Three Dimensional Polarimetric Neutron Tomography of Magnetic Fields

Through the use of Time-of-Flight Three Dimensional Polarimetric Neutron Tomography (ToF 3DPNT) we have for the first time successfully demonstrated a technique capable of measuring and reconstructing three dimensional magnetic field strengths and directions unobtrusively and non-destructively with the potential to probe the interior of bulk samples which is not amenable otherwise. Using a pioneering polarimetric set-up for ToF neutron instrumentation in combination with a newly developed tailored reconstruction algorithm, the magnetic field generated by a current carrying solenoid has been measured and reconstructed, thereby providing the proof-of-principle of a technique able to reveal hitherto unobtainable information on the magnetic fields in the bulk of materials and devices, due to a high degree of penetration into many materials, including metals, and the sensitivity of neutron polarisation to magnetic fields. The technique puts the potential of the ToF time structure of pulsed neutron sources to full use in order to optimise the recorded information quality and reduce measurement time.Comment: 12 pages, 4 figure

Political connections and corporate financial decision making

This paper investigates whether and how political connections influence managerial financial decisions. Our study reveals that those firms that have a politician on its board of directors are highly leveraged, use more long-term debt, hold large excess cash and are associated with low quality financial reporting compared to their non-connected counterparts. These effects escalate with the strength of the connected politician and whether he or his party is in power. The winning party effect is observed to be stronger than victory by the politician himself. Overall, our paper provides strong evidence that political connection is a two-edged sword. It is indeed a valuable resource for connected firms, but it comes at a cost of higher agency problems

Astrocytes: orchestrating synaptic plasticity?

Synaptic plasticity is the capacity of a preexisting connection between two neurons to change in strength as a function of neural activity. Because synaptic plasticity is the major candidate mechanism for learning and memory, the elucidation of its constituting mechanisms is of crucial importance in many aspects of normal and pathological brain function. In particular, a prominent aspect that remains debated is how the plasticity mechanisms, that encompass a broad spectrum of temporal and spatial scales, come to play together in a concerted fashion. Here we review and discuss evidence that pinpoints to a possible non-neuronal, glial candidate for such orchestration: the regulation of synaptic plasticity by astrocytes.Comment: 63 pages, 4 figure

Evacetrapib and Cardiovascular Outcomes in High-Risk Vascular Disease

BACKGROUND: The cholesteryl ester transfer protein inhibitor evacetrapib substantially raises the high-density lipoprotein (HDL) cholesterol level, reduces the low-density lipoprotein (LDL) cholesterol level, and enhances cellular cholesterol efflux capacity. We sought to determine the effect of evacetrapib on major adverse cardiovascular outcomes in patients with high-risk vascular disease. METHODS: In a multicenter, randomized, double-blind, placebo-controlled phase 3 trial, we enrolled 12,092 patients who had at least one of the following conditions: an acute coronary syndrome within the previous 30 to 365 days, cerebrovascular atherosclerotic disease, peripheral vascular arterial disease, or diabetes mellitus with coronary artery disease. Patients were randomly assigned to receive either evacetrapib at a dose of 130 mg or matching placebo, administered daily, in addition to standard medical therapy. The primary efficacy end point was the first occurrence of any component of the composite of death from cardiovascular causes, myocardial infarction, stroke, coronary revascularization, or hospitalization for unstable angina. RESULTS: At 3 months, a 31.1% decrease in the mean LDL cholesterol level was observed with evacetrapib versus a 6.0% increase with placebo, and a 133.2% increase in the mean HDL cholesterol level was seen with evacetrapib versus a 1.6% increase with placebo. After 1363 of the planned 1670 primary end-point events had occurred, the data and safety monitoring board recommended that the trial be terminated early because of a lack of efficacy. After a median of 26 months of evacetrapib or placebo, a primary end-point event occurred in 12.9% of the patients in the evacetrapib group and in 12.8% of those in the placebo group (hazard ratio, 1.01; 95% confidence interval, 0.91 to 1.11; P=0.91). CONCLUSIONS: Although the cholesteryl ester transfer protein inhibitor evacetrapib had favorable effects on established lipid biomarkers, treatment with evacetrapib did not result in a lower rate of cardiovascular events than placebo among patients with high-risk vascular disease. (Funded by Eli Lilly; ACCELERATE ClinicalTrials.gov number, NCT01687998 .)

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

Tensor Tomography

Rich tomography is becoming increasingly popular since we have seen a substantial increase in computational power and storage. Instead of measuring one scalar for each ray, multiple measurements are needed per ray for various imaging modalities. This advancement has allowed the design of experiments and equipment which facilitate a broad spectrum of applications. We present new reconstruction results and methods for several imaging modalities including x-ray diffraction strain tomography, Photoelastic tomography and Polarimetric Neutron Magnetic Field Tomography (PNMFT). We begin with a survey of the Radon and x-ray transforms discussing several procedures for inversion. Furthermore we highlight the Singular Value Decomposition (SVD) of the Radon transform and consider some stability results for reconstruction in Sobolev spaces. We then move onto define the Non-Abelian Ray Transform (NART), Longitudinal Ray Transform (LRT), Transverse Ray Transform (TRT) and the Truncated Transverse Ray Transform (TTRT) where we highlight some results on the complete inversion procedure, SVD and mention stability results in Sobolev spaces. Thereafter we derive some relations between these transforms. Next we discuss the imaging modalities in mind and relate the transforms to their specific inverse problems, primarily being linear. Specifically, NART arises in the formulation of PNMFT where we want to image magnetic structures within magnetic materials with the use of polarized neutrons. After some initial numerical studies we extend the known Radon inversion presented by experimentalists, reconstructing fairly weak magnetic fields, to reconstruct PNMFT data up to phase wrapping. We can recover the strain field tomographically for a polycrystalline material using diffraction data and deduce that a certain moment of that data corresponds to the TRT. Quite naturally the whole strain tensor can be reconstructed from diffraction data measured using rotations about six axes. We develop an innovative explicit plane-by-plane filtered back-projection reconstruction algorithm for the TRT, using data from rotations about three orthogonal axes and state the reasoning why two-axis data is insufficient. For the first time we give the first published results of TRT reconstruction. To complete our discussion we present Photoelastic tomography which relates to the TTRT and implement the algorithm discussing the difficulties that arise in reconstructing data. Ultimately we return to PNMFT highlighting the nonlinear inverse problem due to phase wrapping. We propose an iterative reconstruction algorithm, namely the Modified Newton Kantarovich method (MNK) where we keep the Jacobian (Fréchet derivative) fixed at the first step. However, this is shown to fail for large angles suggesting to develop the Newton Kantarovich (NK) method where we update the Jacobian at each step of the iteration process

An explicit reconstruction algorithm for the transverse ray transform of a second rank tensor field from three axis data

We give an explicit plane-by-plane filtered back-projection reconstruction algorithm for the transverse ray transform of symmetric second rank tensor fields on Euclidean 3-space, using data from rotation about three orthogonal axes. We show that in the general case two axis data is insufficient but give an explicit reconstruction procedure for the potential case with two axis data

Polarimetric Neutron Tomography of Magnetic Fields:Uniqueness of Solution and Reconstruction

We consider the problem of determination of a magnetic field from three dimensional polarimetric neutron tomography data. We see that this is an example of a non-Abelian ray transform and that the problem has a globally unique solution for smooth magnetic fields with compact support, and a locally unique solution for less smooth fields. We derive the linearization of the problem and note that the derivative is injective. We go on to show that the linearised problem about a zero magnetic field reduces to plane Radon transforms and suggest a modified Newton Kantarovich method (MNKM) type algorithm for the numerical solution of the non-linear problem, in which the forward problem is re-solved but the same derivative used each time. Numerical experiments demonstrate that MNKM works for small enough fields (or large enough velocities) and show an example where it fails to reconstruct a slice of the simulated data set. Lastly we show viewed as an optimization problem the inverse problem is non-convex so we expect gradient based methods may fail

An explicit reconstruction algorithm for the transverse ray transform of a second rank tensor field from three axis data

We give an explicit plane-by-plane filtered back-projection reconstruction algorithm for the transverse ray transform of symmetric second rank tensor fields on Euclidean three-space, using data from rotation about three orthogonal axes. We show that in the general case two-axis data is insufficient, but we give an explicit reconstruction procedure for the potential case with two-axis data. We describe a numerical implementation of the three-axis algorithm and give reconstruction results for simulated data

Thigh-length compression stockings and DVT after stroke

Controversy exists as to whether neoadjuvant chemotherapy improves survival in patients with invasive bladder cancer, despite randomised controlled trials of more than 3000 patients. We undertook a systematic review and meta-analysis to assess the effect of such treatment on survival in patients with this disease