947 research outputs found
Levels and patterns of organochlorine pesticides in agricultural soils in an area of extensive historical cotton cultivation in Henan province, China
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/04/2016
- Field of study
Organochlorine pesticides (OCPs) have attracted widespread concern because of their environmental persistence and toxicity. The historical influence of different agricultural land use types on soil concentrations of OCP residues was investigated by collecting a total of 52 surface soil samples from long-term cotton fields and fields with other crops in Lvdian township, Henan province, eastern central China. The concentration, composition, and possible sources of 16 OCPs were determined and a health risk assessment of these soils was conducted. Hexachlorocyclohexane (HCH), heptachlor, chlordane, and dichloro diphenyl trichloroethane plus its main metabolites (DDTs) were the most frequently detected OCPs with concentrations of 2.9-56.4 ng g(-1), 4.3-14.0 ng g(-1), 18.0-1254.4 ng g(-1), and below detection limit (BDL) -206.1 ng g(-1), respectively. Analysis of variance of p,p-DDE shows significant (P < 0.05) differences while other OCPs show no significant differences between historical cotton fields and fields containing other crops. Compositional analysis suggests that the HCH is derived mainly from the use of lindane and that there are recent inputs. Analysis of variance and compositional analysis indicate that the p,p-DDE in surface soil from long-term cotton fields is derived mainly from the aerobic biodegradation of historical residues. The sum of carcinogenic risk values of OCPs for soil samples were found to be 1.58 x 10(-6), posing a low cancer risk to the inhabitants of the region studied
Identification of a Phosphorylation-Dependent Nuclear Localization Motif in Interferon Regulatory Factor 2 Binding Protein 2
- Author
- A Baetz
- AA Tinnikov
- ACT Teng
- Alexandre F. R. Stewart
- Allen C. T. Teng
- BC Harrison
- BJ Lee
- Brian L. M. Cheng
- CF Tsai
- D Van Hoof
- DS Lidke
- F Zhang
- FS Oppermann
- G Han
- H Germain
- H Kuwahara
- HH Chen
- Hsiao-Huei Chen
- JV Olsen
- KS Childs
- KT Yeung
- M Koeppel
- MA Zanta
- MR Fontes
- N Dephoure
- N deSouza
- N Mosammaparast
- Naif A. M. Al-montashiri
- Philip Lou
- Pierre-Antoine
- Pinar Ozmizrak
- PL Paine
- R Raijmakers
- RY Ma
- S Heger
- SA Adam
- T Sheng
- T Yoshida
- V Mayya
- X Zeng
- Y Miyamoto
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
Background - Interferon regulatory factor 2 binding protein 2 (IRF2BP2) is a muscle-enriched transcription factor required to activate vascular endothelial growth factor-A (VEGFA) expression in muscle. IRF2BP2 is found in the nucleus of cardiac and skeletal muscle cells. During the process of skeletal muscle differentiation, some IRF2BP2 becomes relocated to the cytoplasm, although the functional significance of this relocation and the mechanisms that control nucleocytoplasmic localization of IRF2BP2 are not yet known. // Methodology/Principal Findings - Here, by fusing IRF2BP2 to green fluorescent protein and testing a series of deletion and site-directed mutagenesis constructs, we mapped the nuclear localization signal (NLS) to an evolutionarily conserved sequence 354ARKRKPSP361 in IRF2BP2. This sequence corresponds to a classical nuclear localization motif bearing positively charged arginine and lysine residues. Substitution of arginine and lysine with negatively charged aspartic acid residues blocked nuclear localization. However, these residues were not sufficient because nuclear targeting of IRF2BP2 also required phosphorylation of serine 360 (S360). Many large-scale phosphopeptide proteomic studies had reported previously that serine 360 of IRF2BP2 is phosphorylated in numerous human cell types. Alanine substitution at this site abolished IRF2BP2 nuclear localization in C2C12 myoblasts and CV1 cells. In contrast, substituting serine 360 with aspartic acid forced nuclear retention and prevented cytoplasmic redistribution in differentiated C2C12 muscle cells. As for the effects of these mutations on VEGFA promoter activity, the S360A mutation interfered with VEGFA activation, as expected. Surprisingly, the S360D mutation also interfered with VEGFA activation, suggesting that this mutation, while enforcing nuclear entry, may disrupt an essential activation function of IRF2BP2. // Conclusions/Significance - Nuclear localization of IRF2BP2 depends on phosphorylation near a conserved NLS. Changes in phosphorylation status likely control nucleocytoplasmic localization of IRF2BP2 during muscle differentiation
A highly attenuated recombinant human respiratory syncytial virus lacking the G protein induces long-lasting protection in cotton rats
- Author
- A Srikiatkhachorn
- CF Maher
- DA Hendricks
- DC Gruenert
- DK Shay
- EM Castilow
- GA Prince
- GA Prince
- H Jin
- J Schwarze
- JH Schickli
- Jolande Boes
- MA Staat
- Marleen van Bers
- MB Elliott
- MF Delgado
- MN Teng
- Myra N Widjojoatmodjo
- Paul JM Roholl
- PF Wright
- PJ Openshaw
- PL Collins
- PL Collins
- PL Collins
- PR Johnson
- R Arnold
- RA Karron
- RA Karron
- RM Moudy
- S Biacchesi
- TR Johnson
- U Schmidt
- Willem Luytjes
- Y Murata
- Yvonne van Remmerden
- Publication venue
- BioMed Central
- Publication date
- 01/01/2010
- Field of study
<p>Abstract</p> <p>Background</p> <p>Respiratory syncytial virus (RSV) is a primary cause of serious lower respiratory tract illness for which there is still no safe and effective vaccine available. Using reverse genetics, recombinant (r)RSV and an rRSV lacking the G gene (ÎG) were constructed based on a clinical RSV isolate (strain 98-25147-X).</p> <p>Results</p> <p>Growth of both recombinant viruses was equivalent to that of wild type virus in Vero cells, but was reduced in human epithelial cells like Hep-2. Replication in cotton rat lungs could not be detected for ÎG, while rRSV was 100-fold attenuated compared to wild type virus. Upon single dose intranasal administration in cotton rats, both recombinant viruses developed high levels of neutralizing antibodies and conferred comparable long-lasting protection against RSV challenge; protection against replication in the lungs lasted at least 147 days and protection against pulmonary inflammation lasted at least 75 days.</p> <p>Conclusion</p> <p>Collectively, the data indicate that a single dose immunization with the highly attenuated ÎG as well as the attenuated rRSV conferred long term protection in the cotton rat against subsequent RSV challenge, without inducing vaccine enhanced pathology. Since ÎG is not likely to revert to a less attenuated phenotype, we plan to evaluate this deletion mutant further and to investigate its potential as a vaccine candidate against RSV infection.</p
Intensive Cytokine induction in Pandemic H1N1 Influenza Virus Infection Accompanied by Robust Production of IL-10 and IL-6
- Author
- Baihui Zhao
- C Xu
- CA Janeway
- CF Lai
- CI Kingsley
- Fan Wu
- J Rello
- JF Bermejo-Martin
- Jiaren Shen
- Jiayu Wang
- Juan C. de la Torre
- Junjie Shao
- KK McKinstry
- L Kaiser
- M Terai
- MB Rothberg
- ML Heltzer
- N Hagau
- P Ăsterlund
- R Zeng
- S Jain
- S Mukherjee
- T Kamigaki
- T Taga
- TH Mogensen
- TR Maines
- VJ Munster
- XF Liang
- Xi Zhang
- Xuelian Yu
- Y Itoh
- Ye Gao
- Zhaokui Zhu
- Zheng Teng
- Zhengan Yuan
- Publication venue
- Public Library of Science
- Publication date
- 09/12/2011
- Field of study
BACKGROUND: The innate immune system is the first line of defense against viruses by inducing expression of cytokines and chemokines. Many pandemic influenza H1N1 virus [P(H1N1)] infected severe cases occur in young adults under 18 years old who were rarely seriously affected by seasonal influenza. Results regarding host cytokine profiles of P(H1N1) are ambivalent. In the present study we investigated host cytokine profiles in P(H1N1) patients and identified cytokines related to disease severity. METHODS AND PRINCIPAL FINDINGS: We retrieved 77, 59, 26 and 26 sera samples from P(H1N1) and non-flu influenza like illness (non-ILIs) cases with mild symptoms (mild patients), P(H1N1) vaccinees and healthy individuals, respectively. Nine and 16 sera were from hospitalized P(H1N1) and non-ILIs patients with severe symptoms (severe patients). Cytokines of IL-1, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IFN-Îł and TNF-Îą were assayed by cytokine bead array, IL-17 and IL-23 measured with ELISA. Mild P(H1N1) patients produced significantly elevated IL-2, IL-12, IFN-Îł, IL-6, TNF-Îą, IL-5, IL-10, IL-17 and IL-23 versus to healthy controls. While an overwhelming IL-6 and IL-10 production were observed in severe P(H1N1) patients. Higher IL-10 secretion in P(H1N1) vaccinees confirmed our observation that highly increased level of sera IL-6 and IL-10 in P(H1N1) patients may lead to disease progression. CONCLUSION AND SIGNIFICANCE: A comprehensive innate immune response was activated at the early stage of P(H1N1) infection with a combine Th1/Th2/Th3 cytokines production. As disease progression, a systemic production of IL-6 and IL-10 were observed in severe P(H1N1) patients. Further analysis found a strong correlation between IL-6 and IL-10 production in the severe P(H1N1) patients. IL-6 may be served as a mediator to induce IL-10 production. Highly elevated level of sera IL-6 and IL-10 in P(H1N1) patients may lead to disease progression, but the underlying mechanism awaits further detailed investigations
Measurement of the Bottom-Strange Meson Mixing Phase in the Full CDF Data Set
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- Warburton
- Waters
- Wester
- Whiteson
- Wick
- Wicklund
- Wicklund
- Wilbur
- Williams
- Wilson
- Wilson
- Winer
- Wittich
- Wolbers
- Wolfe
- Wright
- Wu
- Wu
- X.
- Y.
- Y.
- Y.
- Y.
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- Y.
- Y.
- Y.C.
- Y.C.
- Y.D.
- Y.J.
- Y.K.
- Y.S.
- Yamamoto
- Yamato
- Yang
- Yang
- Yang
- Yao
- Yeh
- Yi
- Yoh
- Yorita
- Yoshida
- Yu
- Yu
- Yu
- Yun
- Z.
- Zanetti
- Zeng
- Zhou
- Zucchelli
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
We report a measurement of the bottom-strange meson mixing phase \beta_s
using the time evolution of B0_s -> J/\psi (->\mu+\mu-) \phi (-> K+ K-) decays
in which the quark-flavor content of the bottom-strange meson is identified at
production. This measurement uses the full data set of proton-antiproton
collisions at sqrt(s)= 1.96 TeV collected by the Collider Detector experiment
at the Fermilab Tevatron, corresponding to 9.6 fb-1 of integrated luminosity.
We report confidence regions in the two-dimensional space of \beta_s and the
B0_s decay-width difference \Delta\Gamma_s, and measure \beta_s in [-\pi/2,
-1.51] U [-0.06, 0.30] U [1.26, \pi/2] at the 68% confidence level, in
agreement with the standard model expectation. Assuming the standard model
value of \beta_s, we also determine \Delta\Gamma_s = 0.068 +- 0.026 (stat) +-
0.009 (syst) ps-1 and the mean B0_s lifetime, \tau_s = 1.528 +- 0.019 (stat) +-
0.009 (syst) ps, which are consistent and competitive with determinations by
other experiments.Comment: 8 pages, 2 figures, Phys. Rev. Lett 109, 171802 (2012
Precise measurement of the W-boson mass with the CDF II detector
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- Velev G.
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- Vila I.
- Vilar R.
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- Vinogradov A
- Virto AL
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- Vorobyev A
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- Wagner R. L.
- Wakisaka T.
- Wallny R.
- Wallny R.
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- Wang S. M.
- Warburton A.
- Warburton A.
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- Waters D.
- Weinberger M.
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- Wester W. C. III
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- Whiteson D.
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- Wick F.
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- Wicklund A. B.
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- Wicklund E.
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- Wilbur S.
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- Williams H. H.
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- Wilson J. S.
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- Wilson P.
- Winer B. L.
- Winer B. L.
- Wittich P.
- Wittich P.
- Wohri HK
- Wolbers S.
- Wolbers S.
- Wolfe H.
- Wolfe H.
- Wright T.
- Wright T.
- Wrochna G
- Wu X.
- Wu X.
- Wu Z.
- Wu Z.
- Yamamoto K.
- Yamamoto K.
- Yamaoka J.
- Yamato D.
- Yang T.
- Yang T.
- Yang U. K.
- Yang U. K.
- Yang Y. C.
- Yang Y. C.
- Yao W. -M.
- Yao W. -M.
- Yeh G. P.
- Yeh G. P.
- Yi K.
- Yi K.
- Yoh J.
- Yoh J.
- Yorita K.
- Yorita K.
- Yoshida T.
- Yoshida T.
- Yu G. B.
- Yu G. B.
- Yu I
- Yu I.
- Yu I.
- Yu S. S.
- Yu S. S.
- Yun J. C.
- Yun J. C.
- Zalewski R
- Zanetti A.
- Zanetti A.
- Zarubin A
- Zeng Y.
- Zeng Y.
- Zhokin A
- Zhou C.
- Zucchelli S..
- Zucchelli S..ng S
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
We have measured the W-boson mass MW using data corresponding to 2.2/fb of
integrated luminosity collected in proton-antiproton collisions at 1.96 TeV
with the CDF II detector at the Fermilab Tevatron collider. Samples consisting
of 470126 W->enu candidates and 624708 W->munu candidates yield the measurement
MW = 80387 +- 12 (stat) +- 15 (syst) = 80387 +- 19 MeV. This is the most
precise measurement of the W-boson mass to date and significantly exceeds the
precision of all previous measurements combined
Search for the neutral Higgs bosons of the minimal supersymmetric standard model in pp collisions at root s=7 TeV with the ATLAS detector
- Author
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- Abajyan T
- Abbott B
- Abdallah J
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- Publication venue
- Publication date
- 01/02/2013
- Field of study
A search for neutral Higgs bosons of the Minimal Supersymmetric Standard Model (MSSM) is reported. The analysis is based on a sample of proton-proton collisions at a centre-of-mass energy of 7TeV recorded with the ATLAS detector at the Large Hadron Collider. The data were recorded in 2011 and correspond to an integrated luminosity of 4.7 fb-1 to 4.8 fb-1. Higgs boson decays into oppositely-charged muon or Ď lepton pairs are considered for final states requiring either the presence or absence of b-jets. No statistically significant excess over the expected background is observed and exclusion limits at the 95% confidence level are derived. The exclusion limits are for the production cross-section of a generic neutral Higgs boson, Ď, as a function of the Higgs boson mass and for h/A/H production in the MSSM as a function of the parameters mA and tan β in the mhmax scenario for mA in the range of 90GeV to 500 GeV. Copyright CERN
Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV
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- Yilmaz M
- Yoosootiniya R
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- Zajacova Z
- Zalite YK
- Zanello L
- Zarzhitsky P
- Zaytsev A
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- Zeller M
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- Zenin O
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- Zenz S
- Zerwas D
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- Zhemchugov A
- Zheng S
- Zhong J
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- Zhuravlov V
- Zieminska D
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- Zolnierowski Y
- Zsenei A
- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2013
- Field of study
The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of âs = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pTâĽ20 GeV and pseudorapidities {pipe}Ρ{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}Ρ{pipe}<0. 8) for jets with 60â¤pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2â¤{pipe}Ρ{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. Š 2013 CERN for the benefit of the ATLAS collaboration
Measurement of the inclusive and dijet cross-sections of b-jets in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector
- Author
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- Zhemchugov A
- Zheng S
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- Zhuravlov V
- Zieminska D
- Zilka B
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- Zolnierowski Y
- Zsenei A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/12/2010
- Field of study
The inclusive and dijet production cross-sections have been measured for jets
containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass
energy of sqrt(s) = 7 TeV, using the ATLAS detector at the LHC. The
measurements use data corresponding to an integrated luminosity of 34 pb^-1.
The b-jets are identified using either a lifetime-based method, where secondary
decay vertices of b-hadrons in jets are reconstructed using information from
the tracking detectors, or a muon-based method where the presence of a muon is
used to identify semileptonic decays of b-hadrons inside jets. The inclusive
b-jet cross-section is measured as a function of transverse momentum in the
range 20 < pT < 400 GeV and rapidity in the range |y| < 2.1. The bbbar-dijet
cross-section is measured as a function of the dijet invariant mass in the
range 110 < m_jj < 760 GeV, the azimuthal angle difference between the two jets
and the angular variable chi in two dijet mass regions. The results are
compared with next-to-leading-order QCD predictions. Good agreement is observed
between the measured cross-sections and the predictions obtained using POWHEG +
Pythia. MC@NLO + Herwig shows good agreement with the measured bbbar-dijet
cross-section. However, it does not reproduce the measured inclusive
cross-section well, particularly for central b-jets with large transverse
momenta.Comment: 10 pages plus author list (21 pages total), 8 figures, 1 table, final
version published in European Physical Journal
X-ray emission from the Sombrero galaxy: discrete sources
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Acosta D
- Acosta JG
- Acosta MV
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adzic P
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Aguilo E
- Ahmad M
- Ahmad WH
- Ahmed I
- Ahuja S
- Akchurin N
- Akgun B
- Akgun U
- Akin IV
- Alagoz E
- Albajar C
- Albayrak EA
- Albergo S
- Albrow M
- Alexander J
- Aliev T
- Allfrey P
- Almeida N
- Alver B
- Alverson G
- Alves GA
- Amapane N
- Amsler C
- Anagnostou G
- Anastassov A
- Anderson J
- Anderson M
- Andrea J
- Andreev V
- Andreev V
- Andreev Y
- Andrews W
- Anghel IM
- Antonelli L
- Antunes JR
- Antunovic Z
- Apanasevich L
- Apollinari G
- Appelt E
- Aranyi A
- Arce P
- Arcidiacono R
- Arenton MW
- Arfaei H
- Argiro S
- Arisaka K
- Arneodo M
- Asaadi J
- Asghar MI
- Askew A
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- Avetisyan A
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- Azhgirey I
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- Baarmand MM
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- Baesso P
- Baffioni S
- Bagliesi G
- Bai Y
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- Bakirci MN
- Bakken JA
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- Zaganidis N
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- Zalewski P
- Zanetti M
- Zang J
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- Ziebarth EB
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2010
- Field of study
We present a study of discrete X-ray sources in and around the
bulge-dominated, massive Sa galaxy, Sombrero (M104), based on new and archival
Chandra observations with a total exposure of ~200 ks. With a detection limit
of L_X = 1E37 erg/s and a field of view covering a galactocentric radius of ~30
kpc (11.5 arcminute), 383 sources are detected. Cross-correlation with Spitler
et al.'s catalogue of Sombrero globular clusters (GCs) identified from HST/ACS
observations reveals 41 X-rays sources in GCs, presumably low-mass X-ray
binaries (LMXBs). We quantify the differential luminosity functions (LFs) for
both the detected GC and field LMXBs, whose power-low indices (~1.1 for the
GC-LF and ~1.6 for field-LF) are consistent with previous studies for
elliptical galaxies. With precise sky positions of the GCs without a detected
X-ray source, we further quantify, through a fluctuation analysis, the GC LF at
fainter luminosities down to 1E35 erg/s. The derived index rules out a
faint-end slope flatter than 1.1 at a 2 sigma significance, contrary to recent
findings in several elliptical galaxies and the bulge of M31. On the other
hand, the 2-6 keV unresolved emission places a tight constraint on the field
LF, implying a flattened index of ~1.0 below 1E37 erg/s. We also detect 101
sources in the halo of Sombrero. The presence of these sources cannot be
interpreted as galactic LMXBs whose spatial distribution empirically follows
the starlight. Their number is also higher than the expected number of cosmic
AGNs (52+/-11 [1 sigma]) whose surface density is constrained by deep X-ray
surveys. We suggest that either the cosmic X-ray background is unusually high
in the direction of Sombrero, or a distinct population of X-ray sources is
present in the halo of Sombrero.Comment: 11 figures, 5 tables, ApJ in pres
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