De werkwereld van ontwikkelcoaches:een pluralistische casusstudie

The case study aims to systematically describe the work world of a specific group of professionals – from the perspective of the professionals themselves – who are offering ambulatory counselling to clients with autism spectrum disorders at the intersection of the domains of (youth)care, mental (youth)care and welfare and who take a pioneering role because they practice their profession based on an inclusive interpretation of the ideal of participation and integration, and use a matching idiographic-relational counselling method. The research question is:How do professionals who meet the characteristics mentioned in the objective describe their work world?A pluralistic form of research has been conducted. The Grounded Theory was the leading approach. The narrative and discursive psychology have been used as frameworks to find additional, enriching labels and categories. 15 professionals are interviewed. The results confirms that reflection on solutions for the tension fields experienced at the intersection of the three domains requires a focus on the complex and dynamic nature of social reality, social policy and (social) professions, including the consequences this entails for the professional practice of (social) professionals, the scope for development of their clients and the achievement of the ideal of participation and integration. In addition, the importance of reflecting on and making explicit ideological reference frameworks becomes evident, certainly with a view to resolving and/or adopting an alternative approach to the areas of tension experienced. At an operational level, the outline can contribute to the evaluation and reflection of (social) professionals on their professional practice. At a policy level, it can contribute to thinking, knowledge-sharing and policy development with regard to the professional practice of (social) professionals.<br/

Restraining of glycoprotein VI- and integrin α2β1-dependent thrombus formation y platelet PECAM1

The platelet receptors, glycoprotein VI (GPVI) and integrin α2β1 jointly control collagen-dependent thrombus formation via protein tyrosine kinases. It is unresolved to which extent the ITIM (immunoreceptor tyrosine-based inhibitory motif) receptor PECAM1 and its downstream acting protein tyrosine phosphatase PTPN11 interfere in this process. Here, we hypothesized that integrin α2β1 has a co-regulatory role in the PECAM1- and PTPN11-dependent restraint of thrombus formation. We investigated platelet activation under flow on collagens with a different GPVI dependency and using integrin α2β1 blockage. Blood was obtained from healthy subjects and from patients with Noonan syndrome with a gain-of-function mutation of PTPN11 and variable bleeding phenotype. On collagens with decreasing GPVI activity (types I, III, IV), the surface-dependent inhibition of PECAM1 did not alter thrombus parameters using control blood. Blockage of α2β1 generally reduced thrombus parameters, most effectively on collagen IV. Strikingly, simultaneous inhibition of PECAM1 and α2β1 led to a restoration of thrombus formation, indicating that the suppressing signaling effect of PECAM1 is masked by the platelet-adhesive receptor α2β1. Blood from 4 out of 6 Noonan patients showed subnormal thrombus formation on collagen IV. In these patients, effects of α2β1 blockage were counterbalanced by PECAM1 inhibition to a normal phenotype. In summary, we conclude that the suppression of GPVI-dependent thrombus formation by either PECAM1 or a gain-of-function of PTPN11 can be overruled by α2β1 engagement

The role of tunneling in enzyme catalysis of C–H activation

AbstractRecent data from studies of enzyme catalyzed hydrogen transfer reactions implicate a new theoretical context in which to understand C–H activation. This is much closer to the Marcus theory of electron transfer, in that environmental factors influence the probability of effective wave function overlap from donor to acceptor atoms. The larger size of hydrogen and the availability of three isotopes (H, D and T) introduce a dimension to the kinetic analysis that is not available for electron transfer. This concerns the role of gating between donor and acceptor atoms, in particular whether the system in question is able to tune distance between reactants to achieve maximal tunneling efficiency. Analysis of enzyme systems is providing increasing evidence of a role for active site residues in optimizing the inter-nuclear distance for nuclear tunneling. The ease with which this optimization can be perturbed, through site-specific mutagenesis or an alteration in reaction conditions, is also readily apparent from an analysis of the changes in the temperature dependence of hydrogen isotope effects

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

Replication Data for: De werkwereld van ontwikkelcoaches: Een pluralistische casusstudie

De doelstelling van de studie is het, vanuit het perspectief van sociale professionals zelf, systematisch beschrijven van de werkwereld van sociale professionals die hun sociale professie uitoefenen uitgaande van een inclusieve invulling van het participatie-ideaal en hierbij een idiografisch-relationeel georiënteerde begeleidingsvorm hanteren. De bijbehorende vraagstelling is: Hoe beschrijven sociale professionals die hun sociale professie uitoefenen uitgaande van een inclusieve invulling van het participatie- en integratie-ideaal en een bijpassende idiografisch-relationeel georiënteerde begeleidingsvorm hanteren hun werkwereld

Perspectives on collaboration and learning in primary schools: scaffolding as a means to enhance collaborative learning: the role of feedback revisited

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Leerwinst opgevat als het resultaat van effectieve interactiepatronen tijdens de oefenfase van een leertest

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