Hadjadj Samy
- Hall Alistair S.
- Hall Per
- Halperin Eran
- Hammond Christopher J.
- Hammond Naomi
- Hamsten Anders
- Han Chen
- Hansen Torben
- Haritunians Talin
- Harris Tamara B.
- Hartikainen Anna Liisa
- Hassanali Neelam
- Hattersley Andrew T.
- Havulinna Aki S.
- Hayes Richard B.
- Hayward Caroline
- Hazen Stanley L.
- Heard-Costa Nancy L.
- Heath Andrew C.
- Hebebrand Johannes
- Hedman Åsa K.
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- Heid Iris M
- Heinrich Joachim
- Hellénius Mai Lis
- Hengstenberg Christian
- Herder Christian
- Hicks Andrew A.
- Hide Winston A.
- Hinney Anke
- Hirschhorn Joel N.
- Hitman Graham A.
- Hoesel Volker
- Hofman Albert
- Hofmann Oliver M.
- Holm Hilma
- Homuth Georg
- Hopewell Jemma C.
- Horikoshi Momoko
- Horne Benjamin D.
- Hottenga Jouke Jan
- Hu Frank B.
- Hui Jennie
- Huikuri Heikki V.
- Hunter David J.
- Huth Cornelia
- Hveem Kristian
- Ida Chen Yii Der
- Igl Wilmar
- Illig Thomas
- Ingelsson Erik
- Ingle Catherine
- Iribarren Carlos
- Ishaq Muhammad
- Isomaa Bo
- Jackso Anne U.
- Jackson Anne U.
- Jacobs Kevin B.
- James Alan L.
- Jameson Karen A.
- Jansson John Olov
- Jarick Ivonne
- Jarvelin Marjo Riitta
- Jewell Elizabeth
- Johansson Åsa
- John Ulrich
- Johnson Paul
- Johnson Paul R V
- Johnson Toby
- Jones Gregory T.
- Jousilahti Pekka
- Jukema J. Wouter
- Jula Antti
- Jørgensen Torben
- Kaakinen Marika
- Kaiser Michael A.
- Kajantie Eero
- Kanoni Stavroula
- Kao Wen H L
- Kaplan Lee M.
- Kaplan Robert C.
- Kaprio Jaakko
- Karpe Fredrik
- Kastelein John J P
- Kathiresan Sekar
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- Ketkar Shamika
- Kettunen Johannes
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- Kiemeney Lambertus A.
- Kilpeläine Tuomas O.
- Kilpeläinen Tuomas O
- Kinnunen Leena
- Klopp Norman
- Knowles Joshua W.
- Kolcic Ivana
- Kolovou Genovefa
- Kong Augustine
- Kooner Angad S.
- Kooner Jaspal S.
- Koskinen Seppo
- Kovacs Peter
- Kraft Peter
- Krude Heiko
- Kutalik Zoltán
- Kuulasmaa Teemu
- Kuusisto Johanna
- Kvaløy Kirsti
- Kyriakou Theodosios
- Kähönen Mika
- König Inke R.
- Laakso Markku
- Laaksonen Reijo
- Laitinen Jaana
- Lambrechts Diether
- Lamina Claudia
- Langenberg Claudia
- Lango Allen Hana
- Lantieri Olivier
- Lanzani Chiara
- Launer Lenore J.
- Lauritzen Torsten
- Lawlor Debbie A.
- Lawrence Robert W.
- Leander Karin
- Lecoeur Cecile
- Lehtimäki Terho
- Lettre Guillaume
- Levinson Douglas F.
- Li Man
- Li Mingyao
- Li Shengxu
- Lian Liming
- Liang Liming
- Lieb Wolfgang
- Lieverse Aloysius
- Lind Lars
- Lindgre Cecilia M.
- Lindgren Cecilia M.
- Linksted Pamela
- Liu Jianjun
- Lokki Marja Liisa
- Loley Christina
- Loos Ruth J F
- Lorentzon Mattias
- Lotery Andrew J.
- Lua Jian'an
- Luan Jian'an
- Luben Robert N.
- Ludwig Barbara
- Lyssenko Valeriya
- Macciardi Fabio
- MAGIC [Unknown]
- Makrilakis Konstantinos
- Mallick Nadeem
- Mangino Massimo
- Mannila Maria Nastase
- Manning Alisa K.
- Mannucci Pier M.
- Manunta Paolo
- Maouche Seraya
- Marek Diana
- Marre Michel
- Martin Nicholas G.
- Martinelli Nicola
- Martínez-Larrad María Teresa
- McArdle Wendy L.
- McCarroll Steve A.
- McCarroll Steven A.
- McCarthy Anne
- McCarthy Mark
- McCulloch Laura J.
- McKeown Pascal P.
- McKnight Barbara
- McPherson Ruth
- Meigs James B.
- Meisinger Christa
- Meitinger Thomas
- Melander Olle
- Memon Fazal ur Rehman
- Merlini Pier Angelica
- Metspalu Andres
- Meyre David
- Midthjell Kristian
- Min Josine L.
- Moffatt Miriam F.
- Mohlke Karen L.
- Mond Keri L.
- Monda Keri L
- Montgomery Grant W.
- Montgomery Stephen B.
- Mooser Vincent
- Morgan Thomas
- Morken Mario A.
- Morris Andrew D.
- Morris Andrew P.
- Muhlestein Joseph B.
- Mulic Rosanda
- Munroe Patricia B.
- Musunuru Kiran
- Myers Richard H.
- Mäg Reedik
- Mägi Reedik
- Mälarstig Anders
- März Winfried
- Mühleisen Thomas W.
- Münzel Thomas
- Nahrstaedt Janja
- Narisu Narisu
- Navarro Pau
- Nelis Mari
- Nelson Christopher P.
- Nemes James
- Nemesh James
- Nestle Frank O.
- Neville Matt J.
- Ngwa Julius S.
- Nica Alexandra C.
- Nieminen Markku S.
- Nilesh J Samani
- Nilsson Peter
- Nisbet James
- North Kari E.
- Nyholt Dale R.
- Nöthen Markus M.
- O'Connell Jeffrey R.
- O'Donnel Christopher J.
- O'Donnell Christopher J.
- O'Rahilly Stephen
- O'Rahilly Steve
- Offer Alison
- Ohlsson Claes
- Ohrvik John
- Olivieri Oliviero
- Olsson Gunnar
- Ong Ken K.
- Ongen Halit
- Oostra Ben
- Osmond Clive
- Ostenson Claes-Göran
- Ouwehand Willem H.
- Owen Katharine R.
- Palmer Colin N A
- Palmer Lyle J.
- Pankow James S.
- Par Ju Hyun
- Parish Sarah
- Park Ju-Hyun
- Parker Alex N.
- Parts Leopold
- Paré Guillaume
- Pascoe Laura
- Patel Riyaz S.
- Patterson Chris C.
- Pattou François
- Payne Felicity
- Peden John F.
- Pedersen Oluf
- Pellikka Niina
- Peltonen Leena
- Penninx Brenda W.
- Perola Markus
- Perry John R B
- Peter M Visscher
- Peters Annette
- Peters Marjolein J.
- Petersen Ann Kristin
- Peto Richard
- Petrie John R.
- Peyvandi Flora
- Pichler Irene
- Pietiläinen Kirsi H.
- Platou Carl
- Platou Carl G P
- Polasek Ozren
- Potter Simon
- Pouta Anneli
- Pramstaller Peter P.
- Preuss Michael
- Proença Christine
- Prokopenko Inga
- Purcell Shaun
- Qi Lu
- Qu Liming
- Quertermous Thomas
- Quyyumi Arshed A.
- Rader Daniel J.
- Rafelt Suzanne
- Raitakari Olli
- Rallidis Loukianos S.
- Randal Joshua C.
- Randall Joshua C
- Rasheed Asif
- Rathmann Wolfgang
- Raychaudhuri Soumya
- Rayner N. William
- Rayner Nigel W.
- Reilly Muredach P.
- Reinehr Thomas
- Rice Catherine
- Ridderstråel Martin
- Ridderstråle Martin
- Ridker Paul M.
- Rief Winfried
- Ripatti Samuli
- Rissanen Aila
- Rivadeneira Fernando
- Roberts Robert
- Robertson Neil R.
- Rocheleau Ghislain
- Roden Michael
- Rosendaal Frits R.
- Rubin Diana
- Rudan Igor
- Ruokonen Aimo
- Rust Stephan
- Rybin Denis
- Rzehak Peter
- Ríos Manuel Serrano
- Sabater-Lleal Maria
- Saleheen Danish
- Salomaa Veikko
- Samad Adbus
- Samani Nilesh
- Sampietro M. Lourdes
- Sampson Michael J.
- Samuel Maria
- Sanders Alan R.
- Sandholt Camilla
- Sandhu Manj S.
- Sandhu Manjinder S.
- Sanna Serena
- Saramies Jouko
- Savolainen Markku J.
- Saxena Richa
- Sayer Avan A.
- Schadt Eric
- Scherag Andre
- Scherag Susann
- Schillert Arne
- Schipf Sabine
- Schlessinger David
- Schreiber Stefan
- Schrezenmeir Jürgen
- Schunkert Heribert
- Schwartz Stephen M.
- Schwarz Peter E H
- Schäfer Arne
- Scott James
- Scott Laura J.
- Seedorf Udo
- Segrè Ayellet V.
- Sehmi Joban
- Sekowska Magdalena
- Sennblad Bengt
- Shah Nabi
- Shaun Purcell
- Shi Jianxin
- Shields Beverley M.
- Shrader Peter
- Shuldiner Alan R.
- Sigurdsson Gunnar
- Sijbrands Eric
- Silander Kaisa
- Silveira Angela
- Sinisalo Juha
- Siscovick David S.
- Sivananthan Mohan
- Sivapalaratnam Suthesh
- Sladek Rob
- Sleight Peter
- Small Kerrin
- Smit Jan H.
- Smith Albert
- Smith George Davey
- Smith Tamara B.
- Snoep Jaapjan D.
- Soranzo Nicole
- Sovio Ulla
- Sparsø Thomas
- Spector Timothy D.
- Speliote Elizabeth K.
- Speliotes Elizabeth K
- Spertus John A.
- Stancakova Alena
- Stark Klaus
- Stefansson Kari
- Stein Lincoln D.
- Steinthorsdotti Valgerdur
- Steinthorsdottir Valgerdur
- Stephens Jonathan
- Stewart Alexandre F R
- Stirrups Kathy
- Stoll Monika
- Strachan David P.
- Strassburger Klaus
- Strawbridge Rona
- Stringha Heather M.
- Stringham Heather M.
- Stumvoll Michael
- Sun Qi
- Surakka Ida
- Surdulescu Gabriela
- Swift Amy J.
- Syvänen Ann Christine
- Tammesoo Mari Liis
- Taneera Jalal
- Tang W. H Wilson
- Tardif Jean Claude
- Teder-Laving Maris
- Tennstedt Stephanie
- Terho Lehtimäki
- Teslovich Tanya M.
- Thiering Elisabeth
- Thompson John R.
- Thomson Brian
- Thorand Barbara
- Thorgeirsson Gudmundur
- Thorleifsso Gudmar
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Tichet Jean
- Timpson Nicholas J.
- Tognoni Gianni
- Tomaszewski Maciej
- Travers Mary
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Turrini Fabiola
- Tyrer Jonathan P.
- Tzenova Bell Jordana
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- Uda Manuela
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- Uitterlinden Andre G.
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- Valle Timo T.
- van Dam Rob M.
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- van Haeften Timon W.
- van Herpt Thijs
- van Hoek Mandy
- van Meurs Joyce B.
- van Ommen Gert Jan
- van Rij Andre M.
- van Vliet Jana V
- van Vliet-Ostaptchouk Jana V.
- van Wingerden Sophie
- van't Hooft Ferdinand
- Vatin Vincent
- Vedanta Sailaja
- Vedantam Sailaja
- Viikari Jorma
- Visscher Peter M.
- Visvikis-Siest Sophie
- Vitart Veronique
- Vogel Carla I G
- Voight Benjamin F.
- Wabitsch Martin
- Waeber Gérard
- Waite Lindsay L.
- Walker Mark
- Wallaschofski Henri
- Walter G. Bragi
- Wareham Nicholas J.
- Wareham Nick J.
- Watanabe Richard M.
- Watkins Hugh
- Weedo Michael N.
- Weedon Michael N.
- Welch Ryan
- Wells George A.
- Weyan Robert J.
- Weyant Robert J
- Wheele Eleanor
- Wheeler Eleanor
- White Charles C.
- Wichmann H. Erich
- Widen Elisabeth
- Wiegand Susanna
- Wijmenga Cisca
- Wiklund Fredrik
- Wild Philipp S.
- Wild Sarah H.
- Wilk Alicja
- Wille Cristen J.
- Willemsen Gonneke
- Willenborg Christina
- Willer Cristen J.
- Wilson James F.
- Winkle Thomas W.
- Winkler Thomas W
- Witte Daniel R.
- Witteman Jacqueline
- Witteman Jacqueline C.
- Witteman Jaqueline C M
- Woo Andrew R.
- Wood Andrew R
- Workalemah Tsegaselassie
- Workalemahu Tsegaselassie
- Wright Alan F.
- Wright Benjamin J.
- Wu Guanming
- Xie Weijia
- Xu Jianfeng
- Yang Jian
- Yang Tsun Po
- Ye Shu
- Zabena Carina
- Zaidi Moazzam
- Zaman Khan Shah
- Zeggini Eleftheria
- Zeller Tanja
- Zethelius Björn
- Zgaga Lina
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Ziegler Andreas
- Zillikens M. Carola
- Zitting Paavo
- Zondervan Krina T.
- Öhrvik John
- Östenson Claes Göran
- Publication venue
- Diabetes
- Publication date
- 01/01/2011
- Field of study
OBJECTIVE: Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS: We have conducted a meta-analysis of genome-wide association tests of ∼2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS: Nine SNPs at eight loci were associated with proinsulin levels (P < 5 × 10(-8)). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 × 10(-4)), improved β-cell function (P = 1.1 × 10(-5)), and lower risk of T2D (odds ratio 0.88; P = 7.8 × 10(-6)). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS: We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis
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