The organisation of technology and the technology of organisation: the Vehicle Mounted Data System and the provision of UK fire services

Social and organisation theorists have become increasingly interested in studying information and communication technologies over the last two decades. This thesis examines how information and communication technologies are organised, and what is organised by information and communication technologies. The thesis contributes to the interest in detailed studies of information and communication technology through an analysis of the implementation and deployment of a mobile data system-the Vehicle Mounted Data System (VMDS)-by firefighters, fire crews and officers at a United Kingdom fire brigade. This thesis examines what becomes of the Vehicle Mounted Data System when it is introduced into a UK fire brigade. This includes an exposition of how recurring issues including the boundaries of the brigade, what is meant by standardisation and risk, what counts as information, and what is understood by devolved incident management is reordered as the VMDS becomes a constitutive part of the problematic fire service provision. The VMDS is bound up with reality constituting effects and this means that what is meant by technology and organisation becomes an important topic of scholarly study. This thesis develops a non-essentialist ontology of technology and organisation-an ontological turn in organisation theory. It is argued that the VMDS is a relational effect that is aligned with existing boundaries and assumptions at Hereford and Worcester Fire Brigade, that the VMDS is a multiple object that is a mutable mobile and is deployed not only to manage safety at incidents but also for managing performance and organisational flexibility, and that the instabilities of the VMDS are responded to ambivalently by various actors as they are enrolled in the collective upkeep of the VMDS. In analysing the Vehicle Mounted Data System a range of analytical resources are drawn upon, including, most significantly, actor-network theory, but also the writings of Deleuze and Guattari. The thesis concludes with a discussion of the politics of theory and suggests that researchers would remain faithful to their intellectual tradition and a sense of critical and creative purpose if they engaged with and helped to construct the heterogeneous ways in which technological devices such as the Vehicle Mounted Data System transform what organisation theorists understand by organisation

Extractivism, Value and Waste:Organizational Mining of e-Waste in the United Kingdom

In this paper we critically evaluate the mining and extraction of e-waste – electronic waste – and the relationship with the emerging cleaner and greener economy. Drawing on ethnographic data, gathered from an e-waste management organization – e-WasteOrg, we show how e-waste and value are assembled, extracted and circulated within local, national and global contexts. To date little attention has been paid to interdependent systems of waste and value. We argue that e-WasteOrg operates polyphonically in order to secure, routinize and circulate the ongoing disposal of e-waste. Extracting waste becomes associated with a range of differentiated value systems, as sourcing and valuing waste is a continual concern for those in the waste management sector. As more waste is sought, we conclude that a cleaner and greener economy is both constricting in terms of new market entrants and expanding as waste management actors mine for materials across value systems. Keywords: e-waste, extractivism, mining, value, waste, green economy, circular econom

E-Waste Trading Zones and the Economy of Greening:Imbricating Computer Sourcing in the Pre- and Post-WEEE Directive Era

In the context of the environmental impacts caused due to the increasing volumes of discarded technologies (e-Waste), this article critically evaluates whether environmental policy, the Waste of Electronic and Electrical Equipment (WEEE) legislation in particular, can contribute to a shift in logic from neo-liberal growth to green growth. Drawing upon empirical research we show how three computer waste organisations evolve through the imbrication of pre- and post- policy logics in collaborative and heterogeneous ways to create an economy of greening. Extending the concept of a fractionated trading zone, we demonstrate the heterogeneous ways in which computer sourcing is imbricated, providing a taxonomy of imbricating logics. We argue that what is shared in a fractionated trading zone is a diversity of imbrications. This provides for a nuanced perspective on policy and the management of waste, showing how post-WEEE logics become the condition to continue to pursue pre-WEEE logics. Our research focuses on three organisations and the EU 2003 and UK 2006 versions of the WEEE legislation. We conclude that our research findings have important implications, more specifically, for how e-waste policy is enacted as an economy of greening in order to constitute the managerial and organisational adaptation needed to create a sustainable economy and society. Our paper's contribution is threefold. First, theoretically, we extend the literature on trading zones and imbrication by considering how they can complement one another. Our focus on imbrication is a ‘zooming in’ on the managerial and organisational implications and dynamics of a trading zone. Second, we add to the literature on imbrication by identifying a diverse range of imbricating logics that can be used to discern a more nuanced understanding of the translated effects of policy. Last, we ground these ideas in a relevant empirical context – that of e-waste management in the UK, providing a deeper knowledge, over time, of specific actors’ translations of policy into organisational practices

Methylmercury degradation and exposure pathways in streams and wetlands impacted by historical mining

The authors acknowledge financial support from the National Science Foundation: EAR-1226741 (to M.B.S.) and EAR-1225630 (to J.D.B.).Monomethyl mercury (MMHg) and total mercury (THg) concentrations and Hg stable isotope ratios (δ202Hg and Δ199Hg) were measured in sediment and aquatic organisms from Cache Creek (California Coast Range) and Yolo Bypass (Sacramento Valley). Cache Creek sediment had a large range in THg (87 to 3870 ng/g) and δ202Hg (− 1.69 to − 0.20‰) reflecting the heterogeneity of Hg mining sources in sediment. The δ202Hg of Yolo Bypass wetland sediment suggests a mixture of high and low THg sediment sources. Relationships between %MMHg (the percent ratio of MMHg to THg) and Hg isotope values (δ202Hg and Δ199Hg) in fish and macroinvertebrates were used to identify and estimate the isotopic composition of MMHg. Deviation from linear relationships was found between %MMHg and Hg isotope values, which is indicative of the bioaccumulation of isotopically distinct pools of MMHg. The isotopic composition of pre-photodegraded MMHg (i.e., subtracting fractionation from photochemical reactions) was estimated and contrasting relationships were observed between the estimated δ202Hg of pre-photodegraded MMHg and sediment IHg. Cache Creek had mass dependent fractionation (MDF; δ202Hg) of at least − 0.4‰ whereas Yolo Bypass had MDF of + 0.2 to + 0.5‰. This result supports the hypothesis that Hg isotope fractionation between IHg and MMHg observed in rivers (− MDF) is unique compared to + MDF observed in non-flowing water environments such as wetlands, lakes, and the coastal ocean.PostprintPeer reviewe

Neuromatch Academy: a 3-week, online summer school in computational neuroscience

Neuromatch Academy (https://academy.neuromatch.io; (van Viegen et al., 2021)) was designed as an online summer school to cover the basics of computational neuroscience in three weeks. The materials cover dominant and emerging computational neuroscience tools, how they complement one another, and specifically focus on how they can help us to better understand how the brain functions. An original component of the materials is its focus on modeling choices, i.e. how do we choose the right approach, how do we build models, and how can we evaluate models to determine if they provide real (meaningful) insight. This meta-modeling component of the instructional materials asks what questions can be answered by different techniques, and how to apply them meaningfully to get insight about brain function

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

SummaryBackground Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatoryactions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19.Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospitalwith COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients wererandomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once perday by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatmentgroups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment andwere twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants andlocal study staff were not masked to the allocated treatment, but all others involved in the trial were masked to theoutcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treatpopulation. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936.Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) wereeligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomlyallocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall,561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days(rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days(rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, nosignificant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilationor death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24).Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or otherprespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restrictedto patients in whom there is a clear antimicrobial indication

Thigh-length compression stockings and DVT after stroke

Controversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease