New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone-Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation

WOS:000306840400020Peer reviewe

Mobile video communications in wireless environments

Abstract- A novel system providing e ective and e cient access to video archives for mobile users communicating over low bandwidth error-prone wireless links is proposed. The developed system has three components: First, the middleware, implemented as mobile proxy server located at the mobile support station, is chosen for the seamless integration of both mobile users and video servers by hiding the speci c details of the underlying system. Second, for e cient video transmission, our three-dimensional signi cant-linked connected component analysis video codec well suited for wireless environments, is used. Finally, multilayer transmission error control mechanism is applied to cope with channel errors. As a result, no additional requirements are imposed on the mobile client and video server so that mobile users interact with the server in exactly the same way as stationary users, and all they experience are better picture quality, less jerky video, and shorter delays

Efficient Mobile Video Access in Wireless Environments

A novel middleware-based system providing effective and efficient video access for mobile users communicating over low bandwidth error-prone wireless links is proposed. The middleware, implemented as mobile proxy server located at the mobile support station, is chosen for the seamless integration of mobile users and video servers by hiding the specific details of the underlying system. For efficient video transmission, our threedimensional significant-linked connected component analysis video codec well suited for wireless environments, is used. To cope with wireless transmission errors, we propose multilayer error control mechanism, which incorporates synchronization, unequal forward error protection, and retransmission. As a result, mobile users experience better picture quality, less jerky video, and shorter delays when accessing video files. I. Introduction Recent technological developments have led to several mobile systems aimed at personal communications services, which suppor..

Efficient Mobile Video Access in Wireless Environments

A novel middleware-based system providing effective and efficient video access for mobile users com-municating over low bandwidth error-prone wireless links is proposed. The middleware, implemented as mobile proxy server located at the mobile support station, is chosen for the seamless integration of mobile users and video servers by hiding the specific details of the under-lying system. For efficient video transmission, our three-dimensional significant-linked connected component analysis video codec well suited for wireless environments, is used. To cope with wireless transmission errors, we propose multilayer error control mechanism, which incorporates synchronization, unequal forward error protection, and retransmission. As a result, mobile users experience better picture quality, less jerky video, and shorter delays when accessing video files

Host Mobility Using an Internet Indirection Infrastructure

We propose the Robust Overlay Architecture for Mobility (ROAM) to provide seamless mobility for Internet hosts. ROAM is built on top of the Internet Indirection Infrastructure (i3). With i3, instead of explicitly sending a packet to a destination, each packet is associated with an identifier. This identifier defines an indirection point in i3, and is used by the receiver to obtain the packet. ROAM takes . .