A Worldwide Perspective on Viticultural Zoning

This article reviews viticultural zoning concerns and issues, from a worldwide perspective. The needs of the everexpanding international wine market, and thus zoning objectives, have seen significant changes in recent years.  Consequently, more countries and individual wine-producing regions have been involved in zoning studies.  Although many of these studies were initiated in Europe, zoning needs reach far beyond the countries endowed with centuries-old viticultural history. The demarcation of registered designations of origin or protected geographical indications is one of the most obvious zoning aims. Viticultural zoning originated in the XIXth century in Europe, but is now widely applied in even the most recent emerging wine-growing countries of the New World. Other important zoning aims, not necessarily related to demarcating operations, often involve segmenting a vineyard territory into homogeneous units for pest management, land division, vineyard-restructuring operations, harvestquality management or site selection for new vineyards. The homogeneous units obtained through viticultural zoning are frequently referred to as ‘terroirs’. However, their spatial scale and the qualitative and quantitative methods of analysis may vary greatly, depending on the individual authors and the characteristics of the vinegrowing region, and consequently it is difficult to make international comparisons. Viticultural zoning studies can be divided broadly into two main approaches: the first approach is based largely on the geographic differentiation of wine, grape, or grapevine characteristics, while the second approach focuses on the geographical differentiation of land capability or vineyard suitability studies in which soil and climate are normally the key environmental variables used with varying degrees of importance. Although viticultural zoning is not always synonymous with mapping and spatial analysis, this practice is changing due to the enhanced use of geomatics. For example, digital mapping methods and remote sensing techniques have revolutionized viticultural zoning on all levels, ranging from the single plot to the regional level. On the field or local scale, the suitability approaches may include precision viticulture, which is mostly directed towards an understanding of grapevine ecophysiological functioning. On the regional or global scale, suitability approaches may be oriented towards the characterisation of broad geographical patterns of land use. The challenge with the different approaches is to compare the results derived at the regional level with those of the sample sites on the local scale. This paper provides some examples of the various approaches that are likely to enable zoning comparisons at the various spatial scales, including the international level

Cloud microphysical effects of turbulent mixing and entrainment

Turbulent mixing and entrainment at the boundary of a cloud is studied by means of direct numerical simulations that couple the Eulerian description of the turbulent velocity and water vapor fields with a Lagrangian ensemble of cloud water droplets that can grow and shrink by condensation and evaporation, respectively. The focus is on detailed analysis of the relaxation process of the droplet ensemble during the entrainment of subsaturated air, in particular the dependence on turbulence time scales, droplet number density, initial droplet radius and particle inertia. We find that the droplet evolution during the entrainment process is captured best by a phase relaxation time that is based on the droplet number density with respect to the entire simulation domain and the initial droplet radius. Even under conditions favoring homogeneous mixing, the probability density function of supersaturation at droplet locations exhibits initially strong negative skewness, consistent with droplets near the cloud boundary being suddenly mixed into clear air, but rapidly approaches a narrower, symmetric shape. The droplet size distribution, which is initialized as perfectly monodisperse, broadens and also becomes somewhat negatively skewed. Particle inertia and gravitational settling lead to a more rapid initial evaporation, but ultimately only to slight depletion of both tails of the droplet size distribution. The Reynolds number dependence of the mixing process remained weak over the parameter range studied, most probably due to the fact that the inhomogeneous mixing regime could not be fully accessed when phase relaxation times based on global number density are considered.Comment: 17 pages, 10 Postscript figures (figures 3,4,6,7,8 and 10 are in reduced quality), to appear in Theoretical Computational Fluid Dynamic

Short- and long-term outcomes of intensive care patients with acute kidney disease

Background: Acute kidney disease (AKD) is a proposed definition for acute kidney injury (AKI) lasting 7 days or longer. Little has been reported regarding characteristics of patients with AKD and their short- and long-term outcomes. We describe the epidemiology and risk factors for AKD and outcomes following AKD. Methods: This retrospective observational cohort study identified patients aged 16 or older admitted to the Glasgow Royal Infirmary and Queen Elizabeth University Hospital intensive care units (ICUs) in Scotland between 1st July 2015 and 30th June 2018. Baseline serum creatinine and subsequent values were used to identify patients with de-novo kidney injury (DNKI). Patients with recovery prior to day 7 were classified as AKI; recovery at day 7 or beyond was classified as AKD. Outcomes were in-hospital and long-term mortality, and proportion of major adverse kidney events (MAKEs). Multivariable logistic regression was used to identify risk factors for AKD. A Cox proportional hazards model was used to identify factors associated with long-term outcomes. Findings: Of the 5,334 patients admitted to ICU who were assessed for DNKI, 1,620 (30·4%) suffered DNKI and of these, 403 (24·9%) met AKD criteria; 984 (60·7%) were male and the median age was 60·0 (IQR=48·0–72·0). Male sex, sepsis and lower baseline estimated glomerular filtration rate (eGFR) were associated with development of AKD. In-ICU (16·1%vs6·2%) and in-hospital (26·1%vs11·6%) mortality rates were significantly higher in AKD patients than AKI patients. Long-term survival was not different for AKD patients (HR=1·16; p-value=0·261) but AKD was associated with subsequent MAKEs (OR=1·25). Interpretation: One in four ICU patients with DNKI met AKD criteria. These patients had an increased risk of short-term mortality and long-term MAKEs. Whilst the trend for long-term survival was lower, this was not significantly different from shorter-term AKI patients. Patients with AKD during their ICU stay should be identified to initiate interventions to reduce risk of future MAKEs. Funding: No funding was associated with this study

The clustering instability of inertial particles spatial distribution in turbulent flows

A theory of clustering of inertial particles advected by a turbulent velocity field caused by an instability of their spatial distribution is suggested. The reason for the clustering instability is a combined effect of the particles inertia and a finite correlation time of the velocity field. The crucial parameter for the clustering instability is a size of the particles. The critical size is estimated for a strong clustering (with a finite fraction of particles in clusters) associated with the growth of the mean absolute value of the particles number density and for a weak clustering associated with the growth of the second and higher moments. A new concept of compressibility of the turbulent diffusion tensor caused by a finite correlation time of an incompressible velocity field is introduced. In this model of the velocity field, the field of Lagrangian trajectories is not divergence-free. A mechanism of saturation of the clustering instability associated with the particles collisions in the clusters is suggested. Applications of the analyzed effects to the dynamics of droplets in the turbulent atmosphere are discussed. An estimated nonlinear level of the saturation of the droplets number density in clouds exceeds by the orders of magnitude their mean number density. The critical size of cloud droplets required for clusters formation is more than $20 \mu$m.Comment: REVTeX 4, 15 pages, 2 figures(included), PRE submitte

Lymphocytic choriomeningitis arenavirus requires cellular COPI and AP-4 complexes for efficient virion production

Lymphocytic choriomeningitis virus (LCMV) is a bisegmented negative-sense RNA virus classified within the Arenaviridae family of the Bunyavirales order. LCMV is associated with fatal disease in immunocompromized populations, and as the prototypical arenavirus, acts as a model for the many serious human pathogens within this group. Here, we examined the dependence of LCMV multiplication on cellular trafficking components using a recombinant LCMV expressing enhanced green fluorescent protein in conjunction with a curated siRNA library. The screen revealed a requirement for subunits of both the coat protein 1 (COPI) coatomer and adapter protein 4 (AP-4) complexes. By rescuing a recombinant LCMV harboring a FLAG-tagged glycoprotein (GP-1) envelope spike (rLCMV-GP1-FLAG), we showed infection resulted in marked co-localization of individual COPI and AP-4 components with both LCMV nucleoprotein (NP) and GP-1, consistent with their involvement in viral processes. To further investigate the role of both COPI and AP-4 complexes during LCMV infection, we utilized the ARF-I inhibitor brefeldin A (BFA) that prevents complex formation. Within a single 12-h cycle of virus multiplication, BFA pre-treatment caused no significant change in LCMV-specific RNA synthesis, alongside no significant change in LCMV NP expression, as measured by BFA time-of-addition experiments. In contrast, BFA addition resulted in a significant drop in released virus titers, approaching 50-fold over the same 12-h period, rising to over 600-fold over 24 h. Taken together, these findings suggest COPI and AP-4 complexes are important host cell factors required for the formation and release of infectious LCMV

Treatment outcomes of patients with atopic dermatitis (AD) treated with dupilumab through the early access to medicines scheme (EAMS) in the UK

BACKGROUND Dupilumab, a monoclonal antibody against interleukin (IL)-4 receptor alpha that inhibits IL-4/IL-13 signalling is indicated in dermatology for the treatment of moderate-to-severe atopic dermatitis (AD) in adult and adolescent patients 12 years and older and severe AD in children 6-11 years, who are candidates for systemic therapy. Dupilumab received Early Access to Medicines Scheme (EAMS) approval for adults in March 2017. OBJECTIVES The purpose of this study was to assess the efficacy outcomes of treatment with dupilumab in EAMS. METHODS A retrospective analysis of adult patients enrolled in the dupilumab EAMS in the UK. Scores were assessed at baseline and follow up, including the Eczema Area and Severity Index (EASI), Investigator’s Global Assessment Score (IGA) and Dermatology Life Quality Index (DLQI). RESULTS Data were available for 57 adult patients treated with dupilumab for at least 12 weeks; 73.6% of patients had received prior treatment with 3 or 4 immunosuppressants. Baseline scores for the EASI and DLQI were 27.93 (standard deviation, SD 13.09) and 18.26 (SD 6.18) respectively. AD severity scores showed statistically significant improvement at week 16+4 weeks (p <0.001 for all). The mean change in EASI was 14.13 points with 66.7% and 36.7% achieving a 50% (EASI-50) and 75% (EASI-75) improvement in EASI, respectively at 16+/- 4 weeks. IGA scores improved by at least two categories for 75% patients. DLQI scores decreased by a mean of 9.0 points, with 80% patients demonstrating a MCID 4-point improvement. For 85% patients, clinicians rated the treatment response as being either ‘better’ (19%) or ‘much better’ (65%). CONCLUSIONS Dupilumab is associated with a significant and clinically relevant improvements in AD as measured by patient- and physician-reported outcome measures. Importantly, the clinical efficacy, despite the refractory disease of this EAMS cohort, is comparable to that previously reported in clinical trials

Search for Doubly-Charged Higgs Boson Production at HERA

A search for the single production of doubly-charged Higgs bosons H^{\pm \pm} in ep collisions is presented. The signal is searched for via the Higgs decays into a high mass pair of same charge leptons, one of them being an electron. The analysis uses up to 118 pb^{-1} of ep data collected by the H1 experiment at HERA. No evidence for doubly-charged Higgs production is observed and mass dependent upper limits are derived on the Yukawa couplings h_{el} of the Higgs boson to an electron-lepton pair. Assuming that the doubly-charged Higgs only decays into an electron and a muon via a coupling of electromagnetic strength h_{e \mu} = \sqrt{4 \pi \alpha_{em}} = 0.3, a lower limit of 141 GeV on the H^{\pm\pm} mass is obtained at the 95% confidence level. For a doubly-charged Higgs decaying only into an electron and a tau and a coupling h_{e\tau} = 0.3, masses below 112 GeV are ruled out.Comment: 15 pages, 3 figures, 1 tabl

Modeling Translation in Protein Synthesis with TASEP: A Tutorial and Recent Developments

The phenomenon of protein synthesis has been modeled in terms of totally asymmetric simple exclusion processes (TASEP) since 1968. In this article, we provide a tutorial of the biological and mathematical aspects of this approach. We also summarize several new results, concerned with limited resources in the cell and simple estimates for the current (protein production rate) of a TASEP with inhomogeneous hopping rates, reflecting the characteristics of real genes.Comment: 25 pages, 7 figure

Measurement of the Bottom-Strange Meson Mixing Phase in the Full CDF Data Set

We report a measurement of the bottom-strange meson mixing phase \beta_s using the time evolution of B0_s -> J/\psi (->\mu+\mu-) \phi (-> K+ K-) decays in which the quark-flavor content of the bottom-strange meson is identified at production. This measurement uses the full data set of proton-antiproton collisions at sqrt(s)= 1.96 TeV collected by the Collider Detector experiment at the Fermilab Tevatron, corresponding to 9.6 fb-1 of integrated luminosity. We report confidence regions in the two-dimensional space of \beta_s and the B0_s decay-width difference \Delta\Gamma_s, and measure \beta_s in [-\pi/2, -1.51] U [-0.06, 0.30] U [1.26, \pi/2] at the 68% confidence level, in agreement with the standard model expectation. Assuming the standard model value of \beta_s, we also determine \Delta\Gamma_s = 0.068 +- 0.026 (stat) +- 0.009 (syst) ps-1 and the mean B0_s lifetime, \tau_s = 1.528 +- 0.019 (stat) +- 0.009 (syst) ps, which are consistent and competitive with determinations by other experiments.Comment: 8 pages, 2 figures, Phys. Rev. Lett 109, 171802 (2012

Search for displaced vertices arising from decays of new heavy particles in 7 TeV pp collisions at ATLAS

We present the results of a search for new, heavy particles that decay at a significant distance from their production point into a final state containing charged hadrons in association with a high-momentum muon. The search is conducted in a pp-collision data sample with a center-of-mass energy of 7 TeV and an integrated luminosity of 33 pb^-1 collected in 2010 by the ATLAS detector operating at the Large Hadron Collider. Production of such particles is expected in various scenarios of physics beyond the standard model. We observe no signal and place limits on the production cross-section of supersymmetric particles in an R-parity-violating scenario as a function of the neutralino lifetime. Limits are presented for different squark and neutralino masses, enabling extension of the limits to a variety of other models.Comment: 8 pages plus author list (20 pages total), 8 figures, 1 table, final version to appear in Physics Letters