Social Representations Of Diseases Linked To Climate Change In The Population Of A Slum District: A Case Study From Haiti

Faced with the threats posed by climate change to global public health in the 21st century, the island of Haiti has a duty to inform the population and disseminate knowledge on the health consequences of the phenomenon. The effects of climate change are imminent for the country. In terms of health, the consequences will particularly accentuate the prevalence of endemic diseases, water-borne and infectious pathologies, malnutrition and undernourishment. Also, information on this issue must be widely disseminated through environmental and health education in order to raise awareness in the population and encourage them to modify their daily lifestyles through mitigation and adaptation. Previous work on strategies for popularizing scientific knowledge has shown that culture and poverty constitute obstacles to changes in behavior favoring mitigation and adaptation to climate change. The study of the Social Representations of the populations or social groups concerned makes it possible to discarded them.. From this point of view, this article questions and analyzes the social representations of vector pathologies including Malaria, Dengue, Chikungunya and Zika among the residents of Jalousie, one of the vulnerable neighborhoods of the Metropolitan Region of Port-au-Prince (MRPP - Haiti). This work highlights the link established by the population of Jalousie between climate change and the transmission of the vector-borne diseases mentioned. It does this by considering elements of Haitian popular knowledge likely to build understanding that combines the prevention and symptomatology of these pathologies with knowledge of public hygiene and supernatural phenomena. The survey carried out on a representative sample of 121 residents of the Jalousie district, a slum area of MRPP, shows that vector-borne diseases are assimilated with epidemics and their transmission due to changes in the seasons (temperature change: hot weather, rainy weather in Haiti)

Microplastics and Environmental Health: Assessing Environmental Hazards in Haiti

Microplastics (MP) refer to all plastic particles that are less than 5 mm in size. Over the past decades, several studies have highlighted the impact of microplastics (MP) on living organisms. In addition to being pollutants themselves, these synthetic polymers also act as vectors for the transport of various types of chemicals in natural ecosystems. MP has been ubiquitously detected in a wide range of shapes, polymers, sizes and concentrations in marine water, freshwater, agroecosystems, atmospheric, food and water environments. Drinking water, biota, and other remote places. According to the World Bank, over 80% of the world’s marine litter is plastic and the concentration of litter on Caribbean beaches is often high, with a high presence of single-use plastics and food containers. In its work, the World Health Organization (WHO) suggests an in-depth assessment of microplastics present in the environment and their potential consequences on human health, following the publication of an analysis of the state of research on microplastics in drinking water. It also calls for reducing plastic pollution to protect the environment and reduce human exposure. In Haiti, the bay of Port-au-Prince is the natural receptacle of all the urban effluents generated by human activities in the Metropolitan Zone. This urban wastewater carries household waste, sludge from pit latrines and sewage, industrial wastewater which largely contributes to the pollution of the bay. Furthermore, 1,673,750 tonnes per year of household waste, including 93,730 tonnes of plastic waste, are not collected. What are the environmental dangers represented by the MP contained in those wastes for living organisms in exposed tropical ecosystems? The purpose of this paper is: (i) to do a bibliographical review of the physical and chemical properties, as well as the toxicological profile of MP, (ii) to identify the environmental hazards associated with MP contained in urban waste in the metropolitan area of Port-au-Prince

Contribution to the Diagnostic Study of Intestinal Parasitosis, Haiti

Parasitic intestinal diseases are widespread in the world with a higher prevalence in developing countries. They are generally a serious public health problem in tropical countries. In October 2020, a cross-sectional study was undertaken to determine the prevalence of intestinal parasites in patients visiting Fermathe Hospital in Haiti. Data were collected on stool results with the presence of parasites and we used systematic sampling for further information regarding patients with parasitology problems. A summary field survey was also carried out in the surrounding areas with more cases recorded such as Corail, Calbasse, Fort Jacques, Center / Marché Kenscoff, Doco, and Douret for direct observations of the inventory and voluntary interviews with the residents of the area on hygiene practices. The prevalence of intestinal parasites was 31.26% and the most common species were: Endolimax nana (39.13%), followed by Blastocystis hominis (14%), Blastocystis hominis / Giardia intestinales (12.07%), Entamoeba coli (5.31%), and others like Iodamoeba butschlii, Ascaris lumbricoides or combined parasites were less than 5%. The field survey revealed a strong relationship between parasitosis and drinking water, parasitosis, and place of defecation. Although there are health centers in the area, many people use self-medication or empiric therapy. The study highlights the important causes of gastrointestinal disorders that present themselves in this hospital and confirms intestinal parasitosis as a major public health problem in Haiti

Geographically variable biotic interactions and implications for species ranges

The challenge Understanding how biotic interactions affect species' geographical ranges, biodiversity patterns and ecological responses to environmental change is one of the most pressing challenges in macroecology. Extensive efforts are underway to detect signals of biotic interactions in macroecological data. However, efforts are limited by bias in the taxa and spatial scale for which occurrence data are available and by difficulty in ascribing causality to co-occurrence patterns. Moreover, we are not necessarily looking in the right places; analyses are largely ad hoc, depending on availability of data, rather than focusing on regions, taxa, ecosystems or interaction types where biotic interactions might affect species' geographical ranges most strongly. Unpicking biotic interactions We suggest that macroecology would benefit from the recognition that abiotic conditions alter two key components of biotic interaction strength: frequency and intensity. We outline how and why variation in biotic interaction strength occurs, explore the implications for species' geographical ranges and discuss the challenges inherent in quantifying these effects. In addition, we explore the role of behavioural flexibility in mediating biotic interactions potentially to mitigate impacts of environmental change. New data We argue that macroecology should take advantage of "independent" data on the strength of biotic interactions measured by other disciplines, in order to capture a far wider array of taxa, locations and interaction types than are typically studied in macroecology. Data on biotic interactions are readily available from community, disease, microbial and parasite ecology, evolution, palaeontology, invasion biology and agriculture, but most are yet to be exploited within macroecology. Integrating biotic interaction strength data into macroecology Harmonization of data across interdisciplinary sources, taxa and interaction types could be achieved by breaking down interactions into elements that contribute to frequency and intensity. This would allow quantitative biotic interaction data to be incorporated directly into models of species distributions and macroecological patterns

On the Functional Significance of the P1 and N1 Effects to Illusory Figures in the Notch Mode of Presentation

The processing of Kanizsa figures have classically been studied by flashing the full “pacmen” inducers at stimulus onset. A recent study, however, has shown that it is advantageous to present illusory figures in the “notch” mode of presentation, that is by leaving the round inducers on screen at all times and by removing the inward-oriented notches delineating the illusory figure at stimulus onset. Indeed, using the notch mode of presentation, novel P1and N1 effects have been found when comparing visual potentials (VEPs) evoked by an illusory figure and the VEPs to a control figure whose onset corresponds to the removal of outward-oriented notches, which prevents their integration into one delineated form. In Experiment 1, we replicated these findings, the illusory figure was found to evoke a larger P1 and a smaller N1 than its control. In Experiment 2, real grey squares were placed over the notches so that one condition, that with inward-oriented notches, shows a large central grey square and the other condition, that with outward-oriented notches, shows four unconnected smaller grey squares. In response to these “real” figures, no P1 effect was found but a N1 effect comparable to the one obtained with illusory figures was observed. Taken together, these results suggest that the P1 effect observed with illusory figures is likely specific to the processing of the illusory features of the figures. Conversely, the fact that the N1 effect was also obtained with real figures indicates that this effect may be due to more global processes related to depth segmentation or surface/object perception

Recent progress towards development of effective systemic chemotherapy for the treatment of malignant brain tumors

Systemic chemotherapy has been relatively ineffective in the treatment of malignant brain tumors even though systemic chemotherapy drugs are small molecules that can readily extravasate across the porous blood-brain tumor barrier of malignant brain tumor microvasculature. Small molecule systemic chemotherapy drugs maintain peak blood concentrations for only minutes, and therefore, do not accumulate to therapeutic concentrations within individual brain tumor cells. The physiologic upper limit of pore size in the blood-brain tumor barrier of malignant brain tumor microvasculature is approximately 12 nanometers. Spherical nanoparticles ranging between 7 nm and 10 nm in diameter maintain peak blood concentrations for several hours and are sufficiently smaller than the 12 nm physiologic upper limit of pore size in the blood-brain tumor barrier to accumulate to therapeutic concentrations within individual brain tumor cells. Therefore, nanoparticles bearing chemotherapy that are within the 7 to 10 nm size range can be used to deliver therapeutic concentrations of small molecule chemotherapy drugs across the blood-brain tumor barrier into individual brain tumor cells. The initial therapeutic efficacy of the Gd-G5-doxorubicin dendrimer, an imageable nanoparticle bearing chemotherapy within the 7 to 10 nm size range, has been demonstrated in the orthotopic RG-2 rodent malignant glioma model. Herein I discuss this novel strategy to improve the effectiveness of systemic chemotherapy for the treatment of malignant brain tumors and the therapeutic implications thereof

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

Publisher Copyright: © 2021 The Authors, some rights reserved.Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/ml; in plasma diluted 1:10) of IFN-alpha and/or IFN-omega are found in about 10% of patients with critical COVID-19 (coronavirus disease 2019) pneumonia but not in individuals with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-alpha and/or IFN-omega (100 pg/ml; in 1:10 dilutions of plasma) in 13.6% of 3595 patients with critical COVID-19, including 21% of 374 patients >80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1124 deceased patients (aged 20 days to 99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-beta. We also show, in a sample of 34,159 uninfected individuals from the general population, that auto-Abs neutralizing high concentrations of IFN-alpha and/or IFN-omega are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the proportion of individuals carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 uninfected individuals: 1% of individuals 80 years. By contrast, auto-Abs neutralizing IFN-beta do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over 80s and total fatal COVID-19 cases.Peer reviewe

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

Differential cross section measurements for the production of a W boson in association with jets in proton–proton collisions at √s = 7 TeV

Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (pT) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (HT), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb[superscript −1]. The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the pT distributions of the leading jets at high pT values, the distributions of the HT at high-HT and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio